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  • Review
  • Open Access
2,437 Citations
84,967 Views
42 Pages

2 March 2015

This review describes the most common methods for recovery of chitin from marine organisms. In depth, both enzymatic and chemical treatments for the step of deproteinization are compared, as well as different conditions for demineralization. The cond...

(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
  • Review
  • Open Access
1,919 Citations
104,734 Views
25 Pages

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

  • Ranga Rao Ambati,
  • Siew-Moi Phang,
  • Sarada Ravi and
  • Ravishankar Gokare Aswathanarayana

7 January 2014

There is currently much interest in biological active compounds derived from natural resources, especially compounds that can efficiently act on molecular targets, which are involved in various diseases. Astaxanthin (3,3′-dihydroxy-β, β′-carotene-4,4...

(This article belongs to the Special Issue New Approaches for Activating Silent Biogenetic Gene Clusters in Marine Microorganisms)
  • Review
  • Open Access
1,221 Citations
41,100 Views
31 Pages

Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

  • Randy Chi Fai Cheung,
  • Tzi Bun Ng,
  • Jack Ho Wong and
  • Wai Yee Chan

14 August 2015

Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application. Nevertheless, chemical modification into composites or hydrogels brings to it new fu...

(This article belongs to the Collection Marine Polysaccharides)
  • Article
  • Open Access
1,186 Citations
24,326 Views
18 Pages

Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation?

  • Moacir Fernandes Queiroz,
  • Karoline Rachel Teodosio Melo,
  • Diego Araujo Sabry,
  • Guilherme Lanzi Sassaki and
  • Hugo Alexandre Oliveira Rocha

29 December 2014

Chitosan is widely used in the biomedical field due its chemical and pharmacological properties. However, intake of chitosan results in renal tissue accumulation of chitosan and promotes an increase in calcium excretion. On the other hand, the effect...

(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
  • Review
  • Open Access
1,070 Citations
48,255 Views
70 Pages

Application of Spectroscopic Methods for Structural Analysis of Chitin and Chitosan

  • Jolanta Kumirska,
  • Małgorzata Czerwicka,
  • Zbigniew Kaczyński,
  • Anna Bychowska,
  • Krzysztof Brzozowski,
  • Jorg Thöming and
  • Piotr Stepnowski

29 April 2010

Chitin, the second most important natural polymer in the world, and its N-deacetylated derivative chitosan, have been identified as versatile biopolymers for a broad range of applications in medicine, agriculture and the food industry. Two of the ma...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
1,023 Citations
44,098 Views
28 Pages

Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae

  • Guangling Jiao,
  • Guangli Yu,
  • Junzeng Zhang and
  • H. Stephen Ewart

8 February 2011

Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structura...

(This article belongs to the Special Issue Marine Biomaterials)
  • Review
  • Open Access
868 Citations
24,611 Views
28 Pages

1 April 2015

Chitosan—one of the natural multifunctional polymers—due to its unique and versatile biological properties is regarded as a useful compound in medical and pharmaceutical technology. Recently, considerable research effort has been made in order to dev...

(This article belongs to the Collection Marine Polysaccharides)
  • Review
  • Open Access
778 Citations
39,919 Views
45 Pages

10 October 2011

Sea cucumbers, belonging to the class Holothuroidea, are marine invertebrates, habitually found in the benthic areas and deep seas across the world. They have high commercial value coupled with increasing global production and trade. Sea cucumbers, i...

(This article belongs to the Special Issue Marine Functional Food)
  • Review
  • Open Access
747 Citations
37,880 Views
23 Pages

10 October 2011

The marine carotenoid fucoxanthin can be found in marine brown seaweeds, the macroalgae, and diatoms, the microalgae, and has remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable potential and promising appl...

  • Review
  • Open Access
745 Citations
39,424 Views
25 Pages

24 October 2011

Seaweeds—or marine macroalgae—notably brown seaweeds in the class Phaeophyceae, contain fucoidan. Fucoidan designates a group of certain fucose-containing sulfated polysaccharides (FCSPs) that have a backbone built of (1→3)-linked α-l-fucopyranosyl o...

  • Review
  • Open Access
728 Citations
42,606 Views
27 Pages

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

  • Maria Wiese,
  • Paul M. D’Agostino,
  • Troco K. Mihali,
  • Michelle C. Moffitt and
  • Brett A. Neilan

20 July 2010

Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids, commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of paralytic shellfish poisoning (PSP) and are mostly associated with marine...

(This article belongs to the Special Issue Alkaloid Analogs)
  • Review
  • Open Access
723 Citations
34,844 Views
45 Pages

14 June 2011

The marine environment represents a relatively untapped source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine-based compounds have been identified as having d...

(This article belongs to the Special Issue Marine Functional Food)
  • Review
  • Open Access
714 Citations
34,606 Views
18 Pages

15 June 2011

For photosynthesis, phototrophic organisms necessarily synthesize not only chlorophylls but also carotenoids. Many kinds of carotenoids are found in algae and, recently, taxonomic studies of algae have been developed. In this review, the relationship...

(This article belongs to the Special Issue Marine Carotenoids (Special Issue))
  • Feature Paper
  • Review
  • Open Access
690 Citations
29,662 Views
16 Pages

The Rising Tide of Antimicrobial Resistance in Aquaculture: Sources, Sinks and Solutions

  • Joy E. M. Watts,
  • Harold J. Schreier,
  • Lauma Lanska and
  • Michelle S. Hale

1 June 2017

As the human population increases there is an increasing reliance on aquaculture to supply a safe, reliable, and economic supply of food. Although food production is essential for a healthy population, an increasing threat to global human health is a...

(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology II 2016)
  • Review
  • Open Access
688 Citations
32,313 Views
18 Pages

Structures, Properties and Applications of Alginates

  • Roya Abka-khajouei,
  • Latifa Tounsi,
  • Nasim Shahabi,
  • Anil Kumar Patel,
  • Slim Abdelkafi and
  • Philippe Michaud

29 May 2022

Alginate is a hydrocolloid from algae, specifically brown algae, which is a group that includes many of the seaweeds, like kelps and an extracellular polymer of some bacteria. Sodium alginate is one of the best-known members of the hydrogel group. Th...

(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Macrophytes)
  • Review
  • Open Access
673 Citations
30,777 Views
15 Pages

2 August 2010

Bone contains considerable amounts of minerals and proteins. Hydroxyapatite [Ca10(PO4)6(OH)2] is one of the most stable forms of calcium phosphate and it occurs in bones as major component (60 to 65%), along with other materials including collagen, c...

  • Review
  • Open Access
650 Citations
43,215 Views
20 Pages

Chitosan in Plant Protection

  • Abdelbasset El Hadrami,
  • Lorne R. Adam,
  • Ismail El Hadrami and
  • Fouad Daayf

30 March 2010

Chitin and chitosan are naturally-occurring compounds that have potential in agriculture with regard to controlling plant diseases. These molecules were shown to display toxicity and inhibit fungal growth and development. They were reported to be act...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
641 Citations
29,154 Views
62 Pages

Marine Polysaccharides from Algae with Potential Biomedical Applications

  • Maria Filomena De Jesus Raposo,
  • Alcina Maria Bernardo De Morais and
  • Rui Manuel Santos Costa De Morais

15 May 2015

There is a current tendency towards bioactive natural products with applications in various industries, such as pharmaceutical, biomedical, cosmetics and food. This has put some emphasis in research on marine organisms, including macroalgae and micro...

(This article belongs to the Collection Marine Polysaccharides)
  • Review
  • Open Access
640 Citations
28,471 Views
29 Pages

Microalgae for High-Value Products Towards Human Health and Nutrition

  • Ines Barkia,
  • Nazamid Saari and
  • Schonna R. Manning

24 May 2019

Microalgae represent a potential source of renewable nutrition and there is growing interest in algae-based dietary supplements in the form of whole biomass, e.g., Chlorella and Arthrospira, or purified extracts containing omega-3 fatty acids and car...

(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Microalgae)
  • Review
  • Open Access
586 Citations
29,181 Views
20 Pages

Microalgae as Sources of Carotenoids

  • Ana Catarina Guedes,
  • Helena M. Amaro and
  • Francisco Xavier Malcata

20 April 2011

Marine microalgae constitute a natural source of a variety of drugs for pharmaceutical, food and cosmetic applications—which encompass carotenoids, among others. A growing body of experimental evidence has confirmed that these compounds can play impo...

(This article belongs to the Special Issue Marine Carotenoids (Special Issue))
  • Review
  • Open Access
580 Citations
36,605 Views
38 Pages

Antimicrobial Action of Compounds from Marine Seaweed

  • María José Pérez,
  • Elena Falqué and
  • Herminia Domínguez

9 March 2016

Seaweed produces metabolites aiding in the protection against different environmental stresses. These compounds show antiviral, antiprotozoal, antifungal, and antibacterial properties. Macroalgae can be cultured in high volumes and would represent an...

(This article belongs to the Special Issue Antibacterial Marine Pharmacology)
  • Feature Paper
  • Review
  • Open Access
566 Citations
26,697 Views
41 Pages

25 February 2016

In the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marin...

  • Review
  • Open Access
555 Citations
26,369 Views
31 Pages

2 September 2010

The enormous variety of polysaccharides that can be extracted from marine plants and animal organisms or produced by marine bacteria means that the field of marine polysaccharides is constantly evolving. Recent advances in biological techniques allow...

(This article belongs to the Collection Marine Polysaccharides)
  • Review
  • Open Access
555 Citations
26,237 Views
20 Pages

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

  • Maria Filomena de Jesus Raposo,
  • Rui Manuel Santos Costa De Morais and
  • Alcina Maria Miranda Bernardo de Morais

23 January 2013

Marine microalgae have been used for a long time as food for humans, such as Arthrospira (formerly, Spirulina), and for animals in aquaculture. The biomass of these microalgae and the compounds they produce have been shown to possess several biologic...

  • Review
  • Open Access
540 Citations
28,497 Views
36 Pages

Production of Chitooligosaccharides and Their Potential Applications in Medicine

  • Berit B. Aam,
  • Ellinor B. Heggset,
  • Anne Line Norberg,
  • Morten Sørlie,
  • Kjell M. Vårum and
  • Vincent G. H. Eijsink

27 April 2010

Chitooligosaccharides (CHOS) are homo- or heterooligomers of N-acetylglucosamine and D-glucosamine. CHOS can be produced using chitin or chitosan as a starting material, using enzymatic conversions, chemical methods or combinations thereof. Productio...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
527 Citations
44,630 Views
39 Pages

Fish Waste: From Problem to Valuable Resource

  • Daniela Coppola,
  • Chiara Lauritano,
  • Fortunato Palma Esposito,
  • Gennaro Riccio,
  • Carmen Rizzo and
  • Donatella de Pascale

19 February 2021

Following the growth of the global population and the subsequent rapid increase in urbanization and industrialization, the fisheries and aquaculture production has seen a massive increase driven mainly by the development of fishing technologies. Acco...

(This article belongs to the Special Issue Fishery Discards, Processing Waste and Marine By-Products Valorization in the Era of Zero Waste: From Discovery to Profit)
  • Review
  • Open Access
526 Citations
39,010 Views
36 Pages

17 February 2014

The marine environment harbors a number of macro and micro organisms that have developed unique metabolic abilities to ensure their survival in diverse and hostile habitats, resulting in the biosynthesis of an array of secondary metabolites with spec...

(This article belongs to the Special Issue Selected Papers from the 14th International Symposium on Marine Natural Products)
  • Review
  • Open Access
523 Citations
41,900 Views
31 Pages

Marine Natural Products: A Source of Novel Anticancer Drugs

  • Shaden A. M. Khalifa,
  • Nizar Elias,
  • Mohamed A. Farag,
  • Lei Chen,
  • Aamer Saeed,
  • Mohamed-Elamir F. Hegazy,
  • Moustafa S. Moustafa,
  • Aida Abd El-Wahed,
  • Saleh M. Al-Mousawi and
  • Hesham R. El-Seedi
  • + 6 authors

23 August 2019

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes an...

(This article belongs to the Special Issue Selected Papers from 4th International Symposium on Phytochemicals in Medicine and Food)
  • Review
  • Open Access
522 Citations
29,992 Views
18 Pages

19 April 2010

Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
521 Citations
31,099 Views
31 Pages

10 May 2010

The cyanobacteria or “blue-green algae”, as they are commonly termed, comprise a diverse group of oxygenic photosynthetic bacteria that inhabit a wide range of aquatic and terrestrial environments, and display incredible morphological diversity. Many...

(This article belongs to the Special Issue Algal Toxins)
  • Feature Paper
  • Review
  • Open Access
504 Citations
31,341 Views
47 Pages

Seaweed Phenolics: From Extraction to Applications

  • João Cotas,
  • Adriana Leandro,
  • Pedro Monteiro,
  • Diana Pacheco,
  • Artur Figueirinha,
  • Ana M. M. Gonçalves,
  • Gabriela Jorge da Silva and
  • Leonel Pereira

24 July 2020

Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation an...

(This article belongs to the Special Issue Marine Phenolics: Extraction and Purification, Identification, Characterization and Applications)
  • Review
  • Open Access
504 Citations
26,970 Views
18 Pages

20 March 2019

The marine acid polysaccharide fucoidan has attracted attention from both the food and pharmaceutical industries due to its promising therapeutic effects. Fucoidan is a polysaccharide that mainly consists of L-fucose and sulphate groups. Its excellen...

(This article belongs to the Collection Marine Polysaccharides)
  • Review
  • Open Access
484 Citations
25,717 Views
26 Pages

Chitosan Modification and Pharmaceutical/Biomedical Applications

  • Jiali Zhang,
  • Wenshui Xia,
  • Ping Liu,
  • Qinyuan Cheng,
  • Talba Tahi,
  • Wenxiu Gu and
  • Bo Li

25 June 2010

Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
478 Citations
24,043 Views
16 Pages

Biosorption: An Interplay between Marine Algae and Potentially Toxic Elements—A Review

  • Muhammad Bilal,
  • Tahir Rasheed,
  • Juan Eduardo Sosa-Hernández,
  • Ali Raza,
  • Faran Nabeel and
  • Hafiz M. N. Iqbal

19 February 2018

In recent decades, environmental pollution has emerged as a core issue, around the globe, rendering it of fundamental concern to eco-toxicologists, environmental biologists, eco-chemists, pathologists, and researchers from other fields. The dissoluti...

  • Review
  • Open Access
461 Citations
25,220 Views
26 Pages

9 January 2015

Chitosan is considered to be one of the most promising and applicable materials in adsorption applications. The existence of amino and hydroxyl groups in its molecules contributes to many possible adsorption interactions between chitosan and pollutan...

(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan)
  • Review
  • Open Access
456 Citations
21,649 Views
31 Pages

12 January 2018

Carotenoids are natural pigments that play pivotal roles in many physiological functions. The characteristics of carotenoids, their effects on health, and the cosmetic benefits of their usage have been under investigation for a long time; however, mo...

(This article belongs to the Special Issue Marine Carotenoids)
  • Feature Paper
  • Review
  • Open Access
454 Citations
34,225 Views
27 Pages

Seaweeds as a Functional Ingredient for a Healthy Diet

  • Rocío Peñalver,
  • José M. Lorenzo,
  • Gaspar Ros,
  • Ryszard Amarowicz,
  • Mirian Pateiro and
  • Gema Nieto

5 June 2020

Seaweeds have been used since ancient times as food, mainly by Asian countries, while in Western countries, their main application has been as gelling agents and colloids for the food, pharmaceuticals, and the cosmetic industry. Seaweeds are a good s...

  • Article
  • Open Access
444 Citations
19,049 Views
18 Pages

11 December 2015

This study aimed at investigating the potential of microalgae species grown on industrial waste water as a new source of natural antioxidants. Six microalgae from different classes, including Phaeodactylum sp. (Bacillariophyceae), Nannochloropsis sp....

(This article belongs to the Special Issue Green Chemistry Approach to Marine Products)
  • Review
  • Open Access
432 Citations
23,748 Views
21 Pages

Microalgal Carotenoids: A Review of Production, Current Markets, Regulations, and Future Direction

  • Lucie Novoveská,
  • Michael E. Ross,
  • Michele S. Stanley,
  • Rémi Pradelles,
  • Virginie Wasiolek and
  • Jean-François Sassi

13 November 2019

Microalgae produce a variety of compounds that are beneficial to human and animal health. Among these compounds are carotenoids, which are microalgal pigments with unique antioxidant and coloring properties. The objective of this review is to evaluat...

(This article belongs to the Special Issue Marine Antioxidant)
  • Review
  • Open Access
430 Citations
28,677 Views
16 Pages

Impact of Microalgae-Bacteria Interactions on the Production of Algal Biomass and Associated Compounds

  • Juan Luis Fuentes,
  • Inés Garbayo,
  • María Cuaresma,
  • Zaida Montero,
  • Manuel González-del-Valle and
  • Carlos Vílchez

19 May 2016

A greater insight on the control of the interactions between microalgae and other microorganisms, particularly bacteria, should be useful for enhancing the efficiency of microalgal biomass production and associated valuable compounds. Little attentio...

  • Review
  • Open Access
415 Citations
26,987 Views
16 Pages

13 December 2017

Marine algae have attracted a great deal of interest as excellent sources of nutrients. Polysaccharides are the main components in marine algae, hence a great deal of attention has been directed at isolation and characterization of marine algae polys...

(This article belongs to the Special Issue Marine Oligosaccharides and Polysaccharides)
  • Review
  • Open Access
408 Citations
34,617 Views
52 Pages

Marine Drugs from Sponge-Microbe Association—A Review

  • Tresa Remya A. Thomas,
  • Devanand P. Kavlekar and
  • Ponnapakkam A. LokaBharathi

22 April 2010

The subject of this review is the biodiversity of marine sponges and associated microbes which have been reported to produce therapeutically important compounds, along with the contextual information on their geographic distribution. Class Demospongi...

(This article belongs to the Special Issue Bioactive Compound from Marine Sponges)
  • Review
  • Open Access
401 Citations
25,882 Views
21 Pages

21 February 2010

Due to the fact that some individuals are allergic to crustaceans, the presumed relationship between allergy and the presence of chitin in crustaceans has been investigated. In vivo, chitin is part of complex structures with other organic and inorgan...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
398 Citations
26,370 Views
21 Pages

Marine Origin Collagens and Its Potential Applications

  • Tiago H. Silva,
  • Joana Moreira-Silva,
  • Ana L. P. Marques,
  • Alberta Domingues,
  • Yves Bayon and
  • Rui L. Reis

5 December 2014

Collagens are the most abundant high molecular weight proteins in both invertebrate and vertebrate organisms, including mammals, and possess mainly a structural role, existing different types according with their specific organization in distinct tis...

(This article belongs to the Special Issue Marine Biomaterials)
  • Review
  • Open Access
393 Citations
26,475 Views
25 Pages

Chitin Research Revisited

  • Feisal Khoushab and
  • Montarop Yamabhai

28 June 2010

Two centuries after the discovery of chitin, it is widely accepted that this biopolymer is an important biomaterial in many aspects. Numerous studies on chitin have focused on its biomedical applications. In this review, various aspects of chitin res...

(This article belongs to the Special Issue Marine Chitin and Chitosan)
  • Review
  • Open Access
392 Citations
23,866 Views
24 Pages

10 May 2021

Alginates are naturally occurring polysaccharides extracted from brown marine algae and bacteria. Being biocompatible, biodegradable, non-toxic and easy to gel, alginates can be processed into various forms, such as hydrogels, microspheres, fibers an...

(This article belongs to the Special Issue Nanoparticles from Marine Organisms and Their Biological Activity)
  • Review
  • Open Access
392 Citations
22,660 Views
38 Pages

Marine Peptides: Bioactivities and Applications

  • Randy Chi Fai Cheung,
  • Tzi Bun Ng and
  • Jack Ho Wong

29 June 2015

Peptides are important bioactive natural products which are present in many marine species. These marine peptides have high potential nutraceutical and medicinal values because of their broad spectra of bioactivities. Their antimicrobial, antiviral,...

(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
  • Review
  • Open Access
392 Citations
29,972 Views
27 Pages

Prebiotics from Marine Macroalgae for Human and Animal Health Applications

  • Laurie O’Sullivan,
  • Brian Murphy,
  • Peter McLoughlin,
  • Patrick Duggan,
  • Peadar G. Lawlor,
  • Helen Hughes and
  • Gillian E. Gardiner

1 July 2010

The marine environment is an untapped source of bioactive compounds. Specifically, marine macroalgae (seaweeds) are rich in polysaccharides that could potentially be exploited as prebiotic functional ingredients for both human and animal health appli...

(This article belongs to the Collection Marine Polysaccharides)
  • Article
  • Open Access
388 Citations
29,140 Views
22 Pages

11 August 2010

Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell [1], synergistic effects of elevated temperature and CO2-induced OA on energy metabolism will narrow the therm...

(This article belongs to the Special Issue Metabolomic Approaches to Marine Organisms)
  • Review
  • Open Access
387 Citations
22,179 Views
25 Pages

28 May 2019

Bioactive compounds, e.g., protein, polyunsaturated fatty acids, carotenoids, vitamins and minerals, found in commercial form of microalgal biomass (e.g., powder, flour, liquid, oil, tablet, or capsule forms) may play important roles in functional fo...

(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Microalgae)
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Mar. Drugs - ISSN 1660-3397