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Open AccessReview

Marine Natural Products: A Source of Novel Anticancer Drugs

Clinical Research Centre, Karolinska University Hospital, Novum, 14157 Huddinge, Stockholm, Sweden
Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden
Department of Laboratory Medicine, Faculty of Medicine, University of Kalamoon, P.O. Box 222 Dayr Atiyah, Syria
Pharmacognosy Department, College of Pharmacy, Cairo University, Kasr el Aini St., P.B. 11562 Cairo, Egypt
Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, 11835 New Cairo, Egypt
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Department of Chemitry, Quaid-i-Azam University, Islamabad 45320, Pakistan
Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, 55128 Mainz, Germany
Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, 12622 Giza, Egypt
Department of Chemistry, Faculty of Science, University of Kuwait, 13060 Safat, Kuwait
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi 75270, Pakistan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan
Department of Pharmaceutical Biology/Pharmacognosy, Institute of Pharmacy, University of HalleWittenberg, Hoher Weg 8, DE 06120 Halle (Saale), Germany
Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Box 574, SE-75 123 Uppsala, Sweden
Department of Chemistry, Faculty of Science, Menoufia University, 32512 Shebin El-Koom, Egypt
College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Al-Rayan Research and Innovation Center, Al-Rayan Colleges, 42541 Medina, Saudi Arabia
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 491;
Received: 27 June 2019 / Revised: 11 August 2019 / Accepted: 16 August 2019 / Published: 23 August 2019
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed. View Full-Text
Keywords: marine; plants; microorganism; antitumor; anticancer; cytotoxic; clinical trials; drugs marine; plants; microorganism; antitumor; anticancer; cytotoxic; clinical trials; drugs
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Khalifa, S.A.M.; Elias, N.; Farag, M.A.; Chen, L.; Saeed, A.; Hegazy, M.-E.F.; Moustafa, M.S.; Abd El-Wahed, A.; Al-Mousawi, S.M.; Musharraf, S.G.; Chang, F.-R.; Iwasaki, A.; Suenaga, K.; Alajlani, M.; Göransson, U.; El-Seedi, H.R. Marine Natural Products: A Source of Novel Anticancer Drugs. Mar. Drugs 2019, 17, 491.

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