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  • Review
  • Open Access
30 Citations
50,808 Views
16 Pages

Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging

  • Azizur Rahman,
  • Rameesha Rehmani,
  • Diana Gabby Pirvu,
  • Siqi Maggie Huang,
  • Simron Puri and
  • Mateo Arcos

30 March 2024

Aging is closely associated with collagen degradation, impacting the structure and strength of the muscles, joints, bones, and skin. The continuous aging of the skin is a natural process that is influenced by extrinsic factors such as UV exposure, di...

  • Review
  • Open Access
59 Citations
41,205 Views
20 Pages

24 January 2024

The processing of fishery resources results in the production of a growing quantity of byproducts, including heads, skins, viscera, intestines, frames, and fillet cutoffs. These byproducts are either wasted or utilized for the production of low-value...

  • Review
  • Open Access
120 Citations
32,493 Views
156 Pages

Astaxanthin: Past, Present, and Future

  • Yasuhiro Nishida,
  • Pernilla Christina Berg,
  • Behnaz Shakersain,
  • Karen Hecht,
  • Akiko Takikawa,
  • Ruohan Tao,
  • Yumeka Kakuta,
  • Chiasa Uragami,
  • Hideki Hashimoto and
  • Takashi Maoka
  • + 1 author

28 September 2023

Astaxanthin (AX), a lipid-soluble pigment belonging to the xanthophyll carotenoids family, has recently garnered significant attention due to its unique physical properties, biochemical attributes, and physiological effects. Originally recognized pri...

  • Review
  • Open Access
116 Citations
23,930 Views
66 Pages

Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation

  • Susana P. Gaudêncio,
  • Engin Bayram,
  • Lada Lukić Bilela,
  • Mercedes Cueto,
  • Ana R. Díaz-Marrero,
  • Berat Z. Haznedaroglu,
  • Carlos Jimenez,
  • Manolis Mandalakis,
  • Florbela Pereira and
  • Deniz Tasdemir
  • + 1 author

19 May 2023

Natural Products (NP) are essential for the discovery of novel drugs and products for numerous biotechnological applications. The NP discovery process is expensive and time-consuming, having as major hurdles dereplication (early identification of kno...

  • Review
  • Open Access
225 Citations
19,776 Views
23 Pages

Overview and Challenges of Large-Scale Cultivation of Photosynthetic Microalgae and Cyanobacteria

  • Lucie Novoveská,
  • Søren Laurentius Nielsen,
  • Orhan Tufan Eroldoğan,
  • Berat Zeki Haznedaroglu,
  • Baruch Rinkevich,
  • Stefano Fazi,
  • Johan Robbens,
  • Marlen Vasquez and
  • Hjörleifur Einarsson

10 August 2023

Microalgae and cyanobacteria are diverse groups of organisms with great potential to benefit societies across the world. These organisms are currently used in food, feed, pharmaceutical and cosmetic industries. In addition, a variety of novel compoun...

  • Review
  • Open Access
50 Citations
18,779 Views
39 Pages

28 March 2024

Shrimp processing generates substantial waste, which is rich in valuable components such as polysaccharides, proteins, carotenoids, and fatty acids. This review provides a comprehensive overview of the valorization of shrimp waste, mainly shrimp shel...

  • Review
  • Open Access
36 Citations
18,372 Views
23 Pages

18 May 2023

Angiogenesis and metastasis represent two challenging targets to combat cancer development in the later stages of its progression. Numerous studies have indicated the important role of natural products in blocking tumor angiogenesis signaling pathway...

  • Review
  • Open Access
21 Citations
18,328 Views
31 Pages

28 April 2025

Collagen is a structural protein found in the connective tissues of terrestrial and marine animals. Its diverse functional attributes span its applications in several industries, including food, supplements, cosmetics, and pharmaceuticals. Typically...

  • Review
  • Open Access
104 Citations
17,731 Views
20 Pages

Extraction, Modification and Biomedical Application of Agarose Hydrogels: A Review

  • Feng Jiang,
  • Xin-Wei Xu,
  • Fu-Quan Chen,
  • Hui-Fen Weng,
  • Jun Chen,
  • Yi Ru,
  • Qiong Xiao and
  • An-Feng Xiao

14 May 2023

Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitiv...

  • Review
  • Open Access
55 Citations
17,352 Views
67 Pages

Bioactive Compounds of Marine Algae and Their Potential Health and Nutraceutical Applications: A Review

  • Emin Cadar,
  • Antoanela Popescu,
  • Ana-Maria-Laura Dragan,
  • Ana-Maria Pesterau,
  • Carolina Pascale,
  • Valentina Anuta,
  • Irina Prasacu,
  • Bruno Stefan Velescu,
  • Cezar Laurentiu Tomescu and
  • Ana-Maria Ionescu
  • + 2 authors

31 March 2025

Currently, marine algae are still an under-exploited natural bioresource of bioactive compounds. Seaweeds represent a sustainable source for obtaining bioactive compounds that can be useful for the fabrication of new active products with biomedical b...

  • Review
  • Open Access
32 Citations
17,250 Views
26 Pages

Fish Skin Mucus Extracts: An Underexplored Source of Antimicrobial Agents

  • Rocío Díaz-Puertas,
  • Mikolaj Adamek,
  • Ricardo Mallavia and
  • Alberto Falco

7 June 2023

The slow discovery of new antibiotics combined with the alarming emergence of antibiotic-resistant bacteria underscores the need for alternative treatments. In this regard, fish skin mucus has been demonstrated to contain a diverse array of bioactive...

  • Review
  • Open Access
60 Citations
15,059 Views
18 Pages

The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy

  • Atiporn Therdyothin,
  • Nacharin Phiphopthatsanee and
  • Masoud Isanejad

13 July 2023

Sarcopenia, a progressive disease characterized by a decline in muscle strength, quality, and mass, affects aging population worldwide, leading to increased morbidity and mortality. Besides resistance exercise, various nutritional strategies, includi...

  • Review
  • Open Access
50 Citations
14,901 Views
16 Pages

Dietary Astaxanthin: A Promising Antioxidant and Anti-Inflammatory Agent for Brain Aging and Adult Neurogenesis

  • Alessandro Medoro,
  • Sergio Davinelli,
  • Luigi Milella,
  • Bradley J. Willcox,
  • Richard C. Allsopp,
  • Giovanni Scapagnini and
  • Donald Craig Willcox

16 December 2023

Decreased adult neurogenesis, or the gradual depletion of neural stem cells in adult neurogenic niches, is considered a hallmark of brain aging. This review provides a comprehensive overview of the intricate relationship between aging, adult neurogen...

  • Review
  • Open Access
14 Citations
13,801 Views
46 Pages

Unraveling the Omega-3 Puzzle: Navigating Challenges and Innovations for Bone Health and Healthy Aging

  • Zayana Ali,
  • Mohammad Ahmed Al-Ghouti,
  • Haissam Abou-Saleh and
  • Md Mizanur Rahman

28 September 2024

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs, n-3 PUFAs), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), are essential polyunsaturated fats primarily obtained from fatty fish and plant-based...

  • Review
  • Open Access
17 Citations
13,728 Views
32 Pages

26 September 2024

Since the 2005 discovery of the first enzyme capable of depolymerizing polyethylene terephthalate (PET), an aromatic polyester once thought to be enzymatically inert, extensive research has been undertaken to identify and engineer new biocatalysts fo...

  • Review
  • Open Access
41 Citations
13,032 Views
29 Pages

Fucoidan’s Molecular Targets: A Comprehensive Review of Its Unique and Multiple Targets Accounting for Promising Bioactivities Supported by In Silico Studies

  • Ahmed Zayed,
  • Dalal A. Al-Saedi,
  • Emmanuel Ofosu Mensah,
  • Osman Nabayire Kanwugu,
  • Parise Adadi and
  • Roland Ulber

30 December 2023

Fucoidan is a class of multifunctional polysaccharides derived from marine organisms. Its unique and diversified physicochemical and chemical properties have qualified them for potential and promising pharmacological uses in human diseases, including...

  • Review
  • Open Access
23 Citations
12,789 Views
36 Pages

A Comparative Review of Alternative Fucoidan Extraction Techniques from Seaweed

  • Matthew Chadwick,
  • Loïc G. Carvalho,
  • Carlos Vanegas and
  • Simone Dimartino

7 January 2025

Fucoidan is a sulfated polysaccharide found in brown seaweed. Due to its reported biological activities, including antiviral, antibacterial and anti-inflammatory activities, it has garnered significant attention for potential biomedical applications....

  • Review
  • Open Access
11 Citations
12,728 Views
27 Pages

Tetrodotoxin: The State-of-the-Art Progress in Characterization, Detection, Biosynthesis, and Transport Enrichment

  • Xinxin Zhang,
  • Kun Qiao,
  • Ruimin Cui,
  • Min Xu,
  • Shuilin Cai,
  • Qilin Huang and
  • Zhiyu Liu

26 November 2024

Tetrodotoxin (TTX) is a neurotoxin that binds to sodium channels and blocks sodium conduction. Importantly, TTX has been increasingly detected in edible aquatic organisms. Because of this and the lack of specific antidotes, TTX poisoning is now a maj...

  • Review
  • Open Access
47 Citations
12,685 Views
28 Pages

Ulva Seaweed-Derived Ulvan: A Promising Marine Polysaccharide as a Sustainable Resource for Biomaterial Design

  • Rizfi Fariz Pari,
  • Uju Uju,
  • Safrina Dyah Hardiningtyas,
  • Wahyu Ramadhan,
  • Rie Wakabayashi,
  • Masahiro Goto and
  • Noriho Kamiya

24 January 2025

Green seaweed is currently underused compared with other major seaweed types. Many scientists have reported applications of the green seaweed Ulva in various fields in recent years, which makes it a candidate for biomass production in industrial bior...

  • Review
  • Open Access
69 Citations
12,628 Views
41 Pages

26 May 2023

Polyphenols are compounds found in various plants and foods, known for their antioxidant and anti-inflammatory properties. Recently, researchers have been exploring the therapeutic potential of marine polyphenols and other minor nutrients that are fo...

  • Review
  • Open Access
10 Citations
12,479 Views
41 Pages

Omega-3 Fatty Acids for the Treatment of Bipolar Disorder Symptoms: A Narrative Review of the Current Clinical Evidence

  • Evmorfia Psara,
  • Sousana K. Papadopoulou,
  • Maria Mentzelou,
  • Gavriela Voulgaridou,
  • Theophanis Vorvolakos,
  • Thomas Apostolou and
  • Constantinos Giaginis

15 February 2025

Background: Bipolar disorder is a chronic mental disease that is characterized by depressive and manic episodes. Antipsychotics and mood stabilizers are known therapies that work, but their restrictions and disadvantages resulted in the need for comp...

  • Review
  • Open Access
69 Citations
12,443 Views
45 Pages

Microalgae, Seaweeds and Aquatic Bacteria, Archaea, and Yeasts: Sources of Carotenoids with Potential Antioxidant and Anti-Inflammatory Health-Promoting Actions in the Sustainability Era

  • Paula Mapelli-Brahm,
  • Patricia Gómez-Villegas,
  • Mariana Lourdes Gonda,
  • Antonio León-Vaz,
  • Rosa León,
  • Jennifer Mildenberger,
  • Céline Rebours,
  • Verónica Saravia,
  • Silvana Vero and
  • Antonio J. Meléndez-Martínez
  • + 1 author

1 June 2023

Carotenoids are a large group of health-promoting compounds used in many industrial sectors, such as foods, feeds, pharmaceuticals, cosmetics, nutraceuticals, and colorants. Considering the global population growth and environmental challenges, it is...

  • Review
  • Open Access
9 Citations
12,043 Views
18 Pages

30 April 2024

This paper aims to provide an in-depth review of the specific outcomes associated with omega-3 polyunsaturated fatty acids (PUFAs), focusing on their purported effects on post-surgical complications in trauma patients. A comprehensive investigation o...

  • Review
  • Open Access
16 Citations
11,896 Views
25 Pages

Cardiovascular Diseases and Marine Oils: A Focus on Omega-3 Polyunsaturated Fatty Acids and Polar Lipids

  • Cliodhna Caffrey,
  • Anna Leamy,
  • Ellen O’Sullivan,
  • Ioannis Zabetakis,
  • Ronan Lordan and
  • Constantina Nasopoulou

24 October 2023

Cardiovascular diseases (CVD) remain the leading cause of death across the globe, hence, establishing strategies to counteract CVD are imperative to reduce mortality and the burden on health systems. Dietary modification is an effective primary preve...

  • Article
  • Open Access
5 Citations
11,621 Views
21 Pages

26 September 2024

Collagen is a popular nutricosmetic ingredient in food supplements due to its anti-aging and other positive effects on the skin. Due to its widespread use and the lack of regulation in this area, appropriate quality control is required to ensure effi...

  • Review
  • Open Access
22 Citations
11,448 Views
29 Pages

Red Seaweed (Rhodophyta) Phycocolloids: A Road from the Species to the Industry Application

  • Madalena Mendes,
  • João Cotas,
  • Diana Pacheco,
  • Kay Ihle,
  • Alina Hillinger,
  • Miguel Cascais,
  • João Carlos Marques,
  • Leonel Pereira and
  • Ana M. M. Gonçalves

25 September 2024

Seaweed polysaccharides are versatile both in their functions in seaweed physiology and in their practical applications in society. However, their content and quality vary greatly. This review discusses the main factors that influence the yield and q...

  • Review
  • Open Access
7 Citations
11,097 Views
47 Pages

Transition-Metal-Catalyzed Transformations for the Synthesis of Marine Drugs

  • Lucía G. Parte,
  • Sergio Fernández,
  • Eva Sandonís,
  • Javier Guerra and
  • Enol López

29 May 2024

Transition metal catalysis has contributed to the discovery of novel methodologies and the preparation of natural products, as well as new chances to increase the chemical space in drug discovery programs. In the case of marine drugs, this strategy h...

  • Review
  • Open Access
51 Citations
11,004 Views
24 Pages

Algae Food Products as a Healthcare Solution

  • Joana O. Tavares,
  • João Cotas,
  • Ana Valado and
  • Leonel Pereira

5 November 2023

Diseases such as obesity; cardiovascular diseases such as high blood pressure, myocardial infarction and stroke; digestive diseases such as celiac disease; certain types of cancer and osteoporosis are related to food. On the other hand, as the world&...

  • Review
  • Open Access
37 Citations
10,989 Views
22 Pages

29 July 2024

The increase in antimicrobial resistance (AMR) in microorganisms is a significant global health concern. Various factors contribute to AMR, including alterations in cell membrane permeability, increased efflux pump activity, enzymatic modification or...

  • Review
  • Open Access
15 Citations
10,949 Views
24 Pages

The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review

  • Chunhao Gao,
  • Nengyun Gong,
  • Fangtian Chen,
  • Shiran Hu,
  • Qingxin Zhou and
  • Xiang Gao

27 December 2024

Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in s...

  • Review
  • Open Access
26 Citations
10,941 Views
46 Pages

Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies

  • Doralyn S. Dalisay,
  • Chuckcris P. Tenebro,
  • Edna M. Sabido,
  • Angelica Faith L. Suarez,
  • Melissa June V. Paderog,
  • Rikka Reyes-Salarda and
  • Jonel P. Saludes

28 February 2024

Extensive research has been conducted on the isolation and study of bioactive compounds derived from marine sources. Several natural products have demonstrated potential as inducers of apoptosis and are currently under investigation in clinical trial...

  • Review
  • Open Access
21 Citations
10,629 Views
29 Pages

17 January 2024

Macroalgae, particularly red seaweeds, have attracted significant attention due to their economic and health benefits. Chondrus, a red algae genus, despite its economic importance, seems to be undervalued. Among all its species, Chondrus crispus has...

  • Feature Paper
  • Article
  • Open Access
21 Citations
10,415 Views
32 Pages

29 June 2023

Marine macroalgae, such as Padina boergesenii, are gaining recognition in the cosmetics industry as valuable sources of natural bioactive compounds. This study aimed to investigate the biochemical profile of P. boergesenii and evaluate its potential...

  • Article
  • Open Access
33 Citations
10,410 Views
19 Pages

Advanced Extraction Techniques and Physicochemical Properties of Carrageenan from a Novel Kappaphycus alvarezii Cultivar

  • Madalena Mendes,
  • João Cotas,
  • Irene B. Gutiérrez,
  • Ana M. M. Gonçalves,
  • Alan T. Critchley,
  • Lourie Ann R. Hinaloc,
  • Michael Y. Roleda and
  • Leonel Pereira

31 October 2024

Carrageenans are valuable marine polysaccharides derived from specific species of red seaweed (Rhodophyta) widely used as thickening and stabilizing agents across various industries. Kappaphycus alvarezii, predominantly cultivated in tropical countri...

  • Review
  • Open Access
13 Citations
10,339 Views
81 Pages

A Comprehensive Review on the Valorization of Bioactives from Marine Animal By-Products for Health-Promoting, Biofunctional Cosmetics

  • Sofia Neonilli A. Papadopoulou,
  • Theodora Adamantidi,
  • Dimitrios Kranas,
  • Paschalis Cholidis,
  • Chryssa Anastasiadou and
  • Alexandros Tsoupras

26 July 2025

In recent decades, there has been a marked surge in the development of marine-by-product-derived ingredients for cosmetic applications, driven by the increasing demand for natural, sustainable, and high-performance formulations. Marine animal by-prod...

  • Review
  • Open Access
27 Citations
10,173 Views
68 Pages

Cyanobacteria: A Promising Source of Antifungal Metabolites

  • Samuel Cavalcante do Amaral,
  • Luciana Pereira Xavier,
  • Vítor Vasconcelos and
  • Agenor Valadares Santos

14 June 2023

Cyanobacteria are a rich source of secondary metabolites, and they have received a great deal of attention due to their applicability in different industrial sectors. Some of these substances are known for their notorious ability to inhibit fungal gr...

  • Review
  • Open Access
48 Citations
9,988 Views
19 Pages

24 January 2024

In light of the escalating global energy crisis, microalgae have emerged as highly promising producers of biofuel and high-value products. Among these microalgae, Nannochloropsis has received significant attention due to its capacity to generate not...

  • Review
  • Open Access
9 Citations
9,872 Views
21 Pages

Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs

  • Laura F. Peña,
  • Paula González-Andrés,
  • Lucía G. Parte,
  • Raúl Escribano,
  • Javier Guerra,
  • Asunción Barbero and
  • Enol López

13 July 2023

In this perspective, we showcase the benefits of continuous flow chemistry and photochemistry and how these valuable tools have contributed to the synthesis of organic scaffolds from the marine environment. These technologies have not only facilitate...

  • Article
  • Open Access
55 Citations
9,803 Views
23 Pages

28 April 2023

Exploration of seaweeds to unravel their bioactive metabolites from the perspective of wider applications gained substantial importance. The present study was performed to investigate the total phenolic, flavonoid, tannin content, antioxidant activit...

  • Review
  • Open Access
9 Citations
9,530 Views
27 Pages

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

  • Edoardo Andrea Cutolo,
  • Roberto Caferri,
  • Rosanna Campitiello and
  • Maurizio Cutolo

7 December 2023

Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention is an important component in the treatment of RA to mitigate oxidative stress, a major path...

  • Review
  • Open Access
26 Citations
9,525 Views
58 Pages

6 March 2024

Indole is a versatile pharmacophore widely distributed in bioactive natural products. This privileged scaffold has been found in a variety of molecules isolated from marine organisms such as algae and sponges. Among these, indole alkaloids represent...

  • Review
  • Open Access
13 Citations
9,468 Views
22 Pages

Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review

  • Alba Ortigosa-Palomo,
  • Francisco Quiñonero,
  • Raul Ortiz,
  • Francisco Sarabia,
  • Jose Prados and
  • Consolación Melguizo

23 February 2024

Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient...

  • Review
  • Open Access
36 Citations
9,375 Views
33 Pages

Current and Expected Trends for the Marine Chitin/Chitosan and Collagen Value Chains

  • Helena Vieira,
  • Gonçalo Moura Lestre,
  • Runar Gjerp Solstad,
  • Ana Elisa Cabral,
  • Anabela Botelho,
  • Carlos Helbig,
  • Daniela Coppola,
  • Donatella de Pascale,
  • Johan Robbens and
  • Ana I. Lillebø
  • + 10 authors

23 November 2023

Chitin/chitosan and collagen are two of the most important bioactive compounds, with applications in the pharmaceutical, veterinary, nutraceutical, cosmetic, biomaterials, and other industries. When extracted from non-edible parts of fish and shellfi...

  • Article
  • Open Access
28 Citations
9,327 Views
12 Pages

The Influence of Various Crosslinking Conditions of EDC/NHS on the Properties of Fish Collagen Film

  • Alina Sionkowska,
  • Karolina Kulka-Kamińska,
  • Patrycja Brudzyńska,
  • Katarzyna Lewandowska and
  • Łukasz Piwowarski

25 April 2024

The process of crosslinking improves the physicochemical properties of biopolymer-based composites, making them valuable for biomedical applications. EDC/NHS-crosslinked collagen materials have a significant potential for tissue engineering applicati...

  • Review
  • Open Access
21 Citations
9,309 Views
34 Pages

Review of Marine Cyanobacteria and the Aspects Related to Their Roles: Chemical, Biological Properties, Nitrogen Fixation and Climate Change

  • Hesham R. El-Seedi,
  • Mohamed F. El-Mallah,
  • Nermeen Yosri,
  • Muaaz Alajlani,
  • Chao Zhao,
  • Muhammad A. Mehmood,
  • Ming Du,
  • Hammad Ullah,
  • Maria Daglia and
  • Qiyang Shou
  • + 2 authors

3 August 2023

Marine cyanobacteria are an ancient group of photosynthetic microbes dating back to 3.5 million years ago. They are prolific producers of bioactive secondary metabolites. Over millions of years, natural selection has optimized their metabolites to po...

  • Article
  • Open Access
3 Citations
9,255 Views
17 Pages

5 March 2024

The worldwide prevalence of obesity impacts more than 600 million adults. Successfully managing weight is effective in reducing the risk of chronic diseases, but sustaining long-term weight loss remains a challenge. Although there are supplements bas...

  • Article
  • Open Access
11 Citations
9,109 Views
18 Pages

29 August 2023

Fish-derived collagen hydrolysate (CH) has shown promise in improving hair and skin health. Therefore, this study sought to comprehensively assess the effects of CH extracted from Mozambique tilapia (Oreochromis mossambicus) scales on hair and skin u...

  • Review
  • Open Access
56 Citations
9,038 Views
18 Pages

The Structure, Functions and Potential Medicinal Effects of Chlorophylls Derived from Microalgae

  • Danni Sun,
  • Songlin Wu,
  • Xiaohui Li,
  • Baosheng Ge,
  • Chengxu Zhou,
  • Xiaojun Yan,
  • Roger Ruan and
  • Pengfei Cheng

27 January 2024

Microalgae are considered to be natural producers of bioactive pigments, with the production of pigments from microalgae being a sustainable and economical strategy that promises to alleviate growing demand. Chlorophyll, as the main pigment of photos...

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Mar. Drugs - ISSN 1660-3397