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Mar. Drugs, Volume 17, Issue 8 (August 2019)
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Cover Story (view full-size image) Chitin is a polysaccharide produced as waste stream during the processing of crustaceans. It can be [...] Read more. Chitin is a polysaccharide produced as waste stream during the processing of crustaceans. It can be converted into chitosan and partially acetylated chitosan oligomers (COS), which have useful properties, including antimicrobial and anti-inflammatory activities. The chemical production of COS is environmentally hazardous and the degree of polymerization and acetylation cannot be controlled. By using enzymes like chitinases, chitosanases and chitin deacetylases, better-defined COS products can be obtained. This article presents the most recent chemical and enzymatic approaches for the production of COS, and puts forward the design-of-experiments approach for process optimization as a mean to enhance product yield and characteristics. View this paper.