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Open AccessArticle

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca2+-Modulating Activity Isolated from Sea Urchin Eggs

1
Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, Napoli 80131, Italy
2
ISBE Italy/SYSBIO Centro di System Biology, Università di Milano-Bicocca, piazza delle Scienze 2, Milano 20126, Italy
3
Consiglio Nazionale delle Ricerche, Dipartimento di Scienze Biomediche, Istituto di Neuroscienze (Sezione di Padova), viale Giuseppe Colombo 3, Padova 35131, Italy
4
Dipartimento di Scienze Biomediche, Università degli Studi di Padova, via Ugo Bassi 58/b, Padova 35131, Italy
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Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, via Sergio Pansini 5, Napoli 80131, Italy
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Istituto Veneto di Medicina Molecolare, via Orus 2, Padova 35129, Italy
7
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia, 26, Napoli 80126, Italy
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 476; https://doi.org/10.3390/md17080476
Received: 23 July 2019 / Revised: 9 August 2019 / Accepted: 15 August 2019 / Published: 17 August 2019
Herein, we report on the synthesis of a small set of linear precursors of an inosine analogue of cyclic ADP-ribose (cADPR), a second messenger involved in Ca2+ mobilization from ryanodine receptor stores firstly isolated from sea urchin eggs extracts. The synthesized compounds were obtained starting from inosine and are characterized by an N1-alkyl chain replacing the “northern” ribose and a phosphate group attached at the end of the N1-alkyl chain and/or 5′-sugar positions. Preliminary Ca2+ mobilization assays, performed on differentiated C2C12 cells, are reported as well. View Full-Text
Keywords: cADPR; ryanodine receptors; neuroblastoma; caffeine; calcium mobilization; phosphorylation; C2C12 cells; IP3 cADPR; ryanodine receptors; neuroblastoma; caffeine; calcium mobilization; phosphorylation; C2C12 cells; IP3
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D’Errico, S.; Basso, E.; Falanga, A.P.; Marzano, M.; Pozzan, T.; Piccialli, V.; Piccialli, G.; Oliviero, G.; Borbone, N. New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca2+-Modulating Activity Isolated from Sea Urchin Eggs. Mar. Drugs 2019, 17, 476.

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