The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools
Abstract
:1. Introduction
2. Results
2.1. Theoretical Model
2.2. Biophysical Experiments
2.3. QCM Analysis of Collagen Fragments from Cnidaria
2.4. Molecules Constituting the Nematocyst Membrane
3. Discussions
Physical Properties of Nematocysts and Their Potential Targets
4. Materials and Methods
4.1. Tumor Cells: Neuroblastoma Cells
4.2. Hydra Culture
4.3. Proteoglycans, Algae Polysaccharides and Collagen Fragments from Marine Organisms and Bacteria
4.4. Electron Microscopy
4.5. Measurements with a QCM System
4.6. Molecular Modelling
4.7. Preparation of FSNP-Sia
4.7.1. Synthesis of Fluorescent Silica Nanoparticles (FSNP)
4.7.2. Synthesis of Perfluorophenyl Azide (PFPA)-functionalized Fluorescent Silica Nanoparticles (FSNP-PFPA)
4.7.3. Synthesis of Sialic Acid-Conjugated FSNP (FSNP-Sia)
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Δν, Hz | 0 | 300 | 250 | 300 | −300 | 300 | 0 | −300 | −100 | 150 |
T, °C | 15 | 30 | 45 | 40 | 15 | 45 | 30 | 15 | 15 | 15 |
t, sec | >0 | >1000 | >1500 | >2000 | >2500 | >4000 | >4500 | >5000 | >5500 | >6000 |
Δν, Hz | 0 | 700 | 300 | 100 | 700 | 300 | 100 | 700 | 300 | 100 |
T, °C | 15 | 37 | 25 | 15 | 37 | 25 | 15 | 37 | 25 | 15 |
t, sec | 0 | 1500 | 2000 | 2500 | 3500 | 4000 | 4500 | 6000 | 6500 | 7000 |
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Zhang, R.; Jin, L.; Zhang, N.; Petridis, A.K.; Eckert, T.; Scheiner-Bobis, G.; Bergmann, M.; Scheidig, A.; Schauer, R.; Yan, M.; et al. The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools. Mar. Drugs 2019, 17, 469. https://doi.org/10.3390/md17080469
Zhang R, Jin L, Zhang N, Petridis AK, Eckert T, Scheiner-Bobis G, Bergmann M, Scheidig A, Schauer R, Yan M, et al. The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools. Marine Drugs. 2019; 17(8):469. https://doi.org/10.3390/md17080469
Chicago/Turabian StyleZhang, Ruiyan, Li Jin, Ning Zhang, Athanasios K. Petridis, Thomas Eckert, Georgios Scheiner-Bobis, Martin Bergmann, Axel Scheidig, Roland Schauer, Mingdi Yan, and et al. 2019. "The Sialic Acid-Dependent Nematocyst Discharge Process in Relation to Its Physical-Chemical Properties Is a Role Model for Nanomedical Diagnostic and Therapeutic Tools" Marine Drugs 17, no. 8: 469. https://doi.org/10.3390/md17080469