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Open AccessArticle

Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 483;
Received: 29 July 2019 / Revised: 13 August 2019 / Accepted: 18 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Enzyme Inhibitor from Marine Organisms)
Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (511) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 14 were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of 1 was deduced by comparison of ECD data with that of a known structure. The stereostructures of 24 were further confirmed by single-crystal X-ray diffraction. Compounds 1, 8 and 9 exhibited significant α-glucosidase inhibitory activity with IC50 values of 17.1, 26.7 and 15.7 μM, respectively. Compounds 1, 4, 6 and 8 showed antioxidant activity by scavenging DPPH· with EC50 values ranging from 16.3 to 85.8 μM. View Full-Text
Keywords: secondary metabolites; Mycosphaerella sp.; asperchalasine; α-glucosidase secondary metabolites; Mycosphaerella sp.; asperchalasine; α-glucosidase
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MDPI and ACS Style

Qiu, P.; Liu, Z.; Chen, Y.; Cai, R.; Chen, G.; She, Z. Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01. Mar. Drugs 2019, 17, 483.

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