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Open AccessArticle

Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01

1
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China
2
State Key Laboratory of Applied Microbiology Southern China, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China
3
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China
4
South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 483; https://doi.org/10.3390/md17080483
Received: 29 July 2019 / Revised: 13 August 2019 / Accepted: 18 August 2019 / Published: 20 August 2019
(This article belongs to the Special Issue Enzyme Inhibitor from Marine Organisms)
Four new metabolites, asperchalasine I (1), dibefurin B (2) and two epicoccine derivatives (3 and 4), together with seven known compounds (511) were isolated from a mangrove fungus Mycosphaerella sp. SYSU-DZG01. The structures of compounds 14 were established from extensive spectroscopic data and HRESIMS analysis. The absolute configuration of 1 was deduced by comparison of ECD data with that of a known structure. The stereostructures of 24 were further confirmed by single-crystal X-ray diffraction. Compounds 1, 8 and 9 exhibited significant α-glucosidase inhibitory activity with IC50 values of 17.1, 26.7 and 15.7 μM, respectively. Compounds 1, 4, 6 and 8 showed antioxidant activity by scavenging DPPH· with EC50 values ranging from 16.3 to 85.8 μM. View Full-Text
Keywords: secondary metabolites; Mycosphaerella sp.; asperchalasine; α-glucosidase secondary metabolites; Mycosphaerella sp.; asperchalasine; α-glucosidase
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MDPI and ACS Style

Qiu, P.; Liu, Z.; Chen, Y.; Cai, R.; Chen, G.; She, Z. Secondary Metabolites with α-Glucosidase Inhibitory Activity from the Mangrove Fungus Mycosphaerella sp. SYSU-DZG01. Mar. Drugs 2019, 17, 483.

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