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Open AccessFeature PaperArticle

Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi

1
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
2
School of chemistry and Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 475; https://doi.org/10.3390/md17080475
Received: 31 July 2019 / Revised: 13 August 2019 / Accepted: 14 August 2019 / Published: 16 August 2019
Chemical analysis of a cultivation of an Australian Mugil mullet gastrointestinal tract (GIT) derived fungus, Scopulariopsis sp. CMB-F458, yielded the known lipodepsipeptides scopularides A (1) and B (2). A comparative global natural product social (GNPS) molecular networking analysis of ×63 co-isolated fungi, detected two additional fungi producing new scopularides, with Beauveria sp. CMB-F585 yielding scopularides C–G (37) and Scopulariopsis sp. CMB-F115 yielding scopularide H (8). Structures inclusive of absolute configurations were assigned by detailed spectroscopic and C3 Marfey’s analysis, together with X-ray analyses of 3 and 8, and biosynthetic considerations. Scopularides A–H (18) did not exhibit significant growth inhibitory activity against a selection of Gram positive (+ve) and negative (−ve) bacteria, a fungus, or a panel of three human carcinoma cell lines. View Full-Text
Keywords: Scopulariopsis sp.; Beauveria sp.; lipodepsipeptides; scopularides; GNPS; marine fungal biodiscovery Scopulariopsis sp.; Beauveria sp.; lipodepsipeptides; scopularides; GNPS; marine fungal biodiscovery
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MDPI and ACS Style

Elbanna, A.H.; Khalil, Z.G.; Bernhardt, P.V.; Capon, R.J. Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi. Mar. Drugs 2019, 17, 475.

AMA Style

Elbanna AH, Khalil ZG, Bernhardt PV, Capon RJ. Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi. Marine Drugs. 2019; 17(8):475.

Chicago/Turabian Style

Elbanna, Ahmed H.; Khalil, Zeinab G.; Bernhardt, Paul V.; Capon, Robert J. 2019. "Scopularides Revisited: Molecular Networking Guided Exploration of Lipodepsipeptides in Australian Marine Fish Gastrointestinal Tract-Derived Fungi" Mar. Drugs 17, no. 8: 475.

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