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Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11

1
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 446; https://doi.org/10.3390/md17080446
Received: 28 May 2019 / Revised: 18 July 2019 / Accepted: 26 July 2019 / Published: 28 July 2019
Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide (1) and 10,11,16,17-tetrahydrobislongiquinolide (2), as well as four known analogues, bislongiquinolide (3), 16,17-dihydrobislongiquinolide (4), sohirnone A (5), and 2′,3′-dihydrosorbicillin (6). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds. View Full-Text
Keywords: genome mining; global regulator; LaeA; overexpression; Penicillium dipodomyis; sorbicillinoids genome mining; global regulator; LaeA; overexpression; Penicillium dipodomyis; sorbicillinoids
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Yu, J.; Han, H.; Zhang, X.; Ma, C.; Sun, C.; Che, Q.; Gu, Q.; Zhu, T.; Zhang, G.; Li, D. Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11. Mar. Drugs 2019, 17, 446.

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