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Marine Collagen as A Promising Biomaterial for Biomedical Applications

Department of Anatomy, School of Medicine, Pusan National University, Yangsan 50612, Korea
Department of Pharmacology, School of Medicine, Ajou University, Suwon 16499, Korea
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 467;
Received: 19 July 2019 / Revised: 6 August 2019 / Accepted: 7 August 2019 / Published: 10 August 2019
(This article belongs to the Special Issue 3D Cell Culture Based on Marine Resources)
PDF [1968 KB, uploaded 10 August 2019]


This review focuses on the expanding role of marine collagen (MC)-based scaffolds for biomedical applications. A scaffold—a three-dimensional (3D) structure fabricated from biomaterials—is a key supporting element for cell attachment, growth, and maintenance in 3D cell culture and tissue engineering. The mechanical and biological properties of the scaffolds influence cell morphology, behavior, and function. MC, collagen derived from marine organisms, offers advantages over mammalian collagen due to its biocompatibility, biodegradability, easy extractability, water solubility, safety, low immunogenicity, and low production costs. In recent years, the use of MC as an increasingly valuable scaffold biomaterial has drawn considerable attention from biomedical researchers. The characteristics, isolation, physical, and biochemical properties of MC are discussed as an understanding of MC in optimizing the subsequent modification and the chemistries behind important tissue engineering applications. The latest technologies behind scaffold processing are assessed and the biomedical applications of MC and MC-based scaffolds, including tissue engineering and regeneration, wound dressing, drug delivery, and therapeutic approach for diseases, especially those associated with metabolic disturbances such as obesity and diabetes, are discussed. Despite all the challenges, MC holds great promise as a biomaterial for developing medical products and therapeutics. View Full-Text
Keywords: marine collagen; scaffolds; 3D cell culture; tissue engineering; tissue regeneration marine collagen; scaffolds; 3D cell culture; tissue engineering; tissue regeneration

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Lim, Y.-S.; Ok, Y.-J.; Hwang, S.-Y.; Kwak, J.-Y.; Yoon, S. Marine Collagen as A Promising Biomaterial for Biomedical Applications. Mar. Drugs 2019, 17, 467.

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