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Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota

1
Innovation Application Institute, Zhejiang Ocean University, Zhoushan 316022, China
2
Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China
3
College of Life Sciences, Qingdao University, Qingdao 266071, China
4
Zhejiang Marine Development Research Institute, Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 455; https://doi.org/10.3390/md17080455
Received: 14 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
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Abstract

This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health. View Full-Text
Keywords: sea cucumber; long-chain bases; obesity; gut microbiota; lipopolysaccharide; short chain fatty acids sea cucumber; long-chain bases; obesity; gut microbiota; lipopolysaccharide; short chain fatty acids
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Hu, S.; Xu, Y.; Gao, X.; Li, S.; Jiang, W.; Liu, Y.; Su, L.; Yang, H. Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota. Mar. Drugs 2019, 17, 455.

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