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Article

Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota

1
Innovation Application Institute, Zhejiang Ocean University, Zhoushan 316022, China
2
Wenzhou Academy of Agricultural Sciences, Wenzhou 325006, China
3
College of Life Sciences, Qingdao University, Qingdao 266071, China
4
Zhejiang Marine Development Research Institute, Zhoushan 316021, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(8), 455; https://doi.org/10.3390/md17080455
Received: 14 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
This study evaluated the effects of long-chain bases from sea cucumber (SC-LCBs) on modulation of the gut microbiota and inhibition of obesity in high fat diet-fed mice. Results showed that SC-LCBs exerted significant antiobese effects, which were associated with the inhibition of hyperglycemia and lipid accumulation. SC-LCBs also regulated serum adipocytokines toward to normal levels. SC-LCBs caused significant decreases in Firmicutes, Actinobacteria phylum, and obesity-related bacteria (Desulfovibro, Bifidobacterium, Romboutsia etc. genus). SC-LCBs also elevated Bacteroidetes, Proteobacteria, Verrucomicrobia phylum, and short chain fatty acids (SCFAs)-producing bacteria (Bacteroides, Lactobacillus, Lachnospiraceae_NK4A136_group etc. genus). Moreover, serum and fecal lipoplysaccharide (LPS) concentrations and its dependent toll-line receptor 4 pathway were inhibited by SC-LCBs treatment. SC-LCBs caused increases in fecal SCFAs and their mediated G-protein-coupled receptors proteins. These suggest that SC-LCBs alleviate obesity by altering gut microbiota. Thus, it sought to indicate that SC-LCBs can be developed as food supplement for the obesity control and the human gut health. View Full-Text
Keywords: sea cucumber; long-chain bases; obesity; gut microbiota; lipopolysaccharide; short chain fatty acids sea cucumber; long-chain bases; obesity; gut microbiota; lipopolysaccharide; short chain fatty acids
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MDPI and ACS Style

Hu, S.; Xu, Y.; Gao, X.; Li, S.; Jiang, W.; Liu, Y.; Su, L.; Yang, H. Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota. Mar. Drugs 2019, 17, 455. https://doi.org/10.3390/md17080455

AMA Style

Hu S, Xu Y, Gao X, Li S, Jiang W, Liu Y, Su L, Yang H. Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota. Marine Drugs. 2019; 17(8):455. https://doi.org/10.3390/md17080455

Chicago/Turabian Style

Hu, Shiwei, Yangli Xu, Xiang Gao, Shijie Li, Wei Jiang, Yu Liu, Laijin Su, and Huicheng Yang. 2019. "Long-Chain Bases from Sea Cucumber Alleviate Obesity by Modulating Gut Microbiota" Marine Drugs 17, no. 8: 455. https://doi.org/10.3390/md17080455

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