Allogeneic islet transplantation has become an effective treatment option for severe Type 1 diabetes with intractable impaired awareness due to hypoglycemic events. Although current immunosuppressive protocols effectively prevent the acute rejection...
Autoreactive T cells are thought to orchestrate the onset and progression of autoimmune diabetes. Key cognate antigens of these diabetogenic T cells include hybrid insulin peptides, formed by the fusion of insulin fragments to cleavage products of ot...
Multiphase machines allow enhancing the performance of wind energy conversion systems from the point of view of reliability and efficiency. The enhanced robustness has been traditionally achieved with a mandatory post-fault control reconfiguration. N...
Five-phase induction motors have the advantages of high reliability and strong fault-tolerant performance, so it’s open circuit fault model and fault-tolerant control strategy are widely studied. Based on the normal operation of the five-phase...
Oral tolerance is the active absence of response to food allergens, which involves complex mechanisms in the gut-associated lymphoid tissue. Food allergy results from the disruption of such tolerance or the absence of its establishment in the first p...
Until very recently, the fault tolerance in multiphase electric drives could only be achieved after fault localization and a subsequent modification of the control scheme. This scenario was profoundly shaken with the appearance of the natural fault t...
This paper introduces a new solution for the speed and current sensor fault-tolerant direct field-oriented control of induction motor drives. Two self-adjusting observers derived from a modified current-based model reference adaptive system (CB-MRAS)...
The safety of direct torque control (DTC) is strongly reliant on the accuracy and consistency of sensor measurement data. A fault-tolerant control paradigm based on a dual-torque model is proposed in this study. By introducing the vector product and...
In this paper, a fault-tolerant three-phase induction drive based on field-oriented control is studied, and an analytical approach is proposed to elucidate the limitations of FOC in flux-torque regulation from the controller perspective. With an open...
Designing electrical drives resistant to the failures of chosen sensors has recently become increasingly popular due to the possibility of their use in fault-tolerant control (FTC) systems including drives for electric vehicles. In this article, a vi...
Inductive power transfer (IPT) has been widely adopted as an efficient and convenient charging manner for both static and in-motion EVs. In this paper, a new hybrid topology is presented to improve the coupling tolerance under pad misalignment. The d...
Nowadays, induction machines (IMs) are widely used in industrial and transportation applications (electric or hybrid ground vehicle or aerospace actuators) thanks to their significant advantages in comparison to other technologies. Indeed, there is a...
The inductive power transfer (IPT) system for electric vehicle (EV) charging has acquired more research interest in its different facets. However, the misalignment tolerance between the charging coil (installed in the ground) and pick-up coil (mounte...
The growth of using wind energy on a large scale increases the demand for wind energy conversion machines (WECMs), among these converters, the doubly-fed induction generator (DFIG) is the favorite choice. However, DFIG is very sensitive to wind speed...
The developed torque with minimum oscillations is one of the difficulties faced when designing drive systems. High ripple torque contents result in fluctuations and acoustic noise that impact the life of a drive system. A multiphase machine can offer...
Fault Tolerant Control (FTC) systems are crucial in industry to ensure safe and reliable operation, especially of motor drives. This paper proposes the use of multiple controllers for a FTC system of an induction motor drive, selected based on a swit...
Liver-targeting nanoparticles have emerged as a promising platform for the induction of immune tolerance by taking advantage of the liver’s unique tolerogenic properties and nanoparticles’ physicochemical flexibility. Such an approach pro...
This paper presents an efficient and fast fault-tolerant control scheme for a bidirectional Z-source inverter (BiZSI)-fed induction-motor drive system for vehicular applications. The proposed strategy aims for the fault detection, localization and di...
The clinical success of solid organ transplantation is still limited by the insufficiency of immunosuppressive regimens to control chronic rejection and late graft loss. Moreover, serious side effects caused by chronic immunosuppressive treatment inc...
In the speed-sensorless vector control of induction motors (IMs), the speed estimation accuracy suffers from the deteriorated current measurement caused by the current sensor faults, such as open circuit in one phase, DC bias, and odd harmonics. In t...
Multiphase electric motors in cooperation with power semiconductor converters belong to the future of electric drives. This is because of their better properties compared to three-phase motors, such as better fault tolerance. How a multiphase motor w...
Tropomyosin (TM) is an important crustacean (Scylla paramamosain) allergen. This study aimed to assess Maillard-reacted TM (TM-G) induction of allergenic responses with cell and mouse models. We analyzed the difference of sensitization and the abilit...
Fault-tolerant control (FTC) solutions are increasingly being used in modern drive systems with AC motors. Such systems provide a higher degree of security and solutions that allow the on-line detection and localization of failures, as well as the sw...
In the modern induction motor (IM) drive system, the fault-tolerant control (FTC) solution is becoming more and more popular. This approach significantly increases the security of the system. To choose the best control strategy, fault detection (FD)...
The installed energy production capacity of wind turbines is growing intensely on a global scale, making the reliability of wind turbine subsystems of greater significance. However, many faults like Inter-Turn Short-Circuit (ITSC) may affect the turb...
Low temperatures seriously depress germination and seedling establishment in wheat and it is of great significance to explore approaches to improve wheat tolerance to low temperatures. In this study, the effects of seed pre-soaking and parental treat...
Background: Solid organ transplantation is hindered by immune-mediated chronic graft dysfunction and the side effects of immunosuppressive therapy. Regulatory T cells (Tregs) are crucial for modulating immune responses post-transplantation; however,...
Oral tolerance has been defined as the specific suppression of immune responses to an antigen by prior oral administration of the antigen. It has been thought to serve to suppress food allergy. Previous studies have shown that dendritic cells (DCs) a...
Food allergies have become a major healthcare concern, hence preventive efforts to ensure oral tolerance induction to newly introduced antigens are particularly relevant. Given that transforming growth factor-β (TGF-β) plays a key role in i...
In addition to antimicrobial resistance, bacteria contain other mechanisms to survive antibiotic exposure such as tolerance, defined as the ability to slow metabolism by the extension of the lag phase without altering antimicrobial susceptibility. In...
Background: Cancer-induced immunosuppression is antigen-specific rather than systemic and the mechanisms for the antigen specificity are incompletely understood. Here we explore the option that tumor-associated antigens (TAAs) may be transferred to a...
This paper proposes a fault detection and the improved fault-tolerant control for an open fault in the five-phase inverter driving system. The five-phase induction machine has a merit of fault-tolerant control due to its increased number of phases. T...
Oral tolerance is defined as a specific suppression of cellular and humoral immune responses to a particular antigen through prior oral administration of an antigen. It has unique immunological importance since it is a natural and continuous event dr...
Accelerating the induction of tolerance to cow’s milk (CM) reduces the burden of cow’s milk allergy (CMA). In this randomised controlled intervention study, we aimed to investigate the tolerance induction of a novel heated cow milk protei...
Background/Objectives: The administration of human monoclonal antibodies (mAb) in preclinical pharmacokinetics and toxicology studies often triggers an immune response, leading to the formation of anti-drug antibodies (ADA). To mitigate this effect,...
Autoimmune diseases such as multiple sclerosis (MS) are characterized by a loss of self-tolerance, driven by diminished regulatory T cell (Treg) function and elevated Th1/Th17 responses. Existing therapies broadly suppress the immune system without c...
Liver transplant (LT) recipients require life-long immunosuppression (IS) therapy to preserve allograft function. The risks of chronic IS include an increased frequency of malignancy, infection, renal impairment, and other systemic toxicities. Despit...
This paper presents a novel inductive link for wireless power transfer (WPT) system of electric vehicles (EVs). The WPT technology uses an alternating magnetic field to transfer electric power through space. The use of the WPT technology for charging...
Background: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of insulin-producing β-cells. While conventional insulin therapy manages hyperglycemia, it fails to halt autoimmunity. Oral immunotherapy targeting autoanti...
The development of new organic nitrates is still relevant due to the clinical limitations of their use. Tetrahydrofurfuryl nitrate (NTHF) is a new organic nitrate obtained through a synthetic route of sugarcane. The aim of this research was to invest...
The fault tolerance proprieties of multiphase induction machines make them candidate technologies for future electrified transport systems. Indeed, the use of multiphase drives is primarily recommended for their redundancy, which allows them to handl...
Human clinical trials have shown that a specific partially hydrolyzed 100% whey-based infant formula (pHF-W) reduces AD risk in the first yeast of life. Meta-analyses with a specific pHF-W (pHF-W1) confirm a protective effect while other meta-analyse...
Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by the destruction of insulin-producing pancreatic β-cells by autoreactive T cells. Current treatments, including insulin replacement therapy and various immunotherapies, often modu...
Pemphigus vulgaris (PV) is a potentially lethal autoimmune bullous skin disorder caused by IgG autoantibodies against desmoglein 3 (Dsg3) and Dsg1. During the last three decades, high-dose intravenous immunoglobulins (IVIgs) have been applied as an e...
In an underground inductive power transfer (IPT), it is inevitable to produce the phenomenon of misalignment between the transmitter and the receiver, which will reduce the output current, voltage and output efficiency of the whole IPT system. Aiming...
As the phase current sensors and rotor speed/position sensor are prone to fail in the late stage of an offshore doubly-fed induction generator based wind turbine (DFIG-WT), this paper investigates a hybrid fault-tolerant strategy for a severe sensor...
The use of compensation networks increases the power transfer capability of inductive power transfer (IPT) systems in the battery charging process of electric vehicles (EVs). Among the proposed topologies, the Series-Series (SS) and the LCC networks...
Mucopolysaccharidosis IVA (MPS IVA) is caused by the accumulation of undegraded glycosaminoglycans due to the deficiency of the N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme. MPS IVA manifests as progressive systemic skeletal dysplasia. Ge...
The risk of potential yield losses due to heat waves and other challenging weather phenomena is globally increasing. So far, plant producers have only had limited possibilities to adapt their cultivation methods. Plants exposed to (any form of) stres...
Automated guided vehicles (AGVs) operating in uneven environments are typically designed with an elevated chassis to enhance obstacle-crossing. In inductive power transfer (IPT) systems for such AGVs, a long transmission distance along with limited i...
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