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215 Results Found

  • Feature Paper
  • Article
  • Open Access
862 Views
16 Pages

3 October 2024

For 2≤t≤m, let Zm denote the group of integers modulo m, and let TCm(t) denote the t-uniform hypergraph with vertex set Zm and hyperedge set {{i,i+1,i+2,…,i+t−1}:i∈Zm}. Any hypergraph isomorphic to TCm(t) is a t-uniform tight...

  • Article
  • Open Access
2 Citations
3,261 Views
21 Pages

Host–Pathogen Interactions of Chlamydia trachomatis in Porcine Oviduct Epithelial Cells

  • Amanda F. Amaral,
  • Bryan E. McQueen,
  • Kimberly Bellingham-Johnstun,
  • Taylor B. Poston,
  • Toni Darville,
  • Uma M. Nagarajan,
  • Caroline Laplante and
  • Tobias Käser

1 October 2021

Chlamydia trachomatis (Ct) causes the most prevalent bacterial sexually transmitted disease leading to ectopic pregnancy and infertility. Swine not only have many similarities to humans, but they are also susceptible to Ct. Despite these benefits and...

  • Article
  • Open Access
11 Citations
3,175 Views
16 Pages

Integrated Profiles of Transcriptome and mRNA m6A Modification Reveal the Intestinal Cytotoxicity of Aflatoxin B1 on HCT116 Cells

  • Yajiao Wu,
  • Wenqiang Bao,
  • Jinjin Ren,
  • Chutao Li,
  • Mengting Chen,
  • Dongcheng Zhang and
  • An Zhu

27 December 2022

Aflatoxin B1 (AFB1) is widely prevalent in foods and animal feeds and is one of the most toxic and carcinogenic aflatoxin subtypes. Existing studies have proved that the intestine is targeted by AFB1, and adverse organic effects have been observed. T...

  • Article
  • Open Access
5 Citations
2,434 Views
23 Pages

Exploring the Mechanism of Pulse Hydraulic Fracturing in Tight Reservoirs

  • Zhihui Ren,
  • Suling Wang,
  • Kangxing Dong,
  • Weiqiang Yu and
  • Lu Lu

10 December 2023

Pulse hydraulic fracturing is capable of creating intricate seam networks for improved reservoir recovery, but its dynamic damage mechanism remains unclear, limiting its scientific guidance for fracturing construction. This study combined the statist...

  • Article
  • Open Access
20 Citations
3,236 Views
15 Pages

16 October 2020

Low-porosity tight rocks are widely used as building and engineering materials. The freeze–thaw cycle is a common weathering effect that damages building materials in cold climates. Tight rocks are generally supposed to be highly frost-resistan...

  • Article
  • Open Access
6 Citations
2,244 Views
18 Pages

Genome-Wide Association Study for Abscission Failure of Fruit Pericarps (Stick-Tights) in Wild Macadamia Germplasm

  • Jasmine Nunn,
  • Joanne De Faveri,
  • Katie O’Connor,
  • Mobashwer Alam,
  • Craig Hardner,
  • Olufemi Akinsanmi and
  • Bruce Topp

14 August 2022

Macadamia pericarps that fail to abscise (‘stick-tights’) are an important trait to select against in breeding as they can harbour pests and diseases. Traditional macadamia breeding cycles are lengthy and expensive due to long juvenilitie...

  • Article
  • Open Access
2 Citations
2,265 Views
15 Pages

9 December 2024

CO2 huff-n-puff is regarded as an effective method to improve the recovery of low permeability and tight oil reservoirs. To understand the impact of CO2 huff-n-puff on crude oil mobilization in tight reservoirs with different fracture scales, this st...

  • Article
  • Open Access
377 Views
18 Pages

Impact of Autoclaving on the Material Properties of Vat-Photopolymerization-Produced Components Intended for Bioprocess Engineering

  • Lauri Hoffmann,
  • Bruno Gallace,
  • Clara Herr,
  • Kai Scherer,
  • Adrian Huwer,
  • Percy Kampeis,
  • Roland Ulber and
  • Michael Wahl

15 October 2025

Due to a lack of investigated materials for the additive manufacturing of multi-use functional parts in bioprocess engineering, this study aimed to evaluate the influence of multiple autoclaving cycles on the properties of a heat-resistant material (...

  • Article
  • Open Access
1 Citations
1,566 Views
19 Pages

12 November 2023

Although tight oil reservoirs have abundant resources, their recovery efficiency is generally low. In recent years, CO2 injection huff-n-puff has become an effective method for improving oil recovery on the basis of depleted production of volume-frac...

  • Article
  • Open Access
8 Citations
3,107 Views
29 Pages

Hygrothermal Assessment of Insulation Systems for Internal Insulation of Solid Masonry Walls under Various Conditions

  • Ritvars Freimanis,
  • Ruta Vanaga,
  • Viesturs Balodis,
  • Zigmars Zundans and
  • Andra Blumberga

3 October 2023

Energy efficiency renovation of building stock is an essential aspect of the climate change mitigation strategies in many countries. A large proportion of building stock is historical buildings. For this building stock, developing technology for safe...

  • Article
  • Open Access
47 Citations
4,596 Views
14 Pages

Waterflooding Huff-n-puff in Tight Oil Cores Using Online Nuclear Magnetic Resonance

  • Ting Chen,
  • Zhengming Yang,
  • Yunhong Ding,
  • Yutian Luo,
  • Dan Qi,
  • Wei Lin and
  • Xinli Zhao

12 June 2018

Given the difficulty in developing waterflooding in tight oil reservoirs, using waterflooding huff-n-puff is an effective method to improve oil recovery. Online nuclear magnetic resonance (NMR) can detect the change in internal oil and water during t...

  • Article
  • Open Access
1 Citations
1,048 Views
16 Pages

Design of CO2 Huff-n-Puff Parameters for Fractured Tight Oil Reservoirs Considering Geomechanical Effects

  • Yicun Xia,
  • Xiankang Xin,
  • Gaoming Yu,
  • Yanxin Wang,
  • Zexuan Lei and
  • Liyuan Zhang

6 December 2024

CO2-Huff-n-Puff (CO2-HnP) is an effective method for improving oil recovery in conventional reservoirs and has been widely applied to tight oil reservoirs. Recently, there has been a series of studies published on the oil increase mechanism and huff-...

  • Article
  • Open Access
53 Citations
6,975 Views
18 Pages

Air tightness is a challenging task for 3D-printed components, especially for fused filament fabrication (FFF), due to inherent issues, related to the layer-by-layer fabrication method. On the other hand, the capability of 3D print airtight cavities...

  • Review
  • Open Access
26 Citations
6,912 Views
17 Pages

Maintaining a robust epithelial barrier requires the accumulation of tight junction proteins, LSR/angulin-1 and tricellulin, at the tricellular contacts. Alterations in the localization of these proteins temporarily cause epithelial barrier dysfuncti...

  • Article
  • Open Access
6 Citations
3,485 Views
15 Pages

Loss of Blood-Brain Barrier Integrity in an In Vitro Model Subjected to Intermittent Hypoxia: Is Reversion Possible with a HIF-1α Pathway Inhibitor?

  • Anne Cloé Voirin,
  • Morgane Chatard,
  • Anne Briançon-Marjollet,
  • Jean Louis Pepin,
  • Nathalie Perek and
  • Frederic Roche

Several sleep-related breathing disorders provoke repeated hypoxia stresses, which potentially lead to neurological diseases, such as cognitive impairment. Nevertheless, consequences of repeated intermittent hypoxia on the blood-brain barrier (BBB) a...

  • Article
  • Open Access
13 Citations
2,107 Views
26 Pages

Integrity Experiments for Geological Carbon Storage (GCS) in Depleted Hydrocarbon Reservoirs: Wellbore Components under Cyclic CO2 Injection Conditions

  • Taofik H. Nassan,
  • Carsten Freese,
  • Dirk Baganz,
  • Hakan Alkan,
  • Oleksandr Burachok,
  • Jonas Solbakken,
  • Nematollah Zamani,
  • Morten Gunnar Aarra and
  • Mohd Amro

19 June 2024

Integrity of wellbores and near wellbore processes are crucial issues in geological carbon storage (GCS) projects as they both define the confinement and injectivity of CO2. For the proper confinement of CO2, any flow of CO2 along the wellbore trajec...

  • Article
  • Open Access
4 Citations
3,818 Views
18 Pages

Functional Analysis of Membrane-Associated Scaffolding Tight Junction (TJ) Proteins in Tumorigenic Characteristics of B16-F10 Mouse Melanoma Cells

  • Eun-Ji Ko,
  • Do-Ye Kim,
  • Min-Hye Kim,
  • Hyojin An,
  • Jeongtae Kim,
  • Jee-Yeong Jeong,
  • Kyoung Seob Song and
  • Hee-Jae Cha

Tight junction (TJ) proteins (Tjps), Tjp1 and Tjp2, are tight junction-associated scaffold proteins that bind to the transmembrane proteins of tight junctions and the underlying cytoskeleton. In this study, we first analyzed the tumorigenic character...

  • Article
  • Open Access
10 Citations
2,586 Views
16 Pages

1 September 2022

The ureolytic bacteria and nutrients were immobilized in the artificial functional carrier (AFC) and the self-healing cement mortar, based on the AFC-encapsulated bacteria, was prepared for this paper. The crack self-healing effect of mortars with an...

  • Article
  • Open Access
8 Citations
2,305 Views
27 Pages

Modified Split Mandrel Method and Equipment to Improve the Fatigue Performance of Structural Components with Fastener Holes

  • Jordan Maximov,
  • Galya Duncheva,
  • Angel Anchev,
  • Vladimir Dunchev and
  • Petya Daskalova

3 March 2024

Fastener holes are among the most common natural stress concentrators in metal structures. The life cycles of various structural elements, such as those in aircraft structures, automobiles, and rail-end bolt joints, are limited by fatigue damage arou...

  • Article
  • Open Access
1,199 Views
23 Pages

7 January 2025

Curve squeal is a highly disturbing tonal noise produced by railway vehicles on tight curves, primarily attributed to lateral sliding at the wheel–rail interface. An essential step to estimate curve squeal noise levels is to determine the nonli...

  • Article
  • Open Access
20 Citations
7,887 Views
14 Pages

16 October 2012

The reduction of electricity use for heating and domestic hot water in cold climates can be achieved by: (1) reducing the heating loads through the improvement of the thermal performance of house envelopes, and (2) using solar energy through a reside...

  • Review
  • Open Access
71 Citations
16,194 Views
23 Pages

22 December 2016

Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is...

  • Proceeding Paper
  • Open Access
2,611 Views
4 Pages

Multilayer Micromechanics Process with Thick Functional Layers (EPyC40)

  • Latifa Louriki,
  • Peter Staffeld,
  • Arnd Kaelberer and
  • Thomas Otto

The EPyC process (Epi-Poly-Cycle) (by Robert Bosch GmbH) opens up unique opportunities for manufacturing complex 3D MEMS structures having high effectiveness in small space. EPyC40 is an EPyC process with up to 40 μm thick polysilicon layers and sacr...

  • Article
  • Open Access
12 Citations
5,191 Views
10 Pages

Immobilization of Prunus amygdalus Hydroxynitrile Lyase on Celite

  • Paula Bracco,
  • Guzman Torrelo,
  • Sander Noordam,
  • Glenn De Jong and
  • Ulf Hanefeld

17 July 2018

The hydroxynitrile lyase from Prunus amygdalus was immobilized on Celite R-633. The immobilized enzyme could successfully be utilized in buffer saturated MTBE and excellent conversions of benzaldehyde to R-mandelonitrile were observed. No leaching oc...

  • Article
  • Open Access
17 Citations
5,571 Views
12 Pages

Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila

  • Carlos Camilleri-Robles,
  • Florenci Serras and
  • Montserrat Corominas

18 May 2019

The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 du...

  • Article
  • Open Access
31 Citations
3,277 Views
21 Pages

Utilization of Recycled Liquid Crystal Display (LCD) Panel Waste in Concrete

  • Jacek Góra,
  • Małgorzata Franus,
  • Danuta Barnat-Hunek and
  • Wojciech Franus

11 September 2019

The paper presents the possibility of using the liquid crystal display (LCD) waste as a partial substitute of fine aggregate. Concretes with two types of cement, CEM I 42.5 R and CEM II/B-S 42.5 N, with and without LCD addition, were investigated. Th...

  • Review
  • Open Access
59 Citations
13,161 Views
45 Pages

The Role of Caspase-2 in Regulating Cell Fate

  • Vasanthy Vigneswara and
  • Zubair Ahmed

19 May 2020

Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of sign...

  • Article
  • Open Access
2 Citations
1,376 Views
14 Pages

Asynchronous Injection–Production Method in the High Water Cut Stage of Tight Oil Reservoirs

  • Jianwen Chen,
  • Dingning Cai,
  • Tao Zhang,
  • Linjun Yu,
  • Dalin Zhou and
  • Shiqing Cheng

26 September 2024

Asynchronous injection–production cycle (AIPC) in a horizontal–vertical well pattern is an efficient strategy for enhancing water injection in tight reservoirs. However, current studies lack consideration of waterflood-induced fractures (...

  • Article
  • Open Access
10 Citations
6,213 Views
15 Pages

Development of a Pig Mammary Epithelial Cell Culture Model as a Non-Clinical Tool for Studying Epithelial Barrier—A Contribution from the IMI-ConcePTION Project

  • Chiara Bernardini,
  • Debora La Mantia,
  • Roberta Salaroli,
  • Augusta Zannoni,
  • Nina Nauwelaerts,
  • Neel Deferm,
  • Domenico Ventrella,
  • Maria Laura Bacci,
  • Giuseppe Sarli and
  • Michele Bouisset-Leonard
  • + 2 authors

5 July 2021

The ConcePTION project aims at generating further knowledge about the risks related to the use of medication during breastfeeding, as this information is lacking for most commonly used drugs. Taking into consideration multiple aspects, the pig model...

  • Article
  • Open Access
4 Citations
3,613 Views
14 Pages

12 November 2021

The efficient development of oil and gas resources is inseparable from the progress of drilling technology and the safety of the long life cycle of wellbore. At present, exploration and development is expanding to deep and ultra-deep areas. The long...

  • Article
  • Open Access
15 Citations
4,167 Views
18 Pages

Maternal Obesity Alters Placental Cell Cycle Regulators in the First Trimester of Human Pregnancy: New Insights for BRCA1

  • Denise Hoch,
  • Martina Bachbauer,
  • Caroline Pöchlauer,
  • Francisco Algaba-Chueca,
  • Veronika Tandl,
  • Boris Novakovic,
  • Ana Megia,
  • Martin Gauster,
  • Richard Saffery and
  • Andreas Glasner
  • + 2 authors

In the first trimester of pregnancy, placental development involves a wide range of cellular processes. These include trophoblast proliferation, fusion, and differentiation, which are dependent on tight cell cycle control. The intrauterine environmen...

  • Article
  • Open Access
63 Citations
5,066 Views
16 Pages

21 October 2018

The determination of microscopic residual oil distribution is beneficial for exploiting reservoirs to their maximum potential. In order to investigate microscopic residual oil during the carbon dioxide (CO2) huff-and-puff process in tight oil reservo...

  • Article
  • Open Access
1 Citations
719 Views
17 Pages

Analysis of Sand Production Mechanisms in Tight Gas Reservoirs: A Case Study from the Wenxing Gas Area, Northwestern Sichuan Basin

  • Qilin Liu,
  • Xinyao Zhang,
  • Cheng Du,
  • Kaixiang Di,
  • Shiyi Xie,
  • Huiying Tang,
  • Jing Luo and
  • Run Shu

17 July 2025

In tight sandstone gas reservoirs, proppant flowback severely limits stable gas production. This study uses laboratory flowback experiments and field analyses of the ShaXimiao tight sandstone in the Wenxing gas area to investigate the mechanisms cont...

  • Review
  • Open Access
54 Citations
7,799 Views
16 Pages

21 November 2020

Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for norma...

  • Review
  • Open Access
103 Citations
11,574 Views
17 Pages

CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication

  • Sabrina Florencia Mansilla,
  • María Belén De La Vega,
  • Nicolás Luis Calzetta,
  • Sebastián Omar Siri and
  • Vanesa Gottifredi

28 May 2020

p21Waf/CIP1 is a small unstructured protein that binds and inactivates cyclin-dependent kinases (CDKs). To this end, p21 levels increase following the activation of the p53 tumor suppressor. CDK inhibition by p21 triggers cell-cycle arrest in the G1...

  • Article
  • Open Access
16 Citations
5,838 Views
17 Pages

Carbon and Nitrogen Pools and Fluxes in Adjacent Mature Norway Spruce and European Beech Forests

  • Filip Oulehle,
  • Michal Růžek,
  • Karolina Tahovská,
  • Jiří Bárta and
  • Oldřich Myška

17 November 2016

We compared two adjacent mature forest ecosystem types (spruce vs. beech) to unravel the fate of assimilated carbon (C) and the cycling of organic and inorganic nitrogen (N) without the risk of the confounding influences of climatic and site differen...

  • Article
  • Open Access
3 Citations
1,702 Views
12 Pages

Implementation and Review of the Axisymmetric Equilibrium System of RFX-Mod2 within the MARTe2 Framework

  • Nicolò Ferron,
  • Claudio Finotti,
  • Gabriele Manduchi,
  • Giuseppe Marchiori,
  • Paolo Bettini,
  • Domenico Abate and
  • Roberto Cavazzana

1 September 2022

A major refurbishment of the toroidal complex of the RFX-mod device is in progress and it will include the removal of the Inconel vacuum vessel and a modification of the stainless steel supporting structure to be made vacuum-tight. The axisymmetric e...

  • Article
  • Open Access
9 Citations
2,542 Views
30 Pages

Dynamic Changes in Colonic Structure and Protein Expression Suggest Regulatory Mechanisms of Colonic Barrier Function in Torpor–Arousal Cycles of the Daurian Ground Squirrel

  • Weilan Miao,
  • Yuting Han,
  • Yingyu Yang,
  • Ziwei Hao,
  • Ning An,
  • Jiayu Chen,
  • Ziwen Zhang,
  • Xuli Gao,
  • Kenneth B. Storey and
  • Hui Chang
  • + 1 author

12 August 2022

Background: Both pathological conditions and hibernation can affect the barrier function of small intestine mucosa. However, the effect of hibernation on the barrier function of colonic mucosa remains unclear. Methods: We investigated morphological c...

  • Article
  • Open Access
12 Citations
5,590 Views
18 Pages

Lactobacillus paracasei KW3110 (KW3110) has anti-inflammatory effects and mitigates retinal pigment epithelium (RPE) cell damage caused by blue-light exposure. We investigated whether KW3110 suppresses chronic inflammatory stress-induced RPE cell dam...

  • Article
  • Open Access
69 Citations
7,923 Views
14 Pages

The In Vitro Protective Role of Bovine Lactoferrin on Intestinal Epithelial Barrier

  • Xiao Zhao,
  • Xiao-Xi Xu,
  • Yang Liu,
  • En-Ze Xi,
  • Jing-Jing An,
  • Dina Tabys and
  • Ning Liu

2 January 2019

The intestinal epithelial barrier plays a key protective role in the gut lumen. Bovine lactoferrin (bLF) has been reported to improve the intestinal epithelial barrier function, but its impact on tight junction (TJ) proteins has been rarely described...

  • Article
  • Open Access
4 Citations
2,647 Views
16 Pages

The Relationship between Chlorite and Reservoir Quality in the Huagang Formation, Xihu Depression, China

  • Dongping Duan,
  • Xianguo Zhang,
  • Binbin Liu,
  • Jianli Lin and
  • Wenguang Wang

8 May 2022

Low permeability tight gas resources account for 90% of the Xihu Sag. Under the background of extensive development of low permeability and tight reservoirs, the key to economic and effective development is to find sweet reservoir formation. To clari...

  • Article
  • Open Access
12 Citations
3,400 Views
13 Pages

Fumonisin B1 Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells

  • Qing Li,
  • Qiaoling Yuan,
  • Tianjie Wang,
  • Yang Zhan,
  • Lingchen Yang,
  • Ying Fan,
  • Hongyu Lei and
  • Jianming Su

3 December 2021

The fumonisins are a group of common mycotoxins found around the world that mainly contaminate maize. As environmental toxins, they pose a threat to human and animal health. Fumonisin B1 (FB1) is the most widely distributed and the most toxic. FB1 ca...

  • Article
  • Open Access
20 Citations
2,584 Views
18 Pages

12 May 2021

The Chang 7 continental shale oil reservoir is tight. The recovery factor is extremely low, the remaining oil is very high, and injecting water to improve oil recovery effectiveness is too hard. Therefore, in this paper, physical simulation experimen...

  • Review
  • Open Access
80 Citations
57,029 Views
32 Pages

29 January 2013

Eukaryotic cells must accurately and efficiently duplicate their genomes during each round of the cell cycle. Multiple linear chromosomes, an abundance of regulatory elements, and chromosome packaging are all challenges that the eukaryotic DNA replic...

  • Feature Paper
  • Article
  • Open Access
3 Citations
5,817 Views
40 Pages

10 November 2020

We report a natural wind cycle, the Antarctic Centennial Wind Oscillation (ACWO), whose properties explain milestones of climate and human civilization, including contemporary global warming. We explored the wind/temperature relationship in Antarctic...

  • Review
  • Open Access
8 Citations
7,901 Views
16 Pages

28 July 2022

This paper discusses the effect of chrononutrition on the regulation of circadian rhythms; in particular, that of chocolate on the resynchronization of the human internal biological central and peripheral clocks with the main external synchronizers,...

  • Review
  • Open Access
33 Citations
6,303 Views
22 Pages

The Protective Role of Dormant Origins in Response to Replicative Stress

  • Lilas Courtot,
  • Jean-Sébastien Hoffmann and
  • Valérie Bergoglio

12 November 2018

Genome stability requires tight regulation of DNA replication to ensure that the entire genome of the cell is duplicated once and only once per cell cycle. In mammalian cells, origin activation is controlled in space and time by a cell-specific and r...

  • Proceeding Paper
  • Open Access
1 Citations
2,730 Views
6 Pages

Descend technique and performance vary among elite racing cyclists and it is not clear what slower riders should do to improve their performance. An observation study was performed of the descending technique of members of a World Tour cycling team a...

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