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Open AccessReview

The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases

by 1,* and 1,2,*
1
Department of Structural Biology of Signaling Proteins, Division BIOCEV, Institute of Physiology of the Czech Academy of Sciences, 25250 Vestec, Czech Republic
2
Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, 12843 Prague, Czech Republic
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8824; https://doi.org/10.3390/ijms21228824
Received: 29 October 2020 / Revised: 20 November 2020 / Accepted: 20 November 2020 / Published: 21 November 2020
(This article belongs to the Special Issue Protein Kinases: Function, Substrates, and Implication in Diseases)
Phosphorylation by kinases governs many key cellular and extracellular processes, such as transcription, cell cycle progression, differentiation, secretion and apoptosis. Unsurprisingly, tight and precise kinase regulation is a prerequisite for normal cell functioning, whereas kinase dysregulation often leads to disease. Moreover, the functions of many kinases are regulated through protein–protein interactions, which in turn are mediated by phosphorylated motifs and often involve associations with the scaffolding and chaperon protein 14-3-3. Therefore, the aim of this review article is to provide an overview of the state of the art on 14-3-3-mediated kinase regulation, focusing on the most recent mechanistic insights into these important protein–protein interactions and discussing in detail both their structural aspects and functional consequences. View Full-Text
Keywords: 14-3-3; kinase; phosphorylation; RAF kinase; ASK1; CaMKK2; PI4KB; LRRK2; PKC 14-3-3; kinase; phosphorylation; RAF kinase; ASK1; CaMKK2; PI4KB; LRRK2; PKC
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Obsilova, V.; Obsil, T. The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases. Int. J. Mol. Sci. 2020, 21, 8824.

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