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The Role of Caspase-2 in Regulating Cell Fate

Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham B15 2TT, UK
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Author to whom correspondence should be addressed.
Cells 2020, 9(5), 1259; https://doi.org/10.3390/cells9051259
Received: 15 April 2020 / Revised: 11 May 2020 / Accepted: 12 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue Programmed Cell Death in Health and Disease)
Caspase-2 is the most evolutionarily conserved member of the mammalian caspase family and has been implicated in both apoptotic and non-apoptotic signaling pathways, including tumor suppression, cell cycle regulation, and DNA repair. A myriad of signaling molecules is associated with the tight regulation of caspase-2 to mediate multiple cellular processes far beyond apoptotic cell death. This review provides a comprehensive overview of the literature pertaining to possible sophisticated molecular mechanisms underlying the multifaceted process of caspase-2 activation and to highlight its interplay between factors that promote or suppress apoptosis in a complicated regulatory network that determines the fate of a cell from its birth and throughout its life. View Full-Text
Keywords: caspase-2; procaspase; apoptosis; splice variants; activation; intrinsic; extrinsic; neurons caspase-2; procaspase; apoptosis; splice variants; activation; intrinsic; extrinsic; neurons
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Vigneswara, V.; Ahmed, Z. The Role of Caspase-2 in Regulating Cell Fate. Cells 2020, 9, 1259.

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