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Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila

Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona 08028, Spain
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Genes 2019, 10(5), 378; https://doi.org/10.3390/genes10050378
Received: 28 March 2019 / Revised: 14 May 2019 / Accepted: 16 May 2019 / Published: 18 May 2019
(This article belongs to the Section Molecular Genetics and Genomics)
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Abstract

The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death. View Full-Text
Keywords: GADD45; JNK; p38; development; regeneration; imaginal discs GADD45; JNK; p38; development; regeneration; imaginal discs
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Camilleri-Robles, C.; Serras, F.; Corominas, M. Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila. Genes 2019, 10, 378.

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