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The Protective Role of Dormant Origins in Response to Replicative Stress

CRCT, Université de Toulouse, Inserm, CNRS, UPS; Equipe Labellisée Ligue Contre le Cancer, Laboratoire d’excellence Toulouse Cancer, 2 Avenue Hubert Curien, 31037 Toulouse, France
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Int. J. Mol. Sci. 2018, 19(11), 3569; https://doi.org/10.3390/ijms19113569
Received: 2 October 2018 / Revised: 5 November 2018 / Accepted: 7 November 2018 / Published: 12 November 2018
(This article belongs to the Special Issue DNA Replication Stress)
Genome stability requires tight regulation of DNA replication to ensure that the entire genome of the cell is duplicated once and only once per cell cycle. In mammalian cells, origin activation is controlled in space and time by a cell-specific and robust program called replication timing. About 100,000 potential replication origins form on the chromatin in the gap 1 (G1) phase but only 20–30% of them are active during the DNA replication of a given cell in the synthesis (S) phase. When the progress of replication forks is slowed by exogenous or endogenous impediments, the cell must activate some of the inactive or “dormant” origins to complete replication on time. Thus, the many origins that may be activated are probably key to protect the genome against replication stress. This review aims to discuss the role of these dormant origins as safeguards of the human genome during replicative stress. View Full-Text
Keywords: dormant origins; replicative stress; replication timing; DNA damage; genome instability; cancer dormant origins; replicative stress; replication timing; DNA damage; genome instability; cancer
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MDPI and ACS Style

Courtot, L.; Hoffmann, J.-S.; Bergoglio, V. The Protective Role of Dormant Origins in Response to Replicative Stress. Int. J. Mol. Sci. 2018, 19, 3569.

AMA Style

Courtot L, Hoffmann J-S, Bergoglio V. The Protective Role of Dormant Origins in Response to Replicative Stress. International Journal of Molecular Sciences. 2018; 19(11):3569.

Chicago/Turabian Style

Courtot, Lilas; Hoffmann, Jean-Sébastien; Bergoglio, Valérie. 2018. "The Protective Role of Dormant Origins in Response to Replicative Stress" Int. J. Mol. Sci. 19, no. 11: 3569.

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