18,977 Results Found

The design of compounds with directed action to a defined organ or tissue is a very promising approach, since it can decrease considerably the toxicity of the drug/bioactive compound. For this reason, this kind of strategy has been greatly important...

Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including anoxic and hypoxic zones that fo...

This paper presents a new group target tracking method based on the standard multi-sensor multi-target multi-Bernoulli (MS-MeMBer) filter. In the prediction step, the group structure is used to constrain the movement of the constituent members within...

Many multi-target tracking applications (e.g., tracking multiple targets with LiDAR or millimeter-wave radar) are challenged by closely spaced targets. In this work, we propose a method for the tracking of multiple extended targets or unresolvable gr...

In inverse synthetic-aperture radar (ISAR) imaging, it is essential to deal with the Doppler ambiguity of group targets with complex maneuvers in order to avoid the bias of target position towards the actual value. Simultaneously, migration through r...

Network-group targets are a set of objectives that adhere to a shared communication protocol, perform common tasks, and exhibit relatively coordinated movements. Typically, network-group targets emit radar and communication signals. However, they oft...

Group target tracking (GTT) is a promising approach for countering unmanned aerial vehicles (UAVs). However, the complex distribution and high mobility of UAV swarms may limit GTTs performance. To enhance GTT performance for UAV swarms, this paper pr...

For unmanned ground vehicles in squad mission support systems (SMSS-UGVs), tracking the entire squad as a group, rather than focusing on individual members, can effectively mitigate issues such as target loss caused by occlusion and environmental int...

The detection of an infrared small target faces the problems of background interference and non-obvious target features, which have yet to be efficiently solved. By employing the non-local self-correlation characteristic of the infrared images, the p...

This study provides a solution for multiple group/extended target tracking with an arbitrary shape. Many tracking approaches for extended/group targets have been proposed. However, these approaches make assumptions about the target shape, which have...

The identification of sensing group targets and extended targets is of paramount importance in the context of vehicle tracking and early warning detection. As the scope of target monitoring and tracking extends, conventional single-sensor-based track...

Tracking and grasping a moving target is currently a challenging topic in the field of robotics. The current visual servo grasping method is still inadequate, as the real-time performance and robustness of target tracking both need to be improved. A...

Unmanned aerial vehicle (UAV) cluster combat is a typical example of an intelligent cluster application, and it is characterized by its large scale, low cost, retrievability, and intra-cluster autonomous coordination. An unmanned reconnaissance missi...

The Doppler-spread problem is commonly encountered in space target observation scenarios using ground-based radar when prolonged coherent integration techniques are utilized. Even when the translational motion is accurately compensated, the phase res...

Grey target decision making is a useful tool to solve multiple-criteria decision-making problems. Decision makers’ expected information can reflect their preferences and play an important role in decision process. In this paper, a new grey targ...

In the field of resolvable group target tracking, further study on the structure and formation of group targets is helpful to reduce the tracking error of group bluetargets. In this paper, we propose an algorithm to detect whether the structure or fo...

This paper discusses the perception and tracking of individual as well as group targets as applied to multi-lane public traffic. Target tracking problem is formulated as a two hierarchical layer problem—on the first layer, a multi-target tracki...

In this paper, multiple resolvable group target tracking was considered in the frame of random finite sets. In particular, a group target model was introduced by combining graph theory with the labeled random finite sets (RFS). This accounted for dep...

The compounds 2-amino-3-carboxamido-thieno[2,3-b]pyridines have demonstrated excellent anti-proliferative activity against human cancer cell lines, including the triple-negative breast cancer cell line MDA-MB-231. In this study, 81 novel thieno[2,3-b...

The estimation of the target number and individual tracks are two major tasks in multi-target tracking. The main shortcoming of traditional tracking methods is the cumbersome data association between measurements and targets. The cardinalized probabi...

Millimeter-wave-based extended target tracking has attracted extensive interest recently because of its privacy, high precision, and low cost. This paper concentrated on crowded indoor situations and presents a novel method for group tracking. First,...

Accurate group target association is essential for multi-sensor multi-target tracking, particularly in heterogeneous radar systems where systematic biases, asynchronous observations, and dense formations frequently cause ambiguous or incorrect associ...

People with intellectual disabilities have a comparatively low level of physical activity and are affected by associated numerous impairments and diseases. However, target group specific interventions and concepts aiming at sustainable physical activ...

This study investigates the problem of swarm robots searching for multiple targets in an unknown environment. We propose the Historical Optimal Weighting Grey Wolf Optimization (HOWGWO) algorithm based on an improved grouping strategy. In the HOWGWO...

It has been nearly 50 years since the golden age of antibiotic discovery (1945–1975) ended; yet, we still struggle to identify novel drug targets and to deliver new chemical classes of antibiotics to replace those rendered obsolete by drug resi...

In response to the severe fragmentation of Elkhorn coral, Acropora palmata (Lamarck, 1816), stands caused by a major winter swell (“Holy Swell”) in March 2008, an emergency community-based low-tech restoration was initiated in Vega Baja,...

This study sought to understand the behaviors and attitudes of people in Taiwan as they relate to the government’s RE policies by analyzing data from a questionnaire-based telephone survey conducted between 2013 and 2015. Demographic attributes in pe...

Polyamines are highly attractive vectors for tumor targeting, particularly with regards to the development of radiolabeled probes for imaging by positron emission (PET) and single-photon emission computed tomography (SPECT). However, the synthesis of...

This paper explores beneficiary targeting of government programmes in a village in India. The analysis is based on all 228 households of the village and focus group discussions. The results show that there is a large exclusion error in targeted progr...

Migration flocks have different forms, including single individuals, formations, and irregular clusters. The shape of a flock can change swiftly over time. The real-time clustering of multiple groups with different characteristics is crucial for the...

O6-alkylguanine-DNA alkyltransferase (AGT) is the main cause of tumor cell resistance to DNA-alkylating agents, so it is valuable to design tumor-targeted AGT inhibitors with hypoxia activation. Based on the existing benchmark inhibitor O6-benzylguan...

As a significant business activity, merger and acquisition (M&A) generally means transactions in which the ownership of companies, other business organizations or their operating units are transferred or combined. In a typical M&A procedure,...

In the numerical integration of the second-order nonlinear boundary value problem (BVP), the right boundary condition plays the role as a target equation, which is solved either by the half-interval method (HIM) or a new derivative-free Newton method...

Traffic sign recognition plays a crucial role in enhancing the safety and efficiency of traffic systems. However, in snowy conditions, traffic signs are often obscured by particles, leading to a severe decrease in detection accuracy. To address this...

This article reviews the research progress for high-mobility group protein B1 (HMGB1) and its signaling pathway in osteosarcoma (OS) and discusses its application potential in targeted therapy. A large number of domestic and foreign studies were revi...

Human milk oligosaccharides (HMOs) have specific dose-dependent effects on child health outcomes. The HMO profile differs across mothers and is largely dependent on gene expression of specific transferase enzymes in the lactocytes. This study investi...

Biofortification of food crops with iodine is a novel approach to preventing iodine deficiency in humans. The present study analyses the consumer target groups and the market potential of iodine-biofortified fruit and vegetables in Germany. For this...

The current taxonomy of the Lactiplantibacillus plantarum group comprises of 17 closely related species that are indistinguishable from each other by using commonly used 16S rRNA gene sequencing. In this study, a whole-genome-based analysis was carri...

Start codon targeted polymorphism (SCoT) analysis was employed to distinguish 37 whipgrass (Hemarthria compressa L.) clones and assess the genetic diversity and population structure among these genotypes. The informativeness of markers was also estim...

The incorporation of novel agents in recent treatments in multiple myeloma (MM) has improved the clinical outcome of patients. Specifically, the approval of monoclonal antibody (MoAb) against CD38 (daratumumab) and SLAMF7 (elotuzumab) in relapsed and...

Deep learning-based individual recognition of beef cattle has improved the efficiency and effectiveness of individual recognition, providing technical support for modern large-scale farms. However, issues such as over-reliance on back patterns, simil...

In plenty of realistic situations, multi-attribute group decision-making (MAGDM) is ubiquitous and significant in daily activities of individuals and organizations. Among diverse tools for coping with MAGDM, granular computing-based approaches consti...

In intensive aquaculture, the real-time detection and monitoring of common infectious disease is an important basis for scientific fish epidemic prevention strategies that can effectively reduce fish mortality and economic loss. However, low-quality...

A Home Energy Management System (HEMS) has no direct and immediate energy-saving effect. It gives insight into the resident’s behaviour regarding energy use. When this is linked to the appropriate feedback, the resident is in a position to chan...

Palliative chemotherapy is the mainstay of treatment of advanced gastric carcinoma (GC). Monoclonal antibodies including trastuzumab, ramucirumab, and pembrolizumab have been shown to provide additional benefits. However, the clinical outcomes are of...

Healthcare workers (HCWs) from minoritized communities are a critical partner in moving vaccine-hesitant populations toward vaccination, yet a significant number of these HCWs are delaying or deciding against their own COVID-19 vaccinations. Our stud...

E-cigarettes are increasingly popular among both cigarette smokers and non-users. Although smoking cessation yields the most individual and population health benefits, switching to exclusive e-cigarette use offers some individual health benefits for...

Lysosomes are widely present in eukaryotic cells and play an extremely important role in cell growth and development, and their dysfunction is closely related to a variety of diseases. The development of a precise lysosomal targeting strategies is of...

The paper considers the detection of multiple targets by a group of mobile robots that perform under uncertainty. The agents are equipped with sensors with positive and non-negligible probabilities of detecting the targets at different distances. The...

Background: This study used an audience segmentation and message targeting approach to identify three distinct smoker groups—Older Freedom Smokers (OFS), Reluctant Smokers (RS), and Young Enthusiasts (YE)—and examined whether an electroni...