Peptidomimetics are a privileged class of pharmacophores that exhibit improved physicochemical and biological properties. Solid-phase synthesis is a powerful tool for gaining rapid access to libraries of molecules from small molecules to biopolymers...
Tuning the optical properties of carbon dots (CDs) and figuring out the mechanisms underneath the emissive phenomena have been one of the most cutting-edge topics in the development of carbon-based nanomaterials. Dual-emissive CDs possess the intrins...
ZnCo2O4 has emerged as a promising electrode material for supercapacitor applications due to its unique properties and potential for high-performance energy storage. As a transition metal oxide, ZnCo2O4 offers eco-friendly characteristics and favorab...
The usage of fossil fuels has resulted in increasingly severe environmental problems, such as climate change, air pollution, water pollution, etc. Hydrogen energy is considered one of the most promising clean energies to replace fossil fuels due to i...
The divergent total synthesis strategy can be successfully applied to the preparation of families of natural products using a common late-stage pluripotent intermediate. This approach is a powerful tool in organic synthesis as it offers opportunities...
We report herein an original and rapid synthesis of 2,3-diaryl N-tosylaziridines by TDAE strategy starting from ortho- or para-nitro(dichloromethyl)benzene derivatives and N-tosylimines. A mixture of cis/trans isomers was isolated from 1-(dichloromet...
The article presents a synthesis strategy focused on low power implementations of combinatorial circuits in an array-type FPGA structure. Logic functions are described by means of BDD. A new form of the SWitch activity BDD diagram (SWBDD) is proposed...
One of the main areas of interest of synthetic organic chemistry is the rapid construction of small molecules with proven diverse biological activities for the development of new strategies to cure human health. In particular, the development of nove...
Synthesis of the sex pheromone of the tea tussock moth in 33% overall yield over 10 steps was achieved. Moreover, the chiral pool concept was applied in the asymmetric synthesis. The synthesis used a chemical available on a large-scale from recycling...
The first report of deep eutectic solvents (DESs) was released in 2003 and was identified as a new member of ionic liquid (IL), involving innovative chemical and physical characteristics. Using green solvent technology concerning economical, practica...
Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This ap...
2,5-diketopiperazines (2,5-DKPs) are the smallest cyclic peptides in nature and display a variety of antibacterial, antifungal, and anticancer properties. Very little has been reported on the one-pot synthesis of 2,5-DKPs. Herein, we report a novel o...
Carbohydrates are essential constituents of numerous biological systems, playing key roles in fundamental processes such as cellular recognition and immunological responses, while also offering significant potential in medical diagnostics and pharmac...
MoS2 supported on oxides like TiO2 has a broad range of applications. The atomic structure of this system is therefore very useful to study. Previous research work in this area has made use of high-temperature synthesis methods, while the preparation...
Halide perovskites are increasingly exploited as semiconducting materials in diverse optoelectronic applications, including light emitters, photodetectors, and solar cells. The halide perovskite can be easily processed in solution, making microfluidi...
MXenes-based materials are considered to be one of the most promising electrode materials in the field of sodium-ion batteries due to their excellent flexibility, high conductivity and tuneable surface functional groups. However, MXenes often have se...
Distributed coherent synthesis on dynamic platforms suffers from phase misalignment and significantly reduced synthesis efficiency due to navigation errors and communication delays. To address this challenge and dramatically enhance the synthesis eff...
For osteosarcoma (OS), the most common primary malignant bone tumor, overall survival has hardly improved over the last four decades. Especially for metastatic OS, novel therapeutic targets are urgently needed. A hallmark of cancer is aberrant metabo...
The sputter deposition of FeMn thin films with thicknesses in the range of hundred nanometres and beyond requires relatively high growth temperatures for the formation of the face-centred cubic (fcc) phase, which results in high thin film roughness....
Rare earth-doped nanoparticles (RENPs) are promising biomaterials with substantial potential in biomedical applications. Their multilayered core–shell structure design allows for more diverse uses, such as orthogonal excitation. However, the ty...
Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translat...
The development of single-crystal Ni-rich layered cathode materials (SC-NCMs) is regarded as an effective strategy to address the mechanical failure issues commonly associated with polycrystalline counterparts. However, the industrial production of S...
A novel strategy via the triple process (multicomponent reactions (MCR)-domino)/tandem was developed for the synthesis of restricted and constrained bis-1,2,3-triazole-linked pyrrolo[3,4-b]pyridine peptidomimetics dimers in overall yields of 20&ndash...
Dual three–phase synchronous reluctance motors (DTP–SynRM) have the advantages of simple structure, high power density, fast dynamic response, and small torque ripple, and have broad application prospects in flywheel batteries. However, t...
Polyurethanes and polyurethane-ureas, particularly their water-based dispersions, have gained relevance as an extremely versatile area based on environmentally friendly approaches. The evolution of their synthesis methods, and the nature of the react...
The liquid-phase method is the most commonly utilized strategy for synthesizing fluorescent carbon quantum dots (CQDs). However, the liquid-phase synthesis of CQDs faces challenges such as low yield, complex purification, and the use of toxic solvent...
The broad application of the tetrazole scaffold in different fields, such as general and coordination chemistry, material science, microbiological and medicinal chemistry in recent years demands robust and safe methods for their preparation on produc...
MIL-101(Cr), a widely studied chromium-based metal–organic framework material consisting of chromium metal ions and terephthalic acid ligands, has attracted much attention due to its ultra-high specific surface area, large pore size, and excell...
We systematically investigated the morphology-controlled synthesis of Cu2O micro-nano crystals, especially under surfactant-free conditions, targeting a simple, rapid, and morphologically controllable preparation strategy for polyhedral Cu2O micro-na...
Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones have still not...
This paper proposes a novel model predictive current control scheme for two-stage matrix converter. The switching frequency is kept constant by fixing the switching instant. The control strategy achieves to control source reactive power in the input...
Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed. The desired produ...
Resistance to antibiotics is an increasingly serious threat to global public health and its management translates to significant health care costs. The validation of new Gram-negative antibacterial targets as sources for potential new antibiotics rem...
Straightforward design and long-term functionality for tribological considerations has prompted an extensive substitution of polymers for metals across various applications, from industrial machinery to medical devices. Lubrication of and by polymer...
Background/Objectives: Linezolid is a first-in-class oxazolidinone antibiotic that exhibits activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. However, its clinical us...
Hydrogels have emerged as versatile platforms for controlled and sustained drug delivery due to their high biocompatibility, tunable mechanical properties, and ability to mimic the natural extracellular matrix. Incorporating functional nanomaterials...
A sustainable enzymatic strategy for the preparation of amides by using Candida antarctica lipase B as the biocatalyst and cyclopentyl methyl ether as a green and safe solvent was devised. The method is simple and efficient and it produces amides wit...
A diversity-oriented synthesis (DOS) of two new polyheterocyclic compounds was performed via an Ugi-Zhu/cascade (N-acylation/aza Diels-Alder cycloaddition/decarboxylation/dehydration)/click strategy, both step-by-step to optimize all involved experim...
Nanomaterials with large specific surface area (SSA) have emerged as pivotal platforms for energy storage and environmental remediation, primarily due to their enhanced active site exposure, improved mass transport capabilities, and superior interfac...
Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides. A v...
Recently, more and more research has focused on the beautification technology of QR (Quick Response) codes. In this paper, a novel algorithm based on the XOR (exclusive OR) mechanism of hybrid basis vector matrices and a background image synthetic st...
The one-pot synthesis strategy of Au@Pd dendrites nanoparticles (Au@Pd DNPs) was simply synthesized in a high-temperature aqueous solution condition where cetyltrimethylammonium chloride (CTAC) acted as a reducing and capping agent at a high temperat...
An alternating fluorinated copolymer based on chlorotrifluoroethylene (CTFE) and butyl vinyl ether (BVE) was synthesized by RAFT/MADIX living/controlled polymerization in the presence of S-benzyl O-ethyl dithiocarbonate (BEDTC). Then, using the obtai...
Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti...
The paper presents the Mixed-Integer Non-linear Programming (MINLP) approach to the synthesis of trusses. The solution of continuous/discrete non-convex and non-linear optimization problems is discussed with respect to the simultaneous topology, shap...
The exploitation of electrocatalysts with high activity and durability for the hydrogen evolution reaction is significant but also challenging for future energy systems. Transition metal phosphides (TMPs) have attracted a lot of attention due to thei...
Trans-resveratrol, the most well-known polyphenolic stilbenoid, is found in grapes and accordingly in wine and it is considered to be beneficial for human health, especially towards the aging-linked cell alterations by providing numerous biological a...
The escalating issue of water pollution has intensified the demand for efficient remediation technologies. Biochar adsorption and photocatalytic degradation have emerged as promising approaches for water treatment, with each offering distinct advanta...
The Sc(OTf)3-catalyzed dearomative [5+1] annulations between readily available 3-aminophenols and O-alkyl ortho-oxybenzaldehydes were developed for synthesis of spiro[chromane-3,1′-cyclohexane]-2′,4′-dien-6′-ones. The “t...
The post-synthetic modification of an oligonucleotide is a powerful strategy for the synthesis of various analogs of the oligonucleotide, aiming to achieve the desired functions. In this study, we synthesized the thymidine phosphoramidite of 2′...
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