A Sustainable Green Enzymatic Method for Amide Bond Formation
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General
3.2. General Procedure for CALB-Catalyzed Amidation
3.2.1. N-Benzyloctanamide (12)
3.2.2. N-Benzylhexanamide (13)
3.2.3. N-Enzylbutyramide (14)
3.2.4. N-Benzyl-4-phenylbutanamide (15)
3.2.5. N-Allyloctanamide (16)
3.2.6. N-Allylhexanamide (17)
3.2.7. N-Allylbutyramide (18)
3.2.8. N-Allyl-4-phenylbutanamide (19)
3.2.9. N-(Prop-2-yn-1-yl)octanamide (20)
3.2.10. N-(Prop-2-yn-1-yl)hexanamide (21)
3.2.11. N-(Prop-2-yn-1-yl)butyramide (22)
3.2.12. 4-Phenyl-N-(prop-2-yn-1-yl)butanamide (23)
3.2.13. 1-(Piperidin-1-yl)octan-1-one (24)
3.2.14. 1-(Piperidin-1-yl)hexan-1-one (25)
3.2.15. 1-(Piperidin-1-yl)butan-1-one (26)
3.2.16. 4-Phenyl-1-(piperidin-1-yl)butan-1-one (27)
3.2.17. 1-Morpholinooctan-1-one (28)
3.2.18. 1-Morpholinohexan-1-one (29)
3.2.19. 1-Morpholinobutan-1-one (30)
3.2.20. 1-Morpholino-4-phenylbutan-1-one (31)
3.2.21. N-(2-(Dimethylamino)ethyl)octanamide (32)
3.2.22. N-(2-(Dimethylamino)ethyl)hexanamide (33)
3.2.23. N-(2-(Dimethylamino)ethyl)butyramide (34)
3.2.24. N-(2-(Dimethylamino)ethyl)-4-phenylbutanamide (35)
3.2.25. N-(3-(Dimethylamino)propyl)ctanamide (36)
3.2.26. N-(3-(Dimethylamino)propyl)hexanamide (37)
3.2.27. N-(3-(Dimethylamino)propyl)butyramide (38)
3.2.28. N-(3-(Dimethylamino)propyl)-4-phenylbutanamide (39)
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Substrates | Octanoic Acid (1) | Hexanoic Acid (2) | Butyric Acid (3) | 4-Phenylbutyric Acid (4) |
---|---|---|---|---|
benzylamine (5) | 12, 99% | 13, 98%, | 14, 98% | 15, 99% |
allylamine (6) | 16, 96% | 17, 96% | 18, 94% | 19, 98% |
propargylamine (7) | 20, 97% | 21, 98% | 22, 92% | 23, 97% |
piperidine (8) | 24, 95% | 25, 93% | 26, 92% | 27, 97% |
morpholine (9) | 28, 99% | 29, 98% | 30, 94% | 31, 96% |
N1,N1-dimethylethane-1,2-diamine (10) | 32, 96% | 33, 98% | 34, 93% | 35, 97% |
N1,N1-dimethylpropane-1,3-diamine (11) | 36, 99% | 37, 98% | 38, 92% | 39, 99% |
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Orsy, G.; Shahmohammadi, S.; Forró, E. A Sustainable Green Enzymatic Method for Amide Bond Formation. Molecules 2023, 28, 5706. https://doi.org/10.3390/molecules28155706
Orsy G, Shahmohammadi S, Forró E. A Sustainable Green Enzymatic Method for Amide Bond Formation. Molecules. 2023; 28(15):5706. https://doi.org/10.3390/molecules28155706
Chicago/Turabian StyleOrsy, György, Sayeh Shahmohammadi, and Enikő Forró. 2023. "A Sustainable Green Enzymatic Method for Amide Bond Formation" Molecules 28, no. 15: 5706. https://doi.org/10.3390/molecules28155706