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Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore Their Effects on Cell Functions and Dysfunctions

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Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism, EA 7270, Université de Bourgogne Franche-Comté, 6, boulevard Gabriel, 21078 DIJON CEDEX, France
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Institut de Chimie Moléculaire de l’Université de Bourgogne, ICMUB-UMR CNRS 6302, Université de Bourgogne Franche-Comté, 9, avenue A. Savary, 21078 DIJON CEDEX, France
*
Author to whom correspondence should be addressed.
Diseases 2018, 6(4), 110; https://doi.org/10.3390/diseases6040110
Received: 26 October 2018 / Revised: 6 December 2018 / Accepted: 7 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Wine and Vine Components and Health)
Trans-resveratrol, the most well-known polyphenolic stilbenoid, is found in grapes and accordingly in wine and it is considered to be beneficial for human health, especially towards the aging-linked cell alterations by providing numerous biological activities, such as anti-oxidant, antitumoral, antiviral, anti-inflammatory, neuroprotective, and platelet anti-aggregation properties. Although trans-resveratrol is a promising molecule, it cannot be considered as a drug, due to its weak bio-availability and fast metabolism. To overcome these weaknesses, several research teams have undertaken the synthesis of innovative trans-resveratrol derivatives, with the aim to increase its solubility in water and pharmacological activities towards cell targets. The aim of this review is to show the chronological evolution over the last 25 years of different strategies to develop more efficient trans-resveratrol derivatives towards organism physiology and, therefore, to enhance various pharmacological activities. While the literature on the development of new synthetic derivatives is impressive, this review will focus on selected strategies regarding the substitution of trans-resveratrol phenyl rings, first with hydroxy, methoxy, and halogen groups, and next with functionalized substituents. The effects on cell functions and dysfunctions of interesting resveratrol analogs will be addressed in this review. View Full-Text
Keywords: resveratrol derivatives; synthesis strategies; substituents phenyl rings; biological targets; efficacy towards diseases resveratrol derivatives; synthesis strategies; substituents phenyl rings; biological targets; efficacy towards diseases
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MDPI and ACS Style

Latruffe, N.; Vervandier-Fasseur, D. Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore Their Effects on Cell Functions and Dysfunctions. Diseases 2018, 6, 110.

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