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283 Results Found

  • Review
  • Open Access
51 Citations
13,859 Views
16 Pages

14 November 2021

The renin–angiotensin–aldosterone system (RAAS) impacts cardiovascular homeostasis via direct actions on peripheral blood vessels and via modulation of the autonomic nervous system. To date, research has primarily focused on the actions of the RAAS o...

  • Review
  • Open Access
3 Citations
4,282 Views
53 Pages

3 December 2025

It has been demonstrated that prolonged exposure to stress engenders a plethora of neuropsychiatric, immune and metabolic disorders. However, its pathophysiology transcends the conventional hypothalamic–pituitary–adrenal (HPA) axis. This...

  • Article
  • Open Access
621 Views
13 Pages

This study aims to propose a non-pharmacological approach to pain relief by analyzing changes in electrocardiogram (ECG) parameters following transcutaneous microcurrent stimulation generated according to the pulse train characteristics of intensity...

  • Article
  • Open Access
39 Citations
5,238 Views
23 Pages

5 November 2022

The gut microbiota has been demonstrated to play a critical role in maintaining cognitive function via the gut-brain axis, which may be related to the parasympathetic nervous system (PNS). However, the exact mechanism remains to be determined. We inv...

  • Article
  • Open Access
2,129 Views
15 Pages

Parasympathetic Nervous System Functioning Moderates the Associations between Callous-Unemotional Traits and Emotion Understanding Difficulties in Late Childhood

  • Sarah F. Lynch,
  • Samantha Perlstein,
  • Cora Ordway,
  • Callie Jones,
  • Hanna Lembcke,
  • Rebecca Waller and
  • Nicholas J. Wagner

2 February 2024

Background: Callous-unemotional (CU) traits are characterized by low empathy, guilt, and prosociality, putting children at risk for lifespan antisocial behavior. Elevated CU traits have been linked separately to difficulties with emotion understandin...

  • Article
  • Open Access
34 Citations
6,222 Views
13 Pages

13 September 2017

Obstructive sleep apnea (OSA) is a common sleep disorder that often associates with reduced heart rate variability (HRV) indicating autonomic dysfunction. HRV is mainly composed of high frequency components attributed to parasympathetic activity and...

  • Article
  • Open Access
105 Citations
20,066 Views
15 Pages

Autonomic Nervous System Responses to Viewing Green and Built Settings: Differentiating Between Sympathetic and Parasympathetic Activity

  • Magdalena M.H.E. Van den Berg,
  • Jolanda Maas,
  • Rianne Muller,
  • Anoek Braun,
  • Wendy Kaandorp,
  • René Van Lien,
  • Mireille N.M. Van Poppel,
  • Willem Van Mechelen and
  • Agnes E. Van den Berg

This laboratory study explored buffering and recovery effects of viewing urban green and built spaces on autonomic nervous system activity. Forty-six students viewed photos of green and built spaces immediately following, and preceding acute stress i...

  • Article
  • Open Access
11 Citations
3,382 Views
14 Pages

Sympathetic Denervation and Pharmacological Stimulation of Parasympathetic Nervous System Prevent Pulmonary Vascular Bed Remodeling in Rat Model of Chronic Thromboembolic Pulmonary Hypertension

  • Andrei A. Karpov,
  • Nikita S. Vachrushev,
  • Leonid A. Shilenko,
  • Sergey S. Smirnov,
  • Nikolay S. Bunenkov,
  • Maxim G. Butskih,
  • Al-Khalim A. Chervaev,
  • Dariya D. Vaulina,
  • Dmitry Yu. Ivkin and
  • Michael M. Galagudza
  • + 1 author

Chronic thromboembolic pulmonary hypertension (CTEPH) develops in 1.5–2.0% of patients experiencing pulmonary embolism (PE) and is characterized by stable pulmonary artery obstruction, heart failure, and poor prognosis. Little is known about in...

  • Article
  • Open Access
7 Citations
3,636 Views
10 Pages

Sudden cardiac death (SCD) is the leading type of line-of-duty death among firefighters. An inability to restore parasympathetic nervous system (PSNS) control after activity is associated with SCD. Post-exercise heart rate recovery (HRR) provides uni...

  • Article
  • Open Access
7 Citations
3,973 Views
9 Pages

Impaired Modulation of the Autonomic Nervous System in Adult Patients with Major Depressive Disorder

  • Elise Böttcher,
  • Lisa Sofie Schreiber,
  • David Wozniak,
  • Erik Scheller,
  • Frank M. Schmidt and
  • Johann Otto Pelz

Patients with major depressive disorder (MDD) have an increased risk for cardiac events. This is partly attributed to a disbalance of the autonomic nervous system (ANS) indicated by a reduced vagal tone and a (relative) sympathetic hyperactivity. How...

  • Article
  • Open Access
2,023 Views
11 Pages

Can a Sacrococcygeal Epidural of 0.25% Bupivacaine Prevent the Activation of the Sympathetic Nervous System during Feline Ovariectomy?

  • João Martins,
  • António Eliseu,
  • Sónia Campos,
  • Lénio Ribeiro,
  • Pablo Otero,
  • Patrícia Cabral,
  • Bruno Colaço and
  • José Diogo dos-Santos

8 June 2024

The ovariectomy (OVE) procedure can trigger somatosensory and visceral peritoneal nociception. Sacrococcygeal epidural (ScE) anesthesia may complement or replace systemic analgesia used for feline OVE, reducing opioid consumption and their related un...

  • Review
  • Open Access
24 Citations
10,843 Views
20 Pages

Does Exercise Training Improve Cardiac-Parasympathetic Nervous System Activity in Sedentary People? A Systematic Review with Meta-Analysis

  • Antonio Casanova-Lizón,
  • Agustín Manresa-Rocamora,
  • Andrew A. Flatt,
  • José Manuel Sarabia and
  • Manuel Moya-Ramón

The aim of this study was to investigate the training-induced effect on cardiac parasympathetic nervous system (PNS) activity, assessed by resting heart rate variability (HRV) and post-exercise heart rate recovery (HRR), in sedentary healthy people....

  • Review
  • Open Access
90 Citations
14,349 Views
19 Pages

The Role of Heart Rate Variability (HRV) in Different Hypertensive Syndromes

  • Louise Buonalumi Tacito Yugar,
  • Juan Carlos Yugar-Toledo,
  • Nelson Dinamarco,
  • Luis Gustavo Sedenho-Prado,
  • Beatriz Vaz Domingues Moreno,
  • Tatiane de Azevedo Rubio,
  • Andre Fattori,
  • Bruno Rodrigues,
  • Jose Fernando Vilela-Martin and
  • Heitor Moreno

19 February 2023

Cardiac innervation by the parasympathetic nervous system (PNS) and the sympathetic nervous system (SNS) modulates the heart rate (HR) (chronotropic activity) and the contraction of the cardiac muscle (inotropic activity). The peripheral vasculature...

  • Review
  • Open Access
102 Citations
22,852 Views
15 Pages

The Interplay between Autonomic Nervous System and Inflammation across Systemic Autoimmune Diseases

  • Chiara Bellocchi,
  • Angelica Carandina,
  • Beatrice Montinaro,
  • Elena Targetti,
  • Ludovico Furlan,
  • Gabriel Dias Rodrigues,
  • Eleonora Tobaldini and
  • Nicola Montano

23 February 2022

The autonomic nervous system (ANS) and the immune system are deeply interrelated. The ANS regulates both innate and adaptive immunity through the sympathetic and parasympathetic branches, and an imbalance in this system can determine an altered infla...

  • Article
  • Open Access
3 Citations
18,780 Views
16 Pages

The Effects of a Single Vagus Nerve’s Neurodynamics on Heart Rate Variability in Chronic Stress: A Randomized Controlled Trial

  • Ana Isabel Pérez-Alcalde,
  • Fernando Galán-del-Río,
  • Francisco J. Fernández-Rodríguez,
  • Marta de la Plaza San Frutos,
  • María García-Arrabé,
  • María-José Giménez and
  • Beatriz Ruiz-Ruiz

26 October 2024

Background: The modulation of the autonomic nervous system’s activity, particularly increasing its parasympathetic tone, is of significant interest in clinical physiotherapy due to its potential benefits for stress-related conditions and recove...

  • Article
  • Open Access
8 Citations
4,661 Views
11 Pages

Measuring the Pupillary Light Reflex Using Portable Instruments in Applied Settings

  • Nicola S. Gray,
  • Menna Price,
  • Jennifer Pink,
  • Chris O’Connor,
  • Ana Antunes and
  • Robert J. Snowden

1 October 2024

The early components of the pupillary light reflex (PLR) are governed by the parasympathetic nervous system. The use of cheap, portable pupillometry devices may allow for the testing of parasympathetic-system health in field settings. We examined the...

  • Review
  • Open Access
1 Citations
5,283 Views
17 Pages

Brain Regulation of Cardiac Function during Hypoglycemia

  • Matthew E. Chambers,
  • Emily H. Nuibe and
  • Candace M. Reno-Bernstein

18 October 2023

Hypoglycemia occurs frequently in people with type 1 and type 2 diabetes. Hypoglycemia activates the counter-regulatory response. Besides peripheral glucose sensors located in the pancreas, mouth, gastrointestinal tract, portal vein, and carotid body...

  • Review
  • Open Access
43 Citations
10,948 Views
18 Pages

Heart Rate Variability as a Translational Dynamic Biomarker of Altered Autonomic Function in Health and Psychiatric Disease

  • Agorastos Agorastos,
  • Alessandra C. Mansueto,
  • Torben Hager,
  • Eleni Pappi,
  • Angeliki Gardikioti and
  • Oliver Stiedl

The autonomic nervous system (ANS) is responsible for the precise regulation of tissue functions and organs and, thus, is crucial for optimal stress reactivity, adaptive responses and health in basic and challenged states (survival). The fine-tuning...

  • Review
  • Open Access
160 Citations
34,051 Views
34 Pages

Effects of Exercise Training on the Autonomic Nervous System with a Focus on Anti-Inflammatory and Antioxidants Effects

  • Matei Daniela,
  • Luca Catalina,
  • Onu Ilie,
  • Matei Paula,
  • Iordan Daniel-Andrei and
  • Buculei Ioana

10 February 2022

Studies show that the autonomic nervous system (ANS) has an important impact on health in general. In response to environmental demands, homeostatic processes are often compromised, therefore determining an increase in the sympathetic nervous system...

  • Article
  • Open Access
8 Citations
5,243 Views
16 Pages

Autonomic Function Recovery and Physical Activity Levels in Post-COVID-19 Young Adults after Immunization: An Observational Follow-Up Case-Control Study

  • Ana Paula Coelho Figueira Freire,
  • Shaan Amin,
  • Fabio Santos Lira,
  • Ana Elisa von Ah Morano,
  • Telmo Pereira,
  • Manuel-João Coelho-E-Silva,
  • Armando Caseiro,
  • Diego Giulliano Destro Christofaro,
  • Vanessa Ribeiro Dos Santos and
  • Bruna Spolador de Alencar Silva
  • + 2 authors

Coronavirus disease 2019 (COVID-19) has detrimental multi-system consequences. Symptoms may appear during the acute phase of infection, but the literature on long-term recovery of young adults after mild to moderate infection is lacking. Heart rate v...

  • Article
  • Open Access
12 Citations
3,807 Views
10 Pages

The Effects of an Artificial Garden on Heart Rate Variability among Healthy Young Japanese Adults

  • Hiromi Suenaga,
  • Kanako Murakami,
  • Nozomi Murata,
  • Syoriki Nishikawa,
  • Masae Tsutsumi and
  • Hiroshi Nogaki

Spending time in nature might positively influence mental health by inducing a relaxed state. Recently, gardens have been created on hospital rooftops in Japan to help inpatients recover from various physical and mental aliments. However, there is li...

  • Perspective
  • Open Access
4 Citations
3,314 Views
11 Pages

Agitation is a common and difficult-to-manage neuropsychiatric syndrome in dementia. Recently, an association with the autonomous nervous system has been suggested. From the literature researched, however, only two studies investigating autonomic fun...

  • Article
  • Open Access
14 Citations
4,507 Views
10 Pages

This study was conducted to investigate the changes in the autonomic nervous system in middle-aged women induced by aerobic and resistance exercise. A randomized controlled design was adopted; 22 premenopausal middle-aged women were divided into the...

  • Article
  • Open Access
1 Citations
5,825 Views
19 Pages

Background: The beat-by-beat fluctuation of heart rate (HR) in its temporal sequence (HR dynamics) provides information on HR regulation by the autonomic nervous system (ANS) and its dysregulation in pathological states. Commonly, linear analyses of...

  • Article
  • Open Access
12 Citations
5,587 Views
13 Pages

16 October 2018

Congestive heart failure (CHF) is a cardiovascular disease associated with autonomic dysfunction, where sympathovagal imbalance was reported in many studies using heart rate variability (HRV). To learn more about the dynamic interaction in the autono...

  • Article
  • Open Access
5 Citations
4,458 Views
14 Pages

Modulation of Heart Rate Variability following PAP Ion Magnetic Induction Intervention in Subjects with Chronic Musculoskeletal Pain: A Pilot Randomized Controlled Study

  • Antonio Viti,
  • Giulia Panconi,
  • Sara Guarducci,
  • Susanna Garfagnini,
  • Mosè Mondonico,
  • Riccardo Bravi and
  • Diego Minciacchi

Heart rate variability (HRV) analysis has emerged as a simple and non-invasive technique to indirectly evaluate the autonomic nervous system (ANS), and it is considered a sensible and advanced index of health status. Pulsed electromagnetic fields (PE...

  • Article
  • Open Access
42 Citations
5,471 Views
17 Pages

Bisphenol A Causes Liver Damage and Selectively Alters the Neurochemical Coding of Intrahepatic Parasympathetic Nerves in Juvenile Porcine Models under Physiological Conditions

  • Michael Thoene,
  • Liliana Rytel,
  • Ewa Dzika,
  • Andrzej Włodarczyk,
  • Ewa Kruminis-Kaszkiel,
  • Ptaszyński Konrad and
  • Joanna Wojtkiewicz

15 December 2017

Bisphenol A (BPA) is an extremely common polymer that is used in typical everyday products throughout the world, especially in food and beverage containers. Within the last ten years, it has been found that the BPA monomer tends to leach into foodstu...

  • Feature Paper
  • Article
  • Open Access
10 Citations
3,192 Views
10 Pages

Parasympathetic Tone Changes in Anesthetized Horses after Surgical Stimulation, and Morphine, Ketamine, and Dobutamine Administration

  • Patricia Ruíz-López,
  • Juan Morgaz,
  • Setefilla Quirós-Carmona,
  • Rocío Navarrete-Calvo,
  • Juan Manuel Domínguez,
  • Rafael Jesús Gómez-Villamandos and
  • M. M. Granados

15 April 2022

Autonomic nervous system (ANS) activity can modify cardiovascular parameters in response to nociceptive stimuli or drugs in anesthetized animals. The aim of this study was to determine if a surgical nociceptive stimulus and morphine, ketamine, and do...

  • Article
  • Open Access
2 Citations
2,962 Views
12 Pages

Omicron is the dominant strain of COVID-19 in the United States and worldwide. Although this variant is highly transmissible and may evade natural immunity, vaccines, and therapeutic antibodies, preclinical results in animal models and clinical data...

  • Feature Paper
  • Article
  • Open Access
5 Citations
6,918 Views
17 Pages

14 November 2016

This paper is a call for the development of a neuroscientific research protocol for the study of the impact of Tantric practice on the autonomic nervous system. Tantric texts like Abhinavagupta’s Tantrāloka map out a complex meditative ritual system...

  • Case Report
  • Open Access
5 Citations
3,071 Views
10 Pages

MATLAB Analysis of SP Test Results—An Unusual Parasympathetic Nervous System Activity in Low Back Leg Pain: A Case Report

  • Elzbieta Skorupska,
  • Tomasz Dybek,
  • Daria Wotzka,
  • Michał Rychlik,
  • Marta Jokiel,
  • Paweł Pakosz,
  • Mariusz Konieczny,
  • Przemysław Domaszewski and
  • Paweł Dobrakowski

14 February 2022

The Skorupska Protocol (SP) test is a new validated tool used to confirm nociplastic pain related to muscles based on a pathological autonomic nervous system (ANS) activity due to muscle nociceptive noxious stimulation analyzed automatically. Two typ...

  • Protocol
  • Open Access
2 Citations
5,638 Views
10 Pages

Is Acute Lower Back Pain Associated with Heart Rate Variability Changes? A Protocol for Systematic Reviews

  • Gema Sanchis-Soler,
  • Juan Tortosa-Martinez,
  • Sergio Sebastia-Amat,
  • Ivan Chulvi-Medrano and
  • Juan Manuel Cortell-Tormo

3 February 2024

Acute lower back pain (ALBP) is an extremely common musculoskeletal problem. ALBP consists of a sudden onset of short-duration pain in the lower back. However, repeated attacks can make the pain chronic. It can be measured through a self-report scale...

  • Article
  • Open Access
9 Citations
4,501 Views
10 Pages

This study was aimed at evaluation of autonomic dysfunction in patients with multiple sclerosis (MS) by means of time- and frequency-domain parameters of heart rate variability (HRV) and conventional cardiovascular tests (deep breathing (DB) and acti...

  • Review
  • Open Access
27 Citations
8,035 Views
15 Pages

Neuroimmune Crosstalk in Rheumatoid Arthritis

  • Dashuang Gao,
  • Xu Gao,
  • Fan Yang and
  • Qingwen Wang

Recent studies have demonstrated that immunological disease progression is closely related to abnormal function of the central nervous system (CNS). Rheumatoid arthritis (RA) is a chronic, inflammatory synovitis-based systemic immune disease of unkno...

  • Article
  • Open Access
2 Citations
10,470 Views
12 Pages

30 December 2024

Background: The role of autonomic nervous system (ANS) modulation in chronic neck pain remains elusive. Transcutaneous vagus nerve stimulation (t-VNS) provides a novel, non-invasive means of potentially mitigating chronic neck pain. This study aimed...

  • Article
  • Open Access
67 Citations
18,019 Views
12 Pages

6 February 2019

Breathing techniques are part of traditional relaxation methods; however, their influence on psychophysiological variables related to sleep is still unclear. Consequently, the aim of this paper was to investigate the influence of a 30-day slow-paced...

  • Article
  • Open Access
11 Citations
5,140 Views
13 Pages

Allopregnanolone Is Associated with a Stress-Induced Reduction of Heart Rate Variability in Premenstrual Dysphoric Disorder

  • Ajna Hamidovic,
  • John Davis,
  • Fatimata Soumare,
  • Aamina Naveed,
  • Yaseen Ghani,
  • Selma Semiz,
  • Dina Khalil and
  • Margaret Wardle

16 February 2023

Human survival and wellbeing require appropriate responses to stress, including a highly coordinated and efficient nervous system control of the heart rhythm. During stress, a greater disinhibition of the vagal nerve is reflective of poor stress adap...

  • Article
  • Open Access
5 Citations
3,971 Views
13 Pages

Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study

  • Alexandre D. Martins,
  • João Paulo Brito,
  • Rafael Oliveira,
  • Tiago Costa,
  • Fátima Ramalho,
  • Rita Santos-Rocha and
  • Nuno Pimenta

13 September 2021

Background: Breast cancer is the most common malignancy among women worldwide. The treatments may also cause neuromuscular and skeletal disorders; therefore, the aim of this study was to verify the existence of a relationship between heart rate varia...

  • Systematic Review
  • Open Access
41 Citations
12,892 Views
22 Pages

Purpose: This systematic review with meta-analysis was conducted to establish whether heart rate variability (HRV)-guided training enhances cardiac-vagal modulation, aerobic fitness, or endurance performance to a greater extent than predefined traini...

  • Article
  • Open Access
44 Citations
6,717 Views
11 Pages

Heart Rate Variability Frequency Domain Alterations among Healthy Nurses Exposed to Prolonged Work Stress

  • Rossana Borchini,
  • Giovanni Veronesi,
  • Matteo Bonzini,
  • Francesco Gianfagna,
  • Oriana Dashi and
  • Marco Mario Ferrario

The deregulation of the autonomic nervous system assessed through the heart rate variability (HRV) analysis is a promising pathway linking work stress and cardiovascular diseases. We aim to investigate the associations between HRV High Frequency (HF)...

  • Review
  • Open Access
81 Citations
19,131 Views
33 Pages

The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac activity with its dysregulation being involved in various heart diseases, such as cardiac arrhythmias. The CANS comprises the extrinsic and intrinsic innervati...

  • Article
  • Open Access
7 Citations
6,533 Views
11 Pages

10 November 2022

In order to maximize adaptations to reach high performance, sports coaches must regularly monitor the healing process following competitions or important training sessions and maintain psychometric status. As a result, the objective of this study was...

  • Article
  • Open Access
5 Citations
5,543 Views
13 Pages

High-Intensity Interval Training Combined with Different Types of Exercises on Cardiac Autonomic Function. An Analytical Cross-Sectional Study in CrossFit® Athletes

  • Michelle Teles Morlin,
  • Carlos Janssen Gomes da Cruz,
  • Freddy Enrique Ramos Guimarães,
  • Renato André Sousa da Silva,
  • Luiz Guilherme Grossi Porto and
  • Guilherme Eckhardt Molina

It is well established that endurance exercise has positive effects on cardiac autonomic function (CAF). However, there is still a dearth of information about the effects of regular high-intensity interval training combined with different types of ex...

  • Article
  • Open Access
4 Citations
2,791 Views
16 Pages

Effects of Spinal Cord Injury Site on Cardiac Autonomic Regulation: Insight from Analysis of Cardiovascular Beat by Beat Variability during Sleep and Orthostatic Challenge

  • Pietro Guaraldi,
  • Mara Malacarne,
  • Giorgio Barletta,
  • Giuseppe De Scisciolo,
  • Massimo Pagani,
  • Pietro Cortelli and
  • Daniela Lucini

Purpose: The goal of this study on Spinal Cord Injury (SCI) patients with cervical or thoracic lesion was to assess whether disturbances of ANS control, according to location, might differently affect vagal and sympatho-vagal markers during sleep and...

  • Article
  • Open Access
25 Citations
10,127 Views
13 Pages

Emotional Intelligence Training: Influence of a Brief Slow-Paced Breathing Exercise on Psychophysiological Variables Linked to Emotion Regulation

  • Min You,
  • Sylvain Laborde,
  • Nina Zammit,
  • Maša Iskra,
  • Uirassu Borges,
  • Fabrice Dosseville and
  • Robert S. Vaughan

Designing emotional intelligence training programs requires first testing the effectiveness of techniques targeting its main dimensions. The aim of this study was to investigate the effects of a brief slow-paced breathing (SPB) exercise on psychophys...

  • Article
  • Open Access
27 Citations
10,361 Views
11 Pages

Single Slow-Paced Breathing Session at Six Cycles per Minute: Investigation of Dose-Response Relationship on Cardiac Vagal Activity

  • Min You,
  • Sylvain Laborde,
  • Nina Zammit,
  • Maša Iskra,
  • Uirassu Borges and
  • Fabrice Dosseville

The practice of slow-paced breathing (SPB) has been linked to a range of positive outcomes, such as decreasing symptoms of depression, anxiety, and stress, as well as increasing well-being. Among the suggested mechanisms of action, SPB has been shown...

  • Article
  • Open Access
17 Citations
4,429 Views
21 Pages

21 November 2022

The role of gut microbes has been suggested in type 2 diabetes (T2DM) risk. However, their results remain controversial. We hypothesized that Asians with T2DM had different fecal bacterial compositions, co-abundance networks, and metagenome functions...

  • Article
  • Open Access
11,927 Views
13 Pages

21 February 2025

Recent studies have shown that both facial immersion and head-out water immersion up to the chest (HOIC) positively influence cardiac vagal activity, as indexed non-invasively through vagally mediated heart rate variability (vmHRV). While facial imme...

  • Article
  • Open Access
2 Citations
4,098 Views
16 Pages

Whole-Body Cold Stimulation Improves Cardiac Autonomic Control Independently of the Employed Temperature

  • Nadia Solaro,
  • Luca Giovanelli,
  • Laura Bianchi,
  • Paolo Piterà,
  • Federica Verme,
  • Mara Malacarne,
  • Massimo Pagani,
  • Jacopo Maria Fontana,
  • Paolo Capodaglio and
  • Daniela Lucini

18 December 2024

Background/Objectives: The autonomic nervous system (ANS) is considered one of the mechanisms mediating the benefits of whole-body cold stimulation (WBC). Nevertheless, different treatment protocols, different methodologies employed to assess the ANS...

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