Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Procedures
2.2.1. Anthropometric and Body Composition Assessment
2.2.2. Heart Rate Variability Assessment
2.2.3. Functional Fitness Assessment
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variables | Mean ± SD |
---|---|
Age (years) | 50.80 ± 8.80 |
Weight (kg) | 67.10 ± 12.30 |
Height (m) | 1.60 ± 0.70 |
BMI (kg/m2) | 26.30 ± 4.80 |
Muscle Mass (kg) | 23.50 ± 3.76 |
Phase Angle (°) | 5.60 ± 0.42 |
Body fat (kg) | 24.25 ± 9.55 |
SpO2 (%) | 97.16 ± 1.41 |
RHR (bpm) | 69.84 ± 8.93 |
SBP (mmHg) | 117.96 ± 14.22 |
DBP (mmHg) | 80.96 ± 6.83 |
Time after diagnosis (years) | 6.84 ± 5.64 |
Tumor size (mm) | 24.68 ± 14.78 |
Variable | Chemotherapy N (%) | Radiotherapy N (%) | Hormonal Therapy N (%) | Radiotherapy + Chemotherapy N (%) | Radiotherapy + Chemotherapy + Hormone Therapy N (%) |
---|---|---|---|---|---|
Treatment type | 5 (20) | 2 (8) | 1 (4) | 6 (24) | 11 (44) |
Surgery type | |||||
Mastectomy | 5 (20) | 1 (4) | 1 (4) | 5 (20) | 10 (40) |
Quadrantectomy | 0 (0) | 1 (4) | 0 (0) | 1 (0) | 1 (4) |
Hormonal Therapy | |||||
Aromatase Inhibitors | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 4 (16) |
Tamoxifen | 0 (0) | 0 (0) | 1 (4) | 0 (0) | 6 (24) |
Aromatase + Tamoxifen Inhibitors | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (4) |
Did not perform | 5 (20) | 2 (8) | 0 (0) | 6 (24) | 0 (0) |
Tumor Stage | |||||
I | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 2 (8) |
II | 4 (16) | 1 (4) | 0 (0) | 2 (8) | 6 (24) |
III | 1 (4) | 0 (0) | 1 (4) | 2 (8) | 3 (12) |
IV | 0 (0) | 1 (1) | 0 (0) | 2 (8) | 0 (0) |
Type of Breast Carcinoma | |||||
Ductal carcinoma in situ | 2 (8) | 0 (0) | 1 (8) | 2 (8) | 2 (8) |
Non-Special Invasive Type | 3 (12) | 2 (8) | 0 (0) | 2 (8) | 4 (16) |
Invasive Lobular Carcinoma | 0 (0) | 0 (0) | 0 (0) | 2 (8) | 4 (16) |
Invasive Papillary Carcinoma | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (4) |
Secondary Lymphedema | |||||
Yes | 2 (8) | 1 (4) | 0 (0) | 3 (12) | 2 (8) |
No | 3 (12) | 1 (4) | 1 (4) | 3 (12) | 9 (36) |
Variables | Mean ± SD |
---|---|
Functional fitness tests | |
30 s chair-stand test (rep) | 15.24 ± 3.94 |
Timed Up and Go test (TUG) (s) | 5.87 ± 0.76 |
Ball Throw Test (m) | 1.89 ± 0.62 |
6 min walking test (m) | 796.78 ± 99.18 |
HRV—Time Domain | |
Mean RR (ms) | 778.20 ± 157.96 |
SDNN (ms) | 35.78 ± 17.19 |
RMSSD (ms) | 41.31 ± 21.10 |
pNN50 (%) | 10.90 ± 13.62 |
HRV—Frequency Domain | |
LF (ms2) | 169.12 ± 52.04 |
HF (ms2) | 127.08 ± 51.04 |
LF/HF ratio | 1.49 ± 0.56 |
Stress Index | 15.78 ± 17.77 |
Variables | 30 s Chair-Stand Test (rep) | Timed Up and Go Test (s) | Ball Throw Test (m) | 6 min Walking Test (m) |
---|---|---|---|---|
Mean RR (ms) | 0.217 | −0.331 | −0.238 | −0.033 |
SDNN (ms) | 0.267 | −0.171 | 0.183 | −0.026 |
RMSSD (ms) | 0.394 | −0.165 | −0.054 | −0.087 |
pNN50 (%) | 0.287 | −0.338 | 0.061 | 0.040 |
LF (ms2) | 0.115 | −0.061 | 0.132 | 0.056 |
HF (ms2) | 0.445 * | −0.004 | 0.192 | −0.035 |
LF/HF ratio | −0.292 | 0.072 | −0.149 | 0.081 |
Stress Index | 0.334 | 0.124 | −0.416 * | −0.155 |
Model | Unstandardized Coefficients | Standardized Coefficients | Change Statistics | p | |
---|---|---|---|---|---|
Β | Std. Error | Β | R2 Change | ||
Model 1 a—SEE = 3.57 | - | - | - | 0.21 | 0.021 ** |
(Constant) | 10.74 | 1.95 | - | - | <0.01 *** |
HF, ms2 | 0.03 | 0.01 | 0.46 | - | 0.021 ** |
Model 2 a—SEE = 3.73 | - | - | - | 0.22 | NS |
(Constant) | 11.68 | 6.67 | 0.45 | 0.094 * | |
HF, ms2 | 0.04 | 0.02 | −0.03 | 0.034 ** | |
Age, years | −0.12 | 0.13 | −0.05 | NS | |
Time after diagnosis, years | −0.04 | 0.20 | NS | ||
Model 3 b—SEE = 0.60 | - | - | - | 0.09 | NS |
(Constant) | 2.05 | 0.16 | - | - | <0.01 *** |
Stress Index | −0.10 | 0.01 | −0.30 | - | NS |
Model 4 b—SEE = 5.53 | - | - | - | 0.36 | 0.023 ** |
(Constant) | 3.23 | 0.82 | - | - | 0.001 ** |
Stress Index | −0.01 | 0.01 | −0.37 | - | 0.048 ** |
Age, years | −0.02 | 0.02 | −0.25 | - | NS |
Time after diagnosis, years | −0.04 | 0.03 | −0.32 | - | NS |
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Martins, A.D.; Brito, J.P.; Oliveira, R.; Costa, T.; Ramalho, F.; Santos-Rocha, R.; Pimenta, N. Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study. Healthcare 2021, 9, 1205. https://doi.org/10.3390/healthcare9091205
Martins AD, Brito JP, Oliveira R, Costa T, Ramalho F, Santos-Rocha R, Pimenta N. Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study. Healthcare. 2021; 9(9):1205. https://doi.org/10.3390/healthcare9091205
Chicago/Turabian StyleMartins, Alexandre D., João Paulo Brito, Rafael Oliveira, Tiago Costa, Fátima Ramalho, Rita Santos-Rocha, and Nuno Pimenta. 2021. "Relationship between Heart Rate Variability and Functional Fitness in Breast Cancer Survivors: A Cross-Sectional Study" Healthcare 9, no. 9: 1205. https://doi.org/10.3390/healthcare9091205