The purpose of this paper is to analyze the seismic response effect caused by the mass eccentricity of individual equipment when conducting base isolation for the improvement of the seismic performance of a nuclear power plant. Recent research has in...
Signal transducer and activator of transcription 3 (STAT3) is a multifunctional factor that regulates inflammation and immunity. Knowledge of its regulatory mechanisms is very limited. Here, we showed that enterovirus 71 (EV71) infection induced the...
Seismic responses of Nuclear Island (NI) structures have great significance in the foundation adaptability analysis and the seismic design of equipment. However, with the increasing complexity of nuclear power site conditions, establishing a reasonab...
A two-degree-of-freedom (two-DOF) equation of motion was derived in the frequency domain using a substructuring technique for efficiently calculating the in-structure response spectrum (ISRS) considering equipment–structure interaction. The mod...
Given that aging deterioration significantly influences the structural behavior of reinforced concrete (RC) nuclear power plant (NPP) structures, it is crucial to incorporate changes in the material properties of NPPs for accurate prediction of seism...
Astronauts are exposed to considerable doses of space radiation during long-term space missions. As complete shielding of the highly energetic particles is impracticable, the cellular response to space-relevant radiation qualities has to be understoo...
Irregularity in the plane layout of a building structure and the vertical discontinuity of lateral resistance components could lead to torsion and result in the brittle failure of a structure. According to the characteristics of the conventional isla...
The skin sensitization potential of agrochemicals can be assessed using laboratory methods such as the keratinocyte activation assay so that their use in regulatory toxicology might replace experimental animal testing. Here, we evaluated the skin sen...
Nuclear Factor-Y (NF-Y) transcription factors play vital roles in plant abiotic stress response. Here, the NF-Y family in Brassica napus, which is hyper-sensitive to nitrogen (N) deprivation, was comprehensively identified and systematically characte...
Movement proteins (MPs) encoded by plant viruses are essential for cell-to-cell transport of viral genomes through plasmodesmata. The genome of hibiscus green spot virus contains a module of two MP genes termed ‘binary movement block’ (BM...
Mitochondria and chloroplasts are important actors in the plant nutritional efficiency. So, it could be expected that a disruption of the coadaptation between nuclear and organellar genomes impact plant response to nutrient stresses. We addressed thi...
The Keap1-Nrf2 signaling pathway is a central regulator of transcriptional responses to oxidative stress and is strongly linked to diverse pathologies, particularly cancer. In the cytoplasm, Keap1 (Kelch-like ECH-associated protein 1) promotes protea...
In this paper, a nuclear accident emergency response system based on unmanned aerial vehicles (UAVs) and bus collaboration is designed for radiation field estimation and evacuation. When a nuclear accident occurs, the radiation field is estimated fir...
In order to compare and analyze the seismic response characteristics of a safety-related nuclear structure on a non-rock site in the condition of raft and pile group foundations under unidirectional and multidirectional seismic motion input, a large-...
In this paper, a refined 3D direct finite element model including nuclear power plant structures and soil is developed. The wave input method, including free-field loads and a viscous spring artificial boundary, is used. The effects of structural bur...
Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix. Although the nucleus is m...
Cytochrome c oxidase (COX), a multimeric protein complex, is the final electron acceptor in the mitochondrial electron transfer chain. Primary COX deficiency, caused by mutations in either mitochondrial DNA or nuclear-encoded genes, is a heterogenous...
Based on the results of the nuclear accident response education questionnaire, we use system dynamics to develop a nuclear accident response education effectiveness evaluation model. A questionnaire survey was conducted for the pre- and post-tests of...
Radiation therapy is commonly used to treat glioblastoma multiforme (GBM) brain tumors. Ionizing radiation (IR) induces dose-specific variations in transcriptional programs, implicating that they are tightly regulated and critical components in the t...
The safe evacuation of residents near a nuclear power plant during a nuclear accident is vital for emergency response planning. To tackle this challenge, considering the dynamic dispersion of radioactive materials in the atmosphere and its impact on...
SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme for maintaining cellular redox homeostasis. SOD1 dysregulation...
We study the role of short-range correlations, as well as pion and rho loops governing long-range RPA correlations, in nuclear matter properties and response functions. We use an adapted formulation of the Brueckner G-matrix approach to generate a pa...
At the beginning of the 21st century, it became obvious that radical changes had taken place in the concept of living matter and, in particular, in the concept of the organization of intracellular space. The accumulated data testify to the essential...
Iron scarcity provokes a cellular response consisting of the strong expression of high-affinity systems to optimize iron uptake and mobilization. Aft1 is a primary transcription factor involved in iron homeostasis and controls the expression of high-...
The immune system consists of various cells, organs, and processes that interact in a sophisticated manner to defend against pathogens. Upon initial exposure to an invader, nonspecific mechanisms are raised through the activation of macrophages, mono...
Resilience engineering is a new approach to safety, focused on systems for coping with complexity and balancing productivity with safety. Since the early 2000s, several studies have been conducted on the application of resilience to various industrie...
Lamina-associated polypeptide 1 (LAP1) is a nuclear envelope (NE) protein whose function remains poorly characterized. In a recent LAP1 protein interactome study, a putative regulatory role in the DNA damage response (DDR) has emerged and telomeric r...
After the Fukushima nuclear accident in Japan, whether the structural safety of the nuclear power plant (NPP) can be guaranteed under an earthquake has been of wide concern. Automatic seismic trip systems (ASTS) have been deployed in NPPs. There are...
As a transportation hub connecting sea and land, the seismic safety of an undersea tunnel is very important. Based on the structural and stress characteristics of a shield tunnel, a seismic response analysis of a coastal nuclear power plant under a c...
The origin of eukaryotic organisms involved the integration of mitochondria into the ancestor cell, with a massive gene transfer from the original proteobacterium to the host nucleus. Thus, mitochondrial performance relies on a mosaic of nuclear gene...
Despite extraordinary advances in fields of immunology and infectious diseases, vaccine development remains a challenge. The development of a respiratory syncytial virus vaccine, for example, has spanned more than 50 years of research with studies of...
This article investigates the ethical implications of the notion of an Atomic Priesthood, an artificially constructed religion built around the preservation of knowledge related to nuclear-waste storage by using the work of Hans Jonas (1903–1993) and...
Notch is a conserved developmental signaling pathway that is dysregulated in many cancer types, most often through constitutive activation. Tumor cells with nuclear accumulation of the active Notch receptor, NICD, generally exhibit enhanced survival...
Hypercapnia occurs when the partial pressure of carbon dioxide (CO2) in the blood exceeds 45 mmHg. Hypercapnia is associated with several lung pathologies and is transcriptionally linked to suppression of immune and inflammatory signalling through po...
In recent years, it has been suggested that host cells exert intrinsic mechanisms to control nuclear replicating DNA viruses. This cellular response involves nuclear antiviral factors targeting incoming viral genomes. Herpes simplex virus-1 (HSV-1) i...
Dry systems are being employed worldwide as interim storage for Spent Nuclear Fuel (SNF). Despite not being designed as permanent repositories, the safe storage of SNF must still be ensured. In this framework, few experimental campaigns have been con...
Low-voltage cable systems in nuclear power plants are key components that have a crucial role in the safe operation of nuclear facilities. Thus, the aging management of cable systems is of utmost importance as they cannot easily or economically be re...
Oxysterols, important regulators of cholesterol homeostasis in the brain, are affected by neurodegenerative diseases. Early-onset Alzheimer’s disease is associated with higher levels of circulating brain-derived 24S-hydroxycholesterol (24S-OHC)...
In this paper, we present the availability of an active pixel sensor (APS) with four transistors (4T) as a video monitor and radiation detector. Analyzing radiation damage must be one of the first steps in recovering from nuclear accidents, and the r...
Reactive Oxygen Species (ROS) are reactive molecules required for the maintenance of physiological functions. Oxidative stress arises when ROS production exceeds the cellular ability to eliminate such molecules. In this study, we showed that oxidativ...
Influenza A virus (IAV) remains a pandemic threat. Particularly, the evolution and increased interspecies and intercontinental transmission of avian IAV H5N1 subtype highlight the importance of continuously studying the IAV and identifying the determ...
Transcription factors play a significant role during the symptomatic onset and progression of prion diseases. We previously showed the immunomodulatory and nuclear factor of activated T cells’ (NFAT) suppressive effects of an immunosuppressant,...
Deoxynivalenol (DON) is highly toxic to animals and humans, but pigs are most sensitive to it. The porcine mucosal injury related mechanism of DON is not yet fully clarified. Here, we investigated DON-induced injury in the intestinal tissues of pigle...
As a critical component of nuclear power units, the direct cooling water system plays a key role in overall performance. To maintain economic efficiency, it is necessary to adjust the circulating water flow rate as conditions change. Understanding ho...
A multi-unit nuclear accident is an accident that damages the nuclear core and occurs in multiple units simultaneously in a nuclear power plant. Its massive consequences have triggered extensive studies on accident prevention and mitigation. In this...
HER2-enriched tumors are responsible for 20% of breast tumors and have high rates of immune infiltrates in the tumor stroma that respond favorably to neoadjuvant chemotherapy. In the context of tumors, telomeres control cell death and prevent tumor c...
Mediator of DNA damage checkpoint protein 1 (MDC1) plays a vital role in DNA damage response (DDR) by coordinating the repair of double strand breaks (DSBs). Here, we identified a novel interaction between MDC1 and karyopherin α-2 (KPNA2), a nu...
Portulaca oleracea is as a medicinal plant known for its neuroprotective, hepatoprotective, antidiabetic, antioxidant, anticancer, antimicrobial, antiulcerogenic, and anti-inflammatory activities. However, the specific active compounds responsible fo...
Renewable integration into the electricity system of Great Britain (GB) is causing considerable demand for additional flexibility from plants. In particular, a considerable share of this flexibility may be dispatched to secure post-fault transient fr...
Hepatitis C virus (HCV) infection compromises the natural defense mechanisms of the liver leading to a progressive end stage disease such as cirrhosis and hepatocellular carcinoma (HCC). The hepatic stress response generated due to viral replication...
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