Ideal drug carriers should be stable in biological environments but eventually release their drug load once inside the targeted cells. These two aspects can be in contrast with each other, thus they need to be carefully tuned in order to achieve the...
The stability of active pharmaceutical ingredients (APIs) and the corresponding pharmaceutical formulations are nowadays of great importance in pharmaceutical research and technology. The quality of an API or of finished pharmaceutical products (FPPs...
Petroleum-based lubricants raise environmental concerns due to their non-biodegradability and toxicity, whereas biobased lubricants underperform owing to low thermal stability. This study examined and compared three vegetable oils, along with their c...
A crucial aspect of pharmaceutical development is the demonstration of long-term stability of the drug product. Biopharmaceuticals, such as proteins or peptides in liquid formulation, are typically administered via parental routes and should be stabl...
Real-time transient stability studies are based on voltage angle measures obtained with phasor measurement units (PMUs). A more precise calculation to address transient stability is obtained when using the rotor angles. However, these values are comm...
Microwave-based dielectric heating is a suitable method for energy- and time-efficient processes. Considering the energy required in the production of carbon fibers, it is evident that microwave-based dielectric heating during the different phases of...
The thermal stability and degradation kinetics of patulin (PAT, 10 μmol/L) in pH 3.5 of phosphoric-citric acid buffer solutions in the absence and presence of cysteine (CYS, 30 μmol/L) were investigated at temperatures ranging from 90 to 150 °C. The...
The kinetic features of a slow-moving landslide situated above the Wudongde hydropower station were analyzed using particle flow code 3D (PFC3D) software. This research was based on geological investigations, remote sensing interpretation, and digita...
Anthocyanins are flavonoid substances of plant origin with potential antioxidant effects. Because of their intense colors, they are used as natural dyes in food. However, their stability in food matrices is limited. This study aimed to verify the eff...
This research explores the application of germinated mung bean extract, rich in GABA (Gamma-aminobutyric acid) and polyphenols, in enhancing human health. Recognizing the instability of these bioactive compounds in environmental conditions, encapsula...
Nowadays, the incorporation of nanoparticles into thermal fluids has become one of the most suitable strategies for developing high-performance fluids. An unconventional improvement of thermo–physical properties was observed with the addition o...
This study is dedicated to an investigation and comparison of the kinetics of the foam stability of protein foaming agents based on the hydrolysates of solid keratin. The work utilized ready-made hydrolysates based on sodium hydroxide and a mixture o...
Hybrid silica xerogels functionalised with chlorinated organosilanes combine tunable porosity and surface chemistry, rendering them attractive for applications in sensing, membrane technology, and photonics. This study quantitatively investigates the...
This paper presents a comprehensive analysis of the thermal stability and decomposition mechanisms of IPN hydrogels based on polyvinyl alcohol (PVA) and a copolymer network of poly(ethylene glycol) diacrylate–poly(ethylene glycol) methacrylate...
This paper proposes an innovative transient stability index (TSI) designed to enhance the real-time assessment of power system stability. The TSI integrates a corrected kinetic energy approach with a modified equal area criterion, offering a novel me...
This work reports a study on the structural characterization, evaluation of thermal stability, and non-isothermal decomposition kinetics of urea–formaldehyde (UF) resin modified with hydrochar (obtained by the hydrothermal carbonization of spen...
Mathematics and physics are deeply interconnected. In fact, physics relies on mathematical tools like calculus and differential equations. The aim of this article is to introduce tempered Riemann–Liouville (RL) fractional operators and their pr...
The aim of this study was to compare the effectiveness of edible oil (as an extractant) for the extraction of CA (carnosic acid), C (carnosol), and RA (rosmarinic acid) from sage with popular solvents (methanol, ethanol, 70% methanol, 70% ethanol, an...
The aim of this study was to analyze the crystallization of the Mg72Zn24Ca4 metallic glass alloy. The crystallization process of metallic glass Mg72Zn24Ca4 was investigated by means of the differential scanning calorimetry. The glass-forming ability...
Acerola (Malpighia emarginata DC.) is a sub-tropical and tropical fruit renowned for its high levels of vitamin C and phenolic compounds, which offer health benefits. This study aimed to optimize the spray drying process by determining the inlet and...
Sol-gel entrapment is an efficient immobilization technique that allows preparation of robust and highly stable biocatalysts. Lipase from Candida antarctica B was immobilized by sol-gel entrapment and by sol-gel entrapment combined with adsorption on...
Amphoteric amphiphilic compounds, due to their unique properties, may represent a group of safe and biocompatible surface-active agents for effective colloidal stabilization of nanoformulations. For this reason, the aim of this work was to develop an...
In this paper, magnesium oxychloride cement with stoichiometry 3Mg(OH)2∙MgCl2∙8H2O (MOC 3-1-8) was prepared and characterized. The phase composition and kinetics of formation were studied by X-ray diffraction (XRD) and Rietveld analysis of obtained d...
Protein stabilization in white wines commonly involves bentonite fining, yet the influence of bentonite type, dosage, and pre-fermentative treatment on wine composition and fermentation remains underexplored. This study assessed the effects of pre-fe...
Tetraazamacrocycles, cyclic molecules with four nitrogen atoms, have long been known to produce highly stable transition metal complexes. Cross-bridging such molecules with two-carbon chains has been shown to enhance the stability of these complexes...
Bio-oils employed for various industrial purposes, such as biodiesel production, undergo extensive oxidation and degradation during transformation processes. Therefore, it is extremely important to predict their stability at high temperature. We repo...
A simple, precise, and accurate reversed-phase ultra-performance liquid chromatographic (UPLC) method was developed and validated for the determination of a mycophenolic acid-curcumin (MPA-CUR) conjugate in buffer solutions. Chromatographic separatio...
We review the concept of dynamic kinetic stability, a type of stability associated specifically with replicating entities, and show how it differs from the well-known and established (static) kinetic and thermodynamic stabilities associated with regu...
This paper presents the results obtained after studying the thermal stability and decomposition kinetics of perindopril erbumine as a pure active pharmaceutical ingredient as well as a solid pharmaceutical formulation containing the same active pharm...
Amorphous solid dispersion drug delivery systems (ASD DDS) were proved to be efficient for the enhancement of solubility and bioavailability of poorly water-soluble drugs. One of the major keys for successful preparation of ASD is the selection of ap...
Hydroprocessing reactions require several days to reach steady-state, leading to long experimentation times for collecting sufficient data for kinetic modeling purposes. The information contained in the transient data during the evolution toward the...
Vitamin D3 has numerous beneficial effects, such as musculoskeletal, immunomodulatory, and neuroprotective. However, its instability is the main obstacle to formulating quality products. Despite increased attention and growing use, data on vitamin D3...
In this paper, the structural properties of chemical reaction systems obeying the mass action law are investigated and related to the physical and chemical properties of the system. An entropy-based Lyapunov function candidate serves as a tool for pr...
Thymoquinone (TQ) is a potent anticancer phytochemical with confirmed in vitro efficacy. Its clinical use has not yet established, and very few reports have documented its formulation. There also are no reports about the aqueous solubility and stabil...
Anthocyanins are colored valuable biocompounds, of which extraction increases globally, although functional applications are restrained by their limited environmental stability. Temperature is a critical parameter of food industrial processing that i...
Surface microstructure of grains vastly decides the electrochemical performance of nickel-rich oxide cathodes, which can improve their interfacial kinetics and structural stability to realize their further popularization. Herein, taking the represent...
The present study reports the results obtained after the analysis of the thermal stability and decomposition kinetics of widely used synthetic derivative of estradiol, ethinylestradiol (EE), as a pure active pharmaceutical ingredient. As investigatio...
This research was designed to identify thermodynamically and kinetically stable lipidic self-emulsifying formulations through simple energy dynamics in addition to highlighting and clarifying common ambiguities in the literature in this regard. Propo...
Dissociation pathways of the global minimum geometry of Si
This paper is devoted to the comparison of discrete velocity models used for simulation of compressible flows with arbitrary specific heat ratios in the lattice Boltzmann method. The stability of the governing equations is analyzed for the steady flo...
In low-inertia systems with a high penetration of renewable energy, the rotational kinetic energy and inertia constant are significant factors in determining frequency stability. The energy released owing to the frequency decrease during contingency...
Ionic liquids (ILs) are the safest solvent in various high-temperature applications due to their non-flammable properties. In order to obtain their thermal stability properties, thermogravimetric analysis (TGA) is extensively used to analyze the kine...
Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains,...
In this paper, we report on the use of amorphous lignin, a waste by-product of the paper industry, for the production of high performance carbon fibers (CF) as precursor with improved thermal stability and thermo-mechanical properties. The precursor...
Divalent metal ions are essential for the efficient catalysis and structural stability of many nucleotidyl-transfer enzymes. Poly(A)-specific ribonuclease (PARN) belongs to the DEDD superfamily of 3'-exonucleases, and the active site of PARN contains...
Poly(lactic acid) (PLA) nanocomposites with antimicrobial fillers have been increasingly explored as food packaging materials that are made of a biobased matrix and can minimize food loss due to spoilage. Some of the most commonly studied fillers are...
Transthyretin (TTR) is a homotetrameric protein involved in human amyloidosis, including familial amyloid polyneuropathy (FAP). Discovering small-molecule stabilizers of the TTR tetramer is a therapeutic strategy for these diseases. Tafamidis, the on...
Conformational diseases are often caused by mutations, altering protein folding and stability in vivo. We review here our recent work on the effects of mutations on the human phosphoglycerate kinase 1 (hPGK1), with a particular focus on thermodynamic...
A large quantity of food waste (FW) is generated annually across the world and results in environmental pollution and degradation. This study investigated the performance of a 160 L anaerobic biofilm single-stage reactor in treating FW. The reactor w...
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of XBJ injection. At first, the stability of HSYA in solution and in a Xuebijing injection was investigated, then the mechanisms of the increased stability of HSYA in the XBJ injection w...
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