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403 Results Found

  • Article
  • Open Access
22 Citations
6,346 Views
22 Pages

Early diagnosis of medical conditions in infants is crucial for ensuring timely and effective treatment. However, infants are unable to verbalize their symptoms, making it difficult for healthcare professionals to accurately diagnose their conditions...

  • Article
  • Open Access
5 Citations
7,913 Views
21 Pages

21 April 2020

Infant features are physical traits that are characteristic of human infants and include facial features such as large and low-lying eyes, and a small nose and mouth. Animals possessing high levels of infant features elicit care-giving responses in h...

  • Article
  • Open Access
8 Citations
3,300 Views
15 Pages

Infant Low Birth Weight Prediction Using Graph Embedding Features

  • Wasif Khan,
  • Nazar Zaki,
  • Amir Ahmad,
  • Jiang Bian,
  • Luqman Ali,
  • Mohammad Mehedy Masud,
  • Nadirah Ghenimi and
  • Luai A. Ahmed

Low Birth weight (LBW) infants pose a serious public health concern worldwide in both the short and long term for infants and their mothers. Infant weight prediction prior to birth can help to identify risk factors and reduce the risk of infant morbi...

  • Article
  • Open Access
1 Citations
1,948 Views
12 Pages

14 October 2024

Neurodevelopment is a highly intricate process, and early detection of abnormalities is critical for optimizing outcomes through timely intervention. Accurate and cost-effective diagnostic methods for neurological disorders, particularly in infants,...

  • Article
  • Open Access
1,999 Views
11 Pages

A Novel Pathogenic TUBA1A Variant in a Croatian Infant Is Linked to a Severe Tubulinopathy with Walker–Warburg-like Features

  • Akzam Saidin,
  • Anet Papazovska Cherepnalkovski,
  • Zeeshan Shaukat,
  • Todor Arsov,
  • Rashid Hussain,
  • Ben J. Roberts,
  • Marija Bucat,
  • Klara Cogelja,
  • Michael G. Ricos and
  • Leanne M. Dibbens

5 August 2024

Tubulinopathies are associated with malformations of cortical development but not Walker–Warburg Syndrome. Intensive monitoring of a Croatian infant presenting as Walker–Warburg Syndrome in utero began at 21 weeks due to increased growth...

  • Review
  • Open Access
735 Citations
104,102 Views
11 Pages

Review of Infant Feeding: Key Features of Breast Milk and Infant Formula

  • Camilia R. Martin,
  • Pei-Ra Ling and
  • George L. Blackburn

11 May 2016

Mothers’ own milk is the best source of nutrition for nearly all infants. Beyond somatic growth, breast milk as a biologic fluid has a variety of other benefits, including modulation of postnatal intestinal function, immune ontogeny, and brain develo...

  • Article
  • Open Access
36 Citations
6,768 Views
15 Pages

Writhing Movement Detection in Newborns on the Second and Third Day of Life Using Pose-Based Feature Machine Learning Classification

  • Iwona Doroniewicz,
  • Daniel J. Ledwoń,
  • Alicja Affanasowicz,
  • Katarzyna Kieszczyńska,
  • Dominika Latos,
  • Małgorzata Matyja,
  • Andrzej W. Mitas and
  • Andrzej Myśliwiec

22 October 2020

Observation of neuromotor development at an early stage of an infant’s life allows for early diagnosis of deficits and the beginning of the therapeutic process. General movement assessment is a method of spontaneous movement observation, which...

  • Article
  • Open Access
5 Citations
3,407 Views
23 Pages

25 November 2024

An important hurdle in medical diagnostics is the high-quality and interpretable classification of audio signals. In this study, we present an image-based representation of infant crying audio files to predict abnormal infant cries using a vision tra...

  • Article
  • Open Access
3 Citations
6,452 Views
16 Pages

4 June 2022

Several factors may influence cats’ length of stay (LoS) within the shelter environment. The aim of this study was to investigate the potential influence that baby schema (characteristic facial features of infants, related to perceived ‘c...

  • Article
  • Open Access
1,086 Views
14 Pages

12 September 2025

Introduction: Advanced identification and intervention for Congenital Heart Defects (CHDs) in pediatric populations are crucial, as approximately 1% of neonates worldwide present with these conditions. Traditional methods of diagnosing CHDs often rel...

  • Article
  • Open Access
8 Citations
3,964 Views
17 Pages

24 August 2020

Infants’ visual processing of emotion undergoes significant development across the first year of life, yet our knowledge regarding the mechanisms underlying these advances is limited. Additionally, infant emotion processing is commonly examined...

  • Case Report
  • Open Access
7 Citations
5,155 Views
7 Pages

Early Desquamating Perineal Erythema in a Febrile Infant: A Characteristic Clinical Feature of Kawasaki Disease

  • Chiara Isidori,
  • Lisa Sebastiani,
  • Maria Chiara Cardellini,
  • Giuseppe Di Cara,
  • Donato Rigante and
  • Susanna Esposito

Background: The occurrence of a distinctive perineal eruption that appears early in infants with Kawasaki disease (KD), the most relevant type of febrile vasculitis of childhood, has received little attention in pediatric reports. KD diagnosis is bas...

  • Review
  • Open Access
4 Citations
6,141 Views
13 Pages

18 December 2021

Deaths from herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are rare. A major exception is perinatally acquired HSV-1 or HSV-2 infection where the neonatal death rate is substantial. Fatal HSV infection also occurs occasio...

  • Letter
  • Open Access
39 Citations
4,460 Views
11 Pages

Deep-Learning-Based Detection of Infants with Autism Spectrum Disorder Using Auto-Encoder Feature Representation

  • Jung Hyuk Lee,
  • Geon Woo Lee,
  • Guiyoung Bong,
  • Hee Jeong Yoo and
  • Hong Kook Kim

26 November 2020

Autism spectrum disorder (ASD) is a developmental disorder with a life-span disability. While diagnostic instruments have been developed and qualified based on the accuracy of the discrimination of children with ASD from typical development (TD) chil...

  • Article
  • Open Access
1 Citations
1,780 Views
13 Pages

A Pilot Study: Sleep and Activity Monitoring of Newborn Infants by GRU-Stack-Based Model Using Video Actigraphy and Pulse Rate Variability Features

  • Ádám Nagy,
  • Zita Lilla Róka,
  • Imre Jánoki,
  • Máté Siket,
  • Péter Földesy,
  • Judit Varga,
  • Miklós Szabó and
  • Ákos Zarándy

17 June 2025

We introduce a novel system for automatic assessment of newborn and preterm infant behavior—including activity levels, behavioral states, and sleep–wake cycles—in clinical settings for streamlining care and minimizing healthcare pro...

  • Article
  • Open Access
6 Citations
3,251 Views
26 Pages

Neonatal mortality remains a critical global challenge, particularly in resource-limited settings with restricted access to advanced diagnostic tools. Early detection of life-threatening conditions like Sepsis and Respiratory Distress Syndrome (RDS),...

  • Article
  • Open Access
3 Citations
2,139 Views
13 Pages

Numerical Method for Geometrical Feature Extraction and Identification of Patient-Specific Aorta Models in Pediatric Congenital Heart Disease

  • Alex G. Kuchumov,
  • Olga V. Doroshenko,
  • Mikhail V. Golub,
  • Nikita D. Saychenko,
  • Irina O. Rakisheva and
  • Roman M. Shekhmametyev

27 June 2023

An algorithm providing information on the key geometric features of an aorta extracted from multi-slice computed tomography images is proposed. Using the numerical method, the aorta’s geometric characteristics, such as vessel cross-sectional ar...

  • Article
  • Open Access
5 Citations
3,495 Views
10 Pages

Clinical Differences between SARS-CoV-2 and RSV Infections in Infants: Findings from a Case–Control Study

  • Victor Daniel Miron,
  • Raluca-Oana Raianu,
  • Claudiu Filimon and
  • Mihai Craiu

30 December 2023

Infants are a unique pediatric group due to their high hospitalization rates and unfavorable outcomes from acute infectious diseases. Understanding the clinical differences and aftereffects of SARS-CoV-2 in comparison to other prevalent viruses in th...

  • Review
  • Open Access
18 Citations
6,735 Views
20 Pages

Review of Biomedical Applications of Contactless Imaging of Neonates Using Infrared Thermography and Beyond

  • Abbas K. AlZubaidi,
  • Yahya Ethawi,
  • Georg M. Schmölzer,
  • Sherif Sherif,
  • Michael Narvey and
  • Molly Seshia

29 October 2018

The sick preterm infant monitoring is an intriguing job that medical staff in Neonatal Intensive Care Units (NICU) must deal with on a daily basis. As a standards monitoring procedure, preterm infants are monitored via sensors and electrodes that are...

  • Article
  • Open Access
3 Citations
1,754 Views
22 Pages

Investigation of Relationship between Hemodynamic and Morphometric Characteristics of Aortas in Pediatric Patients

  • Olga V. Doroshenko,
  • Alex G. Kuchumov,
  • Mikhail V. Golub,
  • Irina O. Rakisheva,
  • Nikita A. Skripka,
  • Sergey P. Pavlov,
  • Yulija A. Strazhec,
  • Petr V. Lazarkov,
  • Nikita D. Saychenko and
  • Roman M. Shekhmametyev

29 August 2024

Background: The utilization of hemodynamic parameters, whose estimation is often cumbersome, can fasten diagnostics and decision-making related to congenital heart diseases. The main goal of this study is to investigate the relationship between hemod...

  • Article
  • Open Access
9 Citations
2,571 Views
11 Pages

Omicron in Infants—Respiratory or Digestive Disease?

  • Anca Cristina Drăgănescu,
  • Victor Daniel Miron,
  • Oana Săndulescu,
  • Anuţa Bilaşco,
  • Anca Streinu-Cercel,
  • Roxana Gabriela Sandu,
  • Adrian Marinescu,
  • Deniz Gunșahin,
  • Karina Ioana Hoffmann and
  • Doina Anca Pleșca
  • + 3 authors

The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current stu...

  • Article
  • Open Access
21 Citations
6,302 Views
16 Pages

Infants’ early exposure to painful procedures can have negative short and long-term effects on cognitive, neurological, and brain development. However, infants cannot express their subjective pain experience, as they do not communicate in any languag...

  • Article
  • Open Access
14 Citations
8,025 Views
5 Pages

Severe Food Protein-Induced Enterocolitis Syndrome to Cow’s Milk in Infants

  • Min Yang,
  • Lanlan Geng,
  • Zhaohui Xu,
  • Peiyu Chen,
  • Craig A. Friesen,
  • Sitang Gong and
  • Ding-You Li

22 December 2015

Cow’s milk is the most common cause of food-protein-induced enterocolitis syndrome (FPIES). The aim of this study was to examine the clinical features and treatment outcomes of infants with severe FPIES to cow’s milk. We reviewed all infants ≤12 mont...

  • Article
  • Open Access
10 Citations
2,618 Views
21 Pages

Segmentation of Infant Brain Using Nonnegative Matrix Factorization

  • Norah Saleh Alghamdi,
  • Fatma Taher,
  • Heba Kandil,
  • Ahmed Sharafeldeen,
  • Ahmed Elnakib,
  • Ahmed Soliman,
  • Yaser ElNakieb,
  • Ali Mahmoud,
  • Mohammed Ghazal and
  • Ayman El-Baz

26 May 2022

This study develops an atlas-based automated framework for segmenting infants’ brains from magnetic resonance imaging (MRI). For the accurate segmentation of different structures of an infant’s brain at the isointense age (6–12 mont...

  • Article
  • Open Access
12 Citations
9,166 Views
10 Pages

Assessing Mothers’ Postpartum Depression From Their Infants’ Cry Vocalizations

  • Giulio Gabrieli,
  • Marc H. Bornstein,
  • Nanmathi Manian and
  • Gianluca Esposito

6 February 2020

Postpartum Depression (PPD), a condition that affects up to 15% of mothers in high-income countries, reduces attention to the needs of the child and is among the first causes of infanticide. PPD is usually identified using self-report measures and th...

  • Article
  • Open Access
17 Citations
3,668 Views
13 Pages

Prenatal and Neonatal Characteristics of Children with Prader-Willi Syndrome

  • Lionne N. Grootjen,
  • Nathalie E. M. Uyl,
  • Inge A. L. P. van Beijsterveldt,
  • Layla Damen,
  • Gerthe F. Kerkhof and
  • Anita C. S. Hokken-Koelega

28 January 2022

Objective: Prader-Willi syndrome (PWS) is a rare genetic syndrome with a wide spectrum of clinical features in early life. Late diagnoses are still present. We characterized the perinatal and neonatal features of PWS, compared them with those of heal...

  • Article
  • Open Access
62 Citations
7,966 Views
12 Pages

Complexity Analysis of Neonatal EEG Using Multiscale Entropy: Applications in Brain Maturation and Sleep Stage Classification

  • Ofelie De Wel,
  • Mario Lavanga,
  • Alexander Caicedo Dorado,
  • Katrien Jansen,
  • Anneleen Dereymaeker,
  • Gunnar Naulaers and
  • Sabine Van Huffel

26 September 2017

Automated analysis of the electroencephalographic (EEG) data for the brain monitoring of preterm infants has gained attention in the last decades. In this study, we analyze the complexity of neonatal EEG, quantified using multiscale entropy. The aim...

  • Systematic Review
  • Open Access
32 Citations
8,442 Views
31 Pages

Multisystem Inflammatory Syndrome in Neonates Born to Mothers with SARS-CoV-2 Infection (MIS-N) and in Neonates and Infants Younger Than 6 Months with Acquired COVID-19 (MIS-C): A Systematic Review

  • Domenico Umberto De Rose,
  • Flaminia Pugnaloni,
  • Monica Calì,
  • Sara Ronci,
  • Stefano Caoci,
  • Chiara Maddaloni,
  • Ludovica Martini,
  • Alessandra Santisi,
  • Andrea Dotta and
  • Cinzia Auriti

2 April 2022

(1) Introduction: There is an increasing literature describing neonates born to mothers with SARS-CoV-2 infection (MIS-N) and infants infected with SARS-CoV-2 who presented with a severe disease (MIS-C). (2) Methods: To investigate clinical features...

  • Article
  • Open Access
1 Citations
1,535 Views
9 Pages

Automatic Movement Recognition for Evaluating the Gross Motor Development of Infants

  • Yin-Zhang Yang,
  • Jia-An Tsai,
  • Ya-Lan Yu,
  • Mary Hsin-Ju Ko,
  • Hung-Yi Chiou,
  • Tun-Wen Pai and
  • Hui-Ju Chen

28 February 2025

Objective: The objective of this study was to early-detect gross motor abnormalities through video detection in Taiwanese infants aged 2–6 months. Background: The current diagnosis of infant developmental delays primarily relies on clinical exa...

  • Article
  • Open Access
8,604 Views
15 Pages

1 July 2020

Attractiveness is perceived based on both facial physical features and prior experience for adults. Infants also prefer attractive or familiar faces, but it is unclear whether facial physical features and prior experience affect their preference. In...

  • Article
  • Open Access
19 Citations
5,355 Views
17 Pages

Untargeted Metabolomic Analysis of Human Milk from Mothers of Preterm Infants

  • Lila S. Nolan,
  • Angela N. Lewis,
  • Qingqing Gong,
  • James J. Sollome,
  • Olivia N. DeWitt,
  • Robert D. Williams and
  • Misty Good

14 October 2021

The application of metabolomics in neonatology offers an approach to investigate the complex relationship between nutrition and infant health. Characterization of the metabolome of human milk enables an investigation into nutrients that affect the ne...

  • Article
  • Open Access
2 Citations
2,754 Views
12 Pages

Combining Cardiorespiratory Signals and Video-Based Actigraphy for Classifying Preterm Infant Sleep States

  • Dandan Zhang,
  • Zheng Peng,
  • Carola Van Pul,
  • Sebastiaan Overeem,
  • Wei Chen,
  • Jeroen Dudink,
  • Peter Andriessen,
  • Ronald M. Aarts and
  • Xi Long

7 November 2023

The classification of sleep state in preterm infants, particularly in distinguishing between active sleep (AS) and quiet sleep (QS), has been investigated using cardiorespiratory information such as electrocardiography (ECG) and respiratory signals....

  • Article
  • Open Access
6 Citations
3,435 Views
14 Pages

Association between Abnormal Antenatal Doppler Characteristics and Gastrointestinal Outcomes in Preterm Infants

  • Silvia Martini,
  • Mariarosaria Annunziata,
  • Anna Nunzia Della Gatta,
  • Arianna Aceti,
  • Marica Brunetti,
  • Gianluigi Pilu,
  • Giuliana Simonazzi and
  • Luigi Corvaglia

2 December 2022

Antenatal Doppler disturbances are associated with fetal hypoxia and may induce a brain-sparing vascular redistribution at the expense of splanchnic circulation, possibly predisposing to gut complications. We aimed to compare several gastrointestinal...

  • Article
  • Open Access
38 Citations
6,152 Views
10 Pages

Deep Learning for Infant Cry Recognition

  • Yun-Chia Liang,
  • Iven Wijaya,
  • Ming-Tao Yang,
  • Josue Rodolfo Cuevas Juarez and
  • Hou-Tai Chang

Recognizing why an infant cries is challenging as babies cannot communicate verbally with others to express their wishes or needs. This leads to difficulties for parents in identifying the needs and the health of their infants. This study used deep l...

  • Review
  • Open Access
1 Citations
6,294 Views
8 Pages

This review article will address the frequently encountered functional gastrointestinal disorders (FGIDs) occurring in infancy. The clinical features and management of infant regurgitation, infant colic, infant dyschezia, and functional constipation...

  • Article
  • Open Access
29 Citations
6,487 Views
12 Pages

Movidea: A Software Package for Automatic Video Analysis of Movements in Infants at Risk for Neurodevelopmental Disorders

  • Walter Baccinelli,
  • Maria Bulgheroni,
  • Valentina Simonetti,
  • Francesca Fulceri,
  • Angela Caruso,
  • Letizia Gila and
  • Maria Luisa Scattoni

Early detecting the presence of neurodevelopmental disorders plays an important role in the effectiveness of the treatment. In this paper, we present a novel tool to extract motion features using single camera video recordings of infants. The Movidea...

  • Article
  • Open Access
10 Citations
3,560 Views
13 Pages

Machine Learning Detects Intraventricular Haemorrhage in Extremely Preterm Infants

  • Minoo Ashoori,
  • John M. O’Toole,
  • Ken D. O’Halloran,
  • Gunnar Naulaers,
  • Liesbeth Thewissen,
  • Jan Miletin,
  • Po-Yin Cheung,
  • Afif EL-Khuffash,
  • David Van Laere and
  • Fiona B. McDonald
  • + 2 authors

Objective: To test the potential utility of applying machine learning methods to regional cerebral (rcSO2) and peripheral oxygen saturation (SpO2) signals to detect brain injury in extremely preterm infants. Study design: A subset of infants enrolled...

  • Article
  • Open Access
4 Citations
4,167 Views
15 Pages

A Stress Reduction Intervention for Lactating Mothers Alters Maternal Gut, Breast Milk, and Infant Gut Microbiomes: Data from a Randomized Controlled Trial

  • Jinyue Yu,
  • Yan Zhang,
  • Jonathan C. K. Wells,
  • Zhuang Wei,
  • Mona Bajaj-Elliott,
  • Dennis Sandris Nielsen and
  • Mary S. Fewtrell

6 April 2024

Background: This secondary analysis of data from a randomized controlled trial (RCT) investigated how the maternal gut, breast milk, and infant gut microbiomes may contribute to the effects of a relaxation intervention, which reduced maternal stress...

  • Article
  • Open Access
5 Citations
2,833 Views
6 Pages

Larger Physique as a Risk Factor for Infantile Appendicitis: A Retrospective Study

  • Katsuhiro Nishimura,
  • Keita Terui,
  • Naoko Mise,
  • Gen Matsuura,
  • Mitsuyuki Nakata,
  • Shugo Komatsu,
  • Takeshi Saito and
  • Tomoro Hishiki

4 January 2022

The clinical features and risk factors of acute appendicitis in infants are unclear. Our aim was to evaluate the association between anthropometrics and the occurrence of infantile appendicitis. This was a retrospective study of infants (<6 years...

  • Article
  • Open Access
3 Citations
3,252 Views
15 Pages

Vertical Symmetry Is Special to Infants; Vertical Symmetry in Upright Human Faces More So

  • Marc H. Bornstein,
  • Clay Mash,
  • Martha E. Arterberry and
  • Gianluca Esposito

15 September 2023

Symmetry has long been viewed as a feature of objects that facilitates ease of perception. Three experiments investigated 4- to 5-month-old infants’ detection and processing of vertical symmetry, oblique symmetry, and asymmetry in novel pattern...

  • Review
  • Open Access
7 Citations
3,305 Views
11 Pages

17 February 2023

Intracardiac thrombi in preterm infants are not common but may lead to fatal outcomes. Predisposing and risk factors include small vessel size, hemodynamic instability, immaturity of the fibrinolytic system, indwelling central catheters and sepsis. I...

  • Article
  • Open Access
1 Citations
4,194 Views
12 Pages

Psychomotor developmental delay in infants includes failure to acquire abilities such as sitting, walking, grasping objects and communication at the ages when most infants have acquired these abilities. Known risk factors include a large number of as...

  • Article
  • Open Access
2 Citations
3,183 Views
13 Pages

26 June 2024

Functional Near Infrared Spectroscopy (fNIRS) and Electroencephalography (EEG) are commonly employed neuroimaging methods in developmental neuroscience. Since they offer complementary strengths and their simultaneous recording is relatively easy, com...

  • Article
  • Open Access
1,388 Views
16 Pages

30 October 2024

Recent research highlights a growing interest in early interactions between fathers and their infants, acknowledging the significant influence these interactions have on developmental outcomes. However, there is a limited understanding of the specifi...

  • Brief Report
  • Open Access
14 Citations
3,360 Views
9 Pages

With the improvement in survival rates of low-birthweight and very premature infants, neonatal fungal infection, especially fungal pneumonia, is becoming more and more common, but the diagnosis is always challenging. Recently, lung ultrasound (LUS) h...

  • Article
  • Open Access
31 Citations
5,571 Views
16 Pages

Preterm Infants Harbour a Rapidly Changing Mycobiota That Includes Candida Pathobionts

  • Stephen A. James,
  • Sarah Phillips,
  • Andrea Telatin,
  • David Baker,
  • Rebecca Ansorge,
  • Paul Clarke,
  • Lindsay J. Hall and
  • Simon R. Carding

9 November 2020

Fungi and the mycobiome are a fundamental part of the human microbiome that contributes to human health and development. Despite this, relatively little is known about the mycobiome of the preterm infant gut. Here, we have characterised faecal fungal...

  • Article
  • Open Access
12 Citations
2,978 Views
23 Pages

26 August 2022

The acoustic characteristics of cries are an exhibition of an infant’s health condition and these characteristics have been acknowledged as indicators for various pathologies. This study focused on the detection of infants suffering from sepsis...

  • Feature Paper
  • Case Report
  • Open Access
7 Citations
5,687 Views
6 Pages

Respiratory Failure in an Extremely Premature Neonate with COVID-19

  • Vasantha H. S. Kumar,
  • Arun Prasath,
  • Clariss Blanco,
  • Patrick O. Kenney,
  • Christina M. Ostwald,
  • Tracy S. Meyer,
  • Cara F. Clementi,
  • Richard Maciejewski,
  • Mark T. Wilby and
  • Karl O. A. Yu
  • + 2 authors

Coronavirus disease 2019 (COVID-19), a condition associated with SARS-CoV-2, typically results in mild infection in infants and children. However, children with risk factors such as chronic lung disease and immunosuppression have higher risk of sever...

  • Article
  • Open Access
3,302 Views
15 Pages

Maternal Humming during Kangaroo Care: Effects on Preterm Dyads’ Physiological Parameters

  • Maria Eduarda Salgado Carvalho and
  • João Manuel Rosado Miranda Justo

21 March 2024

Humming is probably more effective than speech for improving mothers’ cardiorespiratory function and infants’ self-regulation. We intend to understand the effects of (1) maternal humming vs. speech on preterm infants’ physiological...

  • Review
  • Open Access
30 Citations
4,766 Views
7 Pages

An unintended consequence of newborn screening for cystic fibrosis (CF) is the identification of infants with a positive screening test but an inconclusive diagnostic testing. These infants are designated as CF transmembrane conductance regulator-rel...

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