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280 Results Found

  • Review
  • Open Access
50 Citations
7,026 Views
21 Pages

Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

  • Taxiarchis Konstantinos Nikolouzakis,
  • Luca Falzone,
  • Konstantinos Lasithiotakis,
  • Sabine Krüger-Krasagakis,
  • Alexandra Kalogeraki,
  • Maria Sifaki,
  • Demetrios A. Spandidos,
  • Emmanuel Chrysos,
  • Aristidis Tsatsakis and
  • John Tsiaoussis

4 September 2020

Skin cancer represents the most common type of cancer among Caucasians and presents in two main forms: melanoma and non-melanoma skin cancer (NMSC). NMSC is an umbrella term, under which basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and...

  • Review
  • Open Access
35 Citations
7,516 Views
27 Pages

COVID-19 Biomarkers and Advanced Sensing Technologies for Point-of-Care (POC) Diagnosis

  • Ernst Emmanuel Etienne,
  • Bharath Babu Nunna,
  • Niladri Talukder,
  • Yudong Wang and
  • Eon Soo Lee

COVID-19, also known as SARS-CoV-2 is a novel, respiratory virus currently plaguing humanity. Genetically, at its core, it is a single-strand positive-sense RNA virus. It is a beta-type Coronavirus and is distinct in its structure and binding mechani...

  • Perspective
  • Open Access
4 Citations
3,804 Views
8 Pages

13 November 2021

This paper presents sensor nanotechnologies that can be used for the skin-based gas “smelling” of disease. Skin testing may provide rapid and reliable results, using specific “fingerprints” or unique patterns for a variety of diseases and conditions....

  • Review
  • Open Access
2 Citations
11,464 Views
17 Pages

Capsule Endoscopy: Current Trends, Technological Advancements, and Future Perspectives in Gastrointestinal Diagnostics

  • Chang-Chao Su,
  • Chu-Kuang Chou,
  • Arvind Mukundan,
  • Riya Karmakar,
  • Binusha Fathima Sanbatcha,
  • Chien-Wei Huang,
  • Wei-Chun Weng and
  • Hsiang-Chen Wang

Capsule endoscopy (CE) has revolutionized gastrointestinal (GI) diagnostics by providing a non-invasive, patient-centered approach to observing the digestive tract. Conceived in 2000 by Gavriel Iddan, CE employs a diminutive, ingestible capsule conta...

  • Article
  • Open Access
179 Citations
19,140 Views
19 Pages

Microfluidic Point-of-Care Devices: New Trends and Future Prospects for eHealth Diagnostics

  • Jorge Ricardo Mejía-Salazar,
  • Kamilla Rodrigues Cruz,
  • Elsa María Materón Vásques and
  • Osvaldo Novais de Oliveira Jr.

31 March 2020

Point-of-care (PoC) diagnostics is promising for early detection of a number of diseases, including cancer, diabetes, and cardiovascular diseases, in addition to serving for monitoring health conditions. To be efficient and cost-effective, portable P...

  • Review
  • Open Access
33 Citations
8,358 Views
47 Pages

21 January 2021

This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is follow...

  • Review
  • Open Access
2 Citations
2,119 Views
12 Pages

23 May 2024

In the past few decades, neuropathology has experienced several paradigm shifts with the introduction of new technologies. Deep learning, a rapidly progressing subfield of machine learning, seems to be the next innovation to alter the diagnostic work...

  • Review
  • Open Access
7 Citations
3,348 Views
32 Pages

This review provides a comprehensive overview of the recent advancements in nanosensors and microsensors for body fluid monitoring. The principles behind sensor technologies, their applications in healthcare, and the types of body fluids that they an...

  • Review
  • Open Access
14 Citations
6,493 Views
16 Pages

Current Landscape of Coccidioidomycosis

  • Ryan Boro,
  • Prema C. Iyer and
  • Maciej A. Walczak

17 April 2022

Coccidioidomycosis, also known as Valley fever, is an endemic fungal infection commonly found in the southwestern parts of the United States. However, the disease has seen an increase in both in its area of residency and its prevalence. This review c...

  • Review
  • Open Access
40 Citations
5,841 Views
21 Pages

16 July 2021

Research on the modeling and fault diagnosis of rotor eccentricities has been conducted during the past two decades. A variety of diagnostic theories and methods have been proposed based on different mechanisms, and there are reviews following either...

  • Review
  • Open Access
5 Citations
5,017 Views
28 Pages

Diagnostics and Therapy for Malignant Tumors

  • Chung-Che Tsai,
  • Chun-Yu Wang,
  • Hsu-Hung Chang,
  • Phebe Ting Syuan Chang,
  • Chuan-Hsin Chang,
  • Tin Yi Chu,
  • Po-Chih Hsu and
  • Chan-Yen Kuo

21 November 2024

Malignant tumors remain one of the most significant global health challenges and contribute to high mortality rates across various cancer types. The complex nature of these tumors requires multifaceted diagnostic and therapeutic approaches. This revi...

  • Review
  • Open Access
25 Citations
2,615 Views
19 Pages

Simultaneous diagnostics and targeted therapy provide a theranostic approach, an instrument of personalized medicine—one of the most-promising trends in current medicine. Except for the appropriate drug used during the treatment, a strong focus...

  • Review
  • Open Access
7 Citations
4,148 Views
20 Pages

Application of NGS Technology in Understanding the Pathology of Autoimmune Diseases

  • Anna Wajda,
  • Larysa Sivitskaya and
  • Agnieszka Paradowska-Gorycka

28 July 2021

NGS technologies have transformed clinical diagnostics and broadly used from neonatal emergencies to adult conditions where the diagnosis cannot be made based on clinical symptoms. Autoimmune diseases reveal complicate molecular background and tradit...

  • Article
  • Open Access
30 Citations
5,160 Views
18 Pages

28 June 2021

In the resilient and reliable electrical power system, the condition of high voltage insulation plays a crucial role. In the field of high voltage insulation integrity, the partial discharge (PD) inception and development trends are essential for ass...

  • Review
  • Open Access
4 Citations
3,951 Views
28 Pages

22 July 2025

The Epstein–Barr virus (EBV) is a prevalent virus linked to various diseases, including infectious mononucleosis (IM), nasopharyngeal carcinoma, and Hodgkin’s lymphoma. Over the past few decades, EBV diagnostic strategies have evolved sig...

  • Systematic Review
  • Open Access
10 Citations
5,164 Views
12 Pages

Endoscopic Ultrasound to Identify the Actual Cause of Idiopathic Acute Pancreatitis: A Systematic Review

  • Francesco Cammarata,
  • Lucrezia Rovati,
  • Paola Fontana,
  • Pietro Gambitta,
  • Antonio Armellino and
  • Paolo Aseni

19 October 2023

Idiopathic acute pancreatitis (IAP) presents a diagnostic challenge and refers to cases where the cause of acute pancreatitis remains uncertain despite a comprehensive diagnostic evaluation. Endoscopic ultrasound (EUS) has emerged as a valuable tool...

  • Review
  • Open Access
25 Citations
10,477 Views
20 Pages

The integration of artificial intelligence (AI) into ultrasound medicine has revolutionized medical imaging, enhancing diagnostic accuracy and clinical workflows. This review focuses on the applications, challenges, and future directions of AI techno...

  • Review
  • Open Access
5 Citations
5,229 Views
33 Pages

Conventional and Emerging Diagnostic Approaches for Differentiated Thyroid Carcinoma

  • Kathelina Kristollari,
  • Abraham Abbey Paul,
  • Sagi Angel and
  • Robert S. Marks

Differentiated thyroid carcinoma (DTC) is among the most prevalent endocrine cancers. The diagnosis of DTC has witnessed tremendous progress in terms of technological advancement and clinical operational guidelines. DTC diagnostics have evolved signi...

  • Commentary
  • Open Access
20 Citations
5,888 Views
9 Pages

Point-of-Care Diagnostics for Diagnosis of Active Syphilis Infection: Needs, Challenges and the Way Forward

  • Minh D. Pham,
  • Jason J. Ong,
  • David A. Anderson,
  • Heidi E. Drummer and
  • Mark Stoové

Syphilis, a curable sexually transmitted infection, has re-emerged as a global public health threat with an estimated 5.6 million new cases every year. Pregnant women and men who have sex with men are key target populations for syphilis control and p...

  • Review
  • Open Access
13 Citations
6,218 Views
32 Pages

Recent Trends and Innovations in Bead-Based Biosensors for Cancer Detection

  • Hui-Pin Cheng,
  • Tai-Hua Yang,
  • Jhih-Cheng Wang and
  • Han-Sheng Chuang

1 May 2024

Demand is strong for sensitive, reliable, and cost-effective diagnostic tools for cancer detection. Accordingly, bead-based biosensors have emerged in recent years as promising diagnostic platforms based on wide-ranging cancer biomarkers owing to the...

  • Review
  • Open Access
14 Citations
3,150 Views
20 Pages

Electrochemical Biosensors 3D Printed by Fused Deposition Modeling: Actualities, Trends, and Challenges

  • Luiz Ricardo Guterres Silva,
  • Carlos Eduardo Costa Lopes,
  • Auro Atsushi Tanaka,
  • Luiza Maria Ferreira Dantas,
  • Iranaldo Santos Silva and
  • Jéssica Santos Stefano

17 January 2025

The technology of 3D printing, particularly fused deposition modeling (FDM) 3D printing, has revolutionized the development of electrochemical biosensors, offering a versatile and cost-effective approach for clinical applications. This review explore...

  • Editorial
  • Open Access
16 Citations
7,651 Views
6 Pages

Rapid advancements in artificial intelligence (AI) and machine learning (ML) are currently transforming the field of diagnostics, enabling unprecedented accuracy and efficiency in disease detection, classification, and treatment planning. This Specia...

  • Review
  • Open Access
31 Citations
6,156 Views
14 Pages

26 January 2025

Background/Objectives: Artificial intelligence (AI) and machine learning (ML) are transforming healthcare by enabling predictive, diagnostic, and therapeutic advancements. Pediatric healthcare presents unique challenges, including limited data availa...

  • Review
  • Open Access
3 Citations
2,192 Views
21 Pages

5 July 2025

Over the past two decades, titanium dioxide nanotubes (TiO2 NTs) have gained considerable attention as multifunctional materials in sensing technologies. Their large surface area, adjustable morphology, chemical stability, and photoactivity have posi...

  • Review
  • Open Access
5 Citations
2,429 Views
35 Pages

Background/Objectives: The integration of digitalization in cytopathology is an emerging field with transformative potential, aiming to enhance diagnostic precision and operational efficiency. This narrative review of reviews (NRR) seeks to identify...

  • Review
  • Open Access
28 Citations
6,033 Views
34 Pages

Proteomic Insights into the Biology of the Most Important Foodborne Parasites in Europe

  • Robert Stryiński,
  • Elżbieta Łopieńska-Biernat and
  • Mónica Carrera

3 October 2020

Foodborne parasitoses compared with bacterial and viral-caused diseases seem to be neglected, and their unrecognition is a serious issue. Parasitic diseases transmitted by food are currently becoming more common. Constantly changing eating habits, ne...

  • Feature Paper
  • Review
  • Open Access
27 Citations
8,031 Views
31 Pages

The Spectrum of Extraglandular Manifestations in Primary Sjögren’s Syndrome

  • Ancuta Mihai,
  • Constantin Caruntu,
  • Ciprian Jurcut,
  • Florin Cristian Blajut,
  • Mihnea Casian,
  • Daniela Opris-Belinski,
  • Ruxandra Ionescu and
  • Ana Caruntu

Extraglandular manifestations (EGMs) in primary Sjogren’s syndrome (pSS) represent the clinical expression of the systemic involvement in this disease. EGMs are characterized by a wide heterogeneity; virtually any organ or system can be affecte...

  • Review
  • Open Access
4 Citations
2,307 Views
10 Pages

Role of Artificial Intelligence in Thyroid Cancer Diagnosis

  • Alessio Cece,
  • Massimo Agresti,
  • Nadia De Falco,
  • Pasquale Sperlongano,
  • Giancarlo Moccia,
  • Pasquale Luongo,
  • Francesco Miele,
  • Alfredo Allaria,
  • Francesco Torelli and
  • Domenico Parmeggiani
  • + 7 authors

2 April 2025

The progress of artificial intelligence (AI), particularly its core algorithms—machine learning (ML) and deep learning (DL)—has been significant in the medical field, impacting both scientific research and clinical practice. These algorit...

  • Review
  • Open Access
7 Citations
3,616 Views
32 Pages

Advances and Challenges in the Hunting Instability Diagnosis of High-Speed Trains

  • Jiayi Liang,
  • Jianfeng Sun,
  • Yonghua Jiang,
  • Weifang Pan and
  • Weidong Jiao

2 September 2024

With the continuous increase in train running speeds and the rapid complexity of operation environments, running stability of the high-speed train is facing significant challenges. A series of abnormal vibration issues, caused by hunting instability,...

  • Article
  • Open Access
1 Citations
3,416 Views
15 Pages

Delivery of Pediatric Student-Led Speech and Language Therapy Services at a University Rehabilitation Clinic in Cyprus: Children Accessing Services

  • Theodora Papastefanou,
  • Paris Binos,
  • Despo Minaidou,
  • Kakia Petinou,
  • Costas A. Christophi and
  • Eleni Theodorou

Background/Objectives: Early identification and intervention in speech and language therapy (SLT) are essential for children’s academic, social, and emotional development. In Cyprus, barriers such as long waiting lists, financial constraints, a...

  • Article
  • Open Access
58 Citations
3,445 Views
19 Pages

Analysis of Diagnostic Methods and Energy of Production Systems Drives

  • Ivan Kuric,
  • Ivana Klačková,
  • Yury Rafailovich Nikitin,
  • Ivan Zajačko,
  • Miroslav Císar and
  • Karol Tucki

12 May 2021

This article deals with solving the urgent scientific problem of the diagnostics of drives of technological robotized workplaces with support of sensors. The dependence of diagnostic parameters on the technical state of drives of automated technologi...

  • Review
  • Open Access
7 Citations
5,237 Views
13 Pages

Multidisciplinary Applications of AI in Dentistry: Bibliometric Review

  • Hela Allani,
  • Ana Teresa Santos and
  • Honorato Ribeiro-Vidal

28 August 2024

This review explores the impact of Artificial Intelligence (AI) in dentistry, reflecting on its potential to reshape traditional practices and meet the increasing demands for high-quality dental care. The aim of this research is to examine how AI has...

  • Article
  • Open Access
2 Citations
3,819 Views
17 Pages

13 March 2024

Auscultation is a fundamental diagnostic technique that provides valuable diagnostic information about different parts of the body. With the increasing prevalence of digital stethoscopes and telehealth applications, there is a growing trend towards d...

  • Review
  • Open Access
4,297 Views
15 Pages

Metabolomics Community in Russia: History of Development, Key Participants, and Results

  • Elena E. Balashova,
  • Dmitry L. Maslov and
  • Oxana P. Trifonova

25 October 2020

Metabolomics is the latest trend in the “-omics” sciences, of which technologies are widely used today in all life sciences. Metabolomics gave impetus to the description of biochemical processes that occur in many organisms, search for ne...

  • Perspective
  • Open Access
64 Citations
15,803 Views
19 Pages

24 September 2022

Mass marketing of battery-electric vehicles (EVs) will require that car buyers have high confidence in the performance, reliability and safety of the battery in their vehicles. Over the past decade, steady progress has been made towards the developme...

  • Review
  • Open Access
2 Citations
10,667 Views
10 Pages

Comprehensive Exploration of Antinuclear Antibodies (ANAs): Unveiling Clinical Significance, Associations with Cancer, and the Nuances of Differential Diagnosis in Positive ANA Patients

  • Krasimir Kraev,
  • Bozhidar Hristov,
  • Petar Uchikov,
  • Maria Kraeva,
  • Yordanka Basheva-Kraeva,
  • Siyana Valova,
  • Maria Koleva-Ivanova,
  • Stanislava Popova-Belova,
  • Milena Sandeva and
  • Mariela Geneva-Popova
  • + 1 author

This comprehensive review delves into the complex realm of antinuclear antibodies (ANAs), expanding beyond their traditional involvement in autoimmune rheumatic disorders. By digging into historical changes, diagnostic complexity, and clinical signif...

  • Feature Paper
  • Review
  • Open Access
11 Citations
3,591 Views
35 Pages

31 March 2025

The rapid evolution of micro- and nano-architectures is revolutionizing biomedical engineering, particularly in the fields of therapeutic and diagnostic micromechanics. This review explores the recent innovations in micro- and nanostructured material...

  • Perspective
  • Open Access
27 Citations
10,407 Views
17 Pages

Smart Diagnostics: Combining Artificial Intelligence and In Vitro Diagnostics

  • Michael P. McRae,
  • Kritika S. Rajsri,
  • Timothy M. Alcorn and
  • John T. McDevitt

24 August 2022

We are beginning a new era of Smart Diagnostics—integrated biosensors powered by recent innovations in embedded electronics, cloud computing, and artificial intelligence (AI). Universal and AI-based in vitro diagnostics (IVDs) have the potentia...

  • Brief Report
  • Open Access
1,435 Views
8 Pages

Profiling COVID-19 Cases in Tlemcen, Algeria: PCR and CT Imaging Insights

  • Ilyes Zatla,
  • Lamia Boublenza,
  • Wafaa Lemerini,
  • Chahinez Triqui and
  • Nabahate Selka

5 September 2025

The COVID-19 pandemic caused by SARS-CoV-2 has significantly impacted public health worldwide. This study aimed to assess the clinical and diagnostic features of COVID-19 cases in the Tlemcen region, Algeria, and analyze epidemiological trends from J...

  • Article
  • Open Access
1,080 Views
33 Pages

Statistical Data Processing Technologies for Sustainable Aviation: A Case Study of Ukraine

  • Viktoriia Ivannikova,
  • Maksym Zaliskyi,
  • Oleksandr Solomentsev,
  • Ivan Ostroumov and
  • Nataliia Kuzmenko

23 June 2025

Aviation is widely recognised as a system of systems where interconnected components interact dynamically within a structured framework. Failures in aviation equipment, inconsistencies in technological procedures, and operational inefficiencies contr...

  • Review
  • Open Access
31 Citations
9,864 Views
60 Pages

Label-Free Physical Techniques and Methodologies for Proteins Detection in Microfluidic Biosensor Structures

  • Georgii Konoplev,
  • Darina Agafonova,
  • Liubov Bakhchova,
  • Nikolay Mukhin,
  • Marharyta Kurachkina,
  • Marc-Peter Schmidt,
  • Nikolay Verlov,
  • Alexander Sidorov,
  • Aleksandr Oseev and
  • Soeren Hirsch
  • + 3 authors

Proteins in biological fluids (blood, urine, cerebrospinal fluid) are important biomarkers of various pathological conditions. Protein biomarkers detection and quantification have been proven to be an indispensable diagnostic tool in clinical practic...

  • Review
  • Open Access
23 Citations
16,387 Views
31 Pages

Applications of Microwaves in Medicine Leveraging Artificial Intelligence: Future Perspectives

  • Keerthy Gopalakrishnan,
  • Aakriti Adhikari,
  • Namratha Pallipamu,
  • Mansunderbir Singh,
  • Tasin Nusrat,
  • Sunil Gaddam,
  • Poulami Samaddar,
  • Anjali Rajagopal,
  • Akhila Sai Sree Cherukuri and
  • Shivaram P. Arunachalam
  • + 7 authors

23 February 2023

Microwaves are non-ionizing electromagnetic radiation with waves of electrical and magnetic energy transmitted at different frequencies. They are widely used in various industries, including the food industry, telecommunications, weather forecasting,...

  • Review
  • Open Access
1 Citations
729 Views
36 Pages

Emerging Trends in Optical Fiber Biosensing for Non-Invasive Biomedical Analysis

  • Sajjad Mortazavi,
  • Somayeh Makouei,
  • Karim Abbasian and
  • Sebelan Danishvar

5 December 2025

Optical fiber biosensors have evolved into powerful tools for non-invasive biomedical analysis. While foundational principles are well-established, recent years have marked a paradigm shift, driven by advancements in nanomaterials, fabrication techni...

  • Review
  • Open Access
82 Citations
12,567 Views
23 Pages

Graphene and Graphene-Based Nanomaterials for DNA Detection: A Review

  • Xin Wu,
  • Fengwen Mu,
  • Yinghui Wang and
  • Haiyan Zhao

16 August 2018

DNA detection with high sensitivity and specificity has tremendous potential as molecular diagnostic agents. Graphene and graphene-based nanomaterials, such as graphene nanopore, graphene nanoribbon, graphene oxide, and reduced graphene oxide, graphe...

  • Review
  • Open Access
12 Citations
4,549 Views
15 Pages

Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise

  • Stijn De Schepper,
  • Gopinath Gnanasegaran,
  • John C. Dickson and
  • Tim Van den Wyngaert

11 December 2021

The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this...

  • Review
  • Open Access
2 Citations
5,518 Views
31 Pages

Advancements in LAMP-Based Diagnostics: Emerging Techniques and Applications in Viral Detection with a Focus on Herpesviruses in Transplant Patient Management

  • Ana Cláudia Martins Braga Gomes Torres,
  • Carolina Mathias,
  • Suelen Cristina Soares Baal,
  • Ana Flávia Kohler,
  • Mylena Lemes Cunha and
  • Lucas Blanes

26 October 2024

Loop-mediated isothermal amplification (LAMP) is a highly effective molecular diagnostic technique, particularly advantageous for point-of-care (POC) settings. In recent years, LAMP has expanded to include various adaptations such as DARQ-LAMP, QUASR...

  • Review
  • Open Access
10 Citations
9,631 Views
28 Pages

Decoding Chiari Malformation and Syringomyelia: From Epidemiology and Genetics to Advanced Diagnosis and Management Strategies

  • Corneliu Toader,
  • Horia Ples,
  • Razvan-Adrian Covache-Busuioc,
  • Horia Petre Costin,
  • Bogdan-Gabriel Bratu,
  • David-Ioan Dumitrascu,
  • Luca Andrei Glavan and
  • Alexandru Vlad Ciurea

30 November 2023

Chiari Malformation and Syringomyelia are neurosurgical entities that have been the subject of extensive research and clinical interest. Globally prevalent, these disorders vary demographically and have witnessed evolving temporal trends. Chiari Malf...

  • Article
  • Open Access
10 Citations
12,772 Views
14 Pages

Framework for Building Low-Cost OBD-II Data-Logging Systems for Battery Electric Vehicles

  • Clarence Ramai,
  • Veeresh Ramnarine,
  • Shankar Ramharack,
  • Sanjay Bahadoorsingh and
  • Chandrabhan Sharma

28 October 2022

With the electrification of transport (BEVs) and the growing benefits of smart vehicles, there is a need for a simple solution to perform real-time monitoring of the BEV and its battery for diagnostics and coordinated charging. The On-Board Diagnosti...

  • Review
  • Open Access
1 Citations
6,635 Views
22 Pages

19 June 2025

The rising global burden of chronic diseases and cancer in the workplace has intensified the need for accessible, rapid diagnostic strategies within workplace settings. Point-of-care testing (POCT) offers a decentralized solution, providing timely di...

  • Review
  • Open Access
8 Citations
11,932 Views
18 Pages

Artificial intelligence (AI) is a growing area of computer science that combines technologies with data science to develop intelligent, highly computation-able systems. Its ability to automatically analyze and query huge sets of data has rendered it...

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