Next Article in Journal
Internal Cylinder Identification Based on Different Transmission of Longitudinal and Shear Ultrasonic Waves
Next Article in Special Issue
Design Strategies for Electrochemical Aptasensors for Cancer Diagnostic Devices
Previous Article in Journal
Combined SPRi Sensor for Simultaneous Detection of Nitrate and Ammonium in Wastewater
Open AccessReview

From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics

1
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland
2
Center for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, 02-822 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
Academic Editor: Iwona Grabowska
Sensors 2021, 21(3), 724; https://doi.org/10.3390/s21030724
Received: 21 December 2020 / Revised: 14 January 2021 / Accepted: 15 January 2021 / Published: 21 January 2021
(This article belongs to the Special Issue Electrochemical Aptamer-Based Biosensors)
This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future. View Full-Text
Keywords: aptasensors; electrochemistry; medical diagnostics; SELEX; metal cations; cancer biomarkers; microbial toxins aptasensors; electrochemistry; medical diagnostics; SELEX; metal cations; cancer biomarkers; microbial toxins
Show Figures

Figure 1

MDPI and ACS Style

Ziółkowski, R.; Jarczewska, M.; Górski, Ł.; Malinowska, E. From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics. Sensors 2021, 21, 724. https://doi.org/10.3390/s21030724

AMA Style

Ziółkowski R, Jarczewska M, Górski Ł, Malinowska E. From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics. Sensors. 2021; 21(3):724. https://doi.org/10.3390/s21030724

Chicago/Turabian Style

Ziółkowski, Robert; Jarczewska, Marta; Górski, Łukasz; Malinowska, Elżbieta. 2021. "From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics" Sensors 21, no. 3: 724. https://doi.org/10.3390/s21030724

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop