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28,155 Results Found

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,765 Views
22 Pages

Functional Dynamics of Substrate Recognition in TEM Beta-Lactamase

  • Chris Avery,
  • Lonnie Baker and
  • Donald J. Jacobs

20 May 2022

The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem. Here, the...

  • Article
  • Open Access
3 Citations
2,951 Views
12 Pages

Age of Bilingual Onset Shapes the Dynamics of Functional Connectivity and Laterality in the Resting-State

  • Yucen Sheng,
  • Songyu Yang,
  • Juan Rao,
  • Qin Zhang,
  • Jialong Li,
  • Dianjian Wang and
  • Weihao Zheng

23 August 2023

Bilingualism is known to enhance cognitive function and flexibility of the brain. However, it is not clear how bilingual experience affects the time-varying functional network and whether these changes depend on the age of bilingual onset. This study...

  • Article
  • Open Access
2 Citations
4,338 Views
23 Pages

23 November 2018

The characterisation of functional-trait dynamics of vegetation from remotely sensed data complements the structural characterisation of ecosystems. In this study we characterised for the first time the spatial heterogeneity of the intra-annual dynam...

  • Article
  • Open Access
8 Citations
3,104 Views
16 Pages

13 October 2021

Traumatic brain injury (TBI) is highly prevalent in children. Attention deficits are among the most common and persistent post-TBI cognitive and behavioral sequalae that can contribute to adverse outcomes. This study investigated the topological prop...

  • Article
  • Open Access
3 Citations
2,678 Views
17 Pages

14 November 2021

Complex colloidal fluids, depending on constituent shapes and packing fractions, may have a wide range of shear-thinning and/or shear-thickening behaviors. An interesting way to transition between different types of such behavior is by infusing compl...

  • Article
  • Open Access
305 Views
21 Pages

4 February 2026

Covalent modification of polyphenols effectively enhances functional properties of proteins. This study conjugated potato protein isolate (PPI) with gallic acid (GA) via an alkaline method to investigate structural and functional alterations. Success...

  • Article
  • Open Access
5 Citations
1,953 Views
12 Pages

2 November 2022

In this paper, we study the asymptotic and transient dynamics of a predator–prey model with square root functional responses and random perturbation. Firstly, the mean square stability matrix is obtained from the stability theory of stochastic...

  • Review
  • Open Access
518 Views
17 Pages

20 November 2025

To apply molecular dynamics (MD) simulations in the study of virgin asphalt binder, researchers have relied on basis sets of representative model structures from the SARA categories of saturated aliphatics (S), naphthenic aromatics (A), polar aromati...

  • Article
  • Open Access
37 Citations
5,765 Views
17 Pages

6 June 2019

Qingcaosha Reservoir, an estuary reservoir on the Yangtze River and a drinking water source, is facing phytoplankton blooms and the factors driving changes in phytoplankton composition and distribution have not been well understood so far. To facilit...

  • Article
  • Open Access
14 Citations
4,820 Views
18 Pages

This study comprehensively investigates Al2O3′s mechanical properties, focusing on fracture toughness, surface energy, Young’s modulus, and crack propagation. The density functional theory (DFT) is employed to model the vacancies in Al2O3...

  • Article
  • Open Access
2 Citations
2,381 Views
16 Pages

Unravelling Lithium Interactions in Non-Flammable Gel Polymer Electrolytes: A Density Functional Theory and Molecular Dynamics Study

  • Nasser AL-Hamdani,
  • Paula V. Saravia,
  • Javier Luque Di Salvo,
  • Sergio A. Paz and
  • Giorgio De Luca

14 January 2025

Lithium metal batteries (LiMBs) have emerged as extremely viable options for next-generation energy storage owing to their elevated energy density and improved theoretical specific capacity relative to traditional lithium batteries. However, safety c...

  • Article
  • Open Access
4 Citations
3,653 Views
17 Pages

Structural Investigation of DHICA Eumelanin Using Density Functional Theory and Classical Molecular Dynamics Simulations

  • Sepideh Soltani,
  • Shahin Sowlati-Hashjin,
  • Conrard Giresse Tetsassi Feugmo and
  • Mikko Karttunen

1 December 2022

Eumelanin is an important pigment, for example, in skin, hair, eyes, and the inner ear. It is a highly heterogeneous polymer with 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI) building blocks, of which DHICA is reported...

  • Article
  • Open Access
2 Citations
1,827 Views
17 Pages

22 December 2024

The separation of oxygen (O2) and nitrogen (N2) from air is a process of utmost importance nowadays, as both species are vital for numerous fundamental processes essential for our development. Membranes designed for their selective molecule separatio...

  • Article
  • Open Access
27 Citations
5,016 Views
22 Pages

20 August 2020

Human NQO1 [NAD(H):quinone oxidoreductase 1] is a multi-functional and stress-inducible dimeric protein involved in the antioxidant defense, the activation of cancer prodrugs and the stabilization of oncosuppressors. Despite its roles in human diseas...

  • Article
  • Open Access
1 Citations
2,583 Views
11 Pages

14 November 2024

Polyimide (PI) is widely used in aerospace applications due to its superior insulating properties. However, the high concentration of atomic oxygen (AO) in low Earth orbit leads to significant performance degradation in PI, and the underlying mechani...

  • Article
  • Open Access
38 Citations
6,271 Views
13 Pages

This work provides the experimental and theoretical fundamentals for detecting the molecular fingerprints of six kinds of pesticides by using terahertz (THz) time-domain spectroscopy (THz-TDS). The spectra of absorption coefficient and refractive ind...

  • Article
  • Open Access
8 Citations
2,401 Views
18 Pages

27 August 2022

In this paper, Amomi fructus (Latin) was used to explore the mechanism of ionic liquids (ILs) in improving the extraction efficiency of essential oils. Microwave assisted ionic liquid treatment followed by a hydro-distillation (MILT-HD) process for i...

  • Article
  • Open Access
2 Citations
2,492 Views
18 Pages

6 September 2024

Background: In recent years, the advancement of computational chemistry has offered new insights into the rational design of molecularly imprinted polymers (MIPs). From this aspect, our study tried to give quantitative parameters for evaluating impri...

  • Review
  • Open Access
2 Citations
4,276 Views
18 Pages

23 April 2022

In theoretical biology, robustness refers to the ability of a biological system to function properly even under perturbation of basic parameters (e.g., temperature or pH), which in mathematical models is reflected in not needing to fine-tune basic pa...

  • Article
  • Open Access
3 Citations
3,499 Views
15 Pages

19 January 2022

Latent variable models (LVMs) for neural population spikes have revealed informative low-dimensional dynamics about the neural data and have become powerful tools for analyzing and interpreting neural activity. However, these approaches are unable to...

  • Article
  • Open Access
8 Citations
4,168 Views
17 Pages

Mitochondrial Dynamics Markers and Related Signaling Molecules Are Important Regulators of Spermatozoa Number and Functionality

  • Isidora M. Starovlah,
  • Sava M. Radovic Pletikosic,
  • Tatjana S. Kostic and
  • Silvana A. Andric

Here, we study possible mechanisms of (in/sub)fertility related to the acute or repeated psychological stresses (the most common stresses in human society) by following the transcriptional profile of 22 mitochondrial dynamics/function markers and 22...

  • Article
  • Open Access
1 Citations
1,569 Views
11 Pages

A New Slack Lyapunov Functional for Dynamical System with Time Delay

  • Can Zhao,
  • Kaibo Shi,
  • Yiqian Tang and
  • Shouming Zhong

26 November 2022

The traditional method of constructing a Lyapunov functional for dynamical systems with time delay is usually dependent on positive definite matrices in the quadratic form. In this paper, a new Lyapunov functional is proposed and the corresponding pr...

  • Article
  • Open Access
8 Citations
3,299 Views
26 Pages

About Inverse Laplace Transform of a Dynamic Viscosity Function

  • Kamil Urbanowicz,
  • Anton Bergant,
  • Rafał Grzejda and
  • Michał Stosiak

20 June 2022

A dynamic viscosity function plays an important role in water hammer modeling. It is responsible for dispersion and decay of pressure and velocity histories. In this paper, a novel method for inverse Laplace transform of this complicated function bei...

  • Review
  • Open Access
25 Citations
10,353 Views
19 Pages

27 September 2021

Classical evolutionary game theory allows one to analyze the population dynamics of interacting individuals playing different strategies (broadly defined) in a population. To expand the scope of this framework to allow us to examine the evolution of...

  • Article
  • Open Access
1 Citations
1,611 Views
18 Pages

Progress in the Understanding of Liquids Dynamics via a General Theory of Correlation Functions

  • Eleonora Guarini,
  • Ubaldo Bafile,
  • Daniele Colognesi,
  • Alessandro Cunsolo,
  • Alessio De Francesco and
  • Ferdinando Formisano

26 March 2025

This work provides a comprehensive picture of the advances that the exponential expansion theory (EET) of autocorrelation functions relevant to liquids dynamics made possible in the last decade up to very recent times. The role of both longitudinal a...

  • Article
  • Open Access
1 Citations
1,731 Views
14 Pages

Generating Bent Functions and Dynamic Filters: A Novel Equivalence-Based Approach

  • Joseph Nelson,
  • Chungath Srinivasan,
  • Anand R. Nair and
  • Lakshmy Koduvayur Viswanathan

8 November 2024

Boolean functions are fundamental building blocks in both discrete mathematics and computer science, with applications spanning from cryptography to coding theory. Bent functions, a subset of Boolean functions with maximal nonlinearity, are particula...

  • Article
  • Open Access
662 Views
16 Pages

14 April 2025

Regarding the discretization issue in the process of a simultaneous approach for dynamic optimization problems, a configuration strategy based on the density function has been proposed for the finite element distribution of dynamic optimization probl...

  • Review
  • Open Access
18 Citations
8,800 Views
26 Pages

7 March 2014

Proteins are crucial to the functioning of all lifeforms. Traditional understanding posits that a single protein occupies a single structure (“fold”), which performs a single function. This view is radically challenged with the recognition that high...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,160 Views
16 Pages

26 June 2024

Over the past decade and a half, dynamic functional imaging has revealed low-dimensional brain connectivity measures, identified potential common human spatial connectivity states, tracked the transition patterns of these states, and demonstrated mea...

  • Article
  • Open Access
3 Citations
3,972 Views
26 Pages

4 November 2019

Most previous work on dynamic functional connectivity (dFC) has focused on analyzing temporal traits of functional connectivity (similar coupling patterns at different timepoints), dividing them into functional connectivity states and detecting their...

  • Article
  • Open Access
1 Citations
4,909 Views
17 Pages

Evolution and Trade-Off Dynamics of Functional Load

  • Erich Round,
  • Rikker Dockum and
  • Robin J. Ryder

5 April 2022

Functional load (FL) quantifies the contributions by phonological contrasts to distinctions made across the lexicon. Previous research has linked particularly low values of FL to sound change. Here, we broaden the scope of enquiry into FL to its evol...

  • Feature Paper
  • Article
  • Open Access
10 Citations
2,573 Views
27 Pages

δ-Almost Periodic Functions and Applications to Dynamic Equations

  • Chao Wang,
  • Ravi P. Agarwal and
  • Donal O’Regan

In this paper, by employing matched spaces for time scales, we introduce a δ -almost periodic function and obtain some related properties. Also the hull equation for homogeneous dynamic equation is introduced and results of the existence a...

  • Article
  • Open Access
10 Citations
4,045 Views
21 Pages

12 March 2023

With the advent of Software Defined Network (SDN) and Network Functions Virtualization (NFV), network operators can offer Service Function Chain (SFC) flexibly to accommodate the diverse network function (NF) requirements of their users. However, dep...

  • Article
  • Open Access
19 Citations
4,998 Views
19 Pages

19 August 2022

While naturalistic stimuli, such as movies, better represent the complexity of the real world and are perhaps crucial to understanding the dynamics of emotion processing, there is limited research on emotions with naturalistic stimuli. There is a nee...

  • Article
  • Open Access
11 Citations
2,204 Views
20 Pages

10 July 2023

It is imperative to timely and accurately predict the progressive surface subsidence caused by coal mining in the context of precision coal mining. However, the existing dynamic prediction methods that use time functions still have limitations, espec...

  • Article
  • Open Access
5 Citations
1,772 Views
19 Pages

Application of the Time Function Model for Dynamic Deformation Prediction in Mining Areas under Characteristic Constraints

  • Zhihong Wang,
  • Huayang Dai,
  • Yueguan Yan,
  • Jintong Ren,
  • Jibo Liu,
  • Yanjun Zhang and
  • Guosheng Xu

11 October 2023

The fundamental model for dynamically predicting surface subsidence is the time influence function. However, current research and the application of time functions often neglect the comprehensive characteristics of the entire surface deformation proc...

  • Feature Paper
  • Review
  • Open Access
16 Citations
4,928 Views
17 Pages

16 March 2023

The field of soft matter is rapidly growing and pushing the limits of conventional materials science and engineering. Soft matter refers to materials that are easily deformed by thermal fluctuations and external forces, allowing for better adaptation...

  • Article
  • Open Access
35 Citations
4,235 Views
14 Pages

Melatonin Improves Mitochondrial Dynamics and Function in the Kidney of Zücker Diabetic Fatty Rats

  • Ahmad Agil,
  • Meriem Chayah,
  • Lucia Visiedo,
  • Miguel Navarro-Alarcon,
  • José Manuel Rodríguez Ferrer,
  • Mohamed Tassi,
  • Russel J. Reiter and
  • Gumersindo Fernández-Vázquez

10 September 2020

Obesity and associated diabetes (diabesity) impair kidney mitochondrial dynamics by augmenting fission and diminishing fusion, which results in mitochondrial and renal dysfunction. Based on available evidence, the antioxidant activities of melatonin...

  • Article
  • Open Access
36 Citations
5,216 Views
26 Pages

Computational Investigation of 1, 3, 4 Oxadiazole Derivatives as Lead Inhibitors of VEGFR 2 in Comparison with EGFR: Density Functional Theory, Molecular Docking and Molecular Dynamics Simulation Studies

  • Muhammad Sajjad Bilal,
  • Syeda Abida Ejaz,
  • Seema Zargar,
  • Naveed Akhtar,
  • Tanveer A. Wani,
  • Naheed Riaz,
  • Adullahi Tunde Aborode,
  • Farhan Siddique,
  • Nojood Altwaijry and
  • Haruna Isiyaku Umar
  • + 1 author

1 November 2022

Vascular endothelial growth factor (VEGF) is an angiogenic factor involved in tumor growth and metastasis. Gremlin has been proposed as a novel therapeutic pathway for the treatment of renal inflammatory diseases, acting via VEGFR 2 receptor. To date...

  • Article
  • Open Access
1 Citations
1,051 Views
25 Pages

8 February 2025

This work aims to improve the reliability of dynamic systems by eliminating the effect of random control variables. At first, the reliability-based dynamic optimization problem (RB-DOP) is introduced and defined to account for dynamic systems with un...

  • Article
  • Open Access
3 Citations
1,380 Views
19 Pages

23 January 2025

In the context of model updating of bridge structures, dynamic approaches are currently dominant. This is mainly due to the opportunity of performing dynamic tests under environmental and traffic loadings, without putting the bridges out of service....

  • Article
  • Open Access
6 Citations
2,759 Views
17 Pages

18 May 2022

Particulate matter has become one of the major issues in environmental sustainability, and its accurate measurement has grown in importance recently. Low-cost sensors (LCS) have been widely used to measure particulate concentration, but concerns abou...

  • Article
  • Open Access
1,279 Views
24 Pages

24 June 2024

This paper addresses the challenge of identifying causes for functional dynamic targets, which are functions of various variables over time. We develop screening and local learning methods to learn the direct causes of the target, as well as all indi...

  • Review
  • Open Access
32 Citations
8,019 Views
20 Pages

The Cytoskeleton in Plant Immunity: Dynamics, Regulation, and Function

  • Jingyi Wang,
  • Na Lian,
  • Yue Zhang,
  • Yi Man,
  • Lulu Chen,
  • Haobo Yang,
  • Jinxing Lin and
  • Yanping Jing

8 December 2022

The plant cytoskeleton, consisting of actin filaments and microtubules, is a highly dynamic filamentous framework involved in plant growth, development, and stress responses. Recently, research has demonstrated that the plant cytoskeleton undergoes r...

  • Review
  • Open Access
5 Citations
4,121 Views
43 Pages

17 February 2024

Nanotechnology has advanced the techniques for elucidating phenomena at the atomic, molecular, and nano-level. As a post nanotechnology concept, nanoarchitectonics has emerged to create functional materials from unit structures. Consider the material...

  • Article
  • Open Access
8 Citations
3,609 Views
16 Pages

7 March 2021

In this paper, we elaborate on theoretical and methodological considerations for designing a sequence of tasks for introducing middle and high school students to functions and their graphs. In particular, we present didactical activities with an arti...

  • Article
  • Open Access
8 Citations
3,829 Views
19 Pages

Neurofeedback of real-time functional magnetic resonance imaging (rtfMRI) can enable people to self-regulate motor-related brain regions and lead to alteration of motor performance and functional connectivity (FC) underlying motor execution tasks. Nu...

  • Article
  • Open Access
253 Views
25 Pages

8 January 2026

This study considers the dynamic stability of a three-layered annular plate, whose facings are made of functionally graded material in the radial direction. The plate is subjected to linearly increasing in-plane forces applied at either the inner or...

  • Article
  • Open Access
14 Citations
2,765 Views
18 Pages

4 September 2019

The multi-functionality of land as the basis of land use and utilization is under increasing investigation. This study assesses the spatiotemporal dynamic multi-functionality of land use and analyzes the obstacle indicators in Xiangxi using two metho...

  • Article
  • Open Access
43 Citations
6,389 Views
15 Pages

Altered Dynamic Functional Connectivity of Cuneus in Schizophrenia Patients: A Resting-State fMRI Study

  • Charles Okanda Nyatega,
  • Li Qiang,
  • Mohammed Jajere Adamu,
  • Ayesha Younis and
  • Halima Bello Kawuwa

1 December 2021

Objective: Schizophrenia (SZ) is a functional mental condition that has a significant impact on patients’ social lives. As a result, accurate diagnosis of SZ has attracted researchers’ interest. Based on previous research, resting-state f...

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