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172 Results Found

  • Article
  • Open Access
18 Citations
5,972 Views
16 Pages

Locked and unlocked strategies are at the center of this article, as ways of shedding new light on the cognitive aspects of deep learning machines. The character and the role of these cognitive strategies, which are occurring both in humans and in co...

  • Article
  • Open Access
171 Citations
12,744 Views
16 Pages

In Vitro Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota

  • Sophie Fehlbaum,
  • Kevin Prudence,
  • Jasper Kieboom,
  • Margreet Heerikhuisen,
  • Tim Van den Broek,
  • Frank H. J. Schuren,
  • Robert E. Steinert and
  • Daniel Raederstorff

10 October 2018

Recently, the concept of prebiotics has been revisited to expand beyond non-digestible oligosaccharides, and the requirements for selective stimulation were extended to include microbial groups other than, and additional to, bifidobacteria and lactob...

  • Article
  • Open Access
1 Citations
1,254 Views
24 Pages

21 June 2025

The emergence of connected and automated vehicles (CAVs) offers promising opportunities to enhance traffic control and improve overall transportation system performance. However, the complexity and dynamic nature of modern traffic networks pose signi...

  • Article
  • Open Access
11 Citations
4,645 Views
13 Pages

Locked and unlocked strategies are illustrated in this article as concepts that deal with important cognitive aspects of deep learning systems. They indicate different inference routines that refer to poor (locked) to rich (unlocked) cases of creativ...

  • Article
  • Open Access
17 Citations
11,311 Views
15 Pages

The Game Is Not over Yet—Go in the Post-AlphaGo Era

  • Attila Egri-Nagy and
  • Antti Törmänen

The game of Go was the last great challenge for artificial intelligence in abstract board games. AlphaGo was the first system to reach supremacy, and subsequent implementations further improved the state of the art. As in chess, the fall of the human...

  • Perspective
  • Open Access
2 Citations
7,765 Views
12 Pages

20 August 2020

Video games are sometimes used as environments to evaluate AI agents’ ability to develop and execute complex action sequences to maximize a defined reward. However, humans cannot match the fine precision of the timed actions of AI agents; in ga...

  • Article
  • Open Access
11 Citations
6,829 Views
16 Pages

Computer games have been regarded as an important field of artificial intelligence (AI) for a long time. The AlphaZero structure has been successful in the game of Go, beating the top professional human players and becoming the baseline method in com...

  • Article
  • Open Access
2 Citations
1,351 Views
12 Pages

Decoupling Alpha Desynchronization from Neural Resource Use: Evidence from Cognitive Load Modulation

  • Manuel Vázquez-Marrufo,
  • Rocío Caballero-Díaz,
  • Esteban Sarrias-Arrabal and
  • Rubén Martín-Clemente

In prior studies, desynchronization of the induced alpha band (non-phase-locked but time-locked) has been observed across various cognitive tasks. Proposed hypotheses for the cognitive role of this alpha decrement include neural activation, an inhibi...

  • Article
  • Open Access
10 Citations
4,634 Views
11 Pages

11 December 2021

The human brain is constantly active, even at rest. Alpha coherence is an electroencephalography (EEG) rhythm that regulates functional connectivity between different brain regions. However, the relationships between resting-state alpha coherence and...

  • Article
  • Open Access
2 Citations
2,339 Views
12 Pages

Due to the complexity of search space and move evaluation, the game of Go has been a long-standing challenge for artificial intelligence (AI) to achieve a high level of proficiency. It was not until DeepMind proposed the deep neural network and tree...

  • Article
  • Open Access
1 Citations
2,313 Views
18 Pages

Imitating Human Go Players via Vision Transformer

  • Yu-Heng Hsieh,
  • Chen-Chun Kao and
  • Shyan-Ming Yuan

24 January 2025

Developing AI algorithms for the game of Go has long been a challenging task. While tools such as AlphaGo have revolutionized gameplay, their focus on maximizing win rates often leads to moves that are incomprehensible to human players, limiting thei...

  • Article
  • Open Access
22 Citations
4,430 Views
21 Pages

AlphaTruss: Monte Carlo Tree Search for Optimal Truss Layout Design

  • Ruifeng Luo,
  • Yifan Wang,
  • Weifang Xiao and
  • Xianzhong Zhao

Truss layout optimization under complex constraints has been a hot and challenging problem for decades that aims to find the optimal node locations, connection topology between nodes, and cross-sectional areas of connecting bars. Monte Carlo Tree Sea...

  • Article
  • Open Access
33 Citations
6,349 Views
15 Pages

1 February 2021

Gomoku is a two-player board game that originated in ancient China. There are various cases of developing Gomoku using artificial intelligence, such as a genetic algorithm and a tree search algorithm. Alpha-Gomoku, Gomoku AI built with Alpha-Go’s alg...

  • Article
  • Open Access
1,875 Views
11 Pages

A Formal Representation for Intelligent Decision-Making in Games

  • Chanjuan Liu,
  • Ruining Zhang,
  • Yu Zhang and
  • Enqiang Zhu

7 November 2023

The study of intelligent game-playing has gained tremendous attention in the past few decades. The recent development of artificial intelligence (AI) players (e.g., the Go player AlphaGo) has made intelligent game-playing even more prominent in both...

  • Review
  • Open Access
112 Citations
23,030 Views
17 Pages

Reinforcement Learning in Financial Markets

  • Terry Lingze Meng and
  • Matloob Khushi

28 July 2019

Recently there has been an exponential increase in the use of artificial intelligence for trading in financial markets such as stock and forex. Reinforcement learning has become of particular interest to financial traders ever since the program Alpha...

  • Article
  • Open Access
20 Citations
5,638 Views
22 Pages

25 February 2021

Anomaly detection research was conducted traditionally using mathematical and statistical methods. This topic has been widely applied in many fields. Recently reinforcement learning has achieved exceptional successes in many areas such as the AlphaGo...

  • Article
  • Open Access
11 Citations
6,253 Views
27 Pages

22 August 2023

Deep reinforcement learning (DRL) has attracted strong interest since AlphaGo beat human professionals, and its applications in stock trading are widespread. In this paper, an enhanced stock trading strategy called Dual Action and Dual Environment De...

  • Article
  • Open Access
4 Citations
3,802 Views
13 Pages

27 February 2021

In the field of cognitive science, much research has been conducted on the diverse applications of artificial intelligence (AI). One important area of study is machines imitating human thinking. Although there are various approaches to development of...

  • Article
  • Open Access
7 Citations
3,404 Views
33 Pages

8 August 2022

Reactive and biased human decision-making during well construction operations can result in problems ranging from minor inefficiencies to events that can have far-reaching negative consequences for safety, environmental compliance and cost. A system...

  • Article
  • Open Access
35 Citations
13,694 Views
15 Pages

EEG Dynamics of a Go/Nogo Task in Children with ADHD

  • Simon Baijot,
  • Carlos Cevallos,
  • David Zarka,
  • Axelle Leroy,
  • Hichem Slama,
  • Cecile Colin,
  • Nicolas Deconinck,
  • Bernard Dan and
  • Guy Cheron

20 December 2017

Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children...

  • Article
  • Open Access
12 Citations
6,388 Views
28 Pages

Impact of Stimulation Duration in taVNS—Exploring Multiple Physiological and Cognitive Outcomes

  • Till Bömmer,
  • Luisa M. Schmidt,
  • Katharina Meier,
  • Julius Kricheldorff,
  • Heiko Stecher,
  • Christoph S. Herrmann,
  • Christiane M. Thiel,
  • Kathrin Janitzky and
  • Karsten Witt

29 August 2024

Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique that modulates the noradrenergic activity of the locus coeruleus (LC). Yet, there is still uncertainty about the most effective stimulation and relia...

  • Article
  • Open Access
14 Citations
3,810 Views
14 Pages

(1) Background: The Go/NoGo task and color-word Stroop task were used to investigate the effect of applying different frequency bands of neural oscillations to the lDLPFC on inhibitory control modulation. (2) Methods: Participants were randomly categ...

  • Article
  • Open Access
4 Citations
8,030 Views
10 Pages

20 October 2023

While the training of professional sports athletes and the factors determining sports success are based on well-established scientific research, esports training and markers of esports performance are not yet fully recognized or explored. Knowledge o...

  • Article
  • Open Access
7 Citations
4,120 Views
22 Pages

Infant Fecal Fermentations with Galacto-Oligosaccharides and 2′-Fucosyllactose Show Differential Bifidobacterium longum Stimulation at Subspecies Level

  • Cordula Lindner,
  • Ellen Looijesteijn,
  • Helmie van Dijck,
  • Ingeborg Bovee-Oudenhoven,
  • Margreet Heerikhuisen,
  • Tim J. van den Broek,
  • Massimo Marzorati,
  • Vassilis Triantis and
  • Arjen Nauta

23 February 2023

The objective of the current study was to evaluate the potential of 2′-FL and GOS, individually and combined, in beneficially modulating the microbial composition of infant and toddler (12–18 months) feces using the micro-Matrix bioreacto...

  • Article
  • Open Access
8 Citations
24,887 Views
19 Pages

Investigating the Impact of Guided Imagery on Stress, Brain Functions, and Attention: A Randomized Trial

  • Katarzyna Zemla,
  • Grzegorz Sedek,
  • Krzysztof Wróbel,
  • Filip Postepski and
  • Grzegorz M. Wojcik

7 July 2023

The aim of this study was to investigate the potential impact of guided imagery (GI) on attentional control and cognitive performance and to explore the relationship between guided imagery, stress reduction, alpha brainwave activity, and attentional...

  • Article
  • Open Access
6 Citations
3,890 Views
15 Pages

Dynamical EEG Indices of Progressive Motor Inhibition and Error-Monitoring

  • Trung Van Nguyen,
  • Prasad Balachandran,
  • Neil G. Muggleton,
  • Wei-Kuang Liang and
  • Chi-Hung Juan

Response inhibition has been widely explored using the stop signal paradigm in the laboratory setting. However, the mechanism that demarcates attentional capture from the motor inhibition process is still unclear. Error monitoring is also involved in...

  • Article
  • Open Access
7 Citations
3,718 Views
18 Pages

Graphene Oxide Normal (GO + Mn2+) and Ultrapure: Short-Term Impact on Selected Antioxidant Stress Markers and Cytokines in NHDF and A549 Cell Lines

  • Dominika Stygar,
  • Aleksandra Pogorzelska,
  • Elżbieta Chełmecka,
  • Bronisława Skrzep-Poloczek,
  • Barbara Bażanów,
  • Tomasz Gębarowski,
  • Jerzy Jochem and
  • Jiří Henych

Since biological applications and toxicity of graphene-based materials are structure dependent, studying their interactions with the biological systems is very timely and important. We studied short-term (1, 24, and 48 h) effects of ultrapure (GO) an...

  • Article
  • Open Access
29 Citations
7,141 Views
12 Pages

Alpha-Galacto-Oligosaccharides at Low Dose Improve Liver Steatosis in a High-Fat Diet Mouse Model

  • Eric Chappuis,
  • Fanny Morel-Depeisse,
  • Bruno Bariohay and
  • Julien Roux

14 October 2017

Non-Alcoholic Fatty Liver Disease (NAFLD) is the major liver disease worldwide and is linked to the development of metabolic syndrome and obesity. As alpha-galacto-oligosaccharides (α-GOS) from legumes have been shown to reduce body weight and hyperp...

  • Article
  • Open Access
1,471 Views
14 Pages

Prestimulus EEG Oscillations and Pink Noise Affect Go/No-Go ERPs

  • Robert J. Barry,
  • Frances M. De Blasio,
  • Alexander T. Duda and
  • Beckett S. Munford

11 March 2025

This study builds on the early brain dynamics work of Erol Başar, focusing on the human electroencephalogram (EEG) in relation to the generation of event-related potentials (ERPs) and behaviour. Scalp EEG contains not only oscillations but non-w...

  • Article
  • Open Access
7 Citations
7,685 Views
11 Pages

Versatile Effects of GABA Oolong Tea on Improvements in Diastolic Blood Pressure, Alpha Brain Waves, and Quality of Life

  • Chih-Cheng Lin,
  • Chih-Yu Hsieh,
  • Li-Fen Chen,
  • Yen-Chun Chen,
  • Tien-Hwa Ho,
  • Shao-Chin Chang and
  • Jia-Feng Chang

12 November 2023

Emerging evidence has demonstrated that using a new manufacturing technology to produce γ-aminobutyric acid (GABA)-fortified oolong (GO) tea could relieve human stress and exert versatile physiological benefits. The purpose of this human study...

  • Article
  • Open Access
34 Citations
6,240 Views
19 Pages

3 October 2019

Methylglyoxal (MG) and glyoxal (GO) are suggested to be associated with the development of neurodegenerative pathologies. However, their peripheral levels in relation to cognitive decline and their effects on key factors in neuronal cells are poorly...

  • Article
  • Open Access
1,608 Views
14 Pages

Resting-State EEG Alpha Asymmetry as a Potential Marker of Clinical Features in Parkinson’s Disease

  • Thalita Frigo da Rocha,
  • Valton Costa,
  • Lucas Camargo,
  • Elayne Borges Fernandes and
  • Anna Carolyna Gianlorenço

Background: Asymmetrical brain oscillations may be characteristic of Parkinson’s disease (PD). We investigated differences in oscillation asymmetry between individuals with PD and healthy controls and explored associations between the asymmetry...

  • Article
  • Open Access
20 Citations
5,663 Views
20 Pages

27 August 2019

Auditory alarms are used to direct people’s attention to critical events in complicated environments. The capacity for identifying the auditory alarms in order to take the right action in our daily life is critical. In this work, we investigate...

  • Article
  • Open Access
10 Citations
3,506 Views
9 Pages

25 August 2021

In isoprenaline (ISO)-induced myocardial infarcted rats, garlic oil (GO) and its main ingredient, diallyl disulfide (DADS), were examined for cardioprotective effects when used with carvedilol (CAR). GO, DADS and CAR were given to rats in their respe...

  • Article
  • Open Access
15 Citations
4,494 Views
12 Pages

The Effect of Nutritional Intervention with Lactoferrin, Galactooligosacharides and Vitamin D on the Gut Microbiota Composition of Healthy Elderly Women

  • Prokopis Konstanti,
  • Marloes van Splunter,
  • Erik van den Brink,
  • Clara Belzer,
  • Arjen Nauta,
  • R. J. Joost van Neerven and
  • Hauke Smidt

14 June 2022

Background: Nutritional supplements, such as bovine lactoferrin (bLF), have been studied for their immunomodulatory properties, but little is known of their effect on the gut microbiota composition of the elderly when supplemented alone or combined w...

  • Article
  • Open Access
3 Citations
2,979 Views
13 Pages

Selection of Human Cytomegalovirus Mutants with Resistance against PDGFRα-Derived Entry Inhibitors

  • Kerstin Laib Sampaio,
  • Carolin Lutz,
  • Rebecca Engels,
  • Dagmar Stöhr and
  • Christian Sinzger

8 June 2021

The human cytomegalovirus (HCMV) infects fibroblasts via an interaction of its envelope glycoprotein gO with the cellular platelet-derived growth factor receptor alpha (PDGFRα), and soluble derivatives of this receptor can inhibit viral entry. We aim...

  • Article
  • Open Access
7 Citations
3,721 Views
18 Pages

Decreased Functional Connectivity of Brain Networks in the Alpha Band after Sleep Deprivation Is Associated with Decreased Inhibitory Control in Young Male Adults

  • Jie Lian,
  • Lin Xu,
  • Tao Song,
  • Ziyi Peng,
  • Xinxin Gong,
  • Jie Chen,
  • Xiao Zhong,
  • Xin An,
  • Shufang Chen and
  • Yongcong Shao

Sleep deprivation leads to reduced inhibitory control in individuals. However, the underlying neural mechanisms are poorly understood. Accordingly, this study aimed to investigate the effects of total sleep deprivation (TSD) on inhibitory control and...

  • Article
  • Open Access
4 Citations
2,116 Views
23 Pages

Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder

  • JoAnn Petrie,
  • Logan R. Kowallis,
  • Sarah Kamhout,
  • Kyle B. Bills,
  • Daniel Adams,
  • Donovan E. Fleming,
  • Bruce L. Brown and
  • Scott C. Steffensen

Opioid use disorder (OUD)-associated overdose deaths have reached epidemic proportions worldwide over the past two decades, with death rates for men reported at twice the rate for women. Using a controlled, cross-sectional, age-matched (18–56 y...

  • Brief Report
  • Open Access
3 Citations
4,293 Views
18 Pages

EEG Power Band Asymmetries in Children with and without Classical Ensemble Music Training

  • Gabriel Byczynski,
  • Kylie Schibli,
  • Gary Goldfield,
  • Gerry Leisman and
  • Amedeo D’Angiulli

7 March 2022

Much evidence shows that music training influences the development of functional brain organization and cerebral asymmetry in an auditory-motor integrative neural system also associated with language and speech. Such overlap suggests that music train...

  • Article
  • Open Access
6 Citations
1,799 Views
26 Pages

16 June 2023

A new Type-II generalized progressively hybrid censoring strategy, in which the experiment is ensured to stop at a specified time, is explored when the lifetime model of the test subjects follows a two-parameter alpha-power inverted exponential (Alph...

  • Article
  • Open Access
1 Citations
1,285 Views
13 Pages

Analyzing Information Exchange in Parkinson’s Disease via Eigenvector Centrality: A Source-Level Magnetoencephalography Study

  • Michele Ambrosanio,
  • Emahnuel Troisi Lopez,
  • Maria Maddalena Autorino,
  • Stefano Franceschini,
  • Rosa De Micco,
  • Alessandro Tessitore,
  • Antonio Vettoliere,
  • Carmine Granata,
  • Giuseppe Sorrentino and
  • Fabio Baselice
  • + 1 author

5 February 2025

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder that manifests through motor and non-motor symptoms. Understanding the alterations in brain connectivity associated with PD remains a challenge that is crucial for...

  • Article
  • Open Access
2 Citations
7,835 Views
21 Pages

Bifidogenic Effect of 2′-Fucosyllactose (2′-FL) on the Gut Microbiome of Healthy Formula-Fed Infants: A Randomized Clinical Trial

  • Tamara Lazarini,
  • Karina Merini Tonon,
  • Humberto Bezerra de Araujo Filho and
  • Mauro Batista de Morais

11 March 2025

Breast milk is rich in bioactive components, especially human milk oligosaccharides (HMOs), which are crucial for establishing gut microbiota. The 2′-FL (2-Fucosyllactose), one of the most abundant oligosaccharides in breast milk, functions as a sele...

  • Article
  • Open Access
1,122 Views
13 Pages

Neuroelectric Correlates of Perceptual Awareness During the Auditory Attentional Blink

  • Claude Alain,
  • Mary O’Neil,
  • Lori J. Bernstein,
  • Dawei Shen and
  • Bernhard Ross

Background: Perceptual awareness refers to the conscious detection and identification of a sensory event. In electrophysiological studies, it is associated with a modality-specific negative-going event-related potential, which can be observed as earl...

  • Article
  • Open Access
25 Citations
5,335 Views
13 Pages

Anti-Obesity and Anti-Adipogenic Effects of Chitosan Oligosaccharide (GO2KA1) in SD Rats and in 3T3-L1 Preadipocytes Models

  • Jung-Yun Lee,
  • Tae Yang Kim,
  • Hanna Kang,
  • Jungbae Oh,
  • Joo Woong Park,
  • Se-Chan Kim,
  • Minjoo Kim,
  • Emmanouil Apostolidis,
  • Young-Cheul Kim and
  • Young-In Kwon

11 January 2021

Excess body weight is a major risk factor for type 2 diabetes (T2D) and associated metabolic complications, and weight loss has been shown to improve glycemic control and decrease morbidity and mortality in T2D patients. Weight-loss strategies using...

  • Article
  • Open Access
26 Citations
4,900 Views
18 Pages

De Novo Transcriptome Sequencing Analysis of Goose (Anser anser) Embryonic Skin and the Identification of Genes Related to Feather Follicle Morphogenesis at Three Stages of Development

  • Chang Liu,
  • Cornelius Tlotliso Sello,
  • Yongfeng Sun,
  • Yuxuan Zhou,
  • Hongtao Lu,
  • Yujian Sui,
  • Jingtao Hu,
  • Chenguang Xu,
  • Yue Sun and
  • Kaiyan Zhang
  • + 3 authors

15 October 2018

The objective of this study was to evaluate the changes in the goose embryo transcriptome during feather development. RNA-Sequencing (RNA-Seq) was used to find the transcriptome profiles of feather follicles from three stages of embryonic dorsal skin...

  • Communication
  • Open Access
5 Citations
3,325 Views
11 Pages

The Influence of Lactobacillus paracasei HII01 Supplementation on Performance in Attention (Go/No-Go) Tasks and Quinolinic Acid and 5-Hydroxyindoleacetic Acid Levels in Thai Children—A Preliminary Study

  • Pranom Fukngoen,
  • Bhagavathi Sundaram Sivamaruthi,
  • Sasithorn Sirilun,
  • Ekasit Lalitsuradej,
  • Suchanat Khongtan,
  • Sartjin Peerajan,
  • Phakkharawat Sittiprapaporn and
  • Chaiyavat Chaiyasut

2 June 2022

Cognitive development is defined as the capacity of a child to think, reason, and use language, which are all vital to their overall growth. Attention deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder. Though severa...

  • Article
  • Open Access
5 Citations
1,855 Views
13 Pages

Neurobiological Alterations Induced by SARS-CoV-2: Insights from Variant-Specific Host Gene Expression Patterns in hACE2-Expressing Mice

  • Hamid Reza Jahantigh,
  • Amany Elsharkawy,
  • Anchala Guglani,
  • Komal Arora,
  • Lila D. Patterson and
  • Mukesh Kumar

27 February 2025

Since the onset of the COVID-19 pandemic, various severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have emerged. Although the primary site of SARS-CoV-2 infection is the lungs, it can also affect the brain and induce neurological...

  • Review
  • Open Access
358 Citations
33,674 Views
18 Pages

9 October 2018

Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological cond...

  • Feature Paper
  • Article
  • Open Access
21 Citations
2,373 Views
14 Pages

5 October 2023

The labeling-free and immobilization-free homogeneous aptamer sensor offers advantages including simple operation, low cost, and high sensitivity, demonstrating great potential in rapid detection of tumor biomarkers in biological samples. In this wor...

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