EEG Dynamics of a Go/Nogo Task in Children with ADHD
by
Simon Baijot 1,2,3
, Carlos Cevallos 4,5, David Zarka 4,6, Axelle Leroy 4, Hichem Slama 2,3,7, Cecile Colin 3,8, Nicolas Deconinck 1,4, Bernard Dan 1,4,9 and Guy Cheron 4,10,*
Simon Baijot 1,2,3, Carlos Cevallos 4,5, David Zarka 4,6, Axelle Leroy 4, Hichem Slama 2,3,7, Cecile Colin 3,8, Nicolas Deconinck 1,4, Bernard Dan 1,4,9 and Guy Cheron 4,10,*
1
Department of Neurology, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, 1020 Brussels, Belgium
2
Neuropsychology and Functional Neuroimaging Research Unit, Center for Research in Cognition and Neurosciences, Université Libre de Bruxelles, 1050 Brussels, Belgium
3
Cognitive Neurosciences Research Unit, Center for Research in Cognition and Neurosciences, Université Libre de Bruxelles, 1050 Brussels, Belgium
4
Laboratory of Neurophysiology and Movement Biomechanics, Université Libre de Bruxelles, CP640, 808 route de Lennik, 1070 Brussels, Belgium
5
Departamento de Ingeniería Mecánica, Facultad de Ingeniería Mecánica, Escuela Politécnica Nacional, Quito 170517, Ecuador
6
Research Unit in Osteopathy, Faculty of Motor Sciences, Université Libre de Bruxelles, 1070 Brussels, Belgium
7
Department of Clinical and Cognitive Neuropsychology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, Belgium
8
Laboratory of Cognitive and Sensory Neurophysiology, CHU Brugmann, Université Libre de Bruxelles, 1020 Brussels, Belgium
9
Medical and Rehabilitation Departments, Inkendaal Rehabilitation Hospital, 1602 Vlezenbeek, Belgium
10
Laboratory of Electrophysiology, Université de Mons, 7000 Mons, Belgium
*
Author to whom correspondence should be addressed.
Brain Sci. 2017, 7(12), 167; https://doi.org/10.3390/brainsci7120167
Received: 10 October 2017 / Revised: 7 December 2017 / Accepted: 15 December 2017 / Published: 20 December 2017
Background: Studies investigating event-related potential (ERP) evoked in a Cue-Go/NoGo paradigm have shown lower frontal N1, N2 and central P3 in children with attention-deficit/hyperactivity disorder (ADHD) compared to typically developing children (TDC). However, the electroencephalographic (EEG) dynamics underlying these ERPs remain largely unexplored in ADHD. Methods: We investigate the event-related spectral perturbation and inter-trial coherence linked to the ERP triggered by visual Cue-Go/NoGo stimuli, in 14 children (7 ADHD and 7 TDC) aged 8 to 12 years. Results: Compared to TDC, the EEG dynamics of children with ADHD showed a lower theta-alpha ITC concomitant to lower occipito-parietal P1-N2 and frontal N1-P2 potentials in response to Cue, Go and Nogo stimuli; an upper alpha power preceding lower central Go-P3; a lower theta-alpha power and ITC were coupled to a lower frontal Nogo-N3; a lower low-gamma power overall scalp at 300 ms after Go and Nogo stimuli. Conclusion: These findings suggest impaired ability in children with ADHD to conserve the brain oscillations phase associated with stimulus processing. This physiological trait might serve as a target for therapeutic intervention or be used as monitoring of their effects.
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MDPI and ACS Style
Baijot, S.; Cevallos, C.; Zarka, D.; Leroy, A.; Slama, H.; Colin, C.; Deconinck, N.; Dan, B.; Cheron, G. EEG Dynamics of a Go/Nogo Task in Children with ADHD. Brain Sci. 2017, 7, 167.
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