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Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

by Hao Chi 1, Hui-Yun Chang 2,* and Tzu-Kang Sang 1,*
1
Institute of Biotechnology, National Tsing Hua University, Hsinchu City 30013, Taiwan
2
Institute of Systems Neuroscience, National Tsing Hua University, Hsinchu City 30013, Taiwan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(10), 3082; https://doi.org/10.3390/ijms19103082
Received: 31 August 2018 / Revised: 3 October 2018 / Accepted: 5 October 2018 / Published: 9 October 2018
(This article belongs to the Special Issue Neuron Cell Death)
Neuronal cell death in the central nervous system has always been a challenging process to decipher. In normal physiological conditions, neuronal cell death is restricted in the adult brain, even in aged individuals. However, in the pathological conditions of various neurodegenerative diseases, cell death and shrinkage in a specific region of the brain represent a fundamental pathological feature across different neurodegenerative diseases. In this review, we will briefly go through the general pathways of cell death and describe evidence for cell death in the context of individual common neurodegenerative diseases, discussing our current understanding of cell death by connecting with renowned pathogenic proteins, including Tau, amyloid-beta, alpha-synuclein, huntingtin and TDP-43. View Full-Text
Keywords: apoptosis; necroptosis; neurodegeneration apoptosis; necroptosis; neurodegeneration
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Chi, H.; Chang, H.-Y.; Sang, T.-K. Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases. Int. J. Mol. Sci. 2018, 19, 3082.

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