Transcription and its regulation pose challenges related to DNA torsion and supercoiling of the DNA template. RNA polymerase tracking the helical groove of the DNA introduces positive helical torsion and supercoiling upstream and negative torsion and...
Retinal homeostasis and degeneration are significant contributors to global vision loss, with retinal health primarily assessed by the count and function of photoreceptor cells, the most abundant cells in the retina. Genomic studies have identified t...
Type 1A topoisomerases (topos) are the only topos that bind single-stranded DNA and the only ones found in all cells of the three domains of life. Two subfamilies, topo I and topo III, are present in bacteria. Topo I, found in all of them, relaxes ne...
Human topoisomerase III beta (hTOP3B) is a unique and important enzyme in human cells that plays a role in maintaining genome stability, affecting cellular aging, and potentially impacting viral replication. Its dual activity on both DNA and RNA make...
Although ultraviolet-B (UV-B) radiation reaching the ground represents a tiny fraction of the total solar radiant energy, it significantly affects human health and global ecosystems. Therefore, erythemal UV-B monitoring has recently attracted signifi...
A UV Nonlinear optical (NLO) crystal is one of the key devices in all-solid-state laser technology, and borate halides show outstanding potential due to their abundant structural diversity and short UV cut-off edges. In this article, the sizable UV N...
Members of the plant-specific B3 transcription factor superfamily play important roles in various growth and developmental processes in plants. Even though there are many valuable studies on B3 genes in other species, little is known about the B3 sup...
In this paper, we report the application of zinc phosphate electrostatic-painting top coating on cold sprayed AA7075 leading to a significant improvement in corrosion-fatigue performance. High strength AA7075 powder was sprayed on AZ31B substrate, fo...
The Sentinel-1A/B satellite launched by European Space Agency (ESA) in 2014 provides a huge amount of free Terrain Observation by Progressive Scans (TOPS) data with global coverage to the public. The TOPS data have a frame width of 250 km and have be...
Banana bunchy top disease (BBTD), caused by the banana bunchy top virus (BBTV, genus Babuvirus), is the most destructive viral disease of banana and plantain (Musa spp.). The virus is transmitted persistently by the banana aphid, Pentalonia nigronerv...
Sugarcane (Saccharum officinarum L.) is a tropical plant grown for sugar production. We recently showed that sugarcane top (ST) ameliorates cognitive decline in a mouse model of accelerated aging via promoting neuronal differentiation and neuronal en...
DNA strand breaks excessively accumulate in the brains of patients with Alzheimer’s disease (AD). While traditionally considered random, deleterious events, neuron activity itself induces DNA breaks, and these “adaptive” breaks help...
Inhibitors of DNA topoisomerase I (TOP1), an enzyme relieving torsional stress of DNA by generating transient single-strand breaks, are clinically used to treat ovarian, small cell lung and cervical cancer. As torsional stress is generated during tra...
In this study, an ultra-wideband absorber spanning from UV-B to middle-IR was designed and analyzed using a novel structure. The multilayer metamaterial, arranged from bottom to top, consisted of an Al metal layer, a lower SiO2 layer, a graphite laye...
By utilizing top-of-atmosphere radiation (TOAR) data from China’s new generation of geostationary satellites (FY-4A and FY-4B) along with interpretable machine learning models, near-surface particulate matter concentrations in China were estima...
Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged b...
Zygophyllum coccineum, an edible halophytic plant, is part of the traditional medicine chest in the Mediterranean region for symptomatic relief of diabetes, hypertension, wound healing, burns, infections, and rheumatoid arthritis pain. The current st...
DNA topoisomerase II (TOP2) is an enzyme that resolves DNA topological problems arising in various nuclear processes, such as transcription. Aclarubicin, a member of the anthracyclines, is known to prevent the association of TOP2 with DNA, inhibiting...
This work describes, for the first time, the synthesis of dialkyl (2-arylquinolin-8-yl)phosphonate derivatives. The preparation was carried out through a direct and simple process as a multicomponent Povarov reaction of aminophenylphosphonates, aldeh...
TiB2/316L stainless steel composites were prepared by selective laser melting (SLM), and the adhesion work, interface energy and electronic structure of TiB2/γ-Fe interface in TiB2/316L stainless steel composites were investigated to explore the hete...
An ultrawideband rectangular waveguide to microstrip line transition operating at the whole LMDS and Ka band is presented. The transition is based on exciting three overlapped transversal patches that radiate into the narrow wall of the waveguide, ma...
In order to investigate the dynamic response of a marine riser under the coupling effect of multiparameter, a model experiment of a marine riser was designed and carried out. The main parameters of the model test were divided into riser design parame...
Black carrot (Daucus carota L. ssp. sativus var. atroburens) is a root vegetable with anthocyanins as major phenolic compounds. The accumulation of phenolic compounds is a common response to UV-B exposure, acting as protective compounds and as antiox...
We summarize our recent proposals for probing the
The concept of cancer stem cells has revolutionized our current vision of cancer development and was validated in solid tumors and cancers of the primitive hematopoietic compartment. Proof of the principle is still lacking, however, in malignancies o...
Resistance to chemotherapy is one of the primary obstacles in acute myeloid leukemia (AML) therapy. Micro-RNA-23a (miR-23a) is frequently deregulated in AML and has been linked to chemoresistance in solid cancers. We, therefore, studied its role in c...
Genomic selection (GS) is a predictive methodology that is revolutionizing plant and animal breeding. However, the practical application of the GS methodology is challenging since a successful implementation requires a good identification of the best...
The hard and corrosion resistant coatings of Mo2NiB2 cermet were prepared by the laser cladding technique. The influences of the Mo:B ratio and the laser scanning speed on the microstructure and property of the Mo2NiB2 cermet coatings were investigat...
The blending of woody and herbaceous biomass can influence pellet quality and the energy consumption of the process. This work aims to understand the pelleting characteristics of 2-inch top-pine residue blended with switchgrass at high moisture conte...
Convective updrafts are one of the main characteristics of convective clouds, responsible for the convective mass flux and the redistribution of energy and condensate in the atmosphere. During the early stages of their lifecycle, convective clouds ex...
Shiga-toxin-producing Escherichia coli (STEC) are a burden on agriculture and a threat to public health. Rapid methods are needed to identify STEC strains and characterize the Shiga toxin (Stx) they produce. We analyzed three STEC strains for Stx exp...
Plant-based foods are characterized by significant amounts of bioactive molecules with desirable health benefits beyond basic nutrition. The Brassicaceae (Cruciferae) family consists of 350 genera; among them, Brassica is the most important one, whic...
The results examining the direction (bottom-to-top vs. top-to-bottom) of the mental vertical timeline are not conclusive. The visuospatial processing of temporal stimuli along vertical space could influence this time representation. This study aimed...
A series of model tests were conducted to investigate the bearing capacity and reinforced mechanism of a horizontal–vertical (H–V) geogrid-reinforced foundation. The bearing capacities of the unreinforced foundation, the conventional geog...
Electrogenic bacteria present in bioelectrical devices such as soil microbial fuel cells (SMFCs) are powered by the oxidation of organic and inorganic compounds due to microbial activity. Fourteen soils randomly selected from Bergen Community College...
Tropomyosin kinase receptor B (TrkB) has been explored as a therapeutic target for neurological and psychiatric disorders. However, the development of TrkB agonists was hindered by our poor understanding of the TrkB agonist binding location and affin...
A burgeoning stream of sustainability research explores the role of companies’ top management team (TMT) characteristics in corporate sustainability efforts, while another stream investigates the effect of a company’s supply chain positio...
Reduced fertilization technology is an eco-friendly strategy to minimize nitrogen (N) and phosphorus (P) surpluses and losses in vegetable production. However, little is known about the performance of chemical fertilizer reduction when supplemented w...
Since the initial measurements of single-top quark production at the Tevatron in 2009, tremendous progress has been made at the LHC. While LHC Run 1 marked the beginning of a precision era for the single-top quark measurements in some of the main pro...
In this paper, the cabin noise of four airport express rail systems, namely the Taiwan Taoyuan International Airport MRT, the Hong Kong Airport Express, RER B service from Paris Gare du Nord to Paris Charles de Gaulle Airport, and the Shanghai Maglev...
EphB3 is a major key player in a variety of cellular activities, including cell migration, proliferation, and apoptosis. However, the exact role of EphB3 in cancer remains ambiguous. Accordingly, new EphB3 inhibitors can increase the understanding of...
The write-only oblivious RAM (ORAM) is proposed to efficiently protect the privacy of applications such as cloud storage synchronization and encrypted hidden volumes. For N blocks with size B = Ω(log2N), the most efficient write-only ORAM, DetWoORAM,...
The demand for ecofriendly green catalysts for biofuel synthesis is greatly increasing with the effects of fossil fuel depletion. Fungal lipases are abundantly used as biocatalysts for the synthesis of biofuel. The use of Botrytis cinerea lipase is a...
We demonstrate a kind of grating coupler that generates a high quality flat-top beam with a small beamwidth from photonic integrated circuits into free-space. The grating coupler is designed on a silicon-on-insulator wafer with a 220-nm-thick silicon...
Measurements of the global cloud vertical structure (CVS) are critical to better understanding the effects of the CVS on climate. Current CVS algorithms based on OCO-2 have to be combined with cloud top height products from CALIPSO and CloudSat, whic...
Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase...
Currently, the treatment of pediatric high-grade osteosarcomas systematically includes one topoisomerase IIα inhibitor. This chemotherapy is usually adapted to the response to the neo-adjuvant therapy after surgery. The current and unique marker of c...
Proteins involved in synaptic transmission in normal hearing, acoustic stimulation, and tinnitus were identified using protein–protein interaction (PPI) networks. The gene list for tinnitus was compiled from the GeneCards database using the key...
Reverse gyrase introduces positive supercoils to circular DNA and is implicated in genome stability maintenance in thermophiles. The extremely thermophilic crenarchaeon Sulfolobus encodes two reverse gyrase proteins, TopR1 (topoisomerase reverse gyra...
Background: Energy drinks are one of the most popular packaged beverage products consumed within the United States (US). Energy drinks are considered a functional beverage, a category that also includes sports drinks and nutraceutical beverages. Purp...
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