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Int. J. Mol. Sci. 2018, 19(9), 2765; https://doi.org/10.3390/ijms19092765

TOP2B: The First Thirty Years

1
Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
2
NUPPA, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
3
School of Biomedical Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
*
Authors to whom correspondence should be addressed.
Received: 18 June 2018 / Revised: 7 September 2018 / Accepted: 11 September 2018 / Published: 14 September 2018
(This article belongs to the Special Issue DNA Topoisomerases)
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Abstract

Type II DNA topoisomerases (EC 5.99.1.3) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery. View Full-Text
Keywords: Topoisomerase II; TOP2; Cell cycle; cell biology; transcription; review Topoisomerase II; TOP2; Cell cycle; cell biology; transcription; review
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Austin, C.A.; Lee, K.C.; Swan, R.L.; Khazeem, M.M.; Manville, C.M.; Cridland, P.; Treumann, A.; Porter, A.; Morris, N.J.; Cowell, I.G. TOP2B: The First Thirty Years. Int. J. Mol. Sci. 2018, 19, 2765.

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