TOP2B: The First Thirty Years
AbstractType II DNA topoisomerases (EC 220.127.116.11) are enzymes that catalyse topological changes in DNA in an ATP dependent manner. Strand passage reactions involve passing one double stranded DNA duplex (transported helix) through a transient enzyme-bridged break in another (gated helix). This activity is required for a range of cellular processes including transcription. Vertebrates have two isoforms: topoisomerase IIα and β. Topoisomerase IIβ was first reported in 1987. Here we review the research on DNA topoisomerase IIβ over the 30 years since its discovery. View Full-Text
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Austin, C.A.; Lee, K.C.; Swan, R.L.; Khazeem, M.M.; Manville, C.M.; Cridland, P.; Treumann, A.; Porter, A.; Morris, N.J.; Cowell, I.G. TOP2B: The First Thirty Years. Int. J. Mol. Sci. 2018, 19, 2765.
Austin CA, Lee KC, Swan RL, Khazeem MM, Manville CM, Cridland P, Treumann A, Porter A, Morris NJ, Cowell IG. TOP2B: The First Thirty Years. International Journal of Molecular Sciences. 2018; 19(9):2765.Chicago/Turabian Style
Austin, Caroline A.; Lee, Ka C.; Swan, Rebecca L.; Khazeem, Mushtaq M.; Manville, Catriona M.; Cridland, Peter; Treumann, Achim; Porter, Andrew; Morris, Nick J.; Cowell, Ian G. 2018. "TOP2B: The First Thirty Years." Int. J. Mol. Sci. 19, no. 9: 2765.
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