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  • Article
  • Open Access
543 Views
17 Pages

Intra- and Inter-Rater Reliability Analysis of MMSE-K and Tablet PC-Based MMSE-K Kit in Patients with Neurologic Disease

  • Seung-Ho Choun,
  • Sang-Woo Lee,
  • Yu-Sun Min,
  • Eunhee Park,
  • Jee-Hyun Kim and
  • Tae-Du Jung

21 November 2025

Background: The increasing prevalence of dementia and mild cognitive impairment (MCI) underscores the need for reliable and scalable digital cognitive screening tools. Although several studies have validated smartphone- or tablet-based assessments in...

  • Brief Report
  • Open Access
4 Citations
3,910 Views
7 Pages

Predicting Scores on the Mini-Mental State Examination (MMSE) from Spontaneous Speech

  • Alma M. Bueno-Cayo,
  • Minerva del Rio Carmona,
  • Rosa Castell-Enguix,
  • Isabel Iborra-Marmolejo,
  • Mike Murphy,
  • Tatiana Quarti Irigaray,
  • José Francisco Cervera and
  • Carmen Moret-Tatay

16 September 2022

The aim of this study was to examine the relationship between language components, such as lexical density, length, and content in terms of “Time, Space and Action”, with MMSE scores. For this reason, a group of 33 older participants, wit...

  • Article
  • Open Access
1,340 Views
14 Pages

MMSE-Based Dementia Prediction: Deep vs. Traditional Models

  • Yuyeon Jung,
  • Yeji Park,
  • Jaehyun Jo and
  • Jinhyoung Jeong

1 October 2025

Early and accurate diagnosis of dementia is essential to improving patient outcomes and reducing societal burden. The Mini-Mental State Examination (MMSE) is widely used to assess cognitive function, yet traditional statistical and machine learning a...

  • Article
  • Open Access
23 Citations
4,057 Views
18 Pages

14 September 2021

The accurate detection and alleviation of driving fatigue are of great significance to traffic safety. In this study, we tried to apply the modified multi-scale entropy (MMSE) approach, based on variational mode decomposition (VMD), to driving fatigu...

  • Article
  • Open Access
4 Citations
3,325 Views
12 Pages

28 June 2019

In this paper, we estimate the uplink performance of large-scale multi-user multiple-input multiple-output (MIMO) networks. By applying minimum-mean-square-error (MMSE) detection, a novel statistical distribution of the signal-to-interference-plus-no...

  • Article
  • Open Access
93 Citations
6,174 Views
22 Pages

14 June 2018

Rolling bearings play a crucial role in rotary machinery systems, and their operating state affects the entire mechanical system. In most cases, the fault of a rolling bearing can only be identified when it has developed to a certain degree. At that...

  • Article
  • Open Access
15 Citations
4,054 Views
10 Pages

MoCA vs. MMSE of Fibromyalgia Patients: The Possible Role of Dual-Task Tests in Detecting Cognitive Impairment

  • Alvaro Murillo-Garcia,
  • Juan Luis Leon-Llamas,
  • Santos Villafaina,
  • Paloma Rohlfs-Dominguez and
  • Narcis Gusi

1 January 2021

Fibromyalgia is a syndrome that is characterized by widespread pain; fatigue; stiffness; reduced physical fitness; sleep disturbances; psychological symptoms, such as anxiety and depression; and deficits in cognitive functions, such as attention, exe...

  • Article
  • Open Access
7 Citations
4,521 Views
18 Pages

This paper deals with the problem of the channel estimation of orthogonal frequency division multiplexing (OFDM) signals transmitted through a time-varying fading channel. We show that an accurate power delay profile (PDP) estimator can be obtained b...

  • Article
  • Open Access
2 Citations
3,279 Views
9 Pages

The quasi-orthogonal space–time block code (QO-STBC) was introduced to achieve a full transmission rate for the four antennas system. In this paper, a decoding method for the QO-STBC is proposed to improve the bit-error-rate (BER) and to solve...

  • Article
  • Open Access
793 Views
29 Pages

5 November 2025

This paper presents a detailed performance evaluation of a proposed Orthogonal Time Frequency Space (OTFS) system for Integrated Sensing and Communications (ISAC) in doubly dispersive wireless channels, characterized by both delay and Doppler spreads...

  • Article
  • Open Access
2 Citations
1,754 Views
15 Pages

14 January 2025

Background and Objectives: The aging population has led to a rise in cognitive impairments, including dementia, often associated with multimorbidity. Early diagnosis of cognitive decline is crucial, especially in primary care, where time constraints...

  • Article
  • Open Access
3,147 Views
13 Pages

23 September 2020

The ability to maintain postural stability is essential in our daily lives. Relatedly, hemiparetic stroke patients have a very high risk of falls. This study aimed to improve the traditional rehabilitation treatment for stroke patients with hemipares...

  • Article
  • Open Access
3 Citations
3,879 Views
13 Pages

Patients with psychiatric disorders often have cognitive impairment. Several deficits have been recognized in patients with mood and/or psychotic disorders. We hypothesized that differences in the levels of deterioration exist between patients with b...

  • Article
  • Open Access
30 Citations
4,098 Views
10 Pages

Vitamin D and Folate as Predictors of MMSE in Alzheimer’s Disease: A Machine Learning Analysis

  • Giuseppe Murdaca,
  • Sara Banchero,
  • Alessandro Tonacci,
  • Alessio Nencioni,
  • Fiammetta Monacelli and
  • Sebastiano Gangemi

Vitamin D (VD) and micronutrients, including folic acid, are able to modulate both the innate and the adaptive immune responses. Low VD and folic acid levels appear to promote cognitive decline as in Alzheimer’s disease (AD). A machine learning appro...

  • Review
  • Open Access
57 Citations
12,085 Views
15 Pages

Current Update on the Clinical Utility of MMSE and MoCA for Stroke Patients in Asia: A Systematic Review

  • Julia Khaw,
  • Ponnusamy Subramaniam,
  • Noor Azah Abd Aziz,
  • Azman Ali Raymond,
  • Wan Asyraf Wan Zaidi and
  • Shazli Ezzat Ghazali

Objective: Primary care clinicians in Asia employed the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to aid dementia diagnosis post-stroke. Recent studies questioned their clinical utility in stroke settings for relyi...

  • Article
  • Open Access
9 Citations
3,155 Views
19 Pages

12 January 2023

This paper presents a lossless image compression method with a fast decoding time and flexible adjustment of coder parameters affecting its implementation complexity. A comparison of several approaches for computing non-MMSE prediction coefficients w...

  • Article
  • Open Access
13 Citations
5,721 Views
19 Pages

Applying ACE-III, M-ACE and MMSE to Diagnostic Screening Assessment of Cognitive Functions within the Polish Population

  • Beata Kaczmarek,
  • Zofia Ilkowska,
  • Sylwia Kropinska,
  • Sławomir Tobis,
  • Roma Krzyminska-Siemaszko,
  • Aleksandra Kaluzniak-Szymanowska and
  • Katarzyna Wieczorowska-Tobis

The research aims to compare the accuracy of the mini-mental state examination (MMSE), the Addenbrooke’s cognitive examination III (ACE-III) and the mini-Addenbrooke’s cognitive examination (M-ACE) within the Polish population. The model...

  • Article
  • Open Access
7 Citations
3,361 Views
19 Pages

17 June 2019

Filtered multitone (FMT) modulation divides the communication band into several subbands to shorten the span of symbols affected by multipath in underwater acoustic (UWA) communications. However, there is still intersymbol interference (ISI) in each...

  • Article
  • Open Access
4 Citations
2,395 Views
23 Pages

4 October 2022

For the bearing-only target motion analysis (TMA), the pseudolinear Kalman filter (PLKF) solves the complex nonlinear estimation of the motion model parameters but suffers serious bias problems. The pseudolinear Kalman filter under the minimum mean s...

  • Article
  • Open Access
8 Citations
3,906 Views
19 Pages

Capacity Analysis of Lattice Reduction Aided Equalizers for Massive MIMO Systems

  • Samarendra Nath Sur,
  • Rabindranath Bera,
  • Akash Kumar Bhoi,
  • Mahaboob Shaik and
  • Gonçalo Marques

Massive multi-input-multi-output (MIMO) systems are the future of the communication system. The proper design of the MIMO system needs an appropriate choice of detection algorithms. At the same time, Lattice reduction (LR)-aided equalizers have been...

  • Article
  • Open Access
35 Citations
7,976 Views
14 Pages

Quantitative EEG Markers of Entropy and Auto Mutual Information in Relation to MMSE Scores of Probable Alzheimer’s Disease Patients

  • Carmina Coronel,
  • Heinrich Garn,
  • Markus Waser,
  • Manfred Deistler,
  • Thomas Benke,
  • Peter Dal-Bianco,
  • Gerhard Ransmayr,
  • Stephan Seiler,
  • Dieter Grossegger and
  • Reinhold Schmidt

17 March 2017

Analysis of nonlinear quantitative EEG (qEEG) markers describing complexity of signal in relation to severity of Alzheimer’s disease (AD) was the focal point of this study. In this study, 79 patients diagnosed with probable AD were recruited from the...

  • Article
  • Open Access
2,965 Views
18 Pages

The Impact of Chronic Alcohol Consumption on Cognitive Function in Older People

  • Simona-Dana Mitincu-Caramfil,
  • Alina Plesea-Condratovici,
  • Alexia Anastasia Stefania Balta,
  • Valentin Bulza,
  • Andrei-Vlad Bradeanu,
  • Lavinia-Alexandra Moroianu,
  • Oana-Maria Isailă and
  • Eduard Drima

28 June 2025

Background/Objectives: Cognitive deficiency associated with chronic alcohol consumption in older people remains an under-investigated public health issue in Romania, particularly concerning rural–urban disparities and the impact of reversible h...

  • Article
  • Open Access
1 Citations
2,507 Views
14 Pages

Estimating the Prevalence of Cognitive Impairment and Its Associated Factors in Albania: A Nationwide Cross-Sectional Study

  • Malvina Hoxha,
  • Simonetta Galgani,
  • Jera Kruja,
  • Ilir Alimehmeti,
  • Viktor Rapo,
  • Frenki Çipi,
  • Domenico Tricarico and
  • Bruno Zappacosta

24 September 2024

Background/Objectives: Cognitive impairment is an intermediate state between normal aging and dementia, and its detection in the early stages is essential to prevent dementia, an incurable pathology. The aim of this study is to screen and estimate th...

  • Article
  • Open Access
2 Citations
3,508 Views
10 Pages

APOE Variant (rs405509) might Modulate the Effect of Sex and Educational Level on Cognitive Impairment Risk in a Taiwanese Population

  • Tsui-Wen Hsu,
  • Disline Manli Tantoh,
  • Pang-Li Liu,
  • Pei-Hsin Chen,
  • Oswald Ndi Nfor,
  • Ming-Chih Chou,
  • Long-Yau Lin and
  • Yung-Po Liaw

Education, sex, and the APOE-rs405509 variant are associated with Alzheimer’s disease and cognitive performance. We investigated if the rs405509 TT, TG, and GG genotypes modulate the effect of sex and education on cognitive impairment in Taiwan...

  • Feature Paper
  • Review
  • Open Access
12 Citations
6,551 Views
51 Pages

A View of Information-Estimation Relations in Gaussian Networks

  • Alex Dytso,
  • Ronit Bustin,
  • H. Vincent Poor and
  • Shlomo Shamai (Shitz)

9 August 2017

Relations between estimation and information measures have received considerable attention from the information theory community. One of the most notable such relationships is the I-MMSE identity of Guo, Shamai and Verdú that connects the mutual info...

  • Article
  • Open Access
2 Citations
4,826 Views
9 Pages

Relationship between Cognitive Function and Sway of Body in Standing Posture: A Cross-Sectional Study

  • Takao Naito,
  • Yume Suzuki,
  • Kotaro Yamasue,
  • Kyoko Saito,
  • Masanari Umemura,
  • Narumi Kojima,
  • Hunkyung Kim,
  • Yosuke Osuka,
  • Yoshihiro Ishikawa and
  • Osamu Tochikubo

25 February 2023

Background: The influence of neurological or balance dysfunction on cognitive impairment has not been well studied. We compared the results of the balance test, measured by either head or foot sway to consider whole body sway, with those of the cogni...

  • Feature Paper
  • Article
  • Open Access
31 Citations
22,757 Views
14 Pages

Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment

  • Asako Ueno,
  • Tadanori Hamano,
  • Soichi Enomoto,
  • Norimichi Shirafuji,
  • Miwako Nagata,
  • Hirohiko Kimura,
  • Masamichi Ikawa,
  • Osamu Yamamura,
  • Daiki Yamanaka and
  • Yasunari Nakamoto
  • + 3 authors

2 April 2022

Vitamin B12 deficiency is associated with cognitive impairment, hyperhomocysteinemia, and hippocampal atrophy. However, the recovery of cognition with vitamin B12 supplementation remains controversial. Of the 1716 patients who visited our outpatient...

  • Article
  • Open Access
36 Citations
11,534 Views
14 Pages

Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment

  • Yuka Hama,
  • Tadanori Hamano,
  • Norimichi Shirafuji,
  • Kouji Hayashi,
  • Asako Ueno,
  • Soichi Enomoto,
  • Miwako Nagata,
  • Hirohiko Kimura,
  • Akiko Matsunaga and
  • Yasunari Nakamoto
  • + 5 authors

14 October 2020

Although folate deficiency was reported to be associated with hyperhomocysteinemia, influence of folate supplementation on cognition remains controversial. Therefore, we explored the effects of folate supplementation on the cognition and Homocysteine...

  • Article
  • Open Access
94 Citations
13,377 Views
10 Pages

Considering the need to intercept neurocognitive damage as soon as possible, it would be useful to extend cognitive test screening throughout the population. Here, we propose differential cut-off levels that can be used to identify mild and severe co...

  • Article
  • Open Access
2 Citations
5,225 Views
14 Pages

General Cognitive Impairment as a Risk Factor for Motor Vehicle Collision Involvement: A Prospective Population-Based Study

  • Carrie Huisingh,
  • Cynthia Owsley,
  • Virginia G. Wadley,
  • Emily B. Levitan,
  • Marguerite R. Irvin,
  • Paul MacLennan and
  • Gerald McGwin Jr.

This study examined whether cognitive impairment and decline as assessed by a brief mental status screening test is associated with future crash risk in a cohort of older drivers. A three-year prospective study was conducted in a population-based sam...

  • Article
  • Open Access
1,487 Views
16 Pages

Optimizing the energy spectrum density (ESD) of a transmitted waveform can improve radar performance. The design of a time–domain constant–modulus signal corresponding to the transmitted waveform ESD is practically important because const...

  • Feature Paper
  • Article
  • Open Access
7 Citations
2,589 Views
18 Pages

High-Precision Iterative Preconditioned Gauss–Seidel Detection Algorithm for Massive MIMO Systems

  • Mushtaq Ahmad,
  • Xiaofei Zhang,
  • Imran A. Khoso,
  • Xinlei Shi and
  • Yang Qian

19 November 2022

Signal detection is a serious challenge for uplink massive multiple-input multiple-output (MIMO) systems. The traditional linear minimum-mean-squared error (MMSE) achieves good detection performance for such systems, but involves matrix inversion, wh...

  • Article
  • Open Access
14 Citations
5,330 Views
16 Pages

2 August 2017

This paper presents a novel low probability of intercept (LPI) optimization framework in radar network by minimizing the Schleher intercept factor based on minimum mean-square error (MMSE) estimation. MMSE of the estimate of the target scatterer matr...

  • Article
  • Open Access
9 Citations
3,016 Views
19 Pages

12 August 2021

In bearings-only tracking systems, the pseudolinear Kalman filter (PLKF) has advantages in stability and computational complexity, but suffers from correlation problems. Existing solutions require bias compensation to reduce the correlation between t...

  • Article
  • Open Access
1 Citations
2,909 Views
14 Pages

Assessment of Cognitive Function in Romanian Patients with Chronic Alcohol Consumption

  • Shandiz Morega,
  • Claudiu-Marinel Ionele,
  • Mihaela-Andreea Podeanu,
  • Dan-Nicolae Florescu and
  • Ion Rogoveanu

Alcoholism presents a significant health concern with notable socioeconomic implications. Alcohol withdrawal syndrome (AWS) can manifest when individuals cease or drastically reduce their alcohol consumption after prolonged use. Non-alcoholic fatty l...

  • Article
  • Open Access
6 Citations
2,138 Views
21 Pages

Optical Coherence Tomography Assessment of Macular Thickness in Alzheimer’s Dementia with Different Neuropsychological Severities

  • Chia-Chen Kao,
  • Hui-Min Hsieh,
  • Yo-Chen Chang,
  • Hui-Chen Chu,
  • Yuan-Han Yang and
  • Shwu-Jiuan Sheu

10 July 2023

This retrospective case-control study aimed to investigate associations between disease severity of Alzheimer’s dementia (AD) and macular thickness. Data of patients with AD who were under medication (n = 192) between 2013 and 2020, as well as...

  • Article
  • Open Access
16 Citations
3,056 Views
30 Pages

Assessing Feasibility of Cognitive Impairment Testing Using Social Robotic Technology Augmented with Affective Computing and Emotional State Detection Systems

  • Sergio Russo,
  • Letizia Lorusso,
  • Grazia D’Onofrio,
  • Filomena Ciccone,
  • Michele Tritto,
  • Sergio Nocco,
  • Daniela Cardone,
  • David Perpetuini,
  • Marco Lombardo and
  • Francesco Giuliani
  • + 4 authors

Social robots represent a valid opportunity to manage the diagnosis, treatment, care, and support of older people with dementia. The aim of this study is to validate the Mini-Mental State Examination (MMSE) test administered by the Pepper robot equip...

  • Article
  • Open Access
7 Citations
3,046 Views
11 Pages

17 February 2023

Data linking heart rate variability (HRV) and cognitive status remains controversial and scarce, particularly in cerebral small vessel disease (CSVD) patients. Whether the association between HRV and cognitive performance exists in CSVD patients is u...

  • Article
  • Open Access
7 Citations
3,623 Views
9 Pages

Improvement of Cognitive Function and Interleukin 1 Beta Serum Concentrations Following Cardiac Pacemaker Implantation in Patients with Symptomatic Bradycardia

  • Alexandru Martis,
  • Gabriel Gusetu,
  • Gabriel Cismaru,
  • Dumitru Zdrenghea,
  • Daniel-Corneliu Leucuta and
  • Dana Pop

5 August 2021

Background and aim: Bradyarrhythmias cause a low cerebral blood flow with secondary neuronal ischemia and cognitive dysfunction. This study aims to assess the effect of cardiac pacemaker implantation (PI) on the cognitive function and inflammatory ma...

  • Article
  • Open Access
15 Citations
4,752 Views
12 Pages

Neutrophil-to-Lymphocyte Ratio as a Predictor of Short-Term Functional Outcomes in Acute Ischemic Stroke Patients

  • Min-Su Kim,
  • Min Young Heo,
  • Hyo Jin Joo,
  • Ga Yang Shim,
  • Jinmann Chon,
  • Sung Joon Chung,
  • Yunsoo Soh and
  • Myung Chul Yoo

Background: Neutrophil-to-lymphocyte ratio (NLR), a systemic inflammatory biomarker, has been associated with poorer outcomes in acute ischemic stroke patients. The present study was designed to expand these findings by investigating the association...

  • Review
  • Open Access
144 Citations
26,058 Views
21 Pages

Vitamin C Status and Cognitive Function: A Systematic Review

  • Nikolaj Travica,
  • Karin Ried,
  • Avni Sali,
  • Andrew Scholey,
  • Irene Hudson and
  • Andrew Pipingas

30 August 2017

Vitamin C plays a role in neuronal differentiation, maturation, myelin formation and modulation of the cholinergic, catecholinergic, and glutaminergic systems. This review evaluates the link between vitamin C status and cognitive performance, in both...

  • Article
  • Open Access
1,055 Views
16 Pages

Cognitive Impairment and Psychological Morbidity Among Stroke Survivors in Rehabilitation: A Cross-Sectional Analysis

  • Ana-Maria Bumbea,
  • Daniela Gabriela Glavan,
  • Ramona-Constantina Vasile,
  • Alexandra Daniela Rotaru-Zavaleanu,
  • Andrei Greșiță,
  • Roxana Surugiu,
  • Sorin Nicolae Dinescu,
  • Irina Burlacu and
  • Madalina Aldea

31 October 2025

Background: Stroke represents a leading cause of disability worldwide and is frequently associated with cognitive impairment, anxiety, and post-stroke depression (PSD), all of which can hinder rehabilitation and reduce quality of life. This study aim...

  • Article
  • Open Access
5 Citations
6,227 Views
14 Pages

Association between the Intake/Type of Cheese and Cognitive Function in Community-Dwelling Older Women in Japan: A Cross-Sectional Cohort Study

  • Takao Suzuki,
  • Yosuke Osuka,
  • Narumi Kojima,
  • Hiroyuki Sasai,
  • Kentaro Nakamura,
  • Chisato Oba,
  • Mayuki Sasaki and
  • Hunkyung Kim

22 August 2024

While many studies have described the association between cognitive decline and eating habits, little attention has been paid to its association with cheese intake. In this epidemiological study of 1035 community-dwelling women aged ≥ 65, we inves...

  • Article
  • Open Access
4 Citations
2,694 Views
17 Pages

An Efficient Multistage Approach for Blind Source Separation of Noisy Convolutive Speech Mixture

  • Junaid Bahadar Khan,
  • Tariqullah Jan,
  • Ruhul Amin Khalil,
  • Nasir Saeed and
  • Muhannad Almutiry

27 June 2021

This paper proposes a novel efficient multistage algorithm to extract source speech signals from a noisy convolutive mixture. The proposed approach comprises two stages named Blind Source Separation (BSS) and de-noising. A hybrid source prior model s...

  • Article
  • Open Access
15 Citations
16,477 Views
11 Pages

Inverse Association between Cheese Consumption and Lower Cognitive Function in Japanese Community-Dwelling Older Adults Based on a Cross-Sectional Study

  • Hunkyung Kim,
  • Yosuke Osuka,
  • Narumi Kojima,
  • Hiroyuki Sasai,
  • Kentaro Nakamura,
  • Chisato Oba,
  • Mayuki Sasaki and
  • Takao Suzuki

18 July 2023

Diet modification may contribute to the prevention of age-related cognitive decline. The association between dairy product consumption and cognitive function in older people remains unknown. We investigated whether cheese intake is associated with lo...

  • Article
  • Open Access
3 Citations
4,083 Views
13 Pages

Elderly Body Movement Alteration at 2nd Experience of Digital Art Installation with Cognitive and Motivation Scores

  • Ting Tao,
  • Ryota Sato,
  • Yusuke Matsuda,
  • Jumpei Takata,
  • Fijun Kim,
  • Yukio Daikubara,
  • Koji Fujita,
  • Kotaro Hanamoto,
  • Fumio Kinoshita and
  • Mamiko Koshiba
  • + 1 author

14 April 2020

The prevalence of advanced medical treatment has led to global population aging, resulting in increased numbers of dementia patients. One of the most intractable symptoms of dementia is apathy, or lack of interest and enthusiasm, which can accompany...

  • Article
  • Open Access
647 Views
13 Pages

7 November 2025

Objectives: Dementia and hearing loss are prevalent conditions among older adults. This study aimed to determine the association between hearing loss and cognitive status using data from the Catholic Medical Center Clinical Data Warehouse (CMC–...

  • Communication
  • Open Access
9 Citations
3,713 Views
13 Pages

An Efficient Turbo Decoding and Frequency Domain Turbo Equalization for LTE Based Narrowband Internet of Things (NB-IoT) Systems

  • Mohammed Jajere Adamu,
  • Li Qiang,
  • Rabiu Sale Zakariyya,
  • Charles Okanda Nyatega,
  • Halima Bello Kawuwa and
  • Ayesha Younis

8 August 2021

This paper addresses the main crucial aspects of physical (PHY) layer channel coding in uplink NB-IoT systems. In uplink NB-IoT systems, various channel coding algorithms are deployed due to the nature of the adopted Long-Term Evolution (LTE) channel...

  • Article
  • Open Access
25 Citations
8,099 Views
14 Pages

16 August 2018

The study objective is to investigate whether vitamin D is associated with the cognitive function of geriatric patients. This cross-sectional study involved 357 patients hospitalized in the geriatric ward who complained of memory problems (mean age:...

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