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123 Results Found

  • Article
  • Open Access
12 Citations
3,384 Views
25 Pages

13 October 2022

HVA22 family proteins with a conserved TB2/DP1/HVA22 domain are ubiquitous in eukaryotes. HVA22 family genes have been identified in a variety of plant species. However, there has been no comprehensive genome-wide analysis of HVA22 family genes in to...

  • Article
  • Open Access
42 Citations
4,850 Views
23 Pages

7 March 2022

Plant responses to multiple environmental stresses include various signaling pathways that allow plant acclimation and survival. Amongst different stresses, drought and heat stress severely affect growth and productivity of wheat. HVA1, a member of t...

  • Article
  • Open Access
6 Citations
3,070 Views
12 Pages

A Sea Anemone Lebrunia neglecta Venom Fraction Decreases Boar Sperm Cells Capacitation: Possible Involvement of HVA Calcium Channels

  • Fernando Lazcano-Pérez,
  • Karina Bermeo,
  • Héctor Castro,
  • Zayil Salazar Campos,
  • Isabel Arenas,
  • Ariana Zavala-Moreno,
  • Sheila Narayán Chávez-Villela,
  • Irma Jiménez,
  • Roberto Arreguín-Espinosa and
  • Judith Sánchez-Rodríguez
  • + 3 authors

7 April 2022

Sea anemones produce venoms characterized by a complex mixture of low molecular weight compounds, proteins and peptides acting on voltage-gated ion channels. Mammal sperm cells, like neurons, are characterized by their ion channels. Calcium channels...

  • Article
  • Open Access
4 Citations
1,896 Views
10 Pages

Elderly Patients and Insect Venom Allergy: Are the Clinical Pictures and Immunological Parameters of Venom Allergy Age-Dependent?

  • Robert Pawłowicz,
  • Andrzej Bożek,
  • Anna Dor-Wojnarowska,
  • Marta Rosiek-Biegus,
  • Agnieszka Kopeć,
  • Małgorzata Gillert-Smutnicka,
  • Małgorzata Sobieszczańska and
  • Marita Nittner-Marszalska

9 April 2024

Insect venom is one of the most common triggers of anaphylaxis in the elderly population. Venom immunotherapy (VIT) remains the only treatment for Hymenoptera venom allergy (HVA). However, little is known about the differences in indication for VIT i...

  • Article
  • Open Access
11 Citations
4,454 Views
14 Pages

24 June 2019

A method was developed for solving the relaxation modulus of high viscosity asphalt sand (HVAS) based on the three-point bending creep test, and was verified by comparison with experimental results. In this method, firstly, a transcendental equation...

  • Article
  • Open Access
2 Citations
3,588 Views
17 Pages

Composition and Diversity of LTR Retrotransposons in the Coffee Leaf Rust Genome (Hemileia vastatrix)

  • Simon Orozco-Arias,
  • Mariana S. Candamil,
  • Paula A. Jaimes,
  • Marco Cristancho,
  • Reinel Tabares-Soto and
  • Romain Guyot

13 July 2022

Coffee leaf rust is the most damaging disease for coffee cultivation around the world. It is caused by a fungal pathogen, Hemileia vastatrix (Hva), belonging to the phylum Basidiomycota. Coffee leaf rust causes significant yield losses and increases...

  • Review
  • Open Access
28 Citations
12,106 Views
26 Pages

14 November 2005

This review focuses on the stability of voltammetric signals recorded overperiods of months with carbon paste electrodes (CPEs) implanted in the brain. The keyinteraction underlying this stability is between the pasting oil and brain lipids that arec...

  • Article
  • Open Access
3 Citations
2,571 Views
15 Pages

Investigation of Imidazolium-Based Ionic Liquids as Additives for the Separation of Urinary Biogenic Amines via Capillary Electrophoresis

  • Natalia Kaczmarczyk,
  • Natalia Treder,
  • Piotr Kowalski,
  • Alina Plenis,
  • Anna Roszkowska,
  • Tomasz Bączek and
  • Ilona Olędzka

Ionic liquids (ILs), such as imidazoles, can be used to prevent the sorption of analytes onto the walls of the capillary. Prior works have confirmed that coating the capillary wall with a cationic layer can increase its surface stability, thereby imp...

  • Article
  • Open Access
3 Citations
2,605 Views
12 Pages

27 December 2022

In this paper, N, N’-m-phenylene dimaleimide (HVA-2) grafted crosslinked polyethylene (XLPE) insulation materials with different HVA-2 contents were prepared. The grafting, crosslinking, and crystalline structure were characterized by Fourier-t...

  • Article
  • Open Access
14 Citations
7,212 Views
16 Pages

Effect of the 5-HT2C Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study

  • Sara Whitestone,
  • Philippe De Deurwaerdère,
  • Lynn Baassiri,
  • Julien Manem,
  • Youssef Anouar,
  • Giuseppe Di Giovanni,
  • Rahul Bharatiya and
  • Abdeslam Chagraoui

The effects triggered by serotonin2C (5-hydroxytryptamin2C, 5-HT2C) receptor agonists in the brain are often subtle, and methodologies highlighting their widespread actions to account for their multiple modulatory influences on behaviors are still la...

  • Article
  • Open Access
3 Citations
1,933 Views
11 Pages

1 June 2024

Objective evaluations of transverse tarsometatarsal (TMT) hypermobility/instability are lacking. This study aims to radiographically explore the relationship between transverse TMT instability and metatarsus adductus (MA) in hallux valgus (HV). This...

  • Article
  • Open Access
16 Citations
1,499 Views
20 Pages

20 November 2024

To investigate the feasibility of composite modification techniques in improving the performance of recycled asphalt mixtures, in this study, the high-viscosity agent (HVA) and crumb-rubber materials (CRM) were used to modify asphalt with a styrene-b...

  • Article
  • Open Access
20 Citations
5,735 Views
14 Pages

Adsorption Properties of Hydrocarbons (n-Decane, Methyl Cyclohexane and Toluene) on Clay Minerals: An Experimental Study

  • Jie Zhang,
  • Shuangfang Lu,
  • Junqian Li,
  • Pengfei Zhang,
  • Haitao Xue,
  • Xu Zhao and
  • Liujuan Xie

12 October 2017

Adsorption of hydrocarbons may significantly affect hydrocarbon migration in unconventional reservoirs. Clay minerals form the primary adsorbent surfaces for hydrocarbons adsorbed in mudstone/shale. To study the adsorption properties of hydrocarbons...

  • Article
  • Open Access
11 Citations
3,423 Views
12 Pages

Fibrin Network Formation and Lysis in Septic Shock Patients

  • Julie Brogaard Larsen,
  • Mathies Appel Aggerbeck,
  • Kim Michael Larsen,
  • Christine Lodberg Hvas and
  • Anne-Mette Hvas

2 September 2021

Background: Septic shock patients are prone to altered fibrinolysis, which contributes to microthrombus formation, organ failure and mortality. However, characterisation of the individual patient’s fibrinolytic capacity remains a challenge due to a l...

  • Protocol
  • Open Access
29 Citations
9,368 Views
12 Pages

Fibrin Clot Formation and Lysis in Plasma

  • Julie Brogaard Larsen and
  • Anne-Mette Hvas

25 September 2020

Disturbance in the balance between fibrin formation and fibrinolysis can lead to either bleeding or thrombosis; however, our current routine coagulation assays are not sensitive to altered fibrinolysis. The clot formation and lysis assay is a dynamic...

  • Review
  • Open Access
45 Citations
10,147 Views
19 Pages

16 September 2023

The fibrinolytic system is a key player in keeping the haemostatic balance, and changes in fibrinolytic capacity can lead to both bleeding-related and thrombosis-related disorders. Our knowledge of the fibrinolytic system has expanded immensely durin...

  • Protocol
  • Open Access
7 Citations
4,239 Views
16 Pages

Advanced Flow Cytometry Using the SYTO-13 Dye for the Assessment of Platelet Reactivity and Maturity in Whole Blood

  • Oliver Buchhave Pedersen,
  • Leonardo Pasalic,
  • Erik Lerkevang Grove,
  • Steen Dalby Kristensen,
  • Anne-Mette Hvas and
  • Peter H. Nissen

Newly produced immature platelets are larger, contain higher amounts of residual RNA, and are more reactive than mature platelets. Flow cytometry using the SYTO-13 dye is a method for the subdivision of immature platelets from mature platelets based...

  • Article
  • Open Access
20 Citations
3,895 Views
13 Pages

Long-Term Outcomes in Patients with Intestinal Failure Due to Short Bowel Syndrome and Intestinal Fistula

  • Maja Kopczynska,
  • Gordon Carlson,
  • Antje Teubner,
  • Arun Abraham,
  • Michael Taylor,
  • Sorrel T. Burden,
  • Christian L. Hvas,
  • Peter Jepsen and
  • Simon Lal

30 March 2022

Short bowel syndrome (SBS) and enterocutaneous or enteroatmospheric fistulas are common indications for home parenteral nutrition (HPN). However, there are few data describing factors influencing surgical decision-making or outcomes particularly foll...

  • Article
  • Open Access
7 Citations
3,681 Views
18 Pages

Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis

  • Mette G. Christensen,
  • Nanna Johnsen,
  • Marianne Skals,
  • Aimi D. M. Hamilton,
  • Peter Rubak,
  • Anne-Mette Hvas and
  • Helle Praetorius

Urosepsis is a potentially life-threatening, systemic reaction to uropathogenic bacteria entering the bloodstream of the host. One of the hallmarks of sepsis is early thrombocyte activation with a following fall in circulating thrombocytes as a resul...

  • Review
  • Open Access
7 Citations
3,200 Views
17 Pages

Cell Membrane Capacitance (Cm) Measured by Bioimpedance Spectroscopy (BIS): A Narrative Review of Its Clinical Relevance and Biomarker Potential

  • Steven Brantlov,
  • Leigh C. Ward,
  • Søren Isidor,
  • Christian Lodberg Hvas,
  • Charlotte Lock Rud and
  • Lars Jødal

12 July 2025

Cell membrane capacitance (Cm) is a potential biomarker that reflects the structural and functional integrity of cell membranes. It is essential for physiological processes such as signal transduction, ion transport, and cellular homeostasis. In clin...

  • Article
  • Open Access
6 Citations
3,436 Views
14 Pages

The Pharmaceutical Formulation Plays a Pivotal Role in Hydroxytyrosol Pharmacokinetics

  • Laura Di Renzo,
  • Antonella Smeriglio,
  • Mariarosaria Ingegneri,
  • Paola Gualtieri and
  • Domenico Trombetta

Current evidence supports the use of extra virgin olive oil (EVOO) and its minor components such as hydroxytyrosol or 3,4-dihydroxyphenyl ethanol (DOPET), to improve cardiovascular and metabolic health. Nevertheless, more intervention studies in huma...

  • Article
  • Open Access
15 Citations
4,207 Views
15 Pages

Microstructural and Corrosion Behavior of High Velocity Arc Sprayed FeCrAl/Al Composite Coating on Q235 Steel Substrate

  • Ndumia Joseph Ndiithi,
  • Min Kang,
  • Jiping Zhu,
  • Jinran Lin,
  • Samuel Mbugua Nyambura,
  • Yuntong Liu and
  • Fang Huang

24 August 2019

High velocity arc spraying was used to prepare FeCrAl/Al composite coating on Q235 steel substrate by simultaneously spraying FeCrAl wire as the anode and Al wire as the cathode. The composite coating was sprayed with varying voltage and current to o...

  • Article
  • Open Access
4 Citations
12,318 Views
9 Pages

Background: Hallux valgus (HV) is one of the most common forefoot deformities among females, and its prevalence increases with age. This study aims to evaluate the effectiveness of three different types of orthotics on the reduction in hallux valgus...

  • Article
  • Open Access
6 Citations
2,374 Views
16 Pages

Characteristics of Gaseous/Liquid Hydrocarbon Adsorption Based on Numerical Simulation and Experimental Testing

  • Shansi Tian,
  • Zhentao Dong,
  • Bo Liu,
  • Haitao Xue,
  • Valentina Erastova,
  • Min Wang and
  • Haiyang Yan

19 July 2022

Hydrocarbon vapor adsorption experiments (HVAs) are one of the most prevalent methods used to evaluate the proportion of adsorbed state oil, critical in understanding the recoverable resources of shale oil. HVAs have some limitations, which cannot be...

  • Article
  • Open Access
18 Citations
2,588 Views
9 Pages

Fatal Hymenoptera Venom–Triggered Anaphylaxis in Patients with Unrecognized Clonal Mast Cell Disorder—Is Mastocytosis to Blame?

  • Matija Rijavec,
  • Jezerka Inkret,
  • Urška Bidovec-Stojković,
  • Tanja Carli,
  • Nina Frelih,
  • Andreja Kukec,
  • Peter Korošec and
  • Mitja Košnik

15 November 2023

Hymenoptera venom–triggered anaphylaxis (HVA) affects up to 8.9% of the general population and is the most frequent cause of anaphylaxis in adults, accounting for approximately 20% of all fatal anaphylaxis cases. Quite often, a fatal reaction i...

  • Article
  • Open Access
2 Citations
1,651 Views
13 Pages

Effect of Dietary Patterns on Vascular Aging Using the Brachial–Ankle Index

  • Inés Llamas-Ramos,
  • Rocío Llamas-Ramos,
  • María Cortés-Rodríguez,
  • Emiliano Rodríguez-Sánchez,
  • Luis García-Ortiz,
  • Manuel A. Gómez-Marcos,
  • Marta Gómez-Sánchez and
  • Leticia Gómez-Sánchez

6 December 2024

The Mediterranean diet (MD) plays an important role in delaying vascular aging. The main objective of this study was to analyze the association between adherence to the MD and vascular aging estimated with brachial–ankle pulse wave velocity (ba...

  • Article
  • Open Access
8 Citations
3,087 Views
19 Pages

Preparation and Properties of High-Viscosity Modified Asphalt with a Novel Thermoplastic Rubber

  • Teng Wang,
  • Zhirong Chen,
  • Jinlong Hong,
  • Zhen Liao,
  • Di Wang,
  • Dongdong Yuan,
  • Yufei Zhang and
  • Augusto Cannone Falchetto

9 August 2023

With the increasing demand for improved road performance and sustainable development, modified asphalt is increasingly being used in pavement construction. This study investigates the preparation and properties of a novel high-viscosity modified asph...

  • Article
  • Open Access
3 Citations
3,294 Views
20 Pages

This research presents an approach to the hybrid energy harvesting paradigm (HEHP) based on suspended energy harvest. It uses a harvesting vibration absorber (HVA) with an SC/NMC-lithium battery hybrid energy storage paradigm (SCB-HESP) equipped rege...

  • Article
  • Open Access
2,126 Views
12 Pages

1 October 2025

Hyperechoic vertical artifacts are an essential feature of lung ultrasound (LUS) arising from various pathological states. Those that meet the criteria for B-lines have the most significant diagnostic value and should be differentiated from other hyp...

  • Article
  • Open Access
2 Citations
2,781 Views
20 Pages

The Relationship between Healthy Vascular Aging with the Mediterranean Diet and Other Lifestyles in the Spanish Population: The EVA Study

  • Leticia Gómez-Sánchez,
  • David González-Falcon,
  • Rocío Llamas-Ramos,
  • María Cortés Rodríguez,
  • Emiliano Rodríguez-Sánchez,
  • Luis García-Ortiz,
  • Inés Llamas-Ramos,
  • Marta Gómez-Sánchez and
  • Manuel A. Gómez-Marcos

5 August 2024

The aim of this study was to analyze the relationship between healthy vascular aging (HVA) and the Mediterranean diet alongside other lifestyles in a Spanish population aged 35 to 75 years without previous cardiovascular diseases. Methods: In this cr...

  • Article
  • Open Access
11 Citations
3,211 Views
13 Pages

4 April 2023

Vanillylmandelic acid (VMA) and homovanillic acid (HVA) are diagnostic markers of neuroblastoma. The purpose of this study was to understand the reason for the discrimination of structural analogues (VMA and HVA) onto a graphite electrode coated with...

  • Article
  • Open Access
20 Citations
5,115 Views
10 Pages

Homovanillic acid (HVA) and vanillylmandelic acid (VMA) are end-stage metabolites of catecholamine and are clinical biomarkers for the diagnosis of neuroblastoma. For the first time in Korea, we implemented and validated a liquid chromatography tande...

  • Article
  • Open Access
8 Citations
1,980 Views
19 Pages

Thermal Aging Degradation of High-Viscosity Asphalt Based on Rheological Methods

  • Siyue Zhu,
  • Xiantao Qin,
  • Menghui Liao,
  • Yuxi Ma,
  • Hao Xu,
  • Jingyi Chen and
  • Haobo Gao

17 September 2023

With the acceleration of the construction of sponge cities in China, porous asphalt pavement (PA) is has been widely used. High-viscosity asphalt (HVA) is the core material in building PA because it has good rheology properties, which can provide goo...

  • Article
  • Open Access
14 Citations
5,944 Views
19 Pages

Autism Spectrum Disorders (ASD) are characterized by numerous comorbidities, including various metabolic and nutritional abnormalities. In many children with ASD, problems with proper nutrition can often lead to inadequate nutrient intake and some di...

  • Feature Paper
  • Article
  • Open Access
7 Citations
2,941 Views
20 Pages

8 September 2021

Identifying the provenance of volcanic rocks can be essential for improving geological maps in the field of geology and providing a tool for the geochemical fingerprinting of ancient artifacts like millstones and anchors in the field of geoarchaeolog...

  • Article
  • Open Access
5 Citations
4,095 Views
11 Pages

Background: Hallux valgus (HV) is one of the most common forefoot deformities, and its prevalence increases with age. HV has been associated with poor foot function, difficulty in fitting footwear and poor health-related quality of life. The aims of...

  • Review
  • Open Access
41 Citations
7,215 Views
12 Pages

Prevalence and Predisposing Factors for Recurrence after Hallux Valgus Surgery: A Systematic Review and Meta-Analysis

  • Yasmin Ezzatvar,
  • Laura López-Bueno,
  • Laura Fuentes-Aparicio and
  • Lirios Dueñas

9 December 2021

Recurrence is a frequent and undesirable outcome after hallux valgus (HV) surgery. However, the prevalence of HV recurrence and the pre- and postoperatory factors associated with it have not been adequately studied. This study aimed to quantify the p...

  • Article
  • Open Access
19 Citations
4,597 Views
14 Pages

Heat Stress Modulates Brain Monoamines and Their Metabolites Production in Broiler Chickens Co-Infected with Clostridium perfringens Type A and Eimeria spp.

  • Atilio Sersun Calefi,
  • Juliana Garcia da Silva Fonseca,
  • Catarina Augusta de Queiroz Nunes,
  • Ana Paula Nascimento Lima,
  • Wanderley Moreno Quinteiro-Filho,
  • Jorge Camilo Flório,
  • Adriano Zager,
  • Antonio José Piantino Ferreira and
  • João Palermo-Neto

9 January 2019

Heat stress has been related to the impairment of behavioral and immunological parameters in broiler chickens. However, the literature is not clear on the involvement of neuroimmune interactions in a heat stress situation associated with bacterial an...

  • Article
  • Open Access
6 Citations
2,482 Views
15 Pages

Electrochemical Study and Determination of Homovanillic Acid, the Final Metabolite of Dopamine, Using an Unmodified Disposable Electrode

  • Mihaela Buleandră,
  • Lavinia Georgiana Voica,
  • Dana Elena Popa,
  • Irinel Adriana Badea,
  • Emilia Elena Iorgulescu and
  • Mihaela Carmen Cheregi

17 January 2025

This paper summarizes the main findings of a study which aimed to examine the electrochemical oxidation of homovanillic acid (HVA), the final metabolite of dopamine. A pencil graphite electrode (PGE) was used as working electrode and the measurements...

  • Review
  • Open Access
1 Citations
4,984 Views
29 Pages

Biomarkers for the Molecular Diagnosis of IgE-Mediated Hymenoptera Venom Allergy in Clinical Practice

  • Florin-Dan Popescu,
  • Mariana Preda,
  • Darío Antolín-Amérigo,
  • Natalia Rodríguez-Otero,
  • Elena Ramírez-Mateo and
  • Sylwia Smolinska

31 December 2024

Hymenoptera venom allergy (HVA) is a potentially life-threatening condition, making accurate diagnosis crucial for identifying significant IgE sensitizations and enabling effective venom immunotherapy. In this review, we provide a detailed overview o...

  • Article
  • Open Access
1 Citations
2,732 Views
8 Pages

19 November 2022

Background and Objectives: Many treatment modalities are available for juvenile hallux valgus. However, all of them have some disadvantages. Therefore, we developed a transosseous suturing procedure. Materials and Methods: Six patients (seven feet) w...

  • Feature Paper
  • Review
  • Open Access
41 Citations
7,684 Views
13 Pages

Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (CaV) Channels

  • David Ramírez,
  • Wendy Gonzalez,
  • Rafael A. Fissore and
  • Ingrid Carvacho

13 October 2017

Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental to understand their role in...

  • Article
  • Open Access
6 Citations
3,048 Views
16 Pages

The voltage-gated calcium channel (VGCC) β subunit (Cavβ) protein is a kind of cytosolic auxiliary subunit that plays an important role in regulating the surface expression and gating characteristics of high-voltage-activated (HVA) calcium...

  • Article
  • Open Access
2,214 Views
12 Pages

Natural History and Risk Factors of Hymenoptera Venom Allergy in Dogs

  • Edwin Chapman,
  • Erin Ashley West,
  • Mitja Kosnik,
  • Nina Maria Fischer,
  • Claude Favrot,
  • Leo Beeler and
  • Ana Rostaher

10 November 2024

Hymenoptera, which includes honeybees, wasps, bumblebees, and hornets, is an order of the class Insecta, whose venom can induce anaphylactic reactions in dogs. While several studies have investigated the natural histories and risk factors of Hymenopt...

  • Article
  • Open Access
1 Citations
971 Views
21 Pages

20 May 2025

In this study, the structure of the synthesized Zn(II) complex with homovanillic acid (HVA) was investigated using the FT-IR, UV/Vis, and NMR spectroscopic methods, as well as elemental and thermal (TG, DTG, and DSC) analysis. The stoichiometric mola...

  • Article
  • Open Access
4 Citations
3,771 Views
13 Pages

Assessment of Urinary Dopamine and Serotonin Metabolites in Relation to Dysbiosis Indicators in Patients with Functional Constipation

  • Jan Chojnacki,
  • Tomasz Popławski,
  • Aleksandra Kaczka,
  • Natalia Romanowska,
  • Cezary Chojnacki and
  • Anita Gąsiorowska

4 September 2024

Background: The causes of functional constipation (FC) in adults are unclear, but changes in the gut microbiome may play an important role. The present study aimed to assess the relationship between urinary metabolites of dopamine and serotonin and s...

  • Article
  • Open Access
6 Citations
4,140 Views
14 Pages

Relationship of Different Anthropometric Indices with Vascular Ageing in an Adult Population without Cardiovascular Disease—EVA Study

  • Leticia Gómez-Sánchez,
  • Marta Gómez-Sánchez,
  • Emiliano Rodríguez-Sánchez,
  • Carmen Patino-Alonso,
  • Rosario Alonso-Dominguez,
  • Natalia Sanchez-Aguadero,
  • Cristina Lugones-Sánchez,
  • Ines Llamas-Ramos,
  • Luis García-Ortiz and
  • on behalf of the EVA Investigators
  • + 1 author

The objectives of this study were to analyse the capacity of different anthropometric indices to predict vascular ageing and this association in Spanish adult population without cardiovascular disease. A total of 501 individuals without cardiovascula...

  • Article
  • Open Access
42 Citations
3,983 Views
19 Pages

Mercury Chloride Affects Band 3 Protein-Mediated Anionic Transport in Red Blood Cells: Role of Oxidative Stress and Protective Effect of Olive Oil Polyphenols

  • Pasquale Perrone,
  • Sara Spinelli,
  • Gianluca Mantegna,
  • Rosaria Notariale,
  • Elisabetta Straface,
  • Daniele Caruso,
  • Giuseppe Falliti,
  • Angela Marino,
  • Caterina Manna and
  • Rossana Morabito
  • + 1 author

27 January 2023

Mercury is a toxic heavy metal widely dispersed in the natural environment. Mercury exposure induces an increase in oxidative stress in red blood cells (RBCs) through the production of reactive species and alteration of the endogenous antioxidant def...

  • Article
  • Open Access
22 Citations
5,891 Views
18 Pages

Depressive Symptoms After PCB Exposure: Hypotheses for Underlying Pathomechanisms via the Thyroid and Dopamine System

  • Petra Maria Gaum,
  • Monika Gube,
  • André Esser,
  • Thomas Schettgen,
  • Natalia Quinete,
  • Jens Bertram,
  • Franziska Maria Putschögl,
  • Thomas Kraus and
  • Jessica Lang

Polychlorinated biphenyls’ (PCB) exposure has been reported to be associated with depressive symptoms, which is correlated to lower dopamine- (DA) and thyroxine-concentrations (T4). T4 is necessary for DA-synthesis and it binds to transthyretin...

  • Article
  • Open Access
1 Citations
2,118 Views
17 Pages

Combined Immune Checkpoint Blockade and Helixor® Therapy in Oncology: Real-World Tolerability and Subgroup Survival (ESMO GROW)

  • Anja Thronicke,
  • Patricia Grabowski,
  • Juliane Roos,
  • Hannah Wüstefeld,
  • Christian Grah,
  • Sophia Johnson and
  • Friedemann Schad

Real-world data (RWD) play a crucial role in identifying key subgroups and assessing multimodal oncology therapies, including integrative and palliative care. Immune checkpoint blockade (ICB) has improved survival, and its combination with complement...

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