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328 Results Found

  • Article
  • Open Access
33 Citations
9,415 Views
22 Pages

Reassessing Hydrological Processes That Control Stable Isotope Tracers in Groundwater of the Atacama Desert (Northern Chile)

  • Konstantin W. Scheihing,
  • Claudio E. Moya,
  • Ulrich Struck,
  • Elisabeth Lictevout and
  • Uwe Tröger

26 December 2017

A collection of 514 stable isotope water samples from the Atacama Desert is being reassessed geostatistically. The evaluation reveals that adjacent Andean catchments can exhibit distinct δ18O and δ2H value ranges in meteoric waters, despite similar s...

  • Article
  • Open Access
8 Citations
2,976 Views
14 Pages

8 February 2022

Stable isotopes of lake waters are widely used to identify the relative importance of hydrological processes on the lake water balance across the ungauged landscape via the coupled-isotope tracer model. The isotopic compositions of twenty shallow fre...

  • Article
  • Open Access
1 Citations
1,460 Views
13 Pages

17 November 2023

In order to achieve the rational development and utilization of underground water resources in the Dongsheng mining area under coal mining conditions, we selected the upstream area of Beiniuchuan River as a typical region. Through field investigation...

  • Article
  • Open Access
4 Citations
3,983 Views
16 Pages

Source Water Apportionment of a River Network: Comparing Field Isotopes to Hydrodynamically Modeled Tracers

  • Lily A. Tomkovic,
  • Edward S. Gross,
  • Bobby Nakamoto,
  • Marilyn L. Fogel and
  • Carson Jeffres

15 April 2020

Tributary source water provenance is a primary control on water quality and ecological characteristics in branching tidal river systems. Source water provenance can be estimated both from field observations of chemical characteristics of water and fr...

  • Case Report
  • Open Access
12 Citations
4,392 Views
14 Pages

Application of Stable Isotope Tracer to Study Runoff Generation during Different Types of Rainfall Events

  • Jianfeng Gou,
  • Simin Qu,
  • Peng Shi,
  • Dachen Li,
  • Xueqiu Chen,
  • Yifan Wang,
  • Shuai Shan and
  • Wei Si

24 April 2018

The main purpose of this study is to explore the runoff generation mechanism and isotopic variation of precipitation during typhoon and plum rain events in the mountainous region mainly covered with bamboo in southeastern China. The isotopic value of...

  • Article
  • Open Access
19 Citations
3,859 Views
18 Pages

1 February 2020

Glaciers are shrinking due to global warming, resulting in a diminishing contribution of ice and snowmelt to headwaters and subsequent consequences to freshwater ecosystems. Within this context, we tested whether water-stable isotopes are spatio-temp...

  • Article
  • Open Access
10 Citations
7,217 Views
16 Pages

24 January 2017

This study examines the feasibility of tracing and quantifying the progress of different water sources along the water–effluent–SAT (Soil Aquifer Treatment) chain using 2H and 18O isotopes. The research was conducted at the Dan Region Reclamation Pla...

  • Article
  • Open Access
5 Citations
4,803 Views
24 Pages

Chemical and Isotopic Tracers for Characterization of the Groundwater in the Heterogeneous System: Case from Chichaoua-Imin’tanout (Morocco)

  • Rim Tijani,
  • Abdennebi El Mandour,
  • Driss Chafouq,
  • Malak Elmeknassi,
  • Fatima Ezzahra El Ghazali and
  • Lhoussaine Bouchaou

21 December 2021

The geological and hydrogeological approach of the structure of the basin OuladBouSbaâ led to the definition of the geometry of the main aquifers. In general, the profiles show the complexity of the geological configuration. The filling of the...

  • Article
  • Open Access
9 Citations
3,052 Views
20 Pages

22 September 2021

To elucidate the chemical linkages between lignin and carbohydrates in ginkgo cell walls, 13C-2H-enriched cell wall-dehydrogenation polymers (CW-DHP) were selectively prepared with cambial tissue from Ginkgo biloba L. by feeding D-glucose-[6-2H2], co...

  • Article
  • Open Access
9 Citations
3,058 Views
24 Pages

24 November 2020

Understanding the connectivity between surface water and groundwater is key to sound geo-hazard prevention and mitigation in a waterscape such as the Jiuzhaigou Natural World Heritage Site in the southeast Tibetan Plateau, China. In this study, we us...

  • Article
  • Open Access
2 Citations
2,290 Views
16 Pages

Strontium Isotopic Composition as Tracers for Identifying Groundwater Recharge Sources in the Choushui River Alluvial Plain, Western Taiwan

  • Hao-Wei Huang,
  • Shiuh-Tsuen Huang,
  • Ruo-Mei Wang,
  • Wen-Fu Chen,
  • Chuan-Hsiung Chung and
  • Chen-Feng You

30 July 2024

Groundwater is a vital resource in the Chuoshui River alluvial plain (CSAP), a key agricultural area in Taiwan. Understanding groundwater recharge is crucial for sustainable water management amidst changing climatic conditions and increasing water de...

  • Article
  • Open Access
38 Citations
6,131 Views
16 Pages

24 February 2018

Nitrate is one of the most common pollutants in river systems. This study takes the lower reach of Fenhe River as a case study, combined with a multi-isotope and hydrochemical as the tracers to identify nitrate sources in river system. The results sh...

  • Article
  • Open Access
14 Citations
3,165 Views
14 Pages

Three Bayesian Tracer Models: Which Is Better for Determining Sources of Root Water Uptake Based on Stable Isotopes under Various Soil Water Conditions?

  • Junming Liu,
  • Zhuanyun Si,
  • Shuang Li,
  • Sunusi Amin Abubakar,
  • Yingying Zhang,
  • Lifeng Wu,
  • Yang Gao and
  • Aiwang Duan

14 March 2023

Stable hydrogen and oxygen isotopes provide a powerful technique for quantifying the proportion of root water uptake (RWU) from different potential water sources. Although many models coupled with stable isotopes have been developed to estimate plant...

  • Article
  • Open Access
17 Citations
3,728 Views
24 Pages

Karst Recharge Areas Identified by Combined Application of Isotopes and Hydrogeological Budget

  • Silvia Iacurto,
  • Gerardo Grelle,
  • Francesco Maria De Filippi and
  • Giuseppe Sappa

17 July 2021

The identification of recharge areas in karst aquifers allows us to perform sustainable management of these groundwater resources. Stable isotopes (δ18O and δ2H) have been largely used to provide information about recharge elevation in many mountaino...

  • Review
  • Open Access
1,507 Views
20 Pages

1 August 2025

Karst groundwater systems are critical to water supply and ecological sustainability in northern China, yet their heterogeneity poses challenges for flow characterization. The Yuquan Mountain (YM) Spring, historically a major karst spring in western...

  • Article
  • Open Access
8 Citations
3,909 Views
18 Pages

Stable Isotopic Tracer Phospholipidomics Reveals Contributions of Key Phospholipid Biosynthetic Pathways to Low Hepatocyte Phosphatidylcholine to Phosphatidylethanolamine Ratio Induced by Free Fatty Acids

  • Kang-Yu Peng,
  • Christopher K Barlow,
  • Helene Kammoun,
  • Natalie A Mellett,
  • Jacquelyn M Weir,
  • Andrew J Murphy,
  • Mark A Febbraio and
  • Peter J Meikle

22 March 2021

There is a strong association between hepatocyte phospholipid homeostasis and non-alcoholic fatty liver disease (NAFLD). The phosphatidylcholine to phosphatidylethanolamine ratio (PC/PE) often draws special attention as genetic and dietary disruption...

  • Review
  • Open Access
15 Citations
9,194 Views
15 Pages

13 April 2018

Raman spectroscopy is a powerful tool used to identify mineral phases, study aqueous solutions and gas inclusions as well as providing crystallinity, crystallographic orientation and chemistry of mineral phases. When united with isotopic tracers, the...

  • Article
  • Open Access
4 Citations
3,309 Views
26 Pages

29 December 2023

The pentose phosphate pathway (PPP) plays a key role in the cellular regulation of immune function; however, little is known about the interplay of metabolic adjustments in granulocytes, especially regarding the non-oxidative PPP. For the determinati...

  • Article
  • Open Access
2 Citations
1,516 Views
14 Pages

4 March 2024

Groundwater is one of the key sources of water recharge in Hulun Lake. In order to trace the location of the confined aquifer of the deep groundwater that recharges the lake, hydrogeochemical characteristic analysis and hydrogen and oxygen stable iso...

  • Article
  • Open Access
7 Citations
9,834 Views
15 Pages

12 January 2023

To optimize a suitable fertilization method needed for high nitrogen utilization and growth of mung bean in the black soil of Northeast China, a field experiment was carried out with 10 treatments based on isotope-tracing technology. The nitrogen fer...

  • Article
  • Open Access
2 Citations
1,478 Views
17 Pages

14 August 2024

Graviera Naxos, a renowned cheese with Protected Designation of Origin status, is crafted from a blend of cow, goat, and sheep milk. This study focused on assessing the Sr isotopic and multi-elemental composition of both the processed cheese and its...

  • Article
  • Open Access
6 Citations
2,910 Views
17 Pages

4 June 2021

Biochar is considered to have potential use in carbon (C) sequestration and has been widely used in soil amendment. Humic substances (HSs), assigned as the stable organic C, have obvious agronomic benefits. However, the response mechanisms of these c...

  • Article
  • Open Access
10 Citations
3,402 Views
13 Pages

Comparing Salivary Caffeine Kinetics of 13C and 12C Caffeine for Gastric Emptying of 50 mL Water

  • Michael Grimm,
  • Adrian Rump,
  • Lisa Meilicke,
  • Maximilian Feldmüller,
  • Rebecca Keßler,
  • Eberhard Scheuch,
  • Mladen Vassilev Tzvetkov and
  • Werner Weitschies

Gastric water emptying as a critical parameter for oral drug absorption can be investigated by several imaging techniques or by the interpretation of pharmacokinetics of appropriate substances. Recently introduced salivary caffeine kinetics is a valu...

  • Article
  • Open Access
15 Citations
4,692 Views
22 Pages

Hydrogeochemical and Stable Isotope Data of the Groundwater of a Multi-Aquifer System in the Maknessy Basin (Mediterranean Area, Central Tunisia)

  • Zouhour Moussaoui,
  • Matteo Gentilucci,
  • Khyria Wederni,
  • Naima Hidouri,
  • Monji Hamedi,
  • Zahra Dhaoui and
  • Younes Hamed

22 January 2023

The Maknessy plain in central Tunisia is one of the most important agricultural basins in Tunisia. Given the semi-arid climate conditions, the irrigation of cultivated crops relies principally on the abstraction from groundwater resources. The assess...

  • Article
  • Open Access
24 Citations
6,259 Views
13 Pages

Consumption of a Specially-Formulated Mixture of Essential Amino Acids Promotes Gain in Whole-Body Protein to a Greater Extent than a Complete Meal Replacement in Older Women with Heart Failure

  • Il-Young Kim,
  • Sanghee Park,
  • Ellen T. H. C. Smeets,
  • Scott Schutzler,
  • Gohar Azhar,
  • Jeanne Y. Wei,
  • Arny A. Ferrando and
  • Robert R. Wolfe

17 June 2019

Heart failure in older individuals is normally associated with a high body mass index and relatively low lean body mass due to, in part, a resistance to the normal anabolic effect of dietary protein. In this study we have investigated the hypothesis...

  • Article
  • Open Access
16 Citations
5,565 Views
18 Pages

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

  • Lu-Min Shih,
  • Hsiang-Yu Tang,
  • Ke-Shiuan Lynn,
  • Cheng-Yu Huang,
  • Hung-Yao Ho and
  • Mei-Ling Cheng

2 November 2018

Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer. The role of different types of fatty...

  • Article
  • Open Access
21 Citations
11,546 Views
39 Pages

29 June 2012

The epigenetic Zn-Pb deposits in the Lycksele-Storuman ore district, northern Sweden, are hosted by Paleoproterozoic basement near the margin of the Caledonian mountains. A paleogeographic reconstruction suggests that platform sediments, including Ca...

  • Article
  • Open Access
2 Citations
4,546 Views
18 Pages

Rainstorm Magnitude Likely Regulates Event Water Fraction and Its Transit Time in Mesoscale Mountainous Catchments: Implication for Modelling Parameterization

  • Jun-Yi Lee,
  • Yu-Ting Shih,
  • Chiao-Ying Lan,
  • Tsung-Yu Lee,
  • Tsung-Ren Peng,
  • Cheing-Tung Lee and
  • Jr-Chuan Huang

19 April 2020

Event water transit time estimation has rarely been done for violent rainstorms (e.g., typhoons) in steep and fractured mountainous catchments where the range of transit time, potential controlling factors, and the validity of time-invariant parametr...

  • Article
  • Open Access
6 Citations
1,958 Views
26 Pages

From Contamination to Conservation: A Hydrochemical and Isotopic Evaluation of Groundwater Quality in the Semi-Arid Guire Basin (Morocco)

  • Hanane Marzouki,
  • Nouayti Nordine,
  • El Mustapha Azzirgue,
  • Joaquim C. G. Esteves da Silva and
  • El Khalil Cherif

3 June 2025

Groundwater is a critical resource in semi-arid regions like Morocco’s Guire Basin, yet pollution and overexploitation threaten its sustainability. This study evaluates the groundwater quality of the Guire aquifer (Eastern High Atlas) using an...

  • Article
  • Open Access
2 Citations
1,345 Views
15 Pages

Evaluating Modeling Approaches for Phytoplankton Productivity in Estuaries

  • Reed Hoshovsky,
  • Frances Wilkerson,
  • Alexander Parker and
  • Richard Dugdale

4 March 2025

Phytoplankton comprise the base of the food web in estuaries and their biomass and rates of growth (productivity) exert a bottom-up control in pelagic ecosystems. Reliable means to quantify biomass and productivity are crucial for managing estuarine...

  • Article
  • Open Access
3 Citations
878 Views
16 Pages

Accumulation and Subcellular Distribution Patterns of Carbamazepine in Hydroponic Vegetables

  • Sihan Yao,
  • Yan Chen,
  • Nan Zheng,
  • Ting Chen,
  • Sufen Zhang,
  • Zhiyang Yu and
  • Haiyan Wang

26 March 2025

Pharmaceutical and Personal Care Products (PPCPs), such as carbamazepine, enter the food chain through wastewater irrigation, posing risks to ecosystems and human health. However, research on the translocation and subcellular distribution of carbamaz...

  • Article
  • Open Access
26 Citations
6,290 Views
21 Pages

Quantification of Groundwater Discharge in a Subalpine Stream Using Radon-222

  • Elizabeth Avery,
  • Richard Bibby,
  • Ate Visser,
  • Bradley Esser and
  • Jean Moran

25 January 2018

During the dry months of the water year in Mediterranean climates, groundwater influx is essential to perennial streams for sustaining ecosystem health and regulating water temperature. Predicted earlier peak flow due to climate change may result in...

  • Article
  • Open Access
20 Citations
7,933 Views
21 Pages

The Dahab watershed comprises three aquifers; the alluvial Quaternary, the Early Cambrian sandstone, and the fractured Pre-Cambrian basement aquifers. The Dahab watershed is located in the southeastern part of the arid Sinai Peninsula, where low prec...

  • Article
  • Open Access
26 Citations
5,309 Views
15 Pages

15 September 2018

Water resources management is one of the most important challenges worldwide because water represents a vital resource for sustaining life and the environment. With the aim of sustainable groundwater management, the identification of aquifer recharge...

  • Article
  • Open Access
24 Citations
5,500 Views
21 Pages

On Oxidation Resistance Mechanisms at 1273 K of Tungsten-Based Alloys Containing Chromium and Yttria

  • Felix Klein,
  • Tobias Wegener,
  • Andrey Litnovsky,
  • Marcin Rasinski,
  • Xiaoyue Tan,
  • Janina Schmitz,
  • Christian Linsmeier,
  • Jan Willem Coenen,
  • Hongchu Du and
  • Joachim Mayer
  • + 1 author

26 June 2018

Tungsten (W) is currently deemed the main candidate for the plasma-facing armor material of the first wall of future fusion reactors, such as DEMO. Advantages of W include a high melting point, high thermal conductivity, low tritium retention, and lo...

  • Article
  • Open Access
9 Citations
6,663 Views
17 Pages

3 February 2019

Groundwater studies in the South Fork Palouse River Basin have been unable to determine recharge sources, subsystem connectivity and flow patterns due to the discontinuity of pathways in the heterogeneous and anisotropic aquifers located in Columbia...

  • Article
  • Open Access
2 Citations
4,359 Views
9 Pages

Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep

  • Mukundan Ragavan,
  • Mengchen Li,
  • Anthony G. Giacalone,
  • Charles E. Wood,
  • Maureen Keller-Wood and
  • Matthew E. Merritt

5 January 2021

Ovine models of pregnancy have been used extensively to study maternal–fetal interactions and have provided considerable insight into nutrient transfer to the fetus. Ovine models have also been utilized to study congenital heart diseases. In th...

  • Article
  • Open Access
17 Citations
5,497 Views
13 Pages

The Effect of Fructose Feeding on Intestinal Triacylglycerol Production and De Novo Fatty Acid Synthesis in Humans

  • Simon Steenson,
  • Fariba Shojaee-Moradie,
  • Martin B. Whyte,
  • Kim G. Jackson,
  • Julie A. Lovegrove,
  • Barbara A. Fielding and
  • A. Margot Umpleby

15 June 2020

A high fructose intake exacerbates postprandial plasma triacylglycerol (TAG) concentration, an independent risk factor for cardiovascular disease, although it is unclear whether this is due to increased production or impaired clearance of triacylglyc...

  • Article
  • Open Access
16 Citations
8,217 Views
21 Pages

Tracing Metabolic Fate of Mitochondrial Glycine Cleavage System Derived Formate In Vitro and In Vivo

  • Yee-Ling Tan,
  • Nga-Lai Sou,
  • Feng-Yao Tang,
  • Hsin-An Ko,
  • Wei-Ting Yeh,
  • Jian-Hau Peng and
  • En-Pei Isabel Chiang

20 November 2020

Folate-mediated one-carbon (1C) metabolism is a major target of many therapies in human diseases. Studies have focused on the metabolism of serine 3-carbon as it serves as a major source for 1C units. The serine 3-carbon enters the mitochondria trans...

  • Article
  • Open Access
15 Citations
13,549 Views
11 Pages

The Anabolic Response to Dietary Protein Is Not Limited by the Maximal Stimulation of Protein Synthesis in Healthy Older Adults: A Randomized Crossover Trial

  • Sanghee Park,
  • Jiwoong Jang,
  • Myung Dong Choi,
  • Yun-A Shin,
  • Scott Schutzler,
  • Gohar Azhar,
  • Arny A. Ferrando,
  • Robert R. Wolfe and
  • Il-Young Kim

26 October 2020

We have recently demonstrated in young adults that an anabolic response with mixed meal protein intake above ~35 g/meal, previously recognized as an “optimal” protein dose, was further stimulated. However, it is unknown if this applies to...

  • Article
  • Open Access
2 Citations
2,148 Views
11 Pages

11 January 2023

In areas completely covered by vegetation, the rainwater that passes through the canopy layer and litter layer is the source supplying surface runoff and seeping into the soil layer. To reveal the influence mechanisms of the canopy and litter layer o...

  • Systematic Review
  • Open Access
3 Citations
2,201 Views
21 Pages

Current Insights into the Metabolome during Hypothermic Kidney Perfusion—A Scoping Review

  • Laurence Verstraeten,
  • Rutger Den abt,
  • Bart Ghesquière and
  • Ina Jochmans

23 May 2023

This scoping review summarizes what is known about kidney metabolism during hypothermic perfusion preservation. Papers studying kidney metabolism during hypothermic (<12 °C) perfusion were identified (PubMed, Embase, Web of Science, Cochrane)....

  • Article
  • Open Access
4 Citations
2,623 Views
13 Pages

Understanding Cassiopea andromeda (Scyphozoa) Invasiveness in Different Habitats: A Multiple Biomarker Comparison

  • Jorge Thé,
  • Marta Mammone,
  • Stefano Piraino,
  • Antonio Pennetta,
  • Giuseppe Egidio De Benedetto,
  • Tatiane Martins Garcia,
  • Marcelo de Oliveira Soares and
  • Sergio Rossi

17 July 2023

A dual nutrition mode (i.e., mixotrophy) can be advantageous for alien species in a new environment. In Cearà (Brazil), the symbiotic jellyfish Cassiopea andromeda is rapidly spreading under diverse environmental conditions across natural and...

  • Feature Paper
  • Article
  • Open Access
7 Citations
5,864 Views
10 Pages

Correcting for Naturally Occurring Mass Isotopologue Abundances in Stable-Isotope Tracing Experiments with PolyMID

  • Heesoo Jeong,
  • Yan Yu,
  • Henrik J. Johansson,
  • Frank C. Schroeder,
  • Janne Lehtiö and
  • Nathaniel M. Vacanti

Stable-isotope tracing is a method to measure intracellular metabolic pathway utilization by feeding a cellular system a stable-isotope-labeled tracer nutrient. The power of the method to resolve differential pathway utilization is derived from the e...

  • Article
  • Open Access
3 Citations
3,262 Views
15 Pages

Deuterium Tracer for Accurate Online Lube-Oil-Consumption Measurement: Stability, Compatibility and Tribological Characteristics

  • Martin Vareka,
  • Bernhard Rossegger,
  • Franz Novotny-Farkas,
  • Michael Engelmayer and
  • Andreas Wimmer

Because of the impact of lubrication on the efficiency and the lifecycle cost and emissions, the lubricating-oil consumption (LOC) is one of the key indicators in the research and development of internal combustion engines. State-of-the-art methods f...

  • Review
  • Open Access
34 Citations
7,337 Views
21 Pages

Metabolic Flux Analysis—Linking Isotope Labeling and Metabolic Fluxes

  • Yujue Wang,
  • Fredric E. Wondisford,
  • Chi Song,
  • Teng Zhang and
  • Xiaoyang Su

6 November 2020

Metabolic flux analysis (MFA) is an increasingly important tool to study metabolism quantitatively. Unlike the concentrations of metabolites, the fluxes, which are the rates at which intracellular metabolites interconvert, are not directly measurable...

  • Feature Paper
  • Review
  • Open Access
6 Citations
4,757 Views
21 Pages

Progress of the Analytical Methods and Application of Plutonium Isotopes in the Environment

  • Xidong Liu,
  • Yang Shao,
  • Min Luo,
  • Lingling Ma,
  • Gang Xu and
  • Minghong Wu

8 May 2023

Since the beginning of the use of nuclear energy in the twentieth century, atmospheric nuclear weapons testing, nuclear accidents, and spent fuel reprocessing have released large amounts of radioisotopes into the environment, especially plutonium iso...

  • Article
  • Open Access
21 Citations
5,629 Views
27 Pages

Regional Isotopic Signatures of Groundwater in Croatia

  • Željka Brkić,
  • Mladen Kuhta,
  • Tamara Hunjak and
  • Ozren Larva

13 July 2020

Tracer methods are useful for investigating groundwater travel times and recharge rates and analysing impacts on groundwater quality. The most frequently used tracers are stable isotopes and tritium. Stable isotopes of oxygen (δ18O) and hydrogen (δ2H...

  • Review
  • Open Access
15 Citations
4,797 Views
24 Pages

Advances in Geochemical Monitoring Technologies for CO2 Geological Storage

  • Jianhua Ma,
  • Yongzhang Zhou,
  • Yijun Zheng,
  • Luhao He,
  • Hanyu Wang,
  • Lujia Niu,
  • Xinhui Yu and
  • Wei Cao

7 August 2024

CO2 geological storage, as a large-scale, low-cost, carbon reduction technology, has garnered widespread attention due to its safety. Monitoring potential leaks is critical to ensuring the safety of the carbon storage system. Geochemical monitoring e...

  • Review
  • Open Access
17 Citations
4,379 Views
23 Pages

Meteoric 10Be, 137Cs and 239+240Pu as Tracers of Long- and Medium-Term Soil Erosion—A Review

  • Aleksandra Loba,
  • Jarosław Waroszewski,
  • Marcin Sykuła,
  • Cezary Kabala and
  • Markus Egli

15 March 2022

Isotopes of meteoric 10Be, 137Cs, 239+240Pu have been proposed as a soil redistribution tracer and applied worldwide as an alternative method to classical field-related techniques (e.g., sediment traps). Meteoric 10Be provides information about long-...

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