Announcements

"Exosomes in the Tumor Microenvironment: From Biology to Clinical Applications"
by Vitor Rodrigues da Costa, Rodrigo Pinheiro Araldi, Hugo Vigerelli, Fernanda D’Ámelio, Thais Biude Mendes, Vivian Gonzaga, Bruna Policíquio, Gabriel Avelar Colozza-Gama, Cristiane Wenceslau Valverde and Irina Kerkis
Cells 2021, 10(10), 2617; https://doi.org/10.3390/cells10102617
Available online: https://www.mdpi.com/2073-4409/10/10/2617

"Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner"
by Theresa Maria Holtmann, Maria Eugenia Inzaugarat, Jana Knorr, Lukas Geisler, Marten Schulz, Veerle Bieghs, Mick Frissen, Ariel E. Feldstein, Frank Tacke, Christian Trautwein et al.
Cells 2021, 10(10), 2618; https://doi.org/10.3390/cells10102618
Available online: https://www.mdpi.com/2073-4409/10/10/2618

"The Pro-Survival Oct4/Stat1/Mcl-1 Axis Is Associated with Poor Prognosis in Lung Adenocarcinoma Patients"
by Yu-Chu Su, Yi-Cheng Chen, Yau-Lin Tseng, Gia-Shing Shieh, Pensee Wu, Ai-Li Shiau and Chao-Liang Wu
Cells 2021, 10(10), 2642; https://doi.org/10.3390/cells10102642
Available online: https://www.mdpi.com/2073-4409/10/10/2642

"USP28: Oncogene or Tumor Suppressor? A Unifying Paradigm for Squamous Cell Carcinoma"
by Cristian Prieto-Garcia, Ines Tomašković, Varun Jayeshkumar Shah, Ivan Dikic and Markus Diefenbacher
Cells 2021, 10(10), 2652; https://doi.org/10.3390/cells10102652
Available online: https://www.mdpi.com/2073-4409/10/10/2652

"Anticipating EGFR Targeting in Early Stages of Lung Cancer: Leave No Stone Unturned"
by Lorenzo Belluomini, Silvia Teresa Riva, Michele Simbolo, Riccardo Nocini, Ilaria Trestini, Alice Avancini, Daniela Tregnago, Miriam Grazia Ferrara, Alberto Caldart, Alessandra Dodi et al.
Cells 2021, 10(10), 2685; https://doi.org/10.3390/cells10102685
Available online: https://www.mdpi.com/2073-4409/10/10/2685

"SEA and GATOR 10 Years Later"
by Yahir A. Loissell-Baltazar and Svetlana Dokudovskaya
Cells 2021, 10(10), 2689; https://doi.org/10.3390/cells10102689
Available online: https://www.mdpi.com/2073-4409/10/10/2689

"Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association"
by Deokhwan Kim, Hyunji Moon, Hyeokjin Cho, Chanhyuk Min, Byeongjin Moon, Susumin Yang, Juyeon Lee, Sang-Ah Lee, Hyunjin Park, Dae-Hee Lee et al.
Cells 2021, 10(10), 2702; https://doi.org/10.3390/cells10102702
Available online: https://www.mdpi.com/2073-4409/10/10/2702

"Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase"
by Yasuhiro Fuseya and Kazuhiro Iwai
Cells 2021, 10(10), 2706; https://doi.org/10.3390/cells10102706
Available online: https://www.mdpi.com/2073-4409/10/10/2706

"A Novel Pro-Inflammatory Mechanosensing Pathway Orchestrated by the Disintegrin Metalloproteinase ADAM15 in Synovial Fibroblasts"
by Tomasz Janczi, Florian Meier, Yuliya Fehrl, Raimund W. Kinne, Beate Böhm and Harald Burkhardt
Cells 2021, 10(10), 2705; https://doi.org/10.3390/cells10102705
Available online: https://www.mdpi.com/2073-4409/10/10/2705

"Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine"
by Evan R. Barry, Vladimir Simov, Iris Valtingojer and Olivier Venier
Cells 2021, 10(10), 2715; https://doi.org/10.3390/cells10102715
Available online: https://www.mdpi.com/2073-4409/10/10/2715

"Alteration of STIM1/Orai1-Mediated SOCE in Skeletal Muscle: Impact in Genetic Muscle Diseases and Beyond"
by Elena Conte, Paola Imbrici, Paola Mantuano, Maria Antonietta Coppola, Giulia Maria Camerino, Annamaria De Luca and Antonella Liantonio
Cells 2021, 10(10), 2722; https://doi.org/10.3390/cells10102722
Available online: https://www.mdpi.com/2073-4409/10/10/2722

"The Role of AhR in the Hallmarks of Brain Aging: Friend and Foe"
by Emmanuel S. Ojo and Shelley A. Tischkau
Cells 2021, 10(10), 2729; https://doi.org/10.3390/cells10102729
Available online: https://www.mdpi.com/2073-4409/10/10/2729

"Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis"
by Zhuofu Ni and Xiaodong Cheng
Cells 2021, 10(10), 2750; https://doi.org/10.3390/cells10102750
Available online: https://www.mdpi.com/2073-4409/10/10/2750

"Functional Proteomic Profiling of Triple-Negative Breast Cancer"
by Irina Gromova, Jaime A. Espinoza, Morten Grauslund, Eric Santoni-Rugiu, Maj-Lis Møller Talman, Jan van Oostrum and José M. A. Moreira
Cells 2021, 10(10), 2768; https://doi.org/10.3390/cells10102768
Available online: https://www.mdpi.com/2073-4409/10/10/2768

"Neurogenic Potential of the 18-kDa Mitochondrial Translocator Protein (TSPO) in Pluripotent P19 Stem Cells"
by Laura González-Blanco, Juan Carlos Bermejo-Millo, Gabriela Oliveira, Yaiza Potes, Eduardo Antuña, Iván Menéndez-Valle, Ignacio Vega-Naredo, Ana Coto-Montes and Beatriz Caballero
Cells 2021, 10(10), 2784; https://doi.org/10.3390/cells10102784
Available online: https://www.mdpi.com/2073-4409/10/10/2784

"Neurons Are a Primary Driver of Inflammation via Release of HMGB1"
by Huan Yang, Ulf Andersson and Michael Brines
Cells 2021, 10(10), 2791; https://doi.org/10.3390/cells10102791
Available online: https://www.mdpi.com/2073-4409/10/10/2791

"Fluctuations in AKT and PTEN Activity Are Linked by the E3 Ubiquitin Ligase cCBL"
by Manuel Olazábal-Morán, Miriam Sánchez-Ortega, Laura Martínez-Muñoz, Carmen Hernández, Manuel S. Rodríguez, Mario Mellado and Ana C. Carrera
Cells 2021, 10(11), 2803; https://doi.org/10.3390/cells10112803
Available online: https://www.mdpi.com/2073-4409/10/11/2803

"Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis"
by Jenna A. Dombroski, Jacob M. Hope, Nicole S. Sarna and Michael R. King
Cells 2021, 10(11), 2815; https://doi.org/10.3390/cells10112815
Available online: https://www.mdpi.com/2073-4409/10/11/2815

"The Proapoptotic Gene Bad Regulates Brain Development via p53-Mediated Stress Signals in Zebrafish"
by Jo-Chi Hung, Jen-Leih Wu, Huei-Ching Li, Hsuan-Wen Chiu and Jiann-Ruey Hong
Cells 2021, 10(11), 2820; https://doi.org/10.3390/cells10112820
Available online: https://www.mdpi.com/2073-4409/10/11/2820

"Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle"
by Seung Yeon Jeong, Mi Ri Oh, Jun Hee Choi, Jin Seok Woo and Eun Hui Lee
Cells 2021, 10(11), 2821; https://doi.org/10.3390/cells10112821
Available online: https://www.mdpi.com/2073-4409/10/11/2821

"Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy"
by Rafael Franco, Rafael Rivas-Santisteban, Gemma Navarro and Irene Reyes-Resina
Cells 2021, 10(11), 2831; https://doi.org/10.3390/cells10112831
Available online: https://www.mdpi.com/2073-4409/10/11/2831

"Loss of Endothelial Barrier Function in the Inflammatory Setting: Indication for a Cytokine-Mediated Post-Transcriptional Mechanism by Virtue of Upregulation of miRNAs miR-29a-3p, miR-29b-3p, and miR-155-5p"
by Daniel Maucher, Birte Schmidt and Julia Schumann
Cells 2021, 10(11), 2843; https://doi.org/10.3390/cells10112843
Available online: https://www.mdpi.com/2073-4409/10/11/2843

"Instructions for Flow Cytometric Detection of ASC Specks as a Readout of Inflammasome Activation in Human Blood"
by Nico Wittmann, Ann-Kathrin Behrendt, Neha Mishra, Lukas Bossaller and Almut Meyer-Bahlburg
Cells 2021, 10(11), 2880; https://doi.org/10.3390/cells10112880
Available online: https://www.mdpi.com/2073-4409/10/11/2880

"Global Reprogramming of Apoptosis-Related Genes during Brain Development"
by Wei Jiang, Liang Chen and Sika Zheng
Cells 2021, 10(11), 2901; https://doi.org/10.3390/cells10112901
Available online: https://www.mdpi.com/2073-4409/10/11/2901

"The Multiple Interactions of RUNX with the Hippo–YAP Pathway"
by Linda Shyue Huey Chuang and Yoshiaki Ito
Cells 2021, 10(11), 2925; https://doi.org/10.3390/cells10112925
Available online: https://www.mdpi.com/2073-4409/10/11/2925

"Temporal and Site-Specific ADP-Ribosylation Dynamics upon Different Genotoxic Stresses"
by Sara C. Buch-Larsen, Alexandra K. L. F. S. Rebak, Ivo A. Hendriks and Michael L. Nielsen
Cells 2021, 10(11), 2927; https://doi.org/10.3390/cells10112927
Available online: https://www.mdpi.com/2073-4409/10/11/2927

"Hormonal Regulation of Oxidative Phosphorylation in the Brain in Health and Disease"
by Katarzyna Głombik, Jan Detka and Bogusława Budziszewska
Cells 2021, 10(11), 2937; https://doi.org/10.3390/cells10112937
Available online: https://www.mdpi.com/2073-4409/10/11/2937

"Dynamic Regulation of GH–IGF1 Signaling in Injury and Recovery in Hyperoxia-Induced Neonatal Lung Injury"
by Christina Vohlen, Jasmine Mohr, Alexey Fomenko, Celien Kuiper-Makris, Tiffany Grzembke, Rabia Aydogmus, Rebecca Wilke, Dharmesh Hirani, Jörg Dötsch and Miguel A. Alejandre Alcazar
Cells 2021, 10(11), 2947; https://doi.org/10.3390/cells10112947
Available online: https://www.mdpi.com/2073-4409/10/11/2947

"Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy"
by Dimitri Papukashvili, Nino Rcheulishvili, Cong Liu, Fengfei Xie, Deependra Tyagi, Yunjiao He and Peng George Wang
Cells 2021, 10(11), 2957; https://doi.org/10.3390/cells10112957
Available online: https://www.mdpi.com/2073-4409/10/11/2957

"Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1"
by Elisa D’Alessandro, Billy Scaf, Chantal Munts, Arne van Hunnik, Christopher J. Trevelyan, Sander Verheule, Henri M. H. Spronk, Neil A. Turner, Hugo ten Cate, Ulrich Schotten et al.
Cells 2021, 10(11), 2958; https://doi.org/10.3390/cells10112958
Available online: https://www.mdpi.com/2073-4409/10/11/2958

"Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis"
by Lucas Porras, Houssam Ismail and Sylvie Mader
Cells 2021, 10(11), 2966; https://doi.org/10.3390/cells10112966
Available online: https://www.mdpi.com/2073-4409/10/11/2966

"Glioma Cells Acquire Stem-like Characters by Extrinsic Ribosome Stimuli"
by Yuki Shirakawa, Kunimasa Ohta, Shunsuke Miyake, Ayumi Kanemaru, Akari Kuwano, Kou Yonemaru, Shota Uchino, Michiko Yamaoka, Yuki Ito, Naofumi Ito et al.
Cells 2021, 10(11), 2970; https://doi.org/10.3390/cells10112970
Available online: https://www.mdpi.com/2073-4409/10/11/2970

"The Role of Immune Cells in Oxi-Inflamm-Aging"
by Irene Martínez de Toda, Noemi Ceprián, Estefanía Díaz-Del Cerro and Mónica De la Fuente
Cells 2021, 10(11), 2974; https://doi.org/10.3390/cells10112974
Available online: https://www.mdpi.com/2073-4409/10/11/2974

"FGFR1 Overexpression Induces Cancer Cell Stemness and Enhanced Akt/Erk-ER Signaling to Promote Palbociclib Resistance in Luminal A Breast Cancer Cells"
by Qiong Cheng, Zhikun Ma, Yujie Shi, Amanda B. Parris, Lingfei Kong and Xiaohe Yang
Cells 2021, 10(11), 3008; https://doi.org/10.3390/cells10113008
Available online: https://www.mdpi.com/2073-4409/10/11/3008

"Impact of SOCE Abolition by ORAI1 Knockout on the Proliferation, Adhesion, and Migration of HEK-293 Cells"
by Alexandre Bokhobza, Nathalie Ziental-Gelus, Laurent Allart, Oksana Iamshanova and Fabien Vanden Abeele
Cells 2021, 10(11), 3016; https://doi.org/10.3390/cells10113016
Available online: https://www.mdpi.com/2073-4409/10/11/3016

"Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes"
by Wiebke Nicolay, Rebecca Moeller, Sina Kahl, Florian W. R. Vondran, Thomas Pietschmann, Stefan Kunz and Gisa Gerold
Cells 2021, 10(11), 3019; https://doi.org/10.3390/cells10113019
Available online: https://www.mdpi.com/2073-4409/10/11/3019

"Walking down Skeletal Muscle Lane: From Inflammasome to Disease"
by Nicolas Dubuisson, Romain Versele, María A. Davis-López de Carrizosa, Camille M. Selvais, Sonia M. Brichard and Michel Abou-Samra
Cells 2021, 10(11), 3023; https://doi.org/10.3390/cells10113023
Available online: https://www.mdpi.com/2073-4409/10/11/3023

"Cell-to-Cell Interactions Mediating Functional Recovery after Stroke"
by Claudia Alia, Daniele Cangi, Verediana Massa, Marco Salluzzo, Livia Vignozzi, Matteo Caleo and Cristina Spalletti
Cells 2021, 10(11), 3050; https://doi.org/10.3390/cells10113050
Available online: https://www.mdpi.com/2073-4409/10/11/3050

"TRPV4 Mechanotransduction in Fibrosis"
by Ravi K. Adapala, Venkatesh Katari, Lakshminarayan Reddy Teegala, Sathwika Thodeti, Sailaja Paruchuri and Charles K. Thodeti
Cells 2021, 10(11), 3053; https://doi.org/10.3390/cells10113053
Available online: https://www.mdpi.com/2073-4409/10/11/3053

"Structural Insights into Ca²⁺ Permeation through Orai Channels"
by Yang Li, Xue Yang and Yuequan Shen
Cells 2021, 10(11), 3062; https://doi.org/10.3390/cells10113062
Available online: https://www.mdpi.com/2073-4409/10/11/3062

"Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina"
by Fahad Farhan, Mohammad Almarhoun, Aileen Wong, Amy S. Findlay, Chris Bartholomew, Mark T. S. Williams, Toby W. Hurd and Xinhua Shu
Cells 2021, 10(11), 3066; https://doi.org/10.3390/cells10113066
Available online: https://www.mdpi.com/2073-4409/10/11/3066

"Zinc Ameliorates the Osteogenic Effects of High Glucose in Vascular Smooth Muscle Cells"
by Laura A. Henze, Misael Estepa, Burkert Pieske, Florian Lang, Kai-Uwe Eckardt, Ioana Alesutan and Jakob Voelkl
Cells 2021, 10(11), 3083; https://doi.org/10.3390/cells10113083
Available online: https://www.mdpi.com/2073-4409/10/11/3083

"Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells"
by Jürgen Fritsch, Julia Frankenheim, Lothar Marischen, Timea Vadasz, Anja Troeger, Stefan Rose-John, Dirk Schmidt-Arras and Wulf Schneider-Brachert
Cells 2021, 10(11), 3100; https://doi.org/10.3390/cells10113100
Available online: https://www.mdpi.com/2073-4409/10/11/3100

"Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na⁺ Channel 1.2 Macromolecular Complex"
by Nolan M. Dvorak, Cynthia M. Tapia, Timothy J. Baumgartner, Jully Singh, Fernanda Laezza and Aditya K. Singh
Cells 2021, 10(11), 3103; https://doi.org/10.3390/cells10113103
Available online: https://www.mdpi.com/2073-4409/10/11/3103

"The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma"
by Francesco De Logu, Daniel Souza Monteiro de Araujo, Filippo Ugolini, Luigi Francesco Iannone, Margherita Vannucchi, Francesca Portelli, Lorenzo Landini, Mustafa Titiz, Vincenzo De Giorgi, Pierangelo Geppetti et al.
Cells 2021, 10(11), 3131; https://doi.org/10.3390/cells10113131
Available online: https://www.mdpi.com/2073-4409/10/11/3131

"Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning"
by Juan Pablo Rigalli, Dirk Theile, Julie Nilles and Johanna Weiss
Cells 2021, 10(11), 3137; https://doi.org/10.3390/cells10113137
Available online: https://www.mdpi.com/2073-4409/10/11/3137

"Multi-Tissue Characterization of GILZ Expression in Dendritic Cell Subsets at Steady State and in Inflammatory Contexts"
by Molène Docq, Mathias Vétillard, Carmen Gallego, Agnieszka Jaracz-Ros, Françoise Mercier-Nomé, Françoise Bachelerie and Géraldine Schlecht-Louf
Cells 2021, 10(11), 3153; https://doi.org/10.3390/cells10113153
Available online: https://www.mdpi.com/2073-4409/10/11/3153

"Role of AHR Ligands in Skin Homeostasis and Cutaneous Inflammation"
by Nieves Fernández-Gallego, Francisco Sánchez-Madrid and Danay Cibrian
Cells 2021, 10(11), 3176; https://doi.org/10.3390/cells10113176
Available online: https://www.mdpi.com/2073-4409/10/11/3176

"A Review on the Evolving Roles of MiRNA-Based Technologies in Diagnosing and Treating Heart Failure"
by Peter J. Kennel and P. Christian Schulze
Cells 2021, 10(11), 3191; https://doi.org/10.3390/cells10113191
Available online: https://www.mdpi.com/2073-4409/10/11/3191

"Current Therapeutic Strategies and Prospects for EGFR Mutation-Positive Lung Cancer Based on the Mechanisms Underlying Drug Resistance"
by Yukari Tsubata, Ryosuke Tanino and Takeshi Isobe
Cells 2021, 10(11), 3192; https://doi.org/10.3390/cells10113192
Available online: https://www.mdpi.com/2073-4409/10/11/3192

"Interaction between Non-Coding RNAs and Androgen Receptor with an Especial Focus on Prostate Cancer"
by Mohammad Taheri, Tayyebeh Khoshbakht, Elena Jamali, Julia Kallenbach, Soudeh Ghafouri-Fard and Aria Baniahmad
Cells 2021, 10(11), 3198; https://doi.org/10.3390/cells10113198
Available online: https://www.mdpi.com/2073-4409/10/11/3198

"A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites"
by Simon Peters, Ingo Fohmann, Thomas Rudel and Alexandra Schubert-Unkmeir
Cells 2021, 10(11), 3201; https://doi.org/10.3390/cells10113201
Available online: https://www.mdpi.com/2073-4409/10/11/3201

"microRNA-27a-3p but Not -5p Is a Crucial Mediator of Human Adipogenesis"
by Hang Wu, Taner Pula, Daniel Tews, Ez-Zoubir Amri, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky and Julian Roos
Cells 2021, 10(11), 3205; https://doi.org/10.3390/cells10113205
Available online: https://www.mdpi.com/2073-4409/10/11/3205

"Aberrant Patterns of Sensory-Evoked Activity in the Olfactory Bulb of LRRK2 Knockout Mice"
by Andrea Maset, Marco Albanesi, Antonio di Soccio, Martina Canova, Marco dal Maschio and Claudia Lodovichi
Cells 2021, 10(11), 3212; https://doi.org/10.3390/cells10113212
Available online: https://www.mdpi.com/2073-4409/10/11/3212

"PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes"
by Michael P. Wilczek, Francesca J. Armstrong, Colleen L. Mayberry, Benjamin L. King and Melissa S. Maginnis
Cells 2021, 10(11), 3218; https://doi.org/10.3390/cells10113218
Available online: https://www.mdpi.com/2073-4409/10/11/3218

"The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration"
by Mariya Farooq, Abdul Waheed Khan, Moon Suk Kim and Sangdun Choi
Cells 2021, 10(11), 3242; https://doi.org/10.3390/cells10113242
Available online: https://www.mdpi.com/2073-4409/10/11/3242

"Butyrate and Class I Histone Deacetylase Inhibitors Promote Differentiation of Neonatal Porcine Islet Cells into Beta Cells"
by Yichen Zhang, Yutian Lei, Mohsen Honarpisheh, Elisabeth Kemter, Eckhard Wolf and Jochen Seissler
Cells 2021, 10(11), 3249; https://doi.org/10.3390/cells10113249
Available online: https://www.mdpi.com/2073-4409/10/11/3249

"Hepatitis-D Virus Infection Is Not Impaired by Innate Immunity but Increases Cytotoxic T-Cell Activity"
by Sebastian Maximilian Altstetter, Oliver Quitt, Francesca Pinci, Veit Hornung, Aaron Michael Lucko, Karin Wisskirchen, Stephanie Jung and Ulrike Protzer
Cells 2021, 10(11), 3253; https://doi.org/10.3390/cells10113253
Available online: https://www.mdpi.com/2073-4409/10/11/3253

"Revisiting the Role of GSK3, A Modulator of Innate Immunity, in Idiopathic Inclusion Body Myositis"
by Manuela Piazzi, Alberto Bavelloni, Vittoria Cenni, Irene Faenza and William L. Blalock
Cells 2021, 10(11), 3255; https://doi.org/10.3390/cells10113255
Available online: https://www.mdpi.com/2073-4409/10/11/3255

"The Interface between Cell Signaling Pathways and Pregnane X Receptor"
by Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D’Ambrosio, Gregory Ruddy et al.
Cells 2021, 10(11), 3262; https://doi.org/10.3390/cells10113262
Available online: https://www.mdpi.com/2073-4409/10/11/3262

"MicroRNA-214 in Health and Disease"
by Meer M. J. Amin, Christopher J. Trevelyan and Neil A. Turner
Cells 2021, 10(12), 3274; https://doi.org/10.3390/cells10123274
Available online: https://www.mdpi.com/2073-4409/10/12/3274

"Gas6/TAM Signalling Negatively Regulates Inflammatory Induction of GM-CSF in Mouse Brain Microglia"
by Shannon E. Gilchrist, Grace M. Pennelli and Sassan Hafizi
Cells 2021, 10(12), 3281; https://doi.org/10.3390/cells10123281
Available online: https://www.mdpi.com/2073-4409/10/12/3281

"Translational Stroke Research Review: Using the Mouse to Model Human Futile Recanalization and Reperfusion Injury in Ischemic Brain Tissue"
by Emilia Conti, Benedetta Piccardi, Alessandro Sodero, Laura Tudisco, Ivano Lombardo, Enrico Fainardi, Patrizia Nencini, Cristina Sarti, Anna Letizia Allegra Mascaro and Marzia Baldereschi
Cells 2021, 10(12), 3308; https://doi.org/10.3390/cells10123308
Available online: https://www.mdpi.com/2073-4409/10/12/3308

"Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA–SIRT2 Axis and Its Relationship with Aging-Related Diseases"
by Taku Kaitsuka, Masayuki Matsushita and Nobuko Matsushita
Cells 2021, 10(12), 3316; https://doi.org/10.3390/cells10123316
Available online: https://www.mdpi.com/2073-4409/10/12/3316

"Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of Ca²⁺ Signaling Mechanisms Using Optogenetic Tools"
by Lena Maltan, Hadil Najjar, Adéla Tiffner and Isabella Derler
Cells 2021, 10(12), 3340; https://doi.org/10.3390/cells10123340
Available online: https://www.mdpi.com/2073-4409/10/12/3340

"Role of ADGRG1/GPR56 in Tumor Progression"
by Kwai-Fong Ng, Tse-Ching Chen, Martin Stacey and Hsi-Hsien Lin
Cells 2021, 10(12), 3352; https://doi.org/10.3390/cells10123352
Available online: https://www.mdpi.com/2073-4409/10/12/3352

"The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability"
by Sarah Stiegeler, Kevin Mercurio, Miruna Alexandra Iancu and Sinéad C. Corr
Cells 2021, 10(12), 3358; https://doi.org/10.3390/cells10123358
Available online: https://www.mdpi.com/2073-4409/10/12/3358

"Ion Channel Expression and Electrophysiology of Singular Human (Primary and Induced Pluripotent Stem Cell-Derived) Cardiomyocytes"
by Christina Schmid, Najah Abi-Gerges, Michael Georg Leitner, Dietmar Zellner and Georg Rast
Cells 2021, 10(12), 3370; https://doi.org/10.3390/cells10123370
Available online: https://www.mdpi.com/2073-4409/10/12/3370

"MicroRNA Cues from Nature: A Roadmap to Decipher and Combat Challenges in Human Health and Disease?"
by Gurjit Singh and Kenneth B. Storey
Cells 2021, 10(12), 3374; https://doi.org/10.3390/cells10123374
Available online: https://www.mdpi.com/2073-4409/10/12/3374

"Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes"
by Zhihui Li, Linhao Li, Scott Heyward, Shuaiqian Men, Meishu Xu, Tatsuya Sueyoshi and Hongbing Wang
Cells 2021, 10(12), 3381; https://doi.org/10.3390/cells10123381
Available online: https://www.mdpi.com/2073-4409/10/12/3381

"Evolutionary Adaptation of the Thyroid Hormone Signaling Toolkit in Chordates"
by Alfonso Esposito, Luca Ambrosino, Silvano Piazza, Salvatore D’Aniello, Maria Luisa Chiusano and Annamaria Locascio
Cells 2021, 10(12), 3391; https://doi.org/10.3390/cells10123391
Available online: https://www.mdpi.com/2073-4409/10/12/3391

"Endocannabinoid System and Tumour Microenvironment: New Intertwined Connections for Anticancer Approaches"
by Marta Iozzo, Giovanna Sgrignani, Giuseppina Comito, Paola Chiarugi and Elisa Giannoni
Cells 2021, 10(12), 3396; https://doi.org/10.3390/cells10123396
Available online: https://www.mdpi.com/2073-4409/10/12/3396

"Maresin-1 Prevents Liver Fibrosis by Targeting Nrf2 and NF-κB, Reducing Oxidative Stress and Inflammation"
by María José Rodríguez, Matías Sabaj, Gerardo Tolosa, Francisca Herrera Vielma, María José Zúñiga, Daniel R. González and Jessica Zúñiga-Hernández
Cells 2021, 10(12), 3406; https://doi.org/10.3390/cells10123406
Available online: https://www.mdpi.com/2073-4409/10/12/3406

"Central Suppression of the GH/IGF Axis and Abrogation of Exercise-Related mTORC1/2 Activation in the Muscle of Phenotype-Selected Male Marathon Mice (DUhTP)"
by Julia Brenmoehl, Christina Walz, Caroline Caffier, Elli Brosig, Michael Walz, Daniela Ohde, Nares Trakooljul, Martina Langhammer, Siriluck Ponsuksili, Klaus Wimmers et al.
Cells 2021, 10(12), 3418; https://doi.org/10.3390/cells10123418
Available online: https://www.mdpi.com/2073-4409/10/12/3418

"Therapeutic Potential of Annexin A1 Modulation in Kidney and Cardiovascular Disorders"
by Mahmood S. Mozaffari
Cells 2021, 10(12), 3420; https://doi.org/10.3390/cells10123420
Available online: https://www.mdpi.com/2073-4409/10/12/3420

"Commander Complex—A Multifaceted Operator in Intracellular Signaling and Cargo "
by Saara Laulumaa and Markku Varjosalo
Cells 2021, 10(12), 3447; https://doi.org/10.3390/cells10123447
Available online: https://www.mdpi.com/2073-4409/10/12/3447

"Alternative Splicing of MAPKs in the Regulation of Signaling Specificity"
by Galia Maik-Rachline, Inbal Wortzel and Rony Seger
Cells 2021, 10(12), 3466; https://doi.org/10.3390/cells10123466
Available online: https://www.mdpi.com/2073-4409/10/12/3466

"Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System"
by Ruqaia Abbas and Sarit Larisch
Cells 2021, 10(12), 3465; https://doi.org/10.3390/cells10123465
Available online: https://www.mdpi.com/2073-4409/10/12/3465

"GLIS3: A Critical Transcription Factor in Islet β-Cell Generation"
by David W. Scoville and Anton M. Jetten
Cells 2021, 10(12), 3471; https://doi.org/10.3390/cells10123471
Available online: https://www.mdpi.com/2073-4409/10/12/3471

"Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms"
by Mohamed Chamlali, Sana Kouba, Lise Rodat-Despoix, Luca Matteo Todesca, Zoltán Pethö, Albrecht Schwab and Halima Ouadid-Ahidouch
Cells 2021, 10(12), 3487; https://doi.org/10.3390/cells10123487
Available online: https://www.mdpi.com/2073-4409/10/12/3487

"Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway"
by So-Yeon Kim, Younseo Oh, Sungsin Jo, Jong-Dae Ji and Tae-Hwan Kim
Cells 2021, 10(12), 3498; https://doi.org/10.3390/cells10123498
Available online: https://www.mdpi.com/2073-4409/10/12/3498

"Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog"
by Krisztina Kerekes, Mária Trexler, László Bányai and László Patthy
Cells 2021, 10(12), 3496; https://doi.org/10.3390/cells10123496
Available online: https://www.mdpi.com/2073-4409/10/12/3496

"The Methyltransferase Smyd1 Mediates LPS-Triggered Up-Regulation of IL-6 in Endothelial Cells"
by Ahmed Shamloul, Gustav Steinemann, Kerrin Roos, Celine Huajia Liem, Jonathan Bernd, Thorsten Braun, Andreas Zakrzewicz and Janine Berkholz
Cells 2021, 10(12), 3515; https://doi.org/10.3390/cells10123515
Available online: https://www.mdpi.com/2073-4409/10/12/3515

"Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1β Release during a Uropathogenic Escherichia coli Infection In Vitro"
by Ashok Kumar Kumawat, Geena Varghese Paramel, Kartheyaene Jayaprakash Demirel and Isak Demirel
Cells 2021, 10(12), 3522; https://doi.org/10.3390/cells10123522
Available online: https://www.mdpi.com/2073-4409/10/12/3522

"From NSAIDs to Glucocorticoids and Beyond"
by Ajantha Sinniah, Samia Yazid and Rod J. Flower
Cells 2021, 10(12), 3524; https://doi.org/10.3390/cells10123524
Available online: https://www.mdpi.com/2073-4409/10/12/3524

"Synthesis of Human Bone Morphogenetic Protein-2 (hBMP-2) in E. coli Periplasmic Space: Its Characterization and Preclinical Testing"
by João E. Oliveira, Miriam F. Suzuki, Renata Damiani, Eliana R. Lima, Kleicy C. Amaral, Anderson M. S. Santos, Geraldo S. Magalhães, Leonardo P. Faverani, Luís A. V. D. Pereira and Paolo Bartolini
Cells 2021, 10(12), 3525; https://doi.org/10.3390/cells10123525
Available online: https://www.mdpi.com/2073-4409/10/12/3525

"Characterization of Type 1 Angiotensin II Receptor Activation Induced Dual-Specificity MAPK Phosphatase Gene Expression Changes in Rat Vascular Smooth Muscle Cells"
by Janka Borbála Gém, Kinga Bernadett Kovács, Laura Szalai, Gyöngyi Szakadáti, Edit Porkoláb, Bence Szalai, Gábor Turu, András Dávid Tóth, Mária Szekeres, László Hunyady et al.
Cells 2021, 10(12), 3538; https://doi.org/10.3390/cells10123538
Available online: https://www.mdpi.com/2073-4409/10/12/3538

"PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α"
by Ryota Shizu, Kanako Ezaki, Takumi Sato, Ayaka Sugawara, Takuomi Hosaka, Takamitsu Sasaki and Kouichi Yoshinari
Cells 2021, 10(12), 3550; https://doi.org/10.3390/cells10123550
Available online: https://www.mdpi.com/2073-4409/10/12/3550

"Emerging Molecular Dependencies of Mutant EGFR-Driven Non-Small Cell Lung Cancer"
by Dylan A. Farnsworth, Yankuan T. Chen, Georgia de Rappard Yuswack and William W. Lockwood
Cells 2021, 10(12), 3553; https://doi.org/10.3390/cells10123553
Available online: https://www.mdpi.com/2073-4409/10/12/3553

"Adhesion GPCR GPR56 Expression Profiling in Human Tissues"
by Fyn Kaiser, Markus Morawski, Knut Krohn, Nada Rayes, Cheng-Chih Hsiao, Marianne Quaas and Gabriela Aust
Cells 2021, 10(12), 3557; https://doi.org/10.3390/cells10123557
Available online: https://www.mdpi.com/2073-4409/10/12/3557

"Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases"
by Maddalena Napolitano, Gabriella Fabbrocini, Fabrizio Martora, Vincenzo Picone, Paola Morelli and Cataldo Patruno
Cells 2021, 10(12), 3559; https://doi.org/10.3390/cells10123559
Available online: https://www.mdpi.com/2073-4409/10/12/3559

"Shear Stress Alterations Activate BMP4/pSMAD5 Signaling and Induce Endothelial Mesenchymal Transition in Varicose Veins"
by Karthika Chandran Latha, Ahalya Sreekumar, Vyshna Beena, Binil Raj S.S., RaviKumar B. Lakkappa, Ravi Kalyani, Radhakrishnan Nair, Saligrama Ramegowda Kalpana, Chandrasekharan C. Kartha and Sumi Surendran
Cells 2021, 10(12), 3563; https://doi.org/10.3390/cells10123563
Available online: https://www.mdpi.com/2073-4409/10/12/3563

"The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment"
by Yiling Wang and Audrey Minden
Cells 2021, 10(12), 3565; https://doi.org/10.3390/cells10123565
Available online: https://www.mdpi.com/2073-4409/10/12/3565

"miR-140-5p Attenuates Hypoxia-Induced Breast Cancer Progression by Targeting Nrf2/HO-1 Axis in a Keap1-Independent Mechanism"
by Megharani Mahajan and Sandhya Sitasawad
Cells 2021, 11(1), 12; https://doi.org/10.3390/cells11010012
Available online: https://www.mdpi.com/2073-4409/11/1/12

"A Novel Kinase Inhibitor AX-0085 Inhibits Interferon-γ-Mediated Induction of PD-L1 Expression and Promotes Immune Reaction to Lung Adenocarcinoma Cells"
by Jusong Kim, Haeyeon Jang, Gyu Jin Lee, Yelim Hur, Juhee Keum, Jung Ki Jo, Si-Eun Yun, Sung Jun Park, Young Jun Park, Myeong Jun Choi et al.
Cells 2021, 11(1), 19; https://doi.org/10.3390/cells11010019
Available online: https://www.mdpi.com/2073-4409/11/1/19

"Expression of Proton-Sensitive GPR31, GPR151, TASK1 and TASK3 in Common Skin Tumors"
by Antonia Förch, Susanne Wallner, Florian Zeman, Tobias Ettl, Christoph Brochhausen and Stephan Schreml
Cells 2021, 11(1), 27; https://doi.org/10.3390/cells11010027
Available online: https://www.mdpi.com/2073-4409/11/1/27

"Dopamine D₄ Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum"
by Alicia Rivera, Diana Suárez-Boomgaard, Cristina Miguelez, Alejandra Valderrama-Carvajal, Jérôme Baufreton, Kirill Shumilov, Anne Taupignon, Belén Gago and M. Ángeles Real
Cells 2021, 11(1), 31; https://doi.org/10.3390/cells11010031
Available online: https://www.mdpi.com/2073-4409/11/1/31

"miR-511 Deficiency Protects Mice from Experimental Colitis by Reducing TLR3 and TLR4 Responses via WD Repeat and FYVE-Domain-Containing Protein 1"
by Shafaque Rahman, Jolien Vandewalle, Patricia H. P. van Hamersveld, Caroline Verseijden, Olaf Welting, Aldo Jongejan, Pierina Casanova, Sybren L. Meijer, Claude Libert, Theodorus B. M. Hakvoort et al.
Cells 2021, 11(1), 58; https://doi.org/10.3390/cells11010058
Available online: https://www.mdpi.com/2073-4409/11/1/58

"The Nuclear Receptor PXR in Chronic Liver Disease"
by Katia Sayaf, Ilaria Zanotto, Francesco Paolo Russo, Daniela Gabbia and Sara De Martin
Cells 2021, 11(1), 61; https://doi.org/10.3390/cells11010061
Available online: https://www.mdpi.com/2073-4409/11/1/61

"The Isoquinoline-Sulfonamide Compound H-1337 Attenuates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension in Rats"
by Hiroki Shoji, Yoko Yoshida, Takayuki Jujo Sanada, Akira Naito, Junko Maruyama, Erquan Zhang, Kengo Sumi, Seiichiro Sakao, Kazuo Maruyama, Hiroyoshi Hidaka et al.
Cells 2021, 11(1), 66; https://doi.org/10.3390/cells11010066
Available online: https://www.mdpi.com/2073-4409/11/1/66

"Impaired Glucocorticoid Receptor Signaling Aggravates Lung Injury after Hemorrhagic Shock"
by Jonathan M. Preuss, Ute Burret, Michael Gröger, Sandra Kress, Angelika Scheuerle, Peter Möller, Jan P. Tuckermann, Martin Wepler and Sabine Vettorazzi
Cells 2021, 11(1), 112; https://doi.org/10.3390/cells11010112
Available online: https://www.mdpi.com/2073-4409/11/1/112

"Selectivity of mTOR-Phosphatidic Acid Interactions Is Driven by Acyl Chain Structure and Cholesterol"
by Jolanta Żelasko and Aleksander Czogalla
Cells 2021, 11(1), 119; https://doi.org/10.3390/cells11010119
Available online: https://www.mdpi.com/2073-4409/11/1/119

"Interleukin-8 in Melanoma Pathogenesis, Prognosis and Therapy—An Integrated View into Other Neoplasms and Chemokine Networks"
by Anca Filimon, Iulia A. Preda, Adina F. Boloca and Gabriela Negroiu
Cells 2021, 11(1), 120; https://doi.org/10.3390/cells11010120
Available online: https://www.mdpi.com/2073-4409/11/1/120

"Establishing F1A-CreER^T2 Mice to Trace Fgf1 Expression in Adult Mouse Cardiomyocytes"
by Yi-Chao Hsu, Yu-Fen Chung, Mei-Shu Chen, Chi-Kuang Wang, Si-Tse Jiang and Ing-Ming Chiu
Cells 2021, 11(1), 121; https://doi.org/10.3390/cells11010121
Available online: https://www.mdpi.com/2073-4409/11/1/121

"GILZ as a Regulator of Cell Fate and Inflammation"
by Stefano Bruscoli, Carlo Riccardi and Simona Ronchetti
Cells 2021, 11(1), 122; https://doi.org/10.3390/cells11010122
Available online: https://www.mdpi.com/2073-4409/11/1/122

"KRAS and BRAF Mutations as Prognostic and Predictive Biomarkers for Standard Chemotherapy Response in Metastatic Colorectal Cancer: A Single Institutional Study"
by Nuria Garcia-Carbonero, Javier Martinez-Useros, Weiyao Li, Alberto Orta, Nuria Perez, Cristina Carames, Tatiana Hernandez, Irene Moreno, Gloria Serrano and Jesus Garcia-Foncillas
Cells 2020, 9(1), 219; https://doi.org/10.3390/cells9010219
Available online: https://www.mdpi.com/2073-4409/9/1/219

"miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation"
by Lavanya Adusumilli, Nicola Facchinello, Cathleen Teh, Giorgia Busolin, Minh TN Le, Henry Yang, Giorgia Beffagna, Stefano Campanaro, Wai Leong Tam, Francesco Argenton et al.
Cells 2020, 9(3), 711; https://doi.org/10.3390/cells9030711
Available online: https://www.mdpi.com/2073-4409/9/3/711

"stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae"
by Iga Wasilewska, Rishikesh Kumar Gupta, Bartosz Wojtaś, Oksana Palchevska and Jacek Kuźnicki
Cells 2020, 9(5), 1285; https://doi.org/10.3390/cells9051285
Available online: https://www.mdpi.com/2073-4409/9/5/1285

"PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development"
by Sahar I. Da’as, Waleed Aamer, Waseem Hasan, Aljazi Al-Maraghi, Alya Al-Kurbi, Houda Kilani, Jehan AlRayahi, Khaled Zamel, Mitchell A. Stotland and Khalid A. Fakhro
Cells 2020, 9(8), 1782; https://doi.org/10.3390/cells9081782
Available online: https://www.mdpi.com/2073-4409/9/8/1782

"Naja atra Cardiotoxin 1 Induces the FasL/Fas Death Pathway in Human Leukemia Cells"
by Jing-Ting Chiou, Liang-Jun Wang, Yuan-Chin Lee and Long-Sen Chang
Cells 2021, 10(8), 2073; https://doi.org/10.3390/cells10082073
Available online: https://www.mdpi.com/2073-4409/10/8/2073