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Review

The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability

1
Department of Microbiology, Moyne Institute of Preventative Medicine, School of Genetics and Microbiology, Trinity College Dublin, Dublin, Ireland
2
APC Microbiome Ireland, University College Cork, Cork, Ireland
*
Author to whom correspondence should be addressed.
Equal Contribution.
Academic Editor: Alexander E. Kalyuzhny
Cells 2021, 10(12), 3358; https://doi.org/10.3390/cells10123358
Received: 31 October 2021 / Revised: 23 November 2021 / Accepted: 25 November 2021 / Published: 30 November 2021
(This article belongs to the Collection microRNAs in Health and Diseases)
Research on inflammatory bowel disease (IBD) has produced mounting evidence for the modulation of microRNAs (miRNAs) during pathogenesis. MiRNAs are small, non-coding RNAs that interfere with the translation of mRNAs. Their high stability in free circulation at various regions of the body allows researchers to utilise miRNAs as biomarkers and as a focus for potential treatments of IBD. Yet, their distinct regulatory roles at the gut epithelial barrier remain elusive due to the fact that there are several external and cellular factors contributing to gut permeability. This review focuses on how miRNAs may compromise two components of the gut epithelium that together form the initial physical barrier: the mucus layer and the intercellular epithelial junctions. Here, we summarise the impact of miRNAs on goblet cell secretion and mucin structure, along with the proper function of various junctional proteins involved in paracellular transport, cell adhesion and communication. Knowledge of how this elaborate network of cells at the gut epithelial barrier becomes compromised as a result of dysregulated miRNA expression, thereby contributing to the development of IBD, will support the generation of miRNA-associated biomarker panels and therapeutic strategies that detect and ameliorate gut permeability. View Full-Text
Keywords: microRNAs; inflammatory bowel disease; gut epithelial barrier; mucus layer; intercellular junctions microRNAs; inflammatory bowel disease; gut epithelial barrier; mucus layer; intercellular junctions
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MDPI and ACS Style

Stiegeler, S.; Mercurio, K.; Iancu, M.A.; Corr, S.C. The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability. Cells 2021, 10, 3358. https://doi.org/10.3390/cells10123358

AMA Style

Stiegeler S, Mercurio K, Iancu MA, Corr SC. The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability. Cells. 2021; 10(12):3358. https://doi.org/10.3390/cells10123358

Chicago/Turabian Style

Stiegeler, Sarah, Kevin Mercurio, Miruna A. Iancu, and Sinéad C. Corr. 2021. "The Impact of MicroRNAs during Inflammatory Bowel Disease: Effects on the Mucus Layer and Intercellular Junctions for Gut Permeability" Cells 10, no. 12: 3358. https://doi.org/10.3390/cells10123358

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