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Cells, Volume 14, Issue 22

November-2 2025 - 90 articles

Cover Story: Epicardial cells of the embryonic heart maintain a squamous morphology, allowing only a subset to undergo mesenchymal transformation and contribute to heart development. We found that a null mutation in Plakophilin 2 (Pkp2), a key structural component of desmosomes, severely disrupts epicardial development in embryonic mice. Shortly after the epicardial layer forms on the myocardial surface, Pkp2-null epicardial cells (blue) lose their squamous morphology and detach from the myocardium (Beige). They subsequently acquire mesenchymal characteristics in an unrestrained manner and differentiate into hematopoietic stem cells and erythroid lineage cells (red). These findings demonstrate that desmosomal junctions are essential for proper cardiogenesis by limiting excessive epithelial–mesenchymal transition within the epicardium. View this paper
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Articles (90)

  • Article
  • Open Access
609 Views
16 Pages

Chemically Defined, Efficient Megakaryocyte Production from Human Pluripotent Stem Cells

  • Jae Eun Kim,
  • Yeonmi Lee,
  • Yonghee Kim,
  • Sae-Byeok Hwang,
  • Yoo Bin Choi,
  • Jongsuk Han,
  • Juyeol Jung,
  • Jae-woo Song,
  • Je-Gun Joung and
  • Jeong-Jae Ko
  • + 1 author

20 November 2025

Platelet shortage poses a significant barrier to research and transfusion therapies because native megakaryocytes (MKs) are scarce in blood. To overcome this limitation, pluripotent stem cell–derived MKs (PSC-MKs) offer a standardized, donor-in...

  • Article
  • Open Access
405 Views
15 Pages

Reduced RhoGDI2 Expression Disrupts Centrosome Functions and Promotes Mitotic Errors

  • Mudrika Tripathi,
  • Nancy Garbacki,
  • Jérôme Willems,
  • Gaël Cobraiville,
  • Marianne Fillet,
  • Alain Colige and
  • Christophe F. Deroanne

20 November 2025

RhoGDI2 is a RhoGTPase regulator that has roles in cytoskeleton organization and cell survival, amongst others. It is differentially expressed in many cell types and tissues, including several human cancers, where its expression has been correlated w...

  • Article
  • Open Access
470 Views
19 Pages

Knocking Out Rap1a Attenuates Cardiac Remodeling and Fibrosis in a Male Murine Model of Angiotensin II-Induced Hypertension

  • Cody S. Porter,
  • Larissa T. Brown,
  • Can’Torrius Lacey,
  • Mason T. Hickel and
  • James A. Stewart

20 November 2025

Hypertension is a leading risk factor for cardiovascular disease and is associated with maladaptive cardiac remodeling, including hypertrophy and fibrosis. The roles of the receptor for advanced glycation end-products (RAGE) and the small GTPase Rap1...

  • Review
  • Open Access
703 Views
19 Pages

Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk

  • Kuan Wang,
  • Zi-Lin Li,
  • Lin-Yi Huang,
  • Chih-Jung Yao,
  • Dana R. Crawford,
  • Chih-Yang Wang,
  • Ju-Ku Mo,
  • Ya-Jung Shih,
  • Hung-Yun Lin and
  • Jacqueline Whang-Peng

20 November 2025

Integrin αvβ3, a key member of the integrin family, plays a crucial role in cell localization, mobilization, and signal transduction through collaborating with extracellular proteins. Its unique expression and activation in tumor cells and...

  • Review
  • Open Access
1,384 Views
23 Pages

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

  • Federica De Luca,
  • Valentina Camporeale,
  • Giorgia Leccese,
  • Roberto Cuttano,
  • Dario Troise,
  • Barbara Infante,
  • Giovanni Stallone,
  • Giuseppe Stefano Netti and
  • Elena Ranieri

20 November 2025

Aging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function. Together, these processes contribute to tissue dysfunction and the de...

  • Article
  • Open Access
415 Views
19 Pages

Region-Specific Roles of TGF-β2 and Angiotensin II in Fibrotic and Inflammatory Remodeling of the Optic Nerve Head

  • Si-Eun Oh,
  • Jie-Hyun Kim,
  • Se-Eun Park,
  • Chan-Kee Park and
  • Hae-Young Lopilly Park

20 November 2025

This study investigated the region-specific roles of transforming growth factor-β2 (TGF-β2) and angiotensin II (AngII) in extracellular matrix (ECM) remodeling and inflammatory responses within scleral tissues surrounding the optic nerve he...

  • Perspective
  • Open Access
569 Views
18 Pages

The Crosstalk Between Mycobacterium abscessus and Immune Cells: Exploring Novel Interaction Modalities

  • Ilse Mendoza-Trujillo,
  • Patricia Diez-Echave,
  • Chiara Tontini and
  • Silvia Bulfone-Paus

20 November 2025

Mycobacterium abscessus (Mab) is a rapidly growing, non-tuberculous mycobacterium and opportunistic pathogen that causes lung and skin infections in immunocompromised individuals. In recent years, Mab has gained attention due to its resistance to mul...

  • Article
  • Open Access
531 Views
17 Pages

FGF12 Enhances Prostate Cancer Cell Survival via the YB1-lncRNA Axis

  • Zechao Huang,
  • Sonia H. Y. Kung,
  • Hans Adomat,
  • Htoo Zarni Oo,
  • Connor Forbes,
  • Faraz Hach and
  • Xuesen Dong

20 November 2025

Treatment-induced neuroendocrine prostate cancer (t-NEPC) is a highly aggressive and therapy-resistant subtype of prostate cancer characterized by lineage plasticity and poor response to standard chemotherapy and androgen deprivation therapy. Althoug...

  • Article
  • Open Access
394 Views
20 Pages

Multifaceted Effects of Thymoquinone on Platelet Calcium Homeostasis

  • Natalia Rukoyatkina,
  • Igor Mindukshev,
  • Diana M. Mikhailova,
  • Mikhail A. Panteleev and
  • Stepan Gambaryan

20 November 2025

Thymoquinone (TQ), the main bioactive ingredient of Nigella sativa, exhibits numerous pharmacological activities and is used for the prevention of many diseases including hypertension and cancer. However, information concerning the effects of TQ on p...

  • Review
  • Open Access
714 Views
24 Pages

20 November 2025

Eosinophils, once primarily considered strictly end-stage effector cells in parasitic infections and allergic inflammation, are now emerging as vital immunoregulatory cells. This review focuses on eosinophil contributions to cell-mediated adaptive im...

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Cells - ISSN 2073-4409