Search Results (1,984)

The issue of formulating scientifically sound standards for mercury (Hg) content in Arctic soils is becoming increasingly pertinent in view of the rising human impact and climate change, which serve to augment the mobility of Hg compounds and their involvement in biogeochemical processes. In the absence of uniform criteria for regulating Hg concentrations, it is particularly important to determine its geochemical baseline values and the factors that determine the spatial and vertical distribution of the element in the soil profile. The study conducted a comprehensive investigation of Hg content and patterns of its distribution in various types of tundra soils in the European North-East of Russia. The mass fraction of total Hg was determined by atomic absorption spectrometry, and the spatial features of accumulation were analysed using geoinformation technologies. The distribution of Hg in the soils of the tundra zone was found to be distinctly mosaic in nature, determined by the combined influence of organic matter, granulometric composition, and hydrothermal conditions. It has been established that the complex influence of the physicochemical properties of soils determines the spatial heterogeneity of Hg distribution in the soils of the tundra zone. The most effective Hg accumulators are peat and gley horizons enriched with organic matter and physical clay fraction, while in Podzols, vertical migration of Hg is observed in the presence of a leaching water regime. In order to standardise geochemical baseline Hg values, a 95% upper confidence limit (UCL_95%) is proposed. This approach enables the consideration of natural background fluctuations and the exclusion of extreme values. The results obtained provide a scientific basis for the establishment of standards for Hg content in background soils of the Arctic. Full article

In modern construction, natural materials with a low carbon footprint and full recyclability are becoming increasingly important. A typical group here is products made from solid wood, including glued wood, plywood, and wood-based composites. With their many advantages, however, they all burden the environment with the costs of production processes, as well as the need to use harmful chemicals (adhesives and impregnants). Solid wood is devoid of these disadvantages; however, it is often treated as a rather archaic material. One of the arguments here is its low durability compared to, e.g., glued wood. The article discusses the durability of solid wood using the example of a group of wooden churches preserved in Poland, in Upper Silesia. Some of these buildings are over five hundred years old, making them a reliable source of information about the durability of the material from which they were built. A total of 85 churches, at least 200 years old, were analyzed, evaluating the technical state of the main load-bearing elements of their structures. In view of the number of facilities and the inability to conduct tests in most of them, the assessment was limited to a visual inspection of the technical condition, carried out by an experienced building expert. The assessment estimated the area of corrosion damage, probed its depth, and measured the depth of cracks. The relationship between their technical condition and the environmental conditions in which they were used was described and discussed. In this way, both the threats to the durability of solid wood and the ways to keep it in good condition for hundreds of years were identified, refuting the thesis that solid wood is a material with low durability. Its use in structural elements therefore supports efficient resource management and contributes to sustainable construction, especially in small and medium-sized buildings. Full article

In his innovative and creative attempt to reconcile empiricism and religion, William James made the case for finite theism and a pluralistic conception of the cosmos involving overlapping minds of several scales. In doing so, James also cautioned against abandoning functional psychology in favor of what he called entitative points of view. In his work, Ralph Barton Perry critiqued James for understating the role of embodiment in cognition. In Perry’s view, the central role the body plays in cognition suggests that so-called social or composite minds lack integration and are thus cognitively inferior to embodied minds. However, Perry also believed that the emergent character of embodied cognition provides grounds for an alternative, humanistic spirituality. In this article, I compare James and Perry on theology, and I argue that Perry’s concerns about the importance of embodiment in cognitive integration help illuminate a tripartite distinction between what I call impersonal, subpersonal, and personal theologies that scholars looking for more embodied approaches to theology would do well to consider. Full article

Rubber particles have been proven to have the advantages of improving the energy absorption effect and enhancing the friction between soil particles when used to modify the soil. The rubber-modified soil technology also provides a new solution for the pollution-free disposal of waste rubber. However, when rubber particles are used to modify collapsible loess, they cannot significantly enhance its strength. Previous studies have not systematically clarified whether combining rubber particles with different cementation mechanisms can overcome this limitation, nor compared their shear mechanical effectiveness under identical conditions. In view of this, a dual synergistic strategy is implemented by combining rubber with lime and rubber with enzyme-induced calcium carbonate precipitation (EICP). Direct shear tests and scanning electron microscopy are used to evaluate four modification approaches: rubber alone, lime alone, rubber with EICP, and rubber with lime. Accordingly, shear strength, cohesion, and internal friction angle are quantified. At a vertical normal stress of 100 kPa and above, samples modified with rubber and lime (7–9% lime and 6–8% rubber) achieve peak shear strength values of 200–203 kPa, representing an 86.4% increase compared to rubber alone. Microscopic analysis reveals that calcium silicate hydrate gel effectively anchored rubber particles, forming a composite structure with a rigid skeleton and elastic buffer. In comparison, the rubber and EICP group (10% rubber) shows a substantial increase in internal friction angle (24.25°) but only a modest improvement in cohesion (16.5%), which is due to limited continuity in the calcium carbonate bonding network. It should be noted that the performance of EICP-based modification is constrained by curing efficiency and reaction continuity, which may affect its scalability in conventional engineering applications. Overall, the combination of rubber and lime provided an optimal balance of strength, ductility, and construction efficiency. Meanwhile, the rubber and EICP method demonstrates notable advantages in environmental compatibility and long-term durability, making it suitable for ecologically sensitive applications. The results offer a framework for loess stabilization based on performance adaptation and resource recycling, supporting sustainable use of waste rubber in geotechnical engineering. Full article

This study presents an integrated, low-cost system for measuring extremely small displacements in Ionic Polymer–Metal Composite (IPMC) actuators operating in aqueous environments. A custom optical setup was developed, combining a glass tank, a tubular microscope with a 10× achromatic objective, a digital USB camera and uniform LED backlighting, enabling side-view imaging of the actuator with high contrast. The microscopy system achieves a spatial sampling of 0.536 μm/pixel on the horizontal axis and 0.518 μm/pixel on the vertical axis, while lens distortion is limited to a maximum edge deviation of +0.015 μm/pixel (≈+2.8%), ensuring consistent geometric magnification across the field of view. On the image-processing side, a predictive grid-based tracking algorithm is introduced to localize the free tip of the IPMC. The method combines edge detection, Harris corners and a constant-length geometric constraint with an adaptive search over selected grid cells. On 1920 × 1080-pixel frames, the proposed algorithm achieves a mean processing time of about 10 ms per frame and a frame-level detection accuracy of approximately 99% (98.3–99.4% depending on the allowed search radius) for actuation frequencies below 2 Hz, enabling real-time monitoring at 30 fps. In parallel, dedicated electronic circuitry for supply and load monitoring provides overvoltage, undervoltage, open-circuit and short-circuit detection in 100 injected fault events, all faults were detected and no spurious triggers over 3 h of nominal operation. The proposed microscopy and tracking framework offer a compact, reproducible and high-resolution alternative to laser-based or Digital Image Correlation techniques for IPMC displacement characterization and can be extended to other micro-displacement sensing applications in submerged or challenging environments. Full article

This research focusses on three satellite-derived bathymetry methods and optical satellite instruments: (1) a stereo photogrammetry bathymetry module (SaTSeaD) developed for the NASA Ames stereo pipeline open-source software (version 3.6.0) using stereo WorldView data; (2) physics-based radiative transfer equations (PBSDB) using Landsat data; and (3) a modified composite band-ratio method for Sentinel-2 (SatBathy) with an initial simplified calibration, followed by a more rigorous linear regression against in situ bathymetry data. All methods were tested in three different areas with different geological and environmental conditions, Cabo Rojo, Puerto Rico; Key West, Florida; and Cocos Lagoon and Achang Flat Reef Preserve, Guam. It is demonstrated that all satellite derived bathymetry (SDB) methods have increased accuracy when the results are aligned with higher-accuracy ICESat-2 ATL24 track bathymetry data using the iterative closest point (ICP). SDB vertical accuracy depends more on location characteristics than the method or optical satellite instrument used. All error metrics considered (mean absolute error, median absolute deviation, and root mean square error) can be less than 5% of the maximum bathymetry depth penetration for at least one method, although not necessarily for the same method for all sites. The SDB error distribution tends to be bimodal irrespective of method, satellite instrument, alignment, site, or maximum bathymetry depth, leading to the potential ineffectiveness of traditional error metrics, such as the root mean square error. However, our analysis demonstrates that performing detrending where possible can achieve an error distribution as close to normality as possible for which error metrics are more diagnostic. Full article

Schinus molle L. Essential Oil (SMEO) displays a rich scientific literature, including preliminary studies on its antimicrobial, antioxidant, and anti-cancer properties. This review seeks to systematically analyze the influence of the chemotype diversity of SMEO on its biological and pharmaceutical applications, with a particular focus on antimicrobial, antioxidant, and anti-cancer activities, and to identify research gaps for effective pharmaceutical exploitation. The article selection process was carried out in June 2025 and focused on the PubMed, Scopus, and MDPI databases, producing 176 articles, of which 51 were selected for this review. The present systematic review included the articles published in English and Spanish, with no limitations on the year of publication; data from patent and symposium abstracts were excluded. A qualitative assessment of the selected articles was carried out, including a TRL (Technology Readiness Level) analysis. The results were summarized using hierarchical cluster analysis and a strategic patent search tree, and were processed into tables, graphs, and a heat map, which enabled discussions and proposals for new research trends to be developed. The chemical composition varies significantly depending on the production area, climatic conditions, and seasonality, but the presence of two prevalent chemotypes is evident, α-phellandrene and sabinene, respectively. Data on antimicrobial, antioxidant, and anti-cancer activity were promising, and some formulation prototypes are available, pointing toward the potential development of pharmaceutical and veterinary products. The use of nanotechnology appears to be crucial for the potential pharmaceutical application of SMEO, but further studies are needed. Specifically, further investigation of the properties of SMEO or its components in wound healing applications could represent a new research trend. This review highlights the state of the art of pharmacological research on SMEO and suggests future research directions with a view to develop formulations suitable for safety and efficacy improvements. Full article

Recent studies show that titanium (Ti)-based alloys combine established mechanical strength, corrosion resistance, and biocompatibility with emerging electrical and electrochemical properties relevant to bioelectronics. The main goal of the present manuscript is to give a wide-ranging overview on the use of Ti-alloys in electronics and biomedicine, focusing on a comprehensive analysis and synthesis of the existing literature to identify gaps and future directions. Concurrently, the identification of possible correlations between the effects of the manufacturing process, alloying elements, and other degrees of freedom influencing the material characteristics are put in evidence, aiming to establish a global view on efficient interdisciplinary efforts to realize high-added-value smart devices useful in the field of biomedicine, such as, for example, implantable apparatuses. This review mostly summarizes advances in surface modification approaches—including anodization, conductive coatings, and nanostructuring that improve conductivity while maintaining biological compatibility. Trends in applications demonstrate how these alloys support smart implants, biosensors, and neural interfaces by enabling reliable signal transmission and long-term integration with tissue. Key challenges remain in balancing electrical performance with biological response and in scaling laboratory modifications for clinical use. Perspectives for future work include optimizing alloy composition, refining surface treatments, and developing multifunctional designs that integrate mechanical, biological, and electronic requirements. Together, these directions highlight the potential of titanium alloys to serve as foundational materials for next-generation bioelectronic medical technologies. Full article

Plants secrete a heterogenous population of membrane-enclosed extracellular vesicles that harbour an incredible diversity of molecular cargo. It is the complexity of the molecular cargo encapsulated by plant extracellular vesicles (PEVs) which facilitates the fundamental role PEVs play in mediating communication and signalling. PEV molecular cargo is composed of a diverse mixture of lipids, metabolites, proteins, and nucleic acids. Among the nucleic acids, the microRNA (miRNA) class of small regulatory RNA can be viewed as one of the most biologically relevant. Plant miRNAs regulate the expression of genes essential for all aspects of development as well as to control the gene expression changes required to drive the adaptive and defensive responses of plants to environmental stress and pathogen attack. Furthermore, recent research has shown that specific miRNA cohorts are selectively packaged into PEVs as part of the molecular-level response of a plant to its growth environment. For example, PEVs are loaded with a specific miRNA population for their targeted delivery to sites of pathogen infection in the host plant, or for cross-kingdom delivery of host-plant-encoded miRNAs to the pathogen itself. Here we outline PEV physical properties, compare PEV biogenesis pathways, detail the composition of PEV molecular cargo, and go on to provide detailed commentary on the role of PEV-delivered miRNAs in plant development, environmental stress adaptation, and pathogen defence. We conclude this article with a proposal for the potential future use of PEVs and their miRNA cargo in agriculture and aquaculture. Full article

To systematically investigate how the olfactory system of Bombus terrestris adapts to its social division of labor and reproductive strategies, this study integrated the micromorphology of antennal sensilla and the expression profiles of olfactory receptor (OR) genes from the heads of its three castes (workers, drones, and queens) for a multi-level analysis. Scanning electron microscopy (SEM) revealed that drones possess significantly longer chaetic sensilla (Sch), sensilla trichodea (Str A/B), and sensilla basiconica (Sba A), as well as larger-diameter sensilla coeloconica (Sco) compared to workers and queens, indicating structural and functional specialization for sensitive detection of single key signals (e.g., queen pheromones). In contrast, workers and queens exhibited a more complete composition of sensilla types and a higher sensilla distribution density, suggesting the construction of a perceptual system capable of processing multiple chemical signals simultaneously. RNA-seq combined with qRT-PCR confirmed the significant upregulation of seven OR genes (e.g., BterOR3, BterOR4) in drones, while workers showed upregulation of BterOR3/5/7 accompanied by enrichment of P450 detoxification pathways. Phylogenetic analysis suggested that BterOR5 serves as a conserved co-receptor, and some OR genes may originate from recent duplication events. In summary, distinct differences were observed in the morphological structure and molecular expression of the olfactory system among B. terrestris castes. Drones exhibited structural and gene expression features consistent with specialization in queen pheromone detection, while workers and queens demonstrated sensilla diversity and olfactory receptor expression patterns indicative of a broader response capacity to diverse chemical signals. These findings support the view that the olfactory system has undergone multi-level adaptive evolution driven by social division of labor and reproductive roles. Full article

This paper presents a case study framework for the operational reliability monitoring of a grid-connected photovoltaic (PV) inverter using SCADA measurements collected during February–April 2025. The workflow combines correlation-based drift analysis, probabilistic outputs from established machine learning models (XGBoost and LSTM), and temporal consistency modeled through a hidden Markov model (HMM). The resulting evidence is summarized into two interpretable composite indicators: a Health Index (HI), intended to capture short-term deviations, and a Reliability Score (RS), intended to provide a smoother reliability-oriented summary over time. A time-aware evaluation protocol is employed to reduce temporal leakage and to assess predictive utility under rare-event conditions, complemented by baseline comparisons and sensitivity checks for key thresholds and modeling settings. Within the analyzed dataset, the results suggest that HI is responsive to transient disturbances, while RS supports trend monitoring and maintenance prioritization by consolidating multiple weak signals into a consistent operational view. The proposed indicators are positioned as data-driven risk summaries for decision support rather than direct physical measures of deviation patterns. Generalization to other inverters and sites requires further validation on longer horizons and with additional operational/maintenance records. Full article

As an important natural enemy insect, Harmonia axyridis has significant biological control effects on a variety of pests such as aphids in agroforestry ecosystems. The large-scale application of H. axyridis has long been limited by the unstable supply of natural prey, poor rearing of alternative prey and artificial diets, and high costs. In this paper, we review the research progress on the effects of alternative prey and artificial diets, and present the results and shortcomings of H. axyridis rearing. Focusing on the nutritional requirements of H. axyridis and the nutrient composition of natural prey, the paper aims to analyze and optimize the core components of artificial diets, develop diet formulations that are highly efficient, low-cost, support the ladybird throughout its complete life cycle, and identify the key factors for breaking the bottleneck of large-scale reproduction of H. axyridis, with a view to facilitate the industrialization of H. axyridis, enhancing the efficacy of biocontrol, and providing references to the development of diets for other natural enemy insects. Full article

Due to their high content of bioactive compounds with anticancer properties, essential oils (EO) are increasingly viewed as valuable therapeutic strategies in oncology. The aim of this study was to evaluate the chemical composition and anticancer activity of Cedrus atlantica EO (CAEO) and its PEG-400 and Tween 20 formulations. The gas-chromatography (GC) analysis revealed a sesquiterpene-rich profile, with β-himachalene (39.32%) as the major constituent, followed by α-Himachalene (16.76%) and γ-Himachalene (12.92%). The cytotoxicity studies, performed using Alamar Blue assay on normal HaCaT human keratinocytes and A375 human melanoma and HT-29 colorectal carcinoma cell lines, revealed that CAEO displayed minimal toxicity on HaCaT cells, while significantly reducing A735 and HT-29 cell viability, at any of the concentrations tested. The PEG- and Tween-based formulations of CAEO exhibited the same effect on cell viability as the simple water dispersion of CAEO. The immunofluorescence-based examination of cellular morphology suggested that CAEO induces apoptosis in both cancer cell lines: A375 and HT-29; this apoptosis-related mechanism was further supported by the caspase-3/7 assay, which revealed a significant increase in caspase-3/7 activity after CAEO treatment. To further investigate the underlying mechanism, the JC-1 staining and high-resolution respirometry assays demonstrated that CAEO induces mitochondrial membrane depolarization and reduced mitochondrial active respiration (OXPHOS). Molecular docking further indicated that isoledene and β-himachalene exhibit the highest predicted affinity for PI3Kγ, suggesting a potential involvement of PI3K-related signaling in the pro-apoptotic activity of CAEO. Together, these results suggest that CAEO induces apoptosis through a mitochondria-mediated mechanism. Full article

Cell membrane receptors play key roles in physiological and pathological processes, yet the mechanisms governing their expression and distribution across the plasma membrane remain not completely understood. Broadly, membrane receptors can be categorized into phasic and tonic receptors. Tonic GABA-A receptors have attracted considerable interest due to their distinct molecular composition and their capacity to mediate highly sensitive, sustained inhibitory responses in the presence of ambient GABA. Traditionally, these receptors have been described as residing in peri- and extrasynaptic regions, where they are thought to sense GABA spillover and generate tonic inhibition. However, evidence accumulated over several decades has challenged this canonical view. Multiple studies have reported activity-dependent and pathology-associated relocalization of tonic GABA-A receptor subunits from their typical peri- and extrasynaptic domains into the synaptic cleft. This phenomenon has been documented in both in vivo and in vitro models, yet major questions remain regarding its occurrence, underlying mechanisms, functional significance, and adaptive value. This review synthesizes current evidence and highlights ongoing controversies surrounding the ultrastructural localization of tonic GABA-A receptors. Based on an exhaustive search of the PubMed database, this review summarizes key findings from studies investigating the subcellular distribution of these receptors and discusses emerging perspectives on their potential synaptic presence. Full article

The gut–brain axis is a bidirectional communication network in which gut microbiota and their metabolites influence central nervous system (CNS) function. Among these metabolites, bile acids have emerged as key signaling molecules that modulate metabolic and neuroendocrine pathways. Microbiota-mediated modifications of bile acid composition affect receptors such as farnesoid X receptor (FXR)and Takeda G protein-coupled receptor 5 (TGR5), thereby influencing neuronal activity, appetite control, glucose metabolism, and energy balance. Emerging evidence indicates that bile acids act both directly on the CNS and indirectly via endocrine and immune mediators, linking microbial metabolism to brain function. By integrating microbiological, metabolic, and neuroendocrine perspectives, bile acids can be viewed as critical messengers in the communication between the gut microbiota and the CNS. The purpose of this review is thus to synthesize current mechanisms underlying these interactions and highlight their therapeutic potential in metabolic and neurodegenerative disorders. Full article