Arches and vaults are typical elements of ancient buildings. They are formed by voussoirs that resist the pressure they receive and transmit them through compression forces. The transmission of these forces justifies their curved shape. For this reas...
Domes, vaults and arches are structural components of high vulnerability, due to the horizontal component of the thrust they impose to the supporting vertical elements (piers or walls), accentuated by the asymmetry of loading due to seismic actions....
Non-coding RNAs have been described as crucial regulators of gene expression and guards of cellular homeostasis. Some recent papers focused on vault RNAs, one of the classes of non-coding RNA, and their role in cell proliferation, tumorigenesis, apop...
After the Spanish Civil War, the shortage of building materials in the country and the restrictions imposed by the Dirección General de Arquitectura limited the use of steel in construction, encouraging solutions that reduced the consumption o...
The importance of non-coding RNAs for regulating gene expression has been uncovered in model systems spanning all three domains of life. More recently, their involvement in modulating signal transduction, cell proliferation, tumorigenesis and cancer...
This work investigates the acoustic characteristics of the double elliptical vault, which overlooks the Grand Staircase of the Royal Palace of Caserta (Italy). The Royal Palace was built by the architect Luigi Vanvitelli in the Seventeenth Century an...
Vault particles (VPs) are highly conserved large ribonucleoprotein complexes found exclusively in eukaryotes. They play critical roles in various cellular processes, but their involvement in cancer progression and multidrug resistance (MDR) is the mo...
Vaults are eukaryotic ribonucleoproteins consisting of 78 copies of the major vault protein (MVP), which assemble into a nanoparticle with an about 60 nm volume-based size, enclosing other proteins and RNAs. Regardless of their physiological role(s),...
Content hiding, or vault applications (apps), are designed with a secondary, often concealed purpose, such as encrypting and storing files. While these apps may serve legitimate functions, they unequivocally present significant challenges for law enf...
In seismic areas, masonry construction is prone to brittle failures due to the mechanical behavior of the constituent materials and to the low capacity of force redistributions. The redistribution capacity is mainly due to the presence of horizontal...
This study aimed to compare the achieved vault using a manufacturer’s nomogram and the predicted vault using the currently available prediction formulas after posterior chamber phakic intraocular lens (EVO Implantable Collamer Lens; ICL, STAAR...
We attempted the in vitro scaffold-coordinated refolding of denatured major vault protein monomers into assembled vault-like nanoparticles. DNA or hyaluronic acid-binding tags were added to the MVP monomers, allowing MVP to align rotationally and tra...
Vaults are protein nanoparticles that are found in almost all eukaryotic cells but are absent in prokaryotic ones. Due to their properties (nanometric size, biodegradability, biocompatibility, and lack of immunogenicity), vaults show enormous potenti...
The present work focuses on the solid modeling of the church of Santa Sofia in Benevento, Italy, and is related to a multidisciplinary research project that involved methods typical to both the humanities and mathematical engineering. Starting from t...
Designing a database is a crucial step in providing businesses with high-quality data for decision making. The quality of a data model is the key to the quality of its data. Evaluating the quality of a data model is a complex and time-consuming task....
The application of the elasto-plastic material model known as the Barcelona Model (BM) for numerical assessment of a historical vault subjected to earthquake sequence is presented in this work. As a case study, part of a masonry vault erected in Sout...
The vault nanoparticle is a eukaryotic ribonucleoprotein complex consisting of 78 individual 97 kDa-“major vault protein” (MVP) molecules that form two symmetrical, cup-shaped, hollow halves. It has a huge size (72.5 × 41 × 41 nm) and an internal cav...
The vault nanoparticle is a eukaryotic assembly consisting of 78 copies of the 99-kDa major vault protein. They generate two cup-shaped symmetrical halves, which in vivo enclose protein and RNA molecules. Overall, this assembly is mainly involved in...
Chlamydia trachomatis genital infection is the most common sexually transmitted bacterial disease, causing a significant burden to females due to reproductive dysfunction. Intensive screening and antibiotic treatment are unable to completely prevent...
21 April 2016
Posterior cranial vault distraction (PCVD) has become an important modality in the management of complex craniosynostosis to increase intracranial volume and improve the cranial vault appearance. This technique can safely be performed as early as 3 m...
Background and Objectives: Uterosacral ligaments (USLs) suspension is a well-studied, safe, and long-lasting technique for central compartment correction. Preliminary clinical experiences showed encouraging data for this technique, also for post-hyst...
Until now, the technology behind building systems has largely been neglected, and an exploration of the cultural transmission of these systems has been undervalued as a way of understanding changes in the symbolic worldview of society. This article a...
Cancers display dynamic interactions with their complex microenvironments that influence tumor growth, invasiveness, and immune evasion, thereby also influencing potential resistance to therapeutic treatments. The tumor microenvironment (TME) include...
Precast concrete industrial buildings are typically characterised by high fire risk due to the production or storage of materials/products having high combustion potential and the specific activities carried out in the facility. Due to the large dime...
Background: Cranial vault lesions are common in children, with dermoid and epidermoid cysts being the most frequent. Management is debated due to their slow growth, but early resection can prevent complications and provide a definitive histological d...
1 December 2014
The AOCMF Classification Group developed a hierarchical three-level craniomaxillofacial classification system with increasing level of complexity and details. The highest level 1 system distinguish four major anatomical units, including the mandible...
Introduction: Vault particles are large cytoplasmic ribonucleoprotein particles that participate in inflammation. The aim of this study was to assess the diagnostic and prognostic value of major vault protein (MVP) in patients with inflammation, in o...
The fuzzy vault is an innovative way to share secret keys, combining traditional cryptography with biometrics and biometric template protection. This method forms the basis for the reliable operation of unmanned aerial vehicles (UAVs) through anonymi...
This paper presents a parametric stability study of groin, or cross vaults, a structural element widely used in old masonry construction, particularly in Gothic architecture. The vaults’ stability is measured using the geometric safety factor (GSF),...
The mammalian intestinal epithelium is a rapid self-renewing tissue that functions as a physical barrier against a wide array of noxious substances and the gut microbiome that inhabit the intestinal lumen. Homeostasis of the intestinal epithelium is...
This research concerns the introduction and the structural analysis of masonry vaults in Puglia, a region in the south part of Italy, built between the sixteenth and the seventeen centuries. Such vaults have special shapes that make them unique in th...
The complex structural behaviour of masonry, with its brittle response in tension, frictional response in shear, and anisotropy, makes it challenging to model accurately. Tile vaults, with their unique features such as different binders and bricks pl...
The stabilization and reinforcement of damaged barrel vaults with lunettes over an arcaded walk, applying composite strips based on high-strength carbon fibers and epoxy resin, was performed during the restoration of a historic monastery. The applica...
This article presents the study of an architectural-constructive type located in Valencia: ribless brick vaults built with the “catalan” technique (one single brick plement approximately 5 cm thick). This is a very specific variant of the...
This study explores the innovative application of Artificial Intelligence (AI) in transforming data engineering practices, with a specific focus on optimizing data modeling and data warehouse automation for Business Intelligence (BI) systems. The pro...
The assessment of the equilibrium and the safety of masonry vaults is of high relevance for the conservation and restoration of historical heritage. In the literature many approaches have been proposed for this tasks, starting from the 17th century....
In the present study, large-scale specimens based on the tunnel prototype were prepared and static load tests were carried out to investigate the damage caused by lining voids. Based on the strengthening scheme of the tunnel, the strengthened specime...
The use of smart drug delivery systems (DDSs) is one of the most promising approaches to overcome some of the drawbacks of drug-based therapies, such as improper biodistribution and lack of specific targeting. Some of the most attractive candidates a...
The paper presents the results of experimental and numerical tests on barrel vaults with backfill material. The thickness, internal span, and rise of the vaults were 125 mm, 2000 mm, and 730 mm, respectively. In experimental studies, vaults with back...
Thin-tile vaults, characterized by a wide variety of geometric configurations, represent an important part of the architectural heritage in Southern Italy. Many of these structures are still in serviceable condition. However, the absence of dedicated...
A triangular parabolic cross vault, that was designed by Musmeci in the 1950s as a reinforced concrete structure but remained unbuilt, is revisited from the original perspective of its reinvention as a masonry structure. In the framework of static li...
In recent years, many efforts have been invested in the cultural heritage digitization: surveying, modelling, diagnostic analysis and historic data collection. Nowadays, this effort is finalized in many cases towards historical building information m...
This research examines the structural behavior of the central vault of the Matriz church that collapsed during the 1949 earthquake in Ambato, Ecuador. Following the disaster, the church and Episcopal Palace were demolished. The central vault lacked b...
Performance on vault in artistic gymnastics depends on the difficulty and the execution quality of the performed vault. However, differences of kinetic energy between simple and difficult vaults remain elusive. Therefore, in this study, 48 Tsukahara...
In the field of documentation and preservation of cultural heritage, there is keen interest in 3D metric viewing and rendering of architecture for both formal appearance and color. On the other hand, operative steps of restoration interventions still...
This study analyzes the thermo-mechanical behavior of a brick vault and the effect of a fire on its dynamic characteristics. Based on the results of an experimental test of a real barrel vault with a net span of 161 cm and a net rise of 46.5 cm, an a...
This research presents a new intervention methodology on arches and vaults of a Renaissance factory in the Colegio Santo Domingo de Orihuela (16th century) using 3D software LIDAR technology that verifies the execution process of the works studying t...
The present paper investigates the fundamental characteristics of wind loading on vaulted (cylindrical) free roofs based on a wind tunnel experiment and a computational fluid dynamics (CFD) analysis using Large Eddy Simulation (LES). In the wind tunn...
29 August 2016
Nowadays the reconstruction of craniofacial defects can be performed with different kinds of materials, which include the bone and the so-called biomaterials, which have the advantage of not needing a surgical site donor. Among these materials, great...
Background/Objectives: Facial asymmetry is known to cause not only deformities in the facial skeleton but also alterations in the cranial vault. However, limited research has explored the association between mandibular asymmetry and cranial vault def...
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