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157 Results Found

  • Article
  • Open Access
6 Citations
3,228 Views
23 Pages

30 September 2018

The problem of multilevel diversity coding with secure regeneration (MDC-SR) is considered, which includes the problems of multilevel diversity coding with regeneration (MDC-R) and secure regenerating code (SRC) as special cases. Two outer bounds are...

  • Article
  • Open Access
2 Citations
1,940 Views
11 Pages

Cloud storage is an indispensable part of cloud computing solutions and the security of its stored data has become a key issue in the research and application of cloud storage systems. To solve this problem, this paper studies the anti-eavesdropping...

  • Review
  • Open Access
16 Citations
3,566 Views
19 Pages

18 January 2023

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology in many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) in liver disease and regener...

  • Article
  • Open Access
8 Citations
2,963 Views
10 Pages

Liver regeneration plays a significant role in protecting liver function after liver injury or chronic liver disease. Long non-coding RNAs (lncRNAs) are considered to be involved in the proliferation of hepatocytes and liver regeneration. Therefore,...

  • Review
  • Open Access
10 Citations
11,603 Views
16 Pages

30 September 2015

Growth factors and other agents that could potentially enhance tissue regeneration have been identified, but their therapeutic value in clinical medicine has been limited for reasons such as difficulty to maintain bioactivity of locally applied thera...

  • Article
  • Open Access
12 Citations
3,569 Views
15 Pages

Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/β-Catenin Signaling Pathway

  • Juan Liu,
  • Xin Qi,
  • Xiao-Hong Wang,
  • Hong-Sheng Miao,
  • Zi-Chao Xue,
  • Le-Le Zhang,
  • San-Hu Zhao,
  • Liang-Hao Wu,
  • Guo-Yi Gao and
  • Cheng-Qing Yi
  • + 1 author

13 January 2022

Background: Previous studies have demonstrated that long non-coding RNA maternally expressed gene 3 (MEG3) emerged as a key regulator in development and tumorigenesis. This study aims to investigate the function and mechanism of MEG3 in osteogenic di...

  • Article
  • Open Access
3 Citations
3,193 Views
22 Pages

11 August 2022

Caudal fin regeneration is regulated by a variety of mechanisms, but the role of long non-coding RNA (lncRNA) has rarely been studied. The present study aimed to describe the landscape of lncRNAs during caudal fin regeneration using whole transcripto...

  • Review
  • Open Access
8 Citations
3,646 Views
18 Pages

Non-Coding RNAs in Stem Cell Regulation and Cardiac Regeneration: Current Problems and Future Perspectives

  • Victor Schweiger,
  • Ena Hasimbegovic,
  • Nina Kastner,
  • Andreas Spannbauer,
  • Denise Traxler,
  • Mariann Gyöngyösi and
  • Julia Mester-Tonczar

25 August 2021

Although advances in rapid revascularization strategies following acute myocardial infarction (AMI) have led to improved short and long-term outcomes, the associated loss of cardiomyocytes and the subsequent remodeling result in an impaired ventricul...

  • Retraction
  • Open Access
712 Views
1 Page

31 August 2025

The journal retracts the article titled “Regulation of Long Non-Coding RNA-Dreh Involved in Proliferation and Migration of Hepatic Progenitor Cells during Liver Regeneration in Rats” [...]

  • Feature Paper
  • Article
  • Open Access
12 Citations
4,443 Views
17 Pages

This paper summarizes the details of recently proposed binary locally repairable codes (BLRCs) and their features. The construction of codes over a small alphabet size of symbols is of particular interest for efficient hardware implementation. Theref...

  • Article
  • Open Access
6 Citations
4,695 Views
17 Pages

22 October 2017

Fractional repetition (FR) codes are a class of distributed storage codes that replicate and distribute information data over several nodes for easy repair, as well as efficient reconstruction. In this paper, we propose three new constructions of FR...

  • Article
  • Open Access
3 Citations
3,125 Views
21 Pages

Nano Modification of Antrodia Cinnamomea Exhibits Anti-Inflammatory Action and Improves the Migratory Potential of Myogenic Progenitors

  • Mridula P. Menon,
  • Yi-Hsuan Chien,
  • Joy Thomas,
  • Yu-Hsiang Yu,
  • Chang-Tang Chang and
  • Kuo-Feng Hua

12 August 2022

The skeletal muscle progenitors’ proliferation and migration are crucial stages of myogenesis. Identifying drug candidates that contribute to myogenesis can have a positive impact on atrophying muscle. The purpose of the study is to synthesize...

  • Article
  • Open Access
1,583 Views
21 Pages

This paper proposes a free-space time–frequency phase (TFP)-synchronization transmission architecture based on optoelectronic hybrid technology, addressing the high-precision TFP synchronization and high-speed communication requirements between...

  • Article
  • Open Access
1,001 Views
19 Pages

17 March 2025

A clustered distributed storage system (DSS), also called a rack-aware storage system, is a distributed storage system in which the nodes are grouped into several clusters. The communication between two clusters may be restricted by their connectivit...

  • Review
  • Open Access
26 Citations
5,325 Views
26 Pages

Applications of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

  • Burcak Yavuz,
  • Esra Cansever Mutlu,
  • Zubair Ahmed,
  • Besim Ben-Nissan and
  • Artemis Stamboulis

Extracellular vesicles (EVs), including exosomes, microvesicles, and other lipid vesicles derived from cells, play a pivotal role in intercellular communication by transferring information between cells. EVs secreted by progenitor and stem cells have...

  • Review
  • Open Access
5 Citations
4,812 Views
23 Pages

Cell Responsiveness to Physical Energies: Paving the Way to Decipher a Morphogenetic Code

  • Riccardo Tassinari,
  • Claudia Cavallini,
  • Elena Olivi,
  • Federica Facchin,
  • Valentina Taglioli,
  • Chiara Zannini,
  • Martina Marcuzzi and
  • Carlo Ventura

We discuss emerging views on the complexity of signals controlling the onset of biological shapes and functions, from the nanoarchitectonics arising from supramolecular interactions, to the cellular/multicellular tissue level, and up to the unfolding...

  • Review
  • Open Access
21 Citations
7,825 Views
26 Pages

Acute and chronic liver disease continue to result in significant morbidity and mortality of patients, along with increasing burden on their families, society and the health care system. This in part is due to increased incidence of liver disease ass...

  • Review
  • Open Access
10 Citations
3,364 Views
38 Pages

The Role of ncRNAs in Cardiac Infarction and Regeneration

  • Sheila Caño-Carrillo,
  • Estefanía Lozano-Velasco,
  • Juan Manuel Castillo-Casas,
  • Cristina Sánchez-Fernández and
  • Diego Franco

Myocardial infarction is the most prevalent cardiovascular disease worldwide, and it is defined as cardiomyocyte cell death due to a lack of oxygen supply. Such a temporary absence of oxygen supply, or ischemia, leads to extensive cardiomyocyte cell...

  • Article
  • Open Access
5 Citations
2,629 Views
17 Pages

Whole-Transcriptome Sequencing of Antler Tissue Reveals That circRNA2829 Regulates Chondrocyte Proliferation and Differentiation via the miR-4286-R+1/FOXO4 Axis

  • Haibo Yao,
  • Renfeng Jiang,
  • Danyang Chen,
  • Yanjun Li,
  • Mengmeng Song,
  • Zitong Sun,
  • Guohui Long,
  • Lei Wu and
  • Wei Hu

The antler is the unique mammalian organ found to be able to regenerate completely and periodically after loss, and the continuous proliferation and differentiation of mesenchymal cells and chondrocytes together complete the regeneration of the antle...

  • Review
  • Open Access
15 Citations
5,730 Views
20 Pages

28 January 2020

Growth factors, chemokines and cytokines guide tissue regeneration after injuries. However, their applications as recombinant proteins are almost non-existent due to the difficulty of maintaining their bioactivity in the protease-rich milieu of injur...

  • Review
  • Open Access
17 Citations
4,174 Views
17 Pages

Non-Coding RNAs as Regulators of Myogenesis and Postexercise Muscle Regeneration

  • Karolina Archacka,
  • Maria A. Ciemerych,
  • Anita Florkowska and
  • Karolina Romanczuk

26 October 2021

miRNAs and lncRNAs do not encode proteins, but they play an important role in the regulation of gene expression. They differ in length, biogenesis, and mode of action. In this work, we focus on the selected miRNAs and lncRNAs involved in the regulati...

  • Review
  • Open Access
20 Citations
8,060 Views
16 Pages

Circadian Regulation in Tissue Regeneration

  • Ellen Paatela,
  • Dane Munson and
  • Nobuaki Kikyo

Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of r...

  • Review
  • Open Access
41 Citations
6,640 Views
20 Pages

Genetically Engineered-MSC Therapies for Non-unions, Delayed Unions and Critical-size Bone Defects

  • Jaime Freitas,
  • Susana Gomes Santos,
  • Raquel Madeira Gonçalves,
  • José Henrique Teixeira,
  • Mário Adolfo Barbosa and
  • Maria Inês Almeida

The normal bone regeneration process is a complex and coordinated series of events involving different cell types and molecules. However, this process is impaired in critical-size/large bone defects, with non-unions or delayed unions remaining a majo...

  • Review
  • Open Access
34 Citations
6,885 Views
23 Pages

MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy

  • Amelia Eva Aránega,
  • Estefanía Lozano-Velasco,
  • Lara Rodriguez-Outeiriño,
  • Felicitas Ramírez de Acuña,
  • Diego Franco and
  • Francisco Hernández-Torres

microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystro...

  • Article
  • Open Access
5 Citations
2,622 Views
13 Pages

30 June 2023

The purity of hydrogen finally purified in the hydrogen purification process system is greatly influenced by the uniformity of the purification temperature of the dry tower. An in-house code that can be easily used by field designers has been develop...

  • Article
  • Open Access
2 Citations
5,476 Views
25 Pages

Recent AI-assisted coding tools, such as GitHub Copilot and Cursor, have enhanced developer productivity through real-time snippet suggestions. However, these tools primarily assist with isolated coding tasks and lack a structured approach to automat...

  • Article
  • Open Access
2 Citations
3,180 Views
12 Pages

6 September 2022

Apostichopus japonicus achieves intestinal regeneration in a short period after evisceration, and multiple genes are involved in this process. The transcriptome of A. japonicus was screened for regeneration-associated protein (Aj-Orpin), a gene that...

  • Review
  • Open Access
6 Citations
4,131 Views
17 Pages

23 August 2024

Extracellular vesicles (EVs) are nanoscale particles with a lipid bilayer membrane structure secreted by various cell types. Nearly all human cells secrete EVs, primarily mediating intercellular communication. In recent years, scientists have discove...

  • Feature Paper
  • Article
  • Open Access
7 Citations
2,766 Views
14 Pages

lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

  • Bohao Zhao,
  • Jiali Li,
  • Ming Liu,
  • Shuaishuai Hu,
  • Naisu Yang,
  • Shuang Liang,
  • Xiyu Zhang,
  • Yingying Dai,
  • Zhiyuan Bao and
  • Xinsheng Wu
  • + 1 author

6 August 2022

Hair follicles (HFs) are complex organs that grow cyclically during mammals’ growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, c...

  • Article
  • Open Access
816 Views
14 Pages

Efficient Error Correction Coding for Physically Unclonable Functions

  • Sreehari K. Narayanan,
  • Ramesh Bhakthavatchalu and
  • Remya Ajai Ajayan Sarala

Physically unclonable functions (PUFs) generate keys for cryptographic applications, eliminating the need for conventional key storage mechanisms. Since PUF responses are inherently noise-sensitive, their reliability can decrease under varying condit...

  • Feature Paper
  • Article
  • Open Access
8 Citations
9,833 Views
18 Pages

Hardware-Based Run-Time Code Integrity in Embedded Devices

  • Taimour Wehbe,
  • Vincent Mooney and
  • David Keezer

Attacks on embedded devices are becoming more and more prevalent, primarily due to the extensively increasing plethora of software vulnerabilities. One of the most dangerous types of these attacks targets application code at run-time. Techniques to d...

  • Article
  • Open Access
13 Citations
5,778 Views
16 Pages

Urban villages are a modern heritage in China that provide affordable housing for urban immigrants and accommodate diverse communities of cohabitation. The regeneration and displacement of urban villages in the past decade have raised the potential r...

  • Article
  • Open Access
2,384 Views
36 Pages

The Collective Dwelling of Cooperative Promotion in Caselas

  • Vanda Pereira de Matos and
  • Carlos Alberto Assunção Alho

5 August 2025

To solve the present housing crisis, the Support for Access to Housing Program, in the context of PRR, mainly focuses on social housing to be built or on housing of social interest to be regenerated. To approach this problem, a research question was...

  • Review
  • Open Access
30 Citations
6,019 Views
22 Pages

Accelerated urbanization has led to regional disruptions and exacerbated imbalances in spatial quality, social cohesion, and inequalities. Urban regeneration, as a mitigating strategy for these disruptions, faces significant social challenges, partic...

  • Article
  • Open Access
2,229 Views
23 Pages

A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs

  • Pablo Ruiz-Amezcua,
  • Miguel Nieto Hernández,
  • Javier García Flores,
  • Clara Plaza Alonso,
  • David Reigada,
  • Teresa Muñoz-Galdeano,
  • Eva Vargas,
  • Rodrigo M. Maza,
  • Francisco J. Esteban and
  • Manuel Nieto-Díaz

3 September 2025

The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, whose transcriptional architecture under physiological conditions has been characterized in various studies with restricted numbers of individuals...

  • Review
  • Open Access
4 Citations
2,584 Views
25 Pages

The Role of Non-Coding RNAs in Regulating Cachexia Muscle Atrophy

  • Guoming Chen,
  • Jiayi Zou,
  • Qianhua He,
  • Shuyi Xia,
  • Qili Xiao,
  • Ruoxi Du,
  • Shengmei Zhou,
  • Cheng Zhang,
  • Ning Wang and
  • Yibin Feng

27 September 2024

Cachexia is a late consequence of various diseases that is characterized by systemic muscle loss, with or without fat loss, leading to significant mortality. Multiple signaling pathways and molecules that increase catabolism, decrease anabolism, and...

  • Review
  • Open Access
42 Citations
13,104 Views
21 Pages

Small Engine, Big Power: MicroRNAs as Regulators of Cardiac Diseases and Regeneration

  • Darukeshwara Joladarashi,
  • Rajarajan A. Thandavarayan,
  • Sahana Suresh Babu and
  • Prasanna Krishnamurthy

9 September 2014

Cardiac diseases are the predominant cause of human mortality in the United States and around the world. MicroRNAs (miRNAs) are small non-coding RNAs that have been shown to modulate a wide range of biological functions under various pathophysiologic...

  • Article
  • Open Access
11 Citations
3,495 Views
13 Pages

DNA Methylation Mediates lncRNA2919 Regulation of Hair Follicle Regeneration

  • Bohao Zhao,
  • Jiali Li,
  • Ming Liu,
  • Naisu Yang,
  • Zhiyuan Bao,
  • Xiyu Zhang,
  • Yingying Dai,
  • Jiawei Cai,
  • Yang Chen and
  • Xinsheng Wu

22 August 2022

Hair follicles (HFs) are organs that periodically regenerate during the growth and development of mammals. Long non-coding RNAs (lncRNAs) are non-coding RNAs with crucial roles in many biological processes. Our previous study identified that lncRNA29...

  • Article
  • Open Access
9 Citations
3,832 Views
23 Pages

Integrative Analyses of Antler Cartilage Transcriptome and Proteome of Gansu Red Deer (Cervus elaphus kansuensis) at Different Growth Stages

  • Yanxia Chen,
  • Zhenxiang Zhang,
  • Wenjie Jin,
  • Zhaonan Li,
  • Changhong Bao,
  • Caixia He,
  • Yuqin Guo and
  • Changzhong Li

6 April 2022

The velvet antler is a unique model for cancer and regeneration research due to its periodic regeneration and rapid growth. Antler growth is mainly triggered by the growth center located in its tip, which consists of velvet skin, mesenchyme and carti...

  • Review
  • Open Access
2 Citations
2,287 Views
15 Pages

18 November 2023

Cell responses are usually viewed as transitive events with fixed inputs and outputs that are regulated by feedback loops. In contrast, directed cycles (DCs) have all nodes connected, and the flow is in a single direction. Consequently, DCs can regen...

  • Article
  • Open Access
23 Citations
7,814 Views
19 Pages

Transitional Morphologies and Urban Forms: Generation and Regeneration Processes—An Agenda

  • Marco Trisciuoglio,
  • Michela Barosio,
  • Ana Ricchiardi,
  • Zeynep Tulumen,
  • Martina Crapolicchio and
  • Rossella Gugliotta

1 June 2021

Grounded in the study of urban morphology, this position paper seeks to overcome the analysis of the permanent elements of a city in the search for a transitional paradigm in urban morphology, with the aim of grasping the dynamics of urban evolution...

  • Review
  • Open Access
237 Citations
12,193 Views
17 Pages

The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application

  • Teng Sun,
  • Yan-Han Dong,
  • Wei Du,
  • Chun-Ying Shi,
  • Kun Wang,
  • Muhammad-Akram Tariq,
  • Jian-Xun Wang and
  • Pei-Feng Li

MicroRNAs (miRNAs) are a class of small single-stranded and highly conserved non-coding RNAs, which are closely linked to cardiac disorders such as myocardial infarction (MI), cardiomyocyte hypertrophy, and heart failure. A growing number of studies...

  • Review
  • Open Access
14 Citations
5,391 Views
19 Pages

Non-coding RNAs (ncRNAs) play a key role in the regulation of transcriptional and epigenetic activity in mammalian cells. Comprehensive analysis of these ncRNAs has revealed sophisticated gene regulatory mechanisms which finely tune the proper gene o...

  • Review
  • Open Access
619 Views
22 Pages

Urban regeneration is increasingly expected to integrate environmental resilience, social equity, and cultural heritage alongside economic objectives. This narrative review examines how nature-based solutions (NbS) can be embedded within regeneration...

  • Review
  • Open Access
8 Citations
3,699 Views
18 Pages

Non-coding RNAs (ncRNAs) represent a research hotspot by playing a key role in epigenetic and transcriptional regulation of diverse biological functions and due to their involvement in different diseases, including oral inflammatory diseases. Based o...

  • Article
  • Open Access
8 Citations
4,286 Views
13 Pages

Although the study of aerobic methane-oxidizing bacteria (MOB, methanotrophs) has been carried out for more than a hundred years, there are many uncultivated methanotrophic lineages whose metabolism is largely unknown. Here, we reconstructed a nearly...

  • Article
  • Open Access
10 Citations
4,471 Views
27 Pages

Runtime Construction of Large-Scale Spiking Neuronal Network Models on GPU Devices

  • Bruno Golosio,
  • Jose Villamar,
  • Gianmarco Tiddia,
  • Elena Pastorelli,
  • Jonas Stapmanns,
  • Viviana Fanti,
  • Pier Stanislao Paolucci,
  • Abigail Morrison and
  • Johanna Senk

24 August 2023

Simulation speed matters for neuroscientific research: this includes not only how quickly the simulated model time of a large-scale spiking neuronal network progresses but also how long it takes to instantiate the network model in computer memory. On...

  • Feature Paper
  • Article
  • Open Access
32 Citations
5,041 Views
20 Pages

Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets

  • Simranjeet Kaur,
  • Aashiq H. Mirza and
  • Flemming Pociot

27 November 2018

Understanding distinct cell-type specific gene expression in human pancreatic islets is important for developing islet regeneration strategies and therapies to improve β-cell function in type 1 diabetes (T1D). While numerous transcriptome-wide s...

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