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Open AccessFeature PaperArticle

Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets

Steno Diabetes Center Copenhagen, 2820 Gentofte, Denmark
Weill Cornell Medicine, Department of Pharmacology, New York, NY 10065, USA
Copenhagen Diabetes Research Center (CPH-DIRECT), Department of Pediatrics E, Herlev Hospital, 2730 Herlev, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, DK-1165 Copenhagen, Denmark
Author to whom correspondence should be addressed.
Non-Coding RNA 2018, 4(4), 38;
Received: 20 October 2018 / Revised: 16 November 2018 / Accepted: 21 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Non-Coding RNA and Diabetes)
Understanding distinct cell-type specific gene expression in human pancreatic islets is important for developing islet regeneration strategies and therapies to improve β-cell function in type 1 diabetes (T1D). While numerous transcriptome-wide studies on human islet cell-types have focused on protein-coding genes, the non-coding repertoire, such as long non-coding RNA, including circular RNAs, remains mostly unexplored. Here, we explored transcriptional landscape of human α-, β-, and exocrine cells from published total RNA sequencing (RNA-seq) datasets to identify circular RNAs (circRNAs). Our analysis revealed that circRNAs are highly abundant in both α- and β-cells. We identified 10,830 high-confidence circRNAs expressed in human α-, β-, and exocrine cells. The most highly expressed candidates were MAN1A2, RMST, and HIPK3 across the three cell-types. Alternate circular isoforms were observed for circRNAs in the three cell-types, indicative of potential distinct functions. Highly selective α- and β-cell circRNAs were identified, which is suggestive of their potential role in regulating β-cell function. View Full-Text
Keywords: circular RNAs; circRNA; human islets; RNA-seq; type 1 diabetes; β-cell circular RNAs; circRNA; human islets; RNA-seq; type 1 diabetes; β-cell
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MDPI and ACS Style

Kaur, S.; Mirza, A.H.; Pociot, F. Cell Type-Selective Expression of Circular RNAs in Human Pancreatic Islets. Non-Coding RNA 2018, 4, 38.

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