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Review

Circadian Regulation in Tissue Regeneration

1
Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA
2
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(9), 2263; https://doi.org/10.3390/ijms20092263
Received: 16 April 2019 / Revised: 29 April 2019 / Accepted: 3 May 2019 / Published: 8 May 2019
(This article belongs to the Special Issue Circadian Rhythms: Molecular and Physiological Mechanisms)
Circadian rhythms regulate over 40% of protein-coding genes in at least one organ in the body through mechanisms tied to the central circadian clock and to cell-intrinsic auto-regulatory feedback loops. Distinct diurnal differences in regulation of regeneration have been found in several organs, including skin, intestinal, and hematopoietic systems. Each regenerating system contains a complex network of cell types with different circadian mechanisms contributing to regeneration. In this review, we elucidate circadian regeneration mechanisms in the three representative systems. We also suggest circadian regulation of global translational activity as an understudied global regulator of regenerative capacity. A more detailed understanding of the molecular mechanisms underlying circadian regulation of tissue regeneration would accelerate the development of new regenerative therapies. View Full-Text
Keywords: circadian rhythms; tissue regeneration; skin; intestine; hematopoiesis; ribosome biogenesis circadian rhythms; tissue regeneration; skin; intestine; hematopoiesis; ribosome biogenesis
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MDPI and ACS Style

Paatela, E.; Munson, D.; Kikyo, N. Circadian Regulation in Tissue Regeneration. Int. J. Mol. Sci. 2019, 20, 2263. https://doi.org/10.3390/ijms20092263

AMA Style

Paatela E, Munson D, Kikyo N. Circadian Regulation in Tissue Regeneration. International Journal of Molecular Sciences. 2019; 20(9):2263. https://doi.org/10.3390/ijms20092263

Chicago/Turabian Style

Paatela, Ellen, Dane Munson, and Nobuaki Kikyo. 2019. "Circadian Regulation in Tissue Regeneration" International Journal of Molecular Sciences 20, no. 9: 2263. https://doi.org/10.3390/ijms20092263

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