3,856 Results Found

Large portions of high energy dense (HED) snacks are offered to children from a young age and are pervasive in our food environment. This study aimed to explore the feasibility, acceptability, and preliminary efficacy of two strategies of snack porti...

Despite the growing body of research on fuel alternatives for reducing carbon emissions in maritime shipping, there remains a lack of comprehensive cost–benefit analyses from the perspective of shipowners considering both retrofit and new const...

Many countries, including the UK, recommend nicotine replacement therapy (NRT) for smoking cessation during pregnancy. However, adherence to NRT is generally low, smoking lapse or relapse is common and using NRT to reduce the harm from the number of...

The electrochemical formation of nanostructured materials is a cost effective route to creating substrates that can be employed in a variety of applications. In this work the surface of a copper electrode was electrochemically restructured in an alka...

Gaucher disease (GD) is caused by mutations in the GBA gene, leading to deficient activity of the lysosomal enzyme glucocerebrosidase. Among all the symptoms across various organ systems, bone disease is a major concern as it causes high morbidity an...

Switching between enzyme replacement therapies (ERT) and substrate reduction therapies (SRT) in patients with type 1 Gaucher disease (GD1) is not uncommon; however, the reasons for switchng treatments have not been explored in detail. Data from the G...

Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would red...

The development of effective catalysts for the oxygen reduction reaction (ORR) is crucial for improving the performance of fuel cells. Efficient carbon-supported Pt-Co nanocatalysts were successfully prepared by a generic two-step method: (i) electro...

Breast Cancer Associated Susceptibility Proteins Type 1/2 (BRCA1/2) promote cellular functioning by modulating NRF2-mediated antioxidant signaling. Redox failure in women with BRCA1/2 insufficiency increases the risk for breast/ovarian/uterine cancer...

Ambroxol hydrochloride (ABX), an oral mucolytic drug available over the counter for many years, acts as a pharmacological chaperone for mutant glucocerebrosidase, albeit at higher doses. Proof-of-concept reports have been published over the past deca...

Salt (sodium chloride, NaCl) is commonly used in ready-to-eat (RTE) meat products such as biltong, a South African style dried beef product for flavor, enhanced moisture loss, and reduction of microbial growth. However, increased consumption of high...

Meat products are a staple of many diets around the world, but they have been subject to criticism due to their potential negative impact on human health. In recent years, there has been a growing interest in developing novel approaches to improve th...

Developing bifunctional electrocatalysts that simultaneously enable green hydrogen production and water purification is essential for advancing sustainable energy and environmental technologies. In this study, we present Cu@Pd core–shell nanost...

Cheese has been listed as one of four priority food groups intended for salt reduction reformulation. The present study aimed to investigate the possibility of producing Serbian white brined cheese (Homoljski Sir) with half of NaCl, three quarters of...

As the size of modern infrastructure increases, novelties related to mass concrete mixtures including supplementary cementitious materials (SCMs) become critical. The effects of binary and ternary cement replacement mixtures including metakaolin, sil...

The drive for sustainable societies with more resilient infrastructure networks has catalyzed interest in leakage reduction as a subsequent benefit to energy recovery in water distribution systems. Several researchers have conducted studies and pilot...

Due to the rapid growth in global plastic production, in short-term applications, and negative impacts on natural ecosystems, plastics have received much attention. Additionally, the entire plastic value chain generates a significant amount of GHGs,...

Determining minimum levels of fat and sucrose needed for the sensory acceptance of sponge cake while increasing the nutritional quality was the main objective of this study. Sponge cakes with 0, 25, 50 and 75% sucrose replacement (SR) using a combina...

Lifestyle interventions, including meal replacement, are effective in the prevention and treatment of type-2-diabetes and obesity. Since insulin is the key weight regulator, we hypothesised that the addition of meal replacement to a lifestyle interve...

For several decades, cement production has caused concerns about CO2 emissions. As the production of concrete has increased over the years, the fact that cement is its key component additionally raises a concern. By partially replacing cement with wa...

While obesity impairs health-related quality of life (HRQOL), lifestyle interventions targeting weight reduction have been effective in improving HRQOL. Therefore, we hypothesised that a meal replacement-based lifestyle intervention, which has been s...

Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, contr...

The 3Rs aim to refine animal welfare, reduce animal numbers, and replace animal experiments. Investigations disclose that researchers are positive towards 3Rs recommendations from peers. Communication of 3Rs approaches via primary preclinical animal...

The Chinese government promises to reach peak carbon dioxide (CO2) emissions by 2030 and strives to achieve carbon neutralization by 2060. Against this background, achieving emission reduction in the cement industry is in the spotlight. Material subs...

Nowadays, the dietary sodium chloride intake is higher than the daily recommended levels, especially due to its prominent presence in food products. This may cause an increase of high blood pressure leading to cardiovascular diseases. Cereal products...

Objective: Effective strategies are needed to encourage smoking cessation for smokers without an intention to quit. We systematically reviewed the literature to investigate whether smoking reduction therapy can increase the long-term cessation rates...

Infantile-onset lysosomal acid lipase deficiency (LAL-D) (Wolman disease, historically) is a rare inherited, rapidly progressive disorder caused by pathogenic variants in the LIPA gene, which encodes the enzyme LAL. LAL is essential for the metabolis...

Ventilation plays a key role in underground mining. It is essential due to the natural hazards and technological processes that come with the nature of mining. However, it is highly energy consuming and generates significant operating expenditures. F...

Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by the deficiency of α-galactosidase A (α-GalA) and the consequent accumulation of toxic metabolites such as globotriaosylceramide (Gb3) and globotriaosylsphingosine (lysoGb3). Ea...

Reducing fertilizer use and increasing its efficiency will improve the quality of farmland and resource conservation. These are necessary steps to achieving green development in agriculture. Nevertheless, fertilizer-reduction and efficiency-increasin...

This study examines calcium extraction from Bottom Ash (BA) and the use of Solid Residue (SR) as a substitute for White Lump Clay (WLC) in brick production. Experimental analyses identified calcium and silicon as the main elements in BA, with 50% of...

Gravitational hazards, such as rockfall, constitute a major risk in mountainous areas, threatening dwellers, goods, and infrastructures, and ultimately posing a challenge to their development. Ecosystem-based solutions for Disaster Risk Reduction (Ec...

Fabry disease (FD) is a lysosomal storage disorder caused by mutations of the GLA gene that lead to a deficiency of the enzymatic activity of α-galactosidase A. Available therapies for FD include enzyme replacement therapy (ERT) (agalsidase alf...

Wolman disease (WD) is a lethal disorder defined by the deficiency of the lysosomal acid lipase enzyme. Patients present with intestinal failure, malnutrition, and hepatosplenomegaly. Enzyme replacement therapy (ERT) with dietary substrate reduction...

Proximal humerus fracture (PHF) treatment remains challenging. Multiple therapy options exist, and the optimal choice of management has been increasingly discussed in the literature. The aim of this study was to (1) analyze trends in the propensity o...

Up to 95% of women who use other substances also smoke tobacco during pregnancy. Challenging psychosocial circumstances and other barriers that contribute to high levels of tobacco dependence result in few quitting successfully. This case report desc...

Background/Objectives: Gaucher disease (GD) is a lysosomal disorder caused by a deficiency of β-glucosidase. Disease-modifying therapies (DMTs) include enzyme replacement therapy (ERT) and substrate reduction therapy (SRT). Glucosylsphingosine (...

As global environmental consciousness continues to expand, the issue of refrigerant alternatives has increasingly become a focal point for scholarly attention. Using CiteSpace visualization technology, a comprehensive and innovative research framewor...

In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold standards in the preclinical assessment of anticancer drug efficacy. 3D in v...

Blast furnace ferronickel slag (BFFS) is generated in the production of ferronickel alloys and is used as cement replacement in concrete or mortar. The effectivity in reducing cement consumption and improving performance are limited. By referring to...

Diversified strategies to incorporate healthier lipids in processed meat products are being developed. Alternative fat sources to replace animal fat associated with the reduction of fat content are some of the methods used to obtain healthier meat pr...

In-network caching is the essential part of Content-Centric Networking (CCN). The main aim of a CCN caching module is data distribution within the network. Each CCN node can cache content according to its placement policy. Therefore, it is fully equi...

Higher salt intake is associated with the risk of cardiovascular and kidney diseases, hypertension and gastric cancer. Salt intake reduction represents an effective way to improve people’s health, either by the right choice of food or by a reduction...

Distal humeral fractures are challenging injuries seen in the elderly. Open reduction and internal fixation (ORIF) are the gold standard treatments. Total elbow arthroplasty (TEA) is an alternative to ORIF. This study aimed to pool and analyze the ou...

Ordinary Portland cement (OPC) is currently the preferred material for the creation of barriers in wells during their construction and abandonment globally. OPC, however, is a very carbon-intensive material with some inherent technical weaknesses. Th...

In the present study, a drinking amount of 10 L of milk replacer (MR) was allowed to dairy calves in order to approach the natural drinking behavior. The question is: how much protein is required by calves in order to achieve an intended growth rate?...

Chocolate-flavored milk contributes to excessive intake of added sugars among children and adolescents, which why it is a good candidate product for sucrose replacement. This study investigates how replacing sucrose partially or completely with diffe...

Gaucher disease is an inherited disorder in which there is a deficiency of the enzyme glucocerebrosidase, which leads to the accumulation of glucosylceramide. Although much scientific evidence is now available, there is still limited data on the impa...

For the quantification of insulin activity, United States Pharmacopeia (USP) general chapter <121> continues to require the rabbit blood sugar test. For new insulin or insulin analogue compounds, those quantitative data are expected for stabili...

Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease. Experimentation in animal models is essential to un...