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36 Results Found

  • Article
  • Open Access
2 Citations
2,344 Views
10 Pages

6 May 2021

It was the aim of this study to histometrically evaluate guided tissue regeneration (bioresorbable membrane plus bone mineral) (GTR) with or without platelet-derived growth factor (PDGF) in two different types of class III furcation defects (small ke...

  • Feature Paper
  • Article
  • Open Access
21 Citations
7,426 Views
12 Pages

Evaluation of Osteoconduction of Biphasic Calcium Phosphate Ceramic in the Calvaria of Rats: Microscopic and Histometric Analysis

  • Igor de Oliveira Puttini,
  • Pier Paolo Poli,
  • Carlo Maiorana,
  • Igor Rodrigues de Vasconcelos,
  • Luis Eduardo Schmidt,
  • Luara Teixeira Colombo,
  • Henrique Hadad,
  • Gabriel Mulinari dos Santos,
  • Paulo Sergio Perri de Carvalho and
  • Francisley Ávila Souza

(1) Background: Evaluate the osteoconduction capability of a biphasic calcium phosphate (BCP) ceramic composed of hydroxyapatite and β-tricalcium phosphate 60%/40% in a rat model. (2) Methods: In the calvarial bone of 54 adult male rats, 7-mm di...

  • Article
  • Open Access
3 Citations
3,641 Views
14 Pages

8 April 2020

Fish frequently serve as bioindicators of aquatic environments during their ecological evaluation. Carpathian barbel (Barbus carpathicus, Cyprinidae) is a species common to rivers and lakes of Eurasia and Africa. Seasons of the year can influence its...

  • Article
  • Open Access
30 Citations
10,417 Views
12 Pages

Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model

  • Sergio Alexandre Gehrke,
  • Tiago Luis Eliers Treichel,
  • Letícia Pérez-Díaz,
  • Jose Luis Calvo-Guirado,
  • Jaime Aramburú Júnior,
  • Patricia Mazón and
  • Piedad N. de Aza

Threads of dental implants with healing chamber configurations have become a target to improve osseointegration. This biomechanical and histometric study aimed to evaluate the influence of implant healing chamber configurations on the torque removal...

  • Article
  • Open Access
2 Citations
2,190 Views
15 Pages

Influence of Section Thickness on the Accuracy and Specificity of Histometric Parameters Using Confocal Laser Scanning Microscopy in a Canine Model of Experimental Peri-Implantitis—A Proof of Concept

  • Lucia-Camelia Boldeanu,
  • Aurel Popa-Wagner,
  • Marius Boariu,
  • Stefan-Ioan Stratul,
  • Darian Rusu,
  • Octavia Vela,
  • Alexandra Roman,
  • Petra Surlin,
  • Georgios Kardaras and
  • Adrian Vaduva
  • + 1 author

23 March 2023

Objectives: Tissue breakdown was assessed by confocal laser scanning microscopy (CLSM) using autofluorescence around implants with ligatures, on a dog hemimandible. Influence of section thickness on the accuracy of histometrical observations was also...

  • Article
  • Open Access
15 Citations
3,982 Views
13 Pages

Polydioxanone Membrane Compared with Collagen Membrane for Bone Regeneration

  • Lilian Caldas Quirino,
  • Pedro Henrique de Azambuja Carvalho,
  • Renato Torres Augusto Neto,
  • Cássio Amaro Comachio,
  • Naara Gabriela Monteiro,
  • Ana Cláudia Ervolino-Silva,
  • Roberta Okamoto and
  • Valfrido Antonio Pereira-Filho

9 February 2023

Guided bone regeneration (GBR) is an approach that induces osteopromotion through the regenerative membranes. These barriers exhibit bioactive behavior and mechanical function. Polydioxanone is a synthetic option, already used in medicine and dentist...

  • Article
  • Open Access
1 Citations
3,459 Views
15 Pages

Differences in Soft Tissue Wound Healing between Immediate and Delayed Implant Placement: An Experimental Preclinical In Vivo Investigation

  • Rafael Pla,
  • Javier Sanz-Esporrin,
  • David Palombo,
  • Fabio Vignoletti,
  • Fernando Luengo and
  • Mariano Sanz

20 September 2024

The dynamics of tissue wound healing associated with dental implants placed in fresh extraction sockets or in healed alveolar ridges are not fully understood. Therefore, the aim of this preclinical in vivo investigation was to evaluate soft tissue he...

  • Article
  • Open Access
14 Citations
4,462 Views
16 Pages

3D-Printed Soft Membrane for Periodontal Guided Tissue Regeneration

  • Farshid Vahdatinia,
  • Amirarsalan Hooshyarfard,
  • Shokoofeh Jamshidi,
  • Setareh Shojaei,
  • Kishan Patel,
  • Erfan Moeinifard,
  • Rasool Haddadi,
  • Maryam Farhadian,
  • Leila Gholami and
  • Lobat Tayebi

6 February 2023

Objectives: The current study aimed to perform an in vivo examination using a critical-size periodontal canine model to investigate the capability of a 3D-printed soft membrane for guided tissue regeneration (GTR). This membrane is made of a specific...

  • Article
  • Open Access
48 Citations
6,695 Views
14 Pages

Dietary Mannan Oligosaccharides Modulate Gut Inflammatory Response and Improve Duodenal Villi Height in Post-Weaning Piglets Improving Feed Efficiency

  • Alessandro Agazzi,
  • Vera Perricone,
  • Fabio Omodei Zorini,
  • Silvia Sandrini,
  • Elena Mariani,
  • Xian-Ren Jiang,
  • Alessandra Ferrari,
  • Maurizio Crestani,
  • Thi Xuan Nguyen and
  • Giovanni Savoini
  • + 2 authors

28 July 2020

The aim of this study was to evaluate the effects of mannan oligosaccharides (MOS) on gut health and performance in post-weaning piglets. In total, 40 piglets were divided into two experimental groups and fed a basal diet with (TRT) or without (CON)...

  • Article
  • Open Access
2,532 Views
7 Pages

Which Histometric Analysis Approach Is More Reliable for Assessing Histological Bone Tissue Samples?

  • Rodrigo dos Santos Pereira,
  • Carlos Fernando Mourão,
  • Adriano Piattelli,
  • Georgios E. Romanos,
  • Bruno Coelho Mendes,
  • Flavio Giubilato,
  • Pietro Montemezzi,
  • Jadson Júnior Conforte,
  • Geraldo Luiz Griza and
  • Eduardo Hochuli-Vieira
  • + 1 author

28 September 2022

This study aims to evaluate the grid of Merz and ImageJ methods for histometric quantification, verifying which is more reliable and defining which is most suitable based on the time required to perform. Thirty histological samples of maxillary sinus...

  • Article
  • Open Access
25 Citations
2,934 Views
15 Pages

Comparison between Plasma Electrolytic Oxidation Coating and Sandblasted Acid-Etched Surface Treatment: Histometric, Tomographic, and Expression Levels of Osteoclastogenic Factors in Osteoporotic Rats

  • Gustavo Antonio Correia Momesso,
  • Anderson Maikon de Souza Santos,
  • João Matheus Fonseca e Santos,
  • Nilson Cristino da Cruz,
  • Roberta Okamoto,
  • Valentim Adelino Ricardo Barão,
  • Rafael Shinoske Siroma,
  • Jamil Awad Shibli and
  • Leonardo Perez Faverani

1 April 2020

Plasma electrolytic oxidation (PEO) has been a promising surface coating with better mechanical and antimicrobial parameters comparing to conventional treatment surfaces. This study evaluated the peri-implant bone repair using (PEO) surface coatings...

  • Article
  • Open Access
5 Citations
4,544 Views
9 Pages

19 June 2020

Recent studies have focused on achieving sound osseointegration applying methods of surface reprocessing of dental implants using ultraviolet (UV) irradiation. However, there have been few reports on the effect of UV irradiation on osseointegration i...

  • Article
  • Open Access
32 Citations
8,903 Views
19 Pages

1 September 2017

Bacterial cellulose (BC) is a natural polysaccharide produced by some bacteria, and consists of a linear polymer linked by β-(1,4) glycosidic bonds. BC has been developed as a material for tissue regeneration purposes. This study was conducted to eva...

  • Article
  • Open Access
4 Citations
2,122 Views
18 Pages

Combination of a Synthetic Bioceramic Associated with a Polydioxanone-Based Membrane as an Alternative to Autogenous Bone Grafting

  • Paula Buzo Frigério,
  • Juliana de Moura,
  • Letícia Pitol-Palin,
  • Naara Gabriela Monteiro,
  • Carlos Fernando Mourão,
  • Jamil Awad Shibli and
  • Roberta Okamoto

The purpose of this study was to evaluate the repair process in rat calvaria filled with synthetic biphasic bioceramics (Plenum® Osshp-70:30, HA:βTCP) or autogenous bone, covered with a polydioxanone membrane (PDO). A total of 48 rats were d...

  • Article
  • Open Access
12 Citations
2,855 Views
16 Pages

Calvaria Critical Size Defects Regeneration Using Collagen Membranes to Assess the Osteopromotive Principle: An Animal Study

  • Vinícius Ferreira Bizelli,
  • Edith Umasi Ramos,
  • Allice Santos Cruz Veras,
  • Giovana Rampazzo Teixeira,
  • Leonardo P. Faverani and
  • Ana Paula Farnezi Bassi

Guided bone regeneration (GBR) is a common practice in implantology, and it is necessary to use membranes in this process. The present study aimed to evaluate the osteopromotive principle of two porcine collagen membranes in critical-size defects at...

  • Article
  • Open Access
70 Citations
13,195 Views
17 Pages

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

  • Jin-Hyung Shim,
  • Joo-Yun Won,
  • Su-Jin Sung,
  • Dong-Hyuk Lim,
  • Won-Soo Yun,
  • Young-Chan Jeon and
  • Jung-Bo Huh

21 October 2015

This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to...

  • Article
  • Open Access
64 Citations
7,133 Views
19 Pages

Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration

  • Sung-Jun An,
  • So-Hyoun Lee,
  • Jung-Bo Huh,
  • Sung In Jeong,
  • Jong-Seok Park,
  • Hui-Jeong Gwon,
  • Eun-Sook Kang,
  • Chang-Mo Jeong and
  • Youn-Mook Lim

25 October 2017

Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron...

  • Article
  • Open Access
14 Citations
7,091 Views
11 Pages

Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement

  • Luis Eduardo Schmidt,
  • Henrique Hadad,
  • Igor Rodrigues de Vasconcelos,
  • Luara Teixeira Colombo,
  • Rodrigo Capalbo da Silva,
  • Ana Flavia Piquera Santos,
  • Lara Cristina Cunha Cervantes,
  • Pier Paolo Poli,
  • Fabrizio Signorino and
  • Francisley Ávila Souza
  • + 2 authors

(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in...

  • Article
  • Open Access
10 Citations
3,636 Views
16 Pages

Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles

  • Luis Carlos de Almeida Pires,
  • Rodrigo Capalbo da Silva,
  • Pier Paolo Poli,
  • Fernando Ruas Esgalha,
  • Henrique Hadad,
  • Letícia Pitol Palin,
  • Ana Flávia Piquera Santos,
  • Luara Teixiera Colombo,
  • Laís Kawamata de Jesus and
  • Francisley Ávila Souza
  • + 4 authors

31 October 2020

(1) Background: This study aimed to evaluate the incorporation of hydroxyapatite/β-tricalcium phosphate blocks grafted in rabbit mandibles. (2) Methods: Topographic characterization of biomaterial was performed through scanning electron microsco...

  • Article
  • Open Access
1 Citations
2,867 Views
19 Pages

Effect of Using Prickly Pear Seed Cake (Opuntia ficus indica L.) on Growth Performance, Digestibility, Physiological and Histometric Parameters in Rabbits

  • Nadia Benali,
  • Rafik Belabbas,
  • Mounira Sais,
  • Hacina AinBaziz,
  • Baya Djellout,
  • Fatima Nouara Ettouahria,
  • Nadira Oulebsir,
  • Gabriele Brecchia,
  • Alda Quattrone and
  • Laura Menchetti
  • + 1 author

17 October 2024

Prickly pear (Opuntia ficus indica L.) could be used in rabbit nutrition in compliance with circular economy principles, global warming issues, and reduction of production costs. This study aims to evaluate the effects of dietary incorporation of pri...

  • Article
  • Open Access
9 Citations
2,317 Views
13 Pages

Photobiomodulation and Inorganic Bovine Bone in Guided Bone Regeneration: Histomorphometric Analysis in Rats

  • Nicole Rosa de Freitas,
  • Luísa Belluco Guerrini,
  • Luis Augusto Esper,
  • Michyele Cristhiane Sbrana,
  • Caroline Chepernate Vieira dos Santos and
  • Ana Lúcia Pompéia Fraga de Almeida

The objective of this study was to evaluate the efficacy of photobiomodulation in the bone regeneration of critical-sized defects (CSD) filled with inorganic bovine bone associated or not with collagen membranes. The study has been conducted on 40 cr...

  • Article
  • Open Access
21 Citations
4,431 Views
12 Pages

Bone Regeneration Assessment of Polycaprolactone Membrane on Critical-Size Defects in Rat Calvaria

  • Ana Paula Farnezi Bassi,
  • Vinícius Ferreira Bizelli,
  • Tamires Mello Francatti,
  • Ana Carulina Rezende de Moares Ferreira,
  • Járede Carvalho Pereira,
  • Hesham Mohammed Al-Sharani,
  • Flavia de Almeida Lucas and
  • Leonardo Perez Faverani

9 February 2021

Biomaterials for use in guided bone regeneration (GBR) are constantly being investigated and developed to improve clinical outcomes. The present study aimed to comparatively evaluate the biological performance of different membranes during the bone h...

  • Article
  • Open Access
10 Citations
4,409 Views
18 Pages

Performance of Polydioxanone-Based Membrane in Association with 3D-Printed Bioceramic Scaffolds in Bone Regeneration

  • Letícia Pitol-Palin,
  • Paula Buzo Frigério,
  • Juliana Moura,
  • Livia Pilatti,
  • Letícia Marques Jordão de Oliveira,
  • Elaine Yoshiko Matsubara,
  • Samy Tunchel,
  • Jamil Awad Shibli,
  • Alberto Blay and
  • Roberta Okamoto
  • + 1 author

21 December 2022

This study evaluated the bioactivity of 3D-printed β-tricalcium phosphate (β-TCP) scaffolds or hydroxyapatite (HA) scaffolds associated with polydioxanone (PDO) membrane (Plenum® Guide) for guided bone regeneration in rats. Fifty-four r...

  • Article
  • Open Access
2 Citations
2,828 Views
13 Pages

The Effects of Atmospheric Pressure Argon Plasma Treated Bovine Bone Substitute on Bone Regeneration

  • Jong-Ju Ahn,
  • Ji-Hyun Yoo,
  • Eun-Bin Bae,
  • Gyoo-Cheon Kim,
  • Jae Joon Hwang,
  • Wan-Sun Lee,
  • Hyung-Joon Kim and
  • Jung-Bo Huh

25 November 2019

This study was undertaken to compare new bone formation between non-expired and expired bovine-derived xenogeneic bone substitute (expired, out-of-use period) and to evaluate the efficacy of argon (Ar)-based atmospheric pressure plasma (APP) treatmen...

  • Article
  • Open Access
31 Citations
7,078 Views
11 Pages

Influences of Fucoxanthin on Alveolar Bone Resorption in Induced Periodontitis in Rat Molars

  • Oguz Kose,
  • Taner Arabaci,
  • Hatice Yemenoglu,
  • Adem Kara,
  • Seckin Ozkanlar,
  • Sevki Kayis and
  • Zeynep Yesil Duymus

30 March 2016

The aim of this study was to evaluate the effects of systemic fucoxanthin treatment on alveolar bone resorption in rats with periodontitis. Thirty rats were divided into control, experimental periodontitis (EP), and experimental periodontitis-fucoxan...

  • Article
  • Open Access
3 Citations
2,260 Views
15 Pages

Collagen Membranes Functionalized with 150 Cycles of Atomic Layer Deposited Titania Improve Osteopromotive Property in Critical-Size Defects Created on Rat Calvaria

  • Leonardo P. Faverani,
  • Sarah Hashemi Astaneh,
  • Monique Gonçalves da Costa,
  • Leonardo A. Delanora,
  • Tiburtino J. Lima-Neto,
  • Stéfany Barbosa,
  • Maretaningtias Dwi Ariani,
  • Christos Takoudis and
  • Cortino Sukotjo

23 February 2023

The membranes used in bone reconstructions have been the object of investigation in the field of tissue engineering, seeking to improve their mechanical strength and add other properties, mainly the osteopromotive. This study aimed to evaluate the fu...

  • Article
  • Open Access
26 Citations
7,631 Views
13 Pages

Effects of β-Glucans Ingestion on Alveolar Bone Loss, Intestinal Morphology, Systemic Inflammatory Profile, and Pancreatic β-Cell Function in Rats with Periodontitis and Diabetes

  • Viviam De O. Silva,
  • Raquel V. Lobato,
  • Eric F. Andrade,
  • Débora R. Orlando,
  • Bruno D.B. Borges,
  • Márcio G. Zangeronimo,
  • Raimundo V. De Sousa and
  • Luciano J. Pereira

14 September 2017

This study aimed to evaluate the effects of β-glucan ingestion (Saccharomyces cerevisiae) on the plasmatic levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10), alveolar bone loss, and pancreatic β-cell function (HOMA-BF) in diabetic...

  • Article
  • Open Access
5 Citations
2,308 Views
17 Pages

Enhanced Bladder Regeneration with Adipose-Derived Stem Cell-Seeded Silk Fibroin Scaffolds: A Comparative Analysis

  • Hanan Hendawy,
  • Ahmed Farag,
  • Asmaa Elhaieg,
  • Elsayed Metwllay,
  • Kazumi Shimada,
  • Ahmed Elfadadny and
  • Ryou Tanaka

Effective bladder reconstruction remains a significant challenge in urology, particularly for conditions requiring partial or complete bladder replacement. In this study, the efficacy is evaluated of two types of scaffolds, silk fibroin (SF) and adip...

  • Article
  • Open Access
4 Citations
3,461 Views
20 Pages

Evaluation of Two Configurations of Hydroxyapatite and Beta-Tricalcium Phosphate in Sinus Grafts with Simultaneous Implant Installation: An Experimental Study in Rabbits

  • Ricardo Garcia Mureb Jacob,
  • Ana Cláudia Ervolino da Silva,
  • Liat Chaushu,
  • Niklaus Peter Lang,
  • Ciro Borges Duailibe de Deus,
  • Daniele Botticelli and
  • Idelmo Rangel Garcia Júnior

4 May 2023

Background: This study aimed to evaluate peri-implant bone formation in rabbits after sinus grafting mediated by hydroxyapatite and beta-tricalcium phosphate (HA + β-TCP) in granule or paste configurations, concomitant with immediate implant ins...

  • Article
  • Open Access
26 Citations
4,020 Views
15 Pages

Is the Bacterial Cellulose Membrane Feasible for Osteopromotive Property?

  • Ana Paula Farnezi Bassi,
  • Vinícius Ferreira Bizelli,
  • Leticia Freitas de Mendes Brasil,
  • Járede Carvalho Pereira,
  • Hesham Mohammed Al-Sharani,
  • Gustavo Antonio Correa Momesso,
  • Leonardo P. Faverani and
  • Flavia de Almeida Lucas

12 September 2020

Guided bone regeneration was studied to establish protocols and develop new biomaterials that revealed satisfactory results. The present study aimed to comparatively evaluate the efficiency of the bacterial cellulose membrane (Nanoskin®) and coll...

  • Article
  • Open Access
21 Citations
6,731 Views
18 Pages

Effects of Immobilizations of rhBMP-2 and/or rhPDGF-BB on Titanium Implant Surfaces on Osseointegration and Bone Regeneration

  • So-Hyoun Lee,
  • Eun-Bin Bae,
  • Sung-Eun Kim,
  • Young-Pil Yun,
  • Hak-Jun Kim,
  • Jae-Won Choi,
  • Jin-Ju Lee and
  • Jung-Bo Huh

31 December 2017

The aim of this study was to examine the effects of immobilizing rhPDGF-BB plus rhBMP-2 on heparinized-Ti implants on in vivo osseointegration and vertical bone regeneration at alveolar ridges. Successful immobilizations of rhPDGF-BB and/or rhBMP-2 o...

  • Article
  • Open Access
5 Citations
2,215 Views
20 Pages

Bimetallic Gold–Iron Oxide Nanoparticles as Carriers of Methotrexate: Perspective Tools for Biomedical Applications

  • Tsvetelina Batsalova,
  • Alexander Vasil’kov,
  • Dzhemal Moten,
  • Anastasiia Voronova,
  • Ivanka Teneva,
  • Alexander Naumkin and
  • Balik Dzhambazov

1 December 2023

Bimetallic nanoparticles (BMNPs) combine unique and synergistic properties of two metals, allowing new specific applications. In this study, bimetallic AuFe nanoparticles and their conjugates with methotrexate (MTX) were obtained with an environmenta...

  • Article
  • Open Access
34 Citations
6,294 Views
15 Pages

Benefits of Residual Aluminum Oxide for Sand Blasting Titanium Dental Implants: Osseointegration and Bactericidal Effects

  • Javier Gil,
  • Román Pérez,
  • Mariano Herrero-Climent,
  • Maria Rizo-Gorrita,
  • Daniel Torres-Lagares and
  • Jose Luis Gutierrez

27 December 2021

Objectives. The purpose of this work was to determine the influence of residual alumina after sand blasting treatment in titanium dental implants. This paper studied the effect of alumina on physico-chemical surface properties, such as: surface wetta...

  • Article
  • Open Access
5 Citations
2,299 Views
14 Pages

Contribution to Bone Formation of the Schneiderian Membrane after Sinus Augmentation: A Histological Study in Rabbits

  • Su Tien Lim,
  • Kaoru Kusano,
  • Tomohide Taniyama,
  • Shigeru Sakuma,
  • Yasushi Nakajima,
  • Samuel Porfirio Xavier and
  • Shunsuke Baba

15 November 2022

Aim: to evaluate bone formation in close contact with the sinus mucosa after different periods from sinus augmentation and the influence on healing of the presence of an inward dis-placed bone window. Material and Methods: Eighteen rabbits were inclu...

  • Article
  • Open Access
2 Citations
1,940 Views
24 Pages

Brazilian Green Propolis Carried in Lipid-Based Nanostructures: A Potent Adjuvant Therapy to Non-Surgical Periodontal Treatment in the Management of Experimental Periodontitis

  • Glauco Rodrigues Carmo Silveira,
  • Vinícius Franzão Ganzaroli,
  • Luan Felipe Toro,
  • Leandro Lemes da Costa,
  • Rodrigo Isaias Lopes Pereira,
  • André Bueno da Silva,
  • Iasmin Rosane Silva Ferreira,
  • João Martins de Mello-Neto,
  • Valdir Gouveia Garcia and
  • Edilson Ervolino
  • + 2 authors

Objective: This study aimed to evaluate the effects of local use of Brazilian Green Propolis (BGP), either as an ethanolic extract (the most common formulation) or incorporated into lipid-based nanostructures, as an adjuvant therapy for non-surgical...

  • Article
  • Open Access
286 Views
23 Pages

Effectiveness and Safety of Mechanical Debridement for Treating Experimental Peri-Implantitis in Elderly Rats Receiving Oncological Dosages of Zoledronate

  • Luan Felipe Toro,
  • Eduardo Quintão Manhanini Souza,
  • Vinícius Franzão Ganzaroli,
  • Jéssica de Oliveira Alvarenga Freire,
  • Leandro Lemes da Costa,
  • Estevão Lopes Pereira,
  • Beatriz Alexandrelli Machado,
  • João Martins de Mello-Neto,
  • Mariza Akemi Matsumoto and
  • Edilson Ervolino
  • + 4 authors

29 January 2026

This study evaluated the effectiveness and safety of mechanical debridement (MD) in treating experimental peri-implantitis (EPI) in rats with osseointegrated implants, specifically those treated with high-dose zoledronate. Senescent Wistar rats under...