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Article

Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles

1
Implant Dentistry Post-Graduation Program, São Leopoldo Mandic School of Dentistry and Research Center, Campinas, SP 13 045 755, São Paulo, Brazil
2
Department of Diagnosis and Surgery, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba, SP 16 015 050, São Paulo, Brazil
3
Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCSS Cà Granda Ospedale Maggiore Policlinico, University of Milan, 20122 Milan, Italy
4
Department of Basic Science, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba, SP 16 015 050, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Materials 2020, 13(21), 4902; https://doi.org/10.3390/ma13214902
Received: 16 September 2020 / Revised: 21 October 2020 / Accepted: 29 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering 2020)
(1) Background: This study aimed to evaluate the incorporation of hydroxyapatite/β-tricalcium phosphate blocks grafted in rabbit mandibles. (2) Methods: Topographic characterization of biomaterial was performed through scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (SEM-EDX). Ten rabbits randomly received autogenous bone graft harvested from the tibia (Autogenous Group—AG) or synthetic biomaterial manufactured in β-tricalcium phosphate (Biomaterial Group—BG) at their right and left mandibular angles. Euthanasia was performed at 30 and 60 postoperative days; (3) Results: SEM-EDX showed a surface with the formation of crystals clusters. Histological analyses in BG at 30 days showed a slower process of incorporation than AG. At 60 days, BG showed remnants of biomaterial enveloped by bone tissue in the anabolic modeling phase. Histometric analysis showed that mean values of newly formed bone-like tissue in the AG (6.56%/9.70%) were statistically higher compared to BG (3.14%/6.43%) in both periods, respectively. Immunohistochemical analysis demonstrated early bone formation and maturation in the AG with more intense osteopontin and osteocalcin staining. (4) Conclusions: The biomaterial proved to be a possible bone substitute, being incorporated into the receiving bed; however, it showed delayed bone incorporation compared to autogenous bone. View Full-Text
Keywords: biocompatibility; biomaterials; bone augmentation; bone conduction; bone grafting; calcium hydroxyapatite; tissue regeneration biocompatibility; biomaterials; bone augmentation; bone conduction; bone grafting; calcium hydroxyapatite; tissue regeneration
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MDPI and ACS Style

Pires, L.C.d.A.; da Silva, R.C.; Poli, P.P.; Ruas Esgalha, F.; Hadad, H.; Palin, L.P.; Piquera Santos, A.F.; Teixiera Colombo, L.; Kawamata de Jesus, L.; Bassi, A.P.F.; Maiorana, C.; Okamoto, R.; de Carvalho, P.S.P.; Souza, F.Á. Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles. Materials 2020, 13, 4902. https://doi.org/10.3390/ma13214902

AMA Style

Pires LCdA, da Silva RC, Poli PP, Ruas Esgalha F, Hadad H, Palin LP, Piquera Santos AF, Teixiera Colombo L, Kawamata de Jesus L, Bassi APF, Maiorana C, Okamoto R, de Carvalho PSP, Souza FÁ. Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles. Materials. 2020; 13(21):4902. https://doi.org/10.3390/ma13214902

Chicago/Turabian Style

Pires, Luis Carlos de Almeida, Rodrigo Capalbo da Silva, Pier Paolo Poli, Fernando Ruas Esgalha, Henrique Hadad, Letícia Pitol Palin, Ana Flávia Piquera Santos, Luara Teixiera Colombo, Laís Kawamata de Jesus, Ana Paula Farnezi Bassi, Carlo Maiorana, Roberta Okamoto, Paulo Sérgio Perri de Carvalho, and Francisley Ávila Souza. 2020. "Evaluation of Osteoconduction of a Synthetic Hydroxyapatite/β-Tricalcium Phosphate Block Fixed in Rabbit Mandibles" Materials 13, no. 21: 4902. https://doi.org/10.3390/ma13214902

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