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Strontium and Zinc Substitution in β-Tricalcium Phosphate: An X-ray Diffraction, Solid State NMR and ATR-FTIR Study

Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement

Implant Dentistry Post-Graduation Program, São Leopoldo Mandic School of Dentistry and Research Center, Campinas 13.045-755, Brazil
Department of Surgery and Integrated Clinic, Araçatuba Dental of School, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba, São Paulo 16.015.050, Brazil
Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCSS Cà Granda Maggiore Policlinico Hospital, University of Milan, 47.031 Milan, Italy
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(2), 21;
Received: 27 March 2019 / Revised: 29 April 2019 / Accepted: 7 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Functionalized Biomimetic Calcium Phosphates)
(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities. View Full-Text
Keywords: calcium phosphate cement; biomaterial; bone healing calcium phosphate cement; biomaterial; bone healing
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MDPI and ACS Style

Schmidt, L.E.; Hadad, H.; Vasconcelos, I.R.d.; Colombo, L.T.; da Silva, R.C.; Santos, A.F.P.; Cervantes, L.C.C.; Poli, P.P.; Signorino, F.; Maiorana, C.; Carvalho, P.S.P.d.; Souza, F.Á. Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement. J. Funct. Biomater. 2019, 10, 21.

AMA Style

Schmidt LE, Hadad H, Vasconcelos IRd, Colombo LT, da Silva RC, Santos AFP, Cervantes LCC, Poli PP, Signorino F, Maiorana C, Carvalho PSPd, Souza FÁ. Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement. Journal of Functional Biomaterials. 2019; 10(2):21.

Chicago/Turabian Style

Schmidt, Luis Eduardo, Henrique Hadad, Igor Rodrigues de Vasconcelos, Luara Teixeira Colombo, Rodrigo Capalbo da Silva, Ana Flavia Piquera Santos, Lara Cristina Cunha Cervantes, Pier Paolo Poli, Fabrizio Signorino, Carlo Maiorana, Paulo Sérgio Perri de Carvalho, and Francisley Ávila Souza. 2019. "Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement" Journal of Functional Biomaterials 10, no. 2: 21.

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