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Strontium and Zinc Substitution in β-Tricalcium Phosphate: An X-ray Diffraction, Solid State NMR and ATR-FTIR Study
Open AccessArticle

Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement

1
Implant Dentistry Post-Graduation Program, São Leopoldo Mandic School of Dentistry and Research Center, Campinas 13.045-755, Brazil
2
Department of Surgery and Integrated Clinic, Araçatuba Dental of School, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba, São Paulo 16.015.050, Brazil
3
Implant Center for Edentulism and Jawbone Atrophies, Maxillofacial Surgery and Odontostomatology Unit, Fondazione IRCSS Cà Granda Maggiore Policlinico Hospital, University of Milan, 47.031 Milan, Italy
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(2), 21; https://doi.org/10.3390/jfb10020021
Received: 27 March 2019 / Revised: 29 April 2019 / Accepted: 7 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Functionalized Biomimetic Calcium Phosphates)
(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities. View Full-Text
Keywords: calcium phosphate cement; biomaterial; bone healing calcium phosphate cement; biomaterial; bone healing
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Schmidt, L.E.; Hadad, H.; Vasconcelos, I.R.; Colombo, L.T.; da Silva, R.C.; Santos, A.F.P.; Cervantes, L.C.C.; Poli, P.P.; Signorino, F.; Maiorana, C.; Carvalho, P.S.P.; Souza, F.Á. Critical Defect Healing Assessment in Rat Calvaria Filled with Injectable Calcium Phosphate Cement. J. Funct. Biomater. 2019, 10, 21.

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