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Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model

Department of Research, Biotecnos CP 11100-Montevideo, Uruguay
Instituto de Bioingenieria, Universidad Miguel Hernández, Avda. Ferrocarril s/n, 03202 Elche (Alicante), Spain
Department of Anatomy, Faculty of Veterinary, Universidade de Rio Verde, 104, Rio Verde-GO 75901-970, Brazil
Laboratorio de Interacciones Molecular, Facultad de Ciencias, Universidad de la Republica, Calle Iguá 4225, 11400 Montevideo, Uruguay
Department of Oral and Implant Surgery, Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain
Departamento de Materiales, Óptica y Tecnologia Electrónica, Universidad Miguel Hernández, Avda. Universidad s/n, 03202 Elche (Alicante), Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2019, 8(6), 777;
Received: 14 April 2019 / Revised: 15 May 2019 / Accepted: 17 May 2019 / Published: 31 May 2019
(This article belongs to the Special Issue Biomaterials and Implants in Development Osteointegration)
PDF [19739 KB, uploaded 31 May 2019]


Threads of dental implants with healing chamber configurations have become a target to improve osseointegration. This biomechanical and histometric study aimed to evaluate the influence of implant healing chamber configurations on the torque removal value (RTv), percentage of bone-to-implant contact (BIC%), bone fraction occupancy inside the thread area (BAFO%), and bone and osteocyte density (Ost) in the rabbit tibia after two months of healing. Titanium implants with three different thread configurations were evaluated: Group 1 (G1), with a conventional “v” thread-shaped implant design; Group 2 (G2), with square threads; and Group 3 (G3), the experimental group with longer threads (healing chamber). Ten rabbits (4.5 ± 0.5 kg) received three implants in each tibia (one per group), distributed in a randomized manner. After a period of two months, the tibia blocks (implants and the surrounding tissue) were removed and processed for ground sectioning to evaluate BIC%, BAFO%, and osteocyte density. The ANOVA one-way statistical test was used followed by the Bonferoni’s multiple comparison test to determine individual difference among groups, considering a statistical difference when p < 0.05. Histometric evaluation showed a higher BAFO% values and Ost density for G3 in comparison with the other two groups (G1 and G2), with p < 0.05. However, the RTv and BIC% parameters were not significantly different between groups (p > 0.05). The histological data suggest that the healing chambers in the implant macrogeometry can improve the bone reaction in comparison with the conventional thread design. View Full-Text
Keywords: animal study; dental implants; implant design; healing chamber; thread design animal study; dental implants; implant design; healing chamber; thread design

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Gehrke, S.A.; Eliers Treichel, T.L.; Pérez-Díaz, L.; Calvo-Guirado, J.L.; Aramburú Júnior, J.; Mazón, P.; de Aza, P.N. Impact of Different Titanium Implant Thread Designs on Bone Healing: A Biomechanical and Histometric Study with an Animal Model. J. Clin. Med. 2019, 8, 777.

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